Incidental Mutation 'IGL00324:Cdk12'
ID 4507
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk12
Ensembl Gene ENSMUSG00000003119
Gene Name cyclin dependent kinase 12
Synonyms Crkrs, Crk7, D11Ertd752e, 1810022J16Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL00324
Quality Score
Status
Chromosome 11
Chromosomal Location 98093885-98169330 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 98136214 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 1156 (L1156Q)
Ref Sequence ENSEMBL: ENSMUSP00000103163 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003203] [ENSMUST00000107538] [ENSMUST00000107539]
AlphaFold Q14AX6
Predicted Effect unknown
Transcript: ENSMUST00000003203
AA Change: L1156Q
SMART Domains Protein: ENSMUSP00000003203
Gene: ENSMUSG00000003119
AA Change: L1156Q

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
low complexity region 40 51 N/A INTRINSIC
low complexity region 74 92 N/A INTRINSIC
low complexity region 103 123 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
low complexity region 166 177 N/A INTRINSIC
low complexity region 214 227 N/A INTRINSIC
low complexity region 286 384 N/A INTRINSIC
low complexity region 511 568 N/A INTRINSIC
low complexity region 623 633 N/A INTRINSIC
low complexity region 666 684 N/A INTRINSIC
S_TKc 723 1016 1.49e-95 SMART
Predicted Effect unknown
Transcript: ENSMUST00000107538
AA Change: L1156Q
SMART Domains Protein: ENSMUSP00000103162
Gene: ENSMUSG00000003119
AA Change: L1156Q

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
low complexity region 40 51 N/A INTRINSIC
low complexity region 74 92 N/A INTRINSIC
low complexity region 103 123 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
low complexity region 166 177 N/A INTRINSIC
low complexity region 214 227 N/A INTRINSIC
low complexity region 286 384 N/A INTRINSIC
low complexity region 511 568 N/A INTRINSIC
low complexity region 623 633 N/A INTRINSIC
low complexity region 666 684 N/A INTRINSIC
S_TKc 723 1016 1.49e-95 SMART
low complexity region 1252 1276 N/A INTRINSIC
low complexity region 1467 1483 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000107539
AA Change: L1156Q
SMART Domains Protein: ENSMUSP00000103163
Gene: ENSMUSG00000003119
AA Change: L1156Q

DomainStartEndE-ValueType
low complexity region 8 32 N/A INTRINSIC
low complexity region 40 51 N/A INTRINSIC
low complexity region 74 92 N/A INTRINSIC
low complexity region 103 123 N/A INTRINSIC
low complexity region 124 135 N/A INTRINSIC
low complexity region 166 177 N/A INTRINSIC
low complexity region 214 227 N/A INTRINSIC
low complexity region 286 384 N/A INTRINSIC
low complexity region 511 568 N/A INTRINSIC
low complexity region 623 633 N/A INTRINSIC
low complexity region 666 684 N/A INTRINSIC
S_TKc 723 1016 1.49e-95 SMART
low complexity region 1253 1267 N/A INTRINSIC
low complexity region 1458 1474 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147441
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality between implantation and E6.5 with decreased proliferation and increased apoptosis in the inner cell mass. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd3 T C 3: 121,570,642 (GRCm39) probably benign Het
Ctsl T C 13: 64,515,982 (GRCm39) Y66C probably damaging Het
Esd C T 14: 74,973,467 (GRCm39) H21Y probably damaging Het
Fcrlb A C 1: 170,736,393 (GRCm39) Y128D possibly damaging Het
Gm17027 A T 14: 41,981,267 (GRCm39) N196K unknown Het
Gm4553 T C 7: 141,718,964 (GRCm39) S155G unknown Het
Hpcal1 A G 12: 17,841,146 (GRCm39) S175G probably benign Het
Itgam A T 7: 127,684,833 (GRCm39) D401V probably damaging Het
Kank1 A G 19: 25,389,122 (GRCm39) T932A probably benign Het
Lmod1 A G 1: 135,292,216 (GRCm39) K357R probably benign Het
Muc4 A G 16: 32,599,186 (GRCm39) I3271V probably benign Het
Nlrc5 A G 8: 95,248,107 (GRCm39) K1692E probably damaging Het
Ocln A G 13: 100,671,521 (GRCm39) W279R probably damaging Het
Or4p20 T C 2: 88,254,130 (GRCm39) I80V probably benign Het
Pcsk1 A G 13: 75,280,206 (GRCm39) K677R probably benign Het
Pitrm1 T A 13: 6,618,702 (GRCm39) L586Q probably damaging Het
Plppr3 G A 10: 79,702,503 (GRCm39) S217L probably damaging Het
Pnldc1 A T 17: 13,124,645 (GRCm39) probably benign Het
Pramel12 T A 4: 143,143,237 (GRCm39) M1K probably null Het
Pramel13 A G 4: 144,121,310 (GRCm39) L238P possibly damaging Het
Sema6b C T 17: 56,437,048 (GRCm39) D204N probably damaging Het
Slc12a5 A G 2: 164,839,041 (GRCm39) N1063S probably damaging Het
Tg T C 15: 66,565,273 (GRCm39) V1205A probably benign Het
Tmem260 T C 14: 48,724,336 (GRCm39) F205L probably benign Het
Trappc11 A T 8: 47,956,337 (GRCm39) probably benign Het
Tsen34 A G 7: 3,703,530 (GRCm39) *296W probably null Het
Ubr2 A G 17: 47,296,986 (GRCm39) probably benign Het
Vmn2r23 T A 6: 123,706,684 (GRCm39) W505R possibly damaging Het
Wbp11 A G 6: 136,798,668 (GRCm39) probably benign Het
Znfx1 A T 2: 166,878,649 (GRCm39) M1909K possibly damaging Het
Other mutations in Cdk12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00718:Cdk12 APN 11 98,140,502 (GRCm39) intron probably benign
IGL00850:Cdk12 APN 11 98,113,491 (GRCm39) missense unknown
IGL01299:Cdk12 APN 11 98,101,272 (GRCm39) missense unknown
IGL01443:Cdk12 APN 11 98,136,295 (GRCm39) missense unknown
IGL01597:Cdk12 APN 11 98,141,090 (GRCm39) unclassified probably benign
capsized UTSW 11 98,132,611 (GRCm39) missense unknown
Listing UTSW 11 98,115,293 (GRCm39) nonsense probably null
Torpedoed UTSW 11 98,111,928 (GRCm39) missense unknown
R0124:Cdk12 UTSW 11 98,102,073 (GRCm39) splice site probably benign
R0157:Cdk12 UTSW 11 98,140,602 (GRCm39) unclassified probably benign
R0190:Cdk12 UTSW 11 98,132,657 (GRCm39) critical splice donor site probably null
R0230:Cdk12 UTSW 11 98,094,817 (GRCm39) missense probably damaging 1.00
R0467:Cdk12 UTSW 11 98,094,405 (GRCm39) missense probably damaging 0.99
R0577:Cdk12 UTSW 11 98,094,332 (GRCm39) missense probably damaging 0.99
R0671:Cdk12 UTSW 11 98,120,935 (GRCm39) splice site probably benign
R0834:Cdk12 UTSW 11 98,095,211 (GRCm39) missense probably benign 0.23
R1129:Cdk12 UTSW 11 98,136,201 (GRCm39) missense unknown
R1337:Cdk12 UTSW 11 98,136,497 (GRCm39) critical splice donor site probably null
R1344:Cdk12 UTSW 11 98,132,611 (GRCm39) missense unknown
R1418:Cdk12 UTSW 11 98,132,611 (GRCm39) missense unknown
R1729:Cdk12 UTSW 11 98,140,796 (GRCm39) unclassified probably benign
R1756:Cdk12 UTSW 11 98,132,587 (GRCm39) nonsense probably null
R1784:Cdk12 UTSW 11 98,140,796 (GRCm39) unclassified probably benign
R1807:Cdk12 UTSW 11 98,101,203 (GRCm39) missense unknown
R1956:Cdk12 UTSW 11 98,110,042 (GRCm39) missense probably benign 0.23
R1966:Cdk12 UTSW 11 98,094,916 (GRCm39) nonsense probably null
R2202:Cdk12 UTSW 11 98,101,464 (GRCm39) missense unknown
R2422:Cdk12 UTSW 11 98,109,900 (GRCm39) missense probably benign 0.23
R2570:Cdk12 UTSW 11 98,094,618 (GRCm39) missense possibly damaging 0.94
R4574:Cdk12 UTSW 11 98,111,814 (GRCm39) intron probably benign
R4614:Cdk12 UTSW 11 98,140,603 (GRCm39) unclassified probably benign
R4882:Cdk12 UTSW 11 98,101,272 (GRCm39) missense unknown
R4921:Cdk12 UTSW 11 98,113,513 (GRCm39) missense unknown
R5151:Cdk12 UTSW 11 98,140,749 (GRCm39) unclassified probably benign
R5252:Cdk12 UTSW 11 98,134,335 (GRCm39) missense unknown
R5348:Cdk12 UTSW 11 98,095,118 (GRCm39) missense probably benign 0.23
R5620:Cdk12 UTSW 11 98,101,809 (GRCm39) missense unknown
R5779:Cdk12 UTSW 11 98,109,900 (GRCm39) missense probably benign 0.23
R6085:Cdk12 UTSW 11 98,134,255 (GRCm39) missense unknown
R6293:Cdk12 UTSW 11 98,115,379 (GRCm39) missense unknown
R6371:Cdk12 UTSW 11 98,136,114 (GRCm39) missense unknown
R6438:Cdk12 UTSW 11 98,115,293 (GRCm39) nonsense probably null
R6765:Cdk12 UTSW 11 98,115,355 (GRCm39) missense unknown
R6958:Cdk12 UTSW 11 98,132,525 (GRCm39) missense unknown
R7205:Cdk12 UTSW 11 98,115,451 (GRCm39) missense unknown
R7307:Cdk12 UTSW 11 98,140,626 (GRCm39) nonsense probably null
R7361:Cdk12 UTSW 11 98,101,294 (GRCm39) nonsense probably null
R7365:Cdk12 UTSW 11 98,111,910 (GRCm39) missense unknown
R7447:Cdk12 UTSW 11 98,136,106 (GRCm39) missense unknown
R7514:Cdk12 UTSW 11 98,113,484 (GRCm39) missense unknown
R7831:Cdk12 UTSW 11 98,140,653 (GRCm39) missense unknown
R7877:Cdk12 UTSW 11 98,131,661 (GRCm39) missense unknown
R7975:Cdk12 UTSW 11 98,111,928 (GRCm39) missense unknown
R8507:Cdk12 UTSW 11 98,141,111 (GRCm39) missense unknown
R8558:Cdk12 UTSW 11 98,101,915 (GRCm39) missense unknown
R8693:Cdk12 UTSW 11 98,141,133 (GRCm39) missense unknown
R9250:Cdk12 UTSW 11 98,101,398 (GRCm39) missense probably benign 0.23
R9517:Cdk12 UTSW 11 98,109,910 (GRCm39) missense unknown
R9562:Cdk12 UTSW 11 98,140,628 (GRCm39) missense unknown
R9565:Cdk12 UTSW 11 98,140,628 (GRCm39) missense unknown
R9792:Cdk12 UTSW 11 98,102,051 (GRCm39) missense unknown
R9793:Cdk12 UTSW 11 98,102,051 (GRCm39) missense unknown
R9795:Cdk12 UTSW 11 98,102,051 (GRCm39) missense unknown
Z1176:Cdk12 UTSW 11 98,094,767 (GRCm39) nonsense probably null
Posted On 2012-04-20