Incidental Mutation 'R5715:Vmn2r103'
| ID |
451143 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r103
|
| Ensembl Gene |
ENSMUSG00000091771 |
| Gene Name |
vomeronasal 2, receptor 103 |
| Synonyms |
EG627636 |
| MMRRC Submission |
043336-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.059)
|
| Stock # |
R5715 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
19773363-19812536 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 19794939 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 447
(D447V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
| AlphaFold |
E9PWW0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: D447V
PolyPhen 2
Score 0.175 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: D447V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931423N10Rik |
T |
C |
2: 23,207,977 (GRCm38) |
Y56H |
possibly damaging |
Het |
| 9930111J21Rik2 |
T |
A |
11: 49,019,950 (GRCm38) |
Y552F |
probably damaging |
Het |
| Asprv1 |
T |
A |
6: 86,628,614 (GRCm38) |
D147E |
probably benign |
Het |
| Atg4c |
G |
T |
4: 99,258,402 (GRCm38) |
L405F |
probably damaging |
Het |
| Birc6 |
C |
T |
17: 74,631,620 (GRCm38) |
L2670F |
probably damaging |
Het |
| Cdc20 |
T |
C |
4: 118,434,818 (GRCm38) |
D379G |
probably damaging |
Het |
| Chd6 |
T |
C |
2: 160,949,878 (GRCm38) |
M2520V |
probably benign |
Het |
| Clca4b |
A |
G |
3: 144,913,257 (GRCm38) |
V707A |
probably benign |
Het |
| Cmtm1 |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT |
8: 104,309,470 (GRCm38) |
|
probably benign |
Het |
| Col12a1 |
A |
T |
9: 79,616,065 (GRCm38) |
C2743* |
probably null |
Het |
| Coq6 |
C |
A |
12: 84,366,907 (GRCm38) |
D70E |
probably benign |
Het |
| Cspg4 |
T |
A |
9: 56,891,051 (GRCm38) |
V1450D |
possibly damaging |
Het |
| Dnah7a |
A |
G |
1: 53,413,778 (GRCm38) |
L3847P |
probably damaging |
Het |
| Drd2 |
T |
A |
9: 49,404,889 (GRCm38) |
H316Q |
probably benign |
Het |
| Dusp19 |
T |
A |
2: 80,630,986 (GRCm38) |
N206K |
probably benign |
Het |
| Fam13c |
T |
G |
10: 70,534,840 (GRCm38) |
F270C |
probably damaging |
Het |
| Fam20a |
T |
C |
11: 109,678,431 (GRCm38) |
E246G |
probably damaging |
Het |
| Fbxo31 |
A |
G |
8: 121,578,563 (GRCm38) |
F65L |
probably damaging |
Het |
| Fshr |
T |
A |
17: 88,986,396 (GRCm38) |
|
probably null |
Het |
| Fstl4 |
T |
C |
11: 53,000,416 (GRCm38) |
V127A |
possibly damaging |
Het |
| Gdpd4 |
A |
T |
7: 97,961,597 (GRCm38) |
I75F |
probably benign |
Het |
| Gm13128 |
A |
G |
4: 144,331,300 (GRCm38) |
D159G |
possibly damaging |
Het |
| Grm5 |
C |
A |
7: 88,130,256 (GRCm38) |
A968E |
probably benign |
Het |
| Gucy2g |
A |
C |
19: 55,233,155 (GRCm38) |
F305V |
possibly damaging |
Het |
| Hivep3 |
T |
C |
4: 120,096,373 (GRCm38) |
F629L |
probably benign |
Het |
| Hoxb1 |
A |
G |
11: 96,366,326 (GRCm38) |
E167G |
probably benign |
Het |
| Hoxd4 |
T |
C |
2: 74,727,364 (GRCm38) |
L29P |
probably damaging |
Het |
| Ikbkb |
A |
G |
8: 22,678,850 (GRCm38) |
L211P |
probably damaging |
Het |
| Insc |
T |
C |
7: 114,849,841 (GRCm38) |
V499A |
probably benign |
Het |
| Irak3 |
A |
T |
10: 120,142,736 (GRCm38) |
H511Q |
possibly damaging |
Het |
| Itpripl1 |
T |
C |
2: 127,142,007 (GRCm38) |
E65G |
probably damaging |
Het |
| Lurap1l |
T |
A |
4: 80,953,721 (GRCm38) |
S150R |
possibly damaging |
Het |
| Mab21l3 |
C |
T |
3: 101,823,407 (GRCm38) |
R172Q |
probably benign |
Het |
| Macf1 |
T |
C |
4: 123,684,014 (GRCm38) |
D59G |
probably damaging |
Het |
| Mettl21a |
A |
T |
1: 64,615,155 (GRCm38) |
S68T |
probably benign |
Het |
| Mlxip |
T |
A |
5: 123,440,058 (GRCm38) |
W146R |
probably damaging |
Het |
| Mpp2 |
T |
A |
11: 102,062,261 (GRCm38) |
N285I |
probably damaging |
Het |
| Mrgprb4 |
T |
C |
7: 48,199,039 (GRCm38) |
N47S |
probably damaging |
Het |
| Msi2 |
A |
G |
11: 88,386,063 (GRCm38) |
Y237H |
probably damaging |
Het |
| Muc4 |
C |
T |
16: 32,751,916 (GRCm38) |
T598I |
possibly damaging |
Het |
| Musk |
A |
T |
4: 58,333,663 (GRCm38) |
I253F |
probably damaging |
Het |
| Myo5b |
G |
T |
18: 74,742,175 (GRCm38) |
C1550F |
possibly damaging |
Het |
| Nckap5l |
T |
C |
15: 99,423,576 (GRCm38) |
T1137A |
probably benign |
Het |
| Neb |
T |
C |
2: 52,251,768 (GRCm38) |
D3009G |
probably damaging |
Het |
| Nxph1 |
T |
A |
6: 9,247,740 (GRCm38) |
V237E |
probably damaging |
Het |
| Olfr622 |
A |
C |
7: 103,639,802 (GRCm38) |
S113A |
probably damaging |
Het |
| Pla2g12a |
A |
G |
3: 129,894,942 (GRCm38) |
K150E |
probably damaging |
Het |
| Ptpn23 |
G |
A |
9: 110,387,075 (GRCm38) |
R1238W |
probably damaging |
Het |
| Pts |
C |
T |
9: 50,522,278 (GRCm38) |
G124R |
probably damaging |
Het |
| Rfk |
A |
T |
19: 17,398,638 (GRCm38) |
I99F |
probably benign |
Het |
| Rictor |
A |
T |
15: 6,750,716 (GRCm38) |
R151* |
probably null |
Het |
| Scn2a |
T |
A |
2: 65,717,584 (GRCm38) |
I1040N |
probably benign |
Het |
| Serinc5 |
A |
C |
13: 92,706,202 (GRCm38) |
T387P |
probably damaging |
Het |
| Sh3bp5l |
A |
G |
11: 58,346,015 (GRCm38) |
Q266R |
possibly damaging |
Het |
| Slc14a2 |
T |
C |
18: 78,158,336 (GRCm38) |
Y656C |
probably damaging |
Het |
| Slc26a3 |
T |
A |
12: 31,448,843 (GRCm38) |
|
probably null |
Het |
| Slc3a2 |
G |
T |
19: 8,708,230 (GRCm38) |
H168Q |
probably benign |
Het |
| Smarca2 |
A |
T |
19: 26,649,122 (GRCm38) |
I449L |
probably benign |
Het |
| Smarcc1 |
T |
C |
9: 110,196,367 (GRCm38) |
V704A |
possibly damaging |
Het |
| Sox13 |
A |
G |
1: 133,386,183 (GRCm38) |
|
probably null |
Het |
| Sptbn5 |
T |
C |
2: 120,072,504 (GRCm38) |
E7G |
probably damaging |
Het |
| Stard10 |
A |
G |
7: 101,321,903 (GRCm38) |
D26G |
probably damaging |
Het |
| Tap1 |
A |
T |
17: 34,192,894 (GRCm38) |
R91* |
probably null |
Het |
| Tgfbrap1 |
A |
T |
1: 43,059,937 (GRCm38) |
V239D |
possibly damaging |
Het |
| Tmem209 |
A |
T |
6: 30,497,923 (GRCm38) |
Y124* |
probably null |
Het |
| Tmprss2 |
T |
A |
16: 97,568,983 (GRCm38) |
E327V |
possibly damaging |
Het |
| Ttbk1 |
T |
C |
17: 46,479,207 (GRCm38) |
Y104C |
probably damaging |
Het |
| Ttll10 |
A |
T |
4: 156,045,391 (GRCm38) |
F154I |
probably damaging |
Het |
| Ubn2 |
T |
A |
6: 38,461,477 (GRCm38) |
Y40* |
probably null |
Het |
| Ubr5 |
A |
T |
15: 38,002,233 (GRCm38) |
S1519T |
probably benign |
Het |
| Ugt3a1 |
A |
C |
15: 9,306,344 (GRCm38) |
D193A |
probably damaging |
Het |
| Upf1 |
A |
T |
8: 70,352,978 (GRCm38) |
Y6N |
probably damaging |
Het |
| Vps39 |
T |
C |
2: 120,325,236 (GRCm38) |
N519S |
possibly damaging |
Het |
| Zfp109 |
T |
C |
7: 24,229,570 (GRCm38) |
E138G |
possibly damaging |
Het |
| Znrf3 |
A |
C |
11: 5,286,239 (GRCm38) |
V157G |
possibly damaging |
Het |
|
| Other mutations in Vmn2r103 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00333:Vmn2r103
|
APN |
17 |
19,793,102 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00939:Vmn2r103
|
APN |
17 |
19,794,965 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01120:Vmn2r103
|
APN |
17 |
19,792,997 (GRCm38) |
missense |
probably benign |
0.06 |
|
IGL01403:Vmn2r103
|
APN |
17 |
19,792,967 (GRCm38) |
missense |
probably benign |
|
|
IGL01404:Vmn2r103
|
APN |
17 |
19,812,434 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01713:Vmn2r103
|
APN |
17 |
19,794,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01802:Vmn2r103
|
APN |
17 |
19,799,208 (GRCm38) |
missense |
probably benign |
|
|
IGL02251:Vmn2r103
|
APN |
17 |
19,793,969 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
IGL02466:Vmn2r103
|
APN |
17 |
19,773,369 (GRCm38) |
missense |
probably benign |
|
|
IGL02555:Vmn2r103
|
APN |
17 |
19,811,611 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02668:Vmn2r103
|
APN |
17 |
19,794,127 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02715:Vmn2r103
|
APN |
17 |
19,793,956 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02735:Vmn2r103
|
APN |
17 |
19,812,248 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL03101:Vmn2r103
|
APN |
17 |
19,773,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0003:Vmn2r103
|
UTSW |
17 |
19,811,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0052:Vmn2r103
|
UTSW |
17 |
19,811,641 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,793,464 (GRCm38) |
missense |
probably benign |
0.12 |
|
R0375:Vmn2r103
|
UTSW |
17 |
19,792,859 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0755:Vmn2r103
|
UTSW |
17 |
19,773,568 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0837:Vmn2r103
|
UTSW |
17 |
19,793,927 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1345:Vmn2r103
|
UTSW |
17 |
19,794,247 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Vmn2r103
|
UTSW |
17 |
19,792,968 (GRCm38) |
missense |
probably benign |
|
|
R1488:Vmn2r103
|
UTSW |
17 |
19,793,660 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1533:Vmn2r103
|
UTSW |
17 |
19,773,400 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1590:Vmn2r103
|
UTSW |
17 |
19,794,234 (GRCm38) |
missense |
probably benign |
|
|
R1928:Vmn2r103
|
UTSW |
17 |
19,811,767 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1942:Vmn2r103
|
UTSW |
17 |
19,812,300 (GRCm38) |
missense |
probably benign |
0.02 |
|
R2071:Vmn2r103
|
UTSW |
17 |
19,793,794 (GRCm38) |
missense |
probably benign |
|
|
R2219:Vmn2r103
|
UTSW |
17 |
19,793,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2442:Vmn2r103
|
UTSW |
17 |
19,773,531 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2889:Vmn2r103
|
UTSW |
17 |
19,793,600 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r103
|
UTSW |
17 |
19,812,149 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4014:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R4331:Vmn2r103
|
UTSW |
17 |
19,794,233 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4630:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4631:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4632:Vmn2r103
|
UTSW |
17 |
19,793,696 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4660:Vmn2r103
|
UTSW |
17 |
19,811,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4802:Vmn2r103
|
UTSW |
17 |
19,795,076 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4931:Vmn2r103
|
UTSW |
17 |
19,811,769 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4995:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R5309:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5312:Vmn2r103
|
UTSW |
17 |
19,793,034 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5329:Vmn2r103
|
UTSW |
17 |
19,812,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5611:Vmn2r103
|
UTSW |
17 |
19,793,642 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5684:Vmn2r103
|
UTSW |
17 |
19,792,989 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5907:Vmn2r103
|
UTSW |
17 |
19,812,453 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6029:Vmn2r103
|
UTSW |
17 |
19,794,216 (GRCm38) |
nonsense |
probably null |
|
|
R6114:Vmn2r103
|
UTSW |
17 |
19,812,325 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6285:Vmn2r103
|
UTSW |
17 |
19,812,144 (GRCm38) |
missense |
probably benign |
|
|
R6292:Vmn2r103
|
UTSW |
17 |
19,793,604 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R6334:Vmn2r103
|
UTSW |
17 |
19,794,082 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R6501:Vmn2r103
|
UTSW |
17 |
19,811,904 (GRCm38) |
missense |
probably benign |
0.29 |
|
R6710:Vmn2r103
|
UTSW |
17 |
19,811,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6774:Vmn2r103
|
UTSW |
17 |
19,773,511 (GRCm38) |
missense |
probably benign |
0.14 |
|
R6981:Vmn2r103
|
UTSW |
17 |
19,793,477 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7768:Vmn2r103
|
UTSW |
17 |
19,812,052 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7816:Vmn2r103
|
UTSW |
17 |
19,794,214 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7885:Vmn2r103
|
UTSW |
17 |
19,793,123 (GRCm38) |
missense |
probably benign |
0.25 |
|
R8002:Vmn2r103
|
UTSW |
17 |
19,799,249 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8031:Vmn2r103
|
UTSW |
17 |
19,793,497 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8140:Vmn2r103
|
UTSW |
17 |
19,811,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8186:Vmn2r103
|
UTSW |
17 |
19,811,943 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8559:Vmn2r103
|
UTSW |
17 |
19,812,384 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9413:Vmn2r103
|
UTSW |
17 |
19,811,896 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R9591:Vmn2r103
|
UTSW |
17 |
19,811,659 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9652:Vmn2r103
|
UTSW |
17 |
19,793,765 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9680:Vmn2r103
|
UTSW |
17 |
19,799,263 (GRCm38) |
nonsense |
probably null |
|
|
R9743:Vmn2r103
|
UTSW |
17 |
19,812,213 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r103
|
UTSW |
17 |
19,795,047 (GRCm38) |
missense |
probably benign |
0.08 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAATGAGTCTTGCTAGGCTTC -3'
(R):5'- CCACCTCTGAAAATATTTCTGGCC -3'
Sequencing Primer
(F):5'- CTTGCTAGGCTTCAAAAAGTTGG -3'
(R):5'- GGCCATTGTATCATCTGTTCAG -3'
|
| Posted On |
2017-01-03 |
Incidental Mutation