Incidental Mutation 'R5717:Or8s5'
ID 451238
Institutional Source Beutler Lab
Gene Symbol Or8s5
Ensembl Gene ENSMUSG00000051793
Gene Name olfactory receptor family 8 subfamily S member 5
Synonyms Olfr284, MOR160-4, GA_x6K02T2NBG7-5395976-5396893
MMRRC Submission 043337-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R5717 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 98237903-98238820 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 98238246 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 208 (A208V)
Ref Sequence ENSEMBL: ENSMUSP00000145864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063289] [ENSMUST00000206647]
AlphaFold A0A0U1RP76
Predicted Effect probably benign
Transcript: ENSMUST00000063289
AA Change: A192V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000065626
Gene: ENSMUSG00000051793
AA Change: A192V

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 5.3e-54 PFAM
Pfam:7TM_GPCR_Srsx 33 259 1.3e-5 PFAM
Pfam:7tm_1 39 286 5e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206647
AA Change: A208V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 98% (48/49)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933411K16Rik A T 19: 42,041,484 (GRCm39) H205L probably benign Het
Acss2 T C 2: 155,403,073 (GRCm39) L617S probably damaging Het
Adgrl4 T C 3: 151,197,971 (GRCm39) V77A probably benign Het
Adnp2 A G 18: 80,171,479 (GRCm39) S977P probably benign Het
Ankrd11 T C 8: 123,619,377 (GRCm39) K1492E possibly damaging Het
B4galt5 G A 2: 167,148,549 (GRCm39) R190C probably damaging Het
Bbs1 A G 19: 4,947,354 (GRCm39) V355A possibly damaging Het
Cenpj GTTTT GTTTTT 14: 56,790,978 (GRCm39) probably null Het
Ckap2 T C 8: 22,665,063 (GRCm39) E467G probably damaging Het
Cry1 A T 10: 84,982,280 (GRCm39) H355Q probably damaging Het
Cspg4 G T 9: 56,793,082 (GRCm39) M272I probably benign Het
Dicer1 T A 12: 104,671,387 (GRCm39) Y961F probably damaging Het
Epha2 A T 4: 141,049,382 (GRCm39) M689L probably benign Het
Foxc1 C T 13: 31,991,471 (GRCm39) A94V probably benign Het
Fras1 T C 5: 96,929,596 (GRCm39) V4000A possibly damaging Het
Frmd8 G T 19: 5,923,396 (GRCm39) probably benign Het
Gm5218 A G 15: 81,383,478 (GRCm39) noncoding transcript Het
Gm7735 T C 16: 88,966,430 (GRCm39) L18P unknown Het
Hr C T 14: 70,803,616 (GRCm39) T808I probably benign Het
Hyal6 T C 6: 24,743,690 (GRCm39) M462T probably benign Het
Igkv6-20 T A 6: 70,313,412 (GRCm39) probably benign Het
Igkv8-27 T A 6: 70,148,918 (GRCm39) T59S probably benign Het
Itga11 A G 9: 62,659,531 (GRCm39) T428A probably benign Het
Klk1b16 A G 7: 43,788,913 (GRCm39) I49V probably benign Het
Matn2 G T 15: 34,399,237 (GRCm39) E375* probably null Het
Msgn1 T C 12: 11,258,519 (GRCm39) Y144C probably damaging Het
Myh1 A G 11: 67,099,782 (GRCm39) N564S probably benign Het
Mypn A G 10: 62,963,555 (GRCm39) V972A probably damaging Het
Or4c29 T C 2: 88,740,366 (GRCm39) I124V possibly damaging Het
Or5an11 A G 19: 12,246,520 (GRCm39) K309E probably benign Het
Ppp2r5d A G 17: 46,998,820 (GRCm39) S81P probably damaging Het
Ptgis C T 2: 167,050,284 (GRCm39) probably benign Het
Ptprr A G 10: 115,884,018 (GRCm39) N25S probably benign Het
Rnf123 G A 9: 107,944,623 (GRCm39) T456I probably damaging Het
Rpl6l T C 10: 110,961,884 (GRCm39) noncoding transcript Het
Rps25 A G 9: 44,320,047 (GRCm39) Y23C probably benign Het
Sec24a A G 11: 51,598,037 (GRCm39) V879A probably benign Het
Sema6a G A 18: 47,382,330 (GRCm39) A739V probably benign Het
Senp6 A T 9: 79,999,594 (GRCm39) I4F probably damaging Het
Slc49a4 A G 16: 35,539,799 (GRCm39) F341L probably benign Het
Stoml3 A T 3: 53,412,937 (GRCm39) Q197L probably damaging Het
Ttn T A 2: 76,578,091 (GRCm39) K24267N probably damaging Het
Vmn1r43 T C 6: 89,846,905 (GRCm39) S194G probably damaging Het
Vmn2r17 C T 5: 109,575,140 (GRCm39) T149I possibly damaging Het
Wdr72 T A 9: 74,055,487 (GRCm39) Y239N probably damaging Het
Zfp423 A T 8: 88,413,187 (GRCm39) probably null Het
Zfp759 T A 13: 67,286,772 (GRCm39) C114S probably damaging Het
Other mutations in Or8s5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Or8s5 APN 15 98,238,054 (GRCm39) missense possibly damaging 0.47
IGL02904:Or8s5 APN 15 98,238,729 (GRCm39) missense probably null 0.88
PIT4378001:Or8s5 UTSW 15 98,238,153 (GRCm39) missense possibly damaging 0.95
R0485:Or8s5 UTSW 15 98,238,810 (GRCm39) missense probably benign 0.01
R1435:Or8s5 UTSW 15 98,238,209 (GRCm39) missense possibly damaging 0.69
R4706:Or8s5 UTSW 15 98,238,659 (GRCm39) missense possibly damaging 0.62
R4707:Or8s5 UTSW 15 98,238,659 (GRCm39) missense possibly damaging 0.62
R5272:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5314:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5315:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5316:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5317:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5456:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5458:Or8s5 UTSW 15 98,238,246 (GRCm39) missense probably benign 0.00
R5548:Or8s5 UTSW 15 98,238,253 (GRCm39) missense probably benign 0.21
R5921:Or8s5 UTSW 15 98,238,310 (GRCm39) missense probably benign 0.10
R6519:Or8s5 UTSW 15 98,237,929 (GRCm39) missense probably benign 0.00
R6636:Or8s5 UTSW 15 98,238,831 (GRCm39) missense probably benign 0.23
R7112:Or8s5 UTSW 15 98,238,421 (GRCm39) missense possibly damaging 0.81
R7289:Or8s5 UTSW 15 98,237,943 (GRCm39) missense probably damaging 1.00
R7392:Or8s5 UTSW 15 98,238,192 (GRCm39) missense probably benign 0.03
R7403:Or8s5 UTSW 15 98,238,000 (GRCm39) missense probably damaging 1.00
R7633:Or8s5 UTSW 15 98,237,967 (GRCm39) missense probably damaging 1.00
R7724:Or8s5 UTSW 15 98,238,775 (GRCm39) missense possibly damaging 0.89
R9451:Or8s5 UTSW 15 98,238,144 (GRCm39) missense possibly damaging 0.61
R9707:Or8s5 UTSW 15 98,238,154 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CCTGAAGCCGGTAAGAGATAAC -3'
(R):5'- TCTACAGCCAGGTGATGAGTAG -3'

Sequencing Primer
(F):5'- CGGTAAGAGATAACTGATAAACCCCG -3'
(R):5'- CAGGTGATGAGTAGCCAGCTCTG -3'
Posted On 2017-01-03