Incidental Mutation 'R5732:Letm2'
ID 451494
Institutional Source Beutler Lab
Gene Symbol Letm2
Ensembl Gene ENSMUSG00000037363
Gene Name leucine zipper-EF-hand containing transmembrane protein 2
Synonyms D030041N04Rik
MMRRC Submission 043347-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R5732 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 26068506-26087598 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 26077341 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 250 (S250A)
Ref Sequence ENSEMBL: ENSMUSP00000148035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079160] [ENSMUST00000210616] [ENSMUST00000210810] [ENSMUST00000211422]
AlphaFold Q7TNU7
Predicted Effect probably benign
Transcript: ENSMUST00000079160
AA Change: S250A

PolyPhen 2 Score 0.149 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000078160
Gene: ENSMUSG00000037363
AA Change: S250A

DomainStartEndE-ValueType
low complexity region 106 117 N/A INTRINSIC
Pfam:LETM1 120 384 1.2e-102 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209539
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209982
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210221
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210321
Predicted Effect probably benign
Transcript: ENSMUST00000210616
Predicted Effect possibly damaging
Transcript: ENSMUST00000210810
AA Change: S250A

PolyPhen 2 Score 0.507 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect probably benign
Transcript: ENSMUST00000211422
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211001
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.8%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaa1b T A 9: 118,977,462 (GRCm39) M407L possibly damaging Het
Acsf2 T C 11: 94,460,768 (GRCm39) probably benign Het
Apob A G 12: 8,060,353 (GRCm39) D2945G probably benign Het
Atg2a T C 19: 6,307,490 (GRCm39) Y1475H probably damaging Het
Capn5 A G 7: 97,778,593 (GRCm39) L342P possibly damaging Het
Ccdc152 A G 15: 3,321,860 (GRCm39) probably null Het
Ccdc7b A G 8: 129,799,195 (GRCm39) M91V possibly damaging Het
Cd3g T C 9: 44,884,929 (GRCm39) E105G possibly damaging Het
Cdadc1 A G 14: 59,834,360 (GRCm39) L44P probably damaging Het
Cdh23 A G 10: 60,167,096 (GRCm39) V1852A possibly damaging Het
Cdx2 T C 5: 147,238,833 (GRCm39) Q252R possibly damaging Het
Cps1 A T 1: 67,196,923 (GRCm39) I325F probably benign Het
Dctn1 G A 6: 83,174,931 (GRCm39) probably null Het
Dcun1d3 T C 7: 119,457,256 (GRCm39) K152R probably benign Het
Dhx35 G A 2: 158,673,705 (GRCm39) V379M probably damaging Het
Fam171a2 T C 11: 102,330,807 (GRCm39) E224G possibly damaging Het
Flt1 G T 5: 147,571,293 (GRCm39) Y671* probably null Het
Fndc3b T C 3: 27,515,922 (GRCm39) Y628C probably damaging Het
Foxj3 A T 4: 119,443,008 (GRCm39) D144V probably damaging Het
Gp2 A G 7: 119,048,331 (GRCm39) V429A probably damaging Het
Hydin T A 8: 111,178,690 (GRCm39) I1095N probably benign Het
Kat2a A G 11: 100,599,066 (GRCm39) F571S probably damaging Het
Kcnq1 C A 7: 142,702,493 (GRCm39) probably benign Het
Llgl1 T C 11: 60,600,286 (GRCm39) V545A probably benign Het
Lrfn3 T C 7: 30,059,031 (GRCm39) D398G probably benign Het
Lrig1 G T 6: 94,676,520 (GRCm39) C49* probably null Het
Mug1 A G 6: 121,855,452 (GRCm39) I929V probably benign Het
Naaa G A 5: 92,411,314 (GRCm39) T291I probably damaging Het
Ndufaf1 G A 2: 119,490,521 (GRCm39) Q180* probably null Het
Nr3c1 A T 18: 39,548,752 (GRCm39) H741Q probably damaging Het
Nsun5 T C 5: 135,400,204 (GRCm39) L109P probably damaging Het
Pacsin3 A G 2: 91,090,605 (GRCm39) E18G probably damaging Het
Rpgr G A X: 10,032,511 (GRCm39) P857L probably benign Het
Siglec1 G A 2: 130,916,188 (GRCm39) T1254M probably benign Het
Slc35a4 A T 18: 36,815,394 (GRCm39) T75S probably benign Het
Slc52a2 T C 15: 76,425,274 (GRCm39) I434T probably benign Het
Slco2a1 C T 9: 102,927,455 (GRCm39) T116I probably damaging Het
Snrpd2 T C 7: 18,886,538 (GRCm39) probably null Het
Tbc1d32 T A 10: 55,964,489 (GRCm39) L903F probably damaging Het
Tex10 G T 4: 48,460,046 (GRCm39) T435K probably damaging Het
Tmem266 T C 9: 55,288,120 (GRCm39) S66P probably damaging Het
Top2b A T 14: 16,400,106 (GRCm38) E581D possibly damaging Het
Uggt1 A T 1: 36,200,852 (GRCm39) probably null Het
Wdr47 T A 3: 108,540,472 (GRCm39) Y622* probably null Het
Zfp644 A T 5: 106,784,989 (GRCm39) H519Q probably damaging Het
Zfp687 T C 3: 94,918,528 (GRCm39) M415V possibly damaging Het
Other mutations in Letm2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02738:Letm2 APN 8 26,076,789 (GRCm39) missense probably damaging 1.00
selbstlob UTSW 8 26,083,977 (GRCm39) missense probably benign 0.03
IGL03098:Letm2 UTSW 8 26,071,745 (GRCm39) missense possibly damaging 0.73
R0062:Letm2 UTSW 8 26,077,464 (GRCm39) splice site probably benign
R0062:Letm2 UTSW 8 26,077,464 (GRCm39) splice site probably benign
R0207:Letm2 UTSW 8 26,068,786 (GRCm39) missense probably damaging 0.96
R0485:Letm2 UTSW 8 26,082,574 (GRCm39) missense probably damaging 1.00
R1869:Letm2 UTSW 8 26,071,729 (GRCm39) missense probably damaging 0.98
R1870:Letm2 UTSW 8 26,086,460 (GRCm39) splice site probably benign
R1871:Letm2 UTSW 8 26,086,460 (GRCm39) splice site probably benign
R3881:Letm2 UTSW 8 26,083,884 (GRCm39) nonsense probably null
R4115:Letm2 UTSW 8 26,070,343 (GRCm39) nonsense probably null
R4459:Letm2 UTSW 8 26,076,715 (GRCm39) missense probably damaging 1.00
R4461:Letm2 UTSW 8 26,076,715 (GRCm39) missense probably damaging 1.00
R4961:Letm2 UTSW 8 26,084,108 (GRCm39) missense possibly damaging 0.86
R5063:Letm2 UTSW 8 26,071,795 (GRCm39) missense probably benign 0.26
R5069:Letm2 UTSW 8 26,083,980 (GRCm39) nonsense probably null
R6527:Letm2 UTSW 8 26,082,522 (GRCm39) utr 3 prime probably benign
R6706:Letm2 UTSW 8 26,083,977 (GRCm39) missense probably benign 0.03
R7624:Letm2 UTSW 8 26,082,553 (GRCm39) nonsense probably null
R7968:Letm2 UTSW 8 26,083,766 (GRCm39) missense probably damaging 1.00
R8272:Letm2 UTSW 8 26,076,672 (GRCm39) missense probably damaging 1.00
R8356:Letm2 UTSW 8 26,071,729 (GRCm39) missense probably damaging 0.98
R8456:Letm2 UTSW 8 26,071,729 (GRCm39) missense probably damaging 0.98
R8481:Letm2 UTSW 8 26,070,375 (GRCm39) missense possibly damaging 0.86
R9023:Letm2 UTSW 8 26,077,236 (GRCm39) missense
R9234:Letm2 UTSW 8 26,084,102 (GRCm39) missense probably benign 0.03
R9366:Letm2 UTSW 8 26,084,165 (GRCm39) missense probably damaging 1.00
R9636:Letm2 UTSW 8 26,083,719 (GRCm39) missense probably benign 0.33
R9690:Letm2 UTSW 8 26,077,435 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTGGGTTCAATGCCTAGTCC -3'
(R):5'- CGGGGATGAACCTTAGTGAG -3'

Sequencing Primer
(F):5'- GGGTTCAATGCCTAGTCCAAACC -3'
(R):5'- AGGAGGGAGTTATTTTTCTCAGTACC -3'
Posted On 2017-01-03