Incidental Mutation 'R5702:Cnot10'
ID 451751
Institutional Source Beutler Lab
Gene Symbol Cnot10
Ensembl Gene ENSMUSG00000056167
Gene Name CCR4-NOT transcription complex, subunit 10
Synonyms 2600001P13Rik
MMRRC Submission 043182-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5702 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 114414946-114469252 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 114458078 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Valine at position 143 (F143V)
Ref Sequence ENSEMBL: ENSMUSP00000148963 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070117] [ENSMUST00000213955] [ENSMUST00000215155] [ENSMUST00000216785] [ENSMUST00000217148]
AlphaFold Q8BH15
Predicted Effect probably benign
Transcript: ENSMUST00000070117
AA Change: F143V

PolyPhen 2 Score 0.046 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000064840
Gene: ENSMUSG00000056167
AA Change: F143V

DomainStartEndE-ValueType
Blast:TPR 27 60 2e-10 BLAST
coiled coil region 73 107 N/A INTRINSIC
TPR 110 143 4.32e1 SMART
low complexity region 182 198 N/A INTRINSIC
TPR 293 326 3.37e-2 SMART
TPR 355 388 6.75e1 SMART
low complexity region 496 508 N/A INTRINSIC
TPR 643 676 7.87e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213539
Predicted Effect probably benign
Transcript: ENSMUST00000213955
Predicted Effect possibly damaging
Transcript: ENSMUST00000215155
AA Change: F143V

PolyPhen 2 Score 0.662 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215701
Predicted Effect possibly damaging
Transcript: ENSMUST00000216785
AA Change: F143V

PolyPhen 2 Score 0.588 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect probably damaging
Transcript: ENSMUST00000217148
AA Change: F143V

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217296
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a G A 5: 8,787,752 (GRCm39) S1018N probably benign Het
Adat1 G T 8: 112,704,704 (GRCm39) T414K probably benign Het
Ahnak G T 19: 8,979,204 (GRCm39) V163L probably damaging Het
Atf6b T C 17: 34,869,978 (GRCm39) I288T possibly damaging Het
Blm A T 7: 80,108,675 (GRCm39) V1323E probably benign Het
Brap T A 5: 121,803,206 (GRCm39) L118Q probably damaging Het
C1qbp G A 11: 70,869,570 (GRCm39) T171I probably benign Het
Ccdc136 C A 6: 29,412,981 (GRCm39) H455Q probably damaging Het
Chd3 A T 11: 69,252,261 (GRCm39) V47D possibly damaging Het
Cnot8 T C 11: 58,004,873 (GRCm39) S191P possibly damaging Het
Coro2b G A 9: 62,333,859 (GRCm39) T345I probably damaging Het
Dennd1b T C 1: 139,061,413 (GRCm39) I365T probably damaging Het
Dnah11 C A 12: 118,077,642 (GRCm39) A1284S probably benign Het
Dock4 G A 12: 40,787,490 (GRCm39) D802N probably benign Het
Dsg1a T C 18: 20,469,922 (GRCm39) probably null Het
Elp3 C T 14: 65,815,431 (GRCm39) R187Q probably damaging Het
Ercc3 G A 18: 32,387,206 (GRCm39) R473Q probably damaging Het
F5 G A 1: 164,022,116 (GRCm39) W1530* probably null Het
Fmnl1 T C 11: 103,076,491 (GRCm39) I219T probably damaging Het
Gemin4 G A 11: 76,101,663 (GRCm39) R1033C probably benign Het
Gm2381 T A 7: 42,471,820 (GRCm39) I20F probably benign Het
Hmgcll1 A G 9: 75,991,672 (GRCm39) M129V possibly damaging Het
Ltbp3 G T 19: 5,797,849 (GRCm39) R496L probably benign Het
Mettl13 A G 1: 162,373,549 (GRCm39) V234A probably benign Het
Minar1 G A 9: 89,473,208 (GRCm39) A901V probably benign Het
Or1j4 A G 2: 36,740,946 (GRCm39) D296G probably damaging Het
Pde7a A T 3: 19,295,371 (GRCm39) C146* probably null Het
Pla2g4e T A 2: 120,018,992 (GRCm39) N202Y possibly damaging Het
Plk5 G A 10: 80,196,401 (GRCm39) probably null Het
Plscr1l1 G A 9: 92,225,741 (GRCm39) probably null Het
Ptpn7 A G 1: 135,061,582 (GRCm39) T15A probably benign Het
Rrn3 T A 16: 13,631,130 (GRCm39) Y655* probably null Het
Scarb2 C T 5: 92,599,255 (GRCm39) G355D probably damaging Het
Scd2 G A 19: 44,286,502 (GRCm39) A111T possibly damaging Het
Smim8 TTTAATGAAGAGCT TT 4: 34,771,261 (GRCm39) probably benign Het
Smurf1 T C 5: 144,838,021 (GRCm39) T57A possibly damaging Het
Spire2 C T 8: 124,073,402 (GRCm39) P94S probably benign Het
Tex2 T C 11: 106,435,221 (GRCm39) H237R possibly damaging Het
Vmn2r109 T C 17: 20,774,407 (GRCm39) D316G probably benign Het
Zfp830 T A 11: 82,655,800 (GRCm39) F201L possibly damaging Het
Zic1 A G 9: 91,246,133 (GRCm39) F313S probably damaging Het
Other mutations in Cnot10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01313:Cnot10 APN 9 114,460,923 (GRCm39) missense probably benign 0.19
IGL02004:Cnot10 APN 9 114,451,998 (GRCm39) missense probably damaging 1.00
IGL03297:Cnot10 APN 9 114,427,784 (GRCm39) missense possibly damaging 0.87
BB003:Cnot10 UTSW 9 114,446,883 (GRCm39) missense probably damaging 1.00
BB013:Cnot10 UTSW 9 114,446,883 (GRCm39) missense probably damaging 1.00
R0348:Cnot10 UTSW 9 114,427,838 (GRCm39) missense probably benign 0.10
R0390:Cnot10 UTSW 9 114,458,218 (GRCm39) nonsense probably null
R1256:Cnot10 UTSW 9 114,439,749 (GRCm39) missense probably damaging 1.00
R1471:Cnot10 UTSW 9 114,420,619 (GRCm39) missense probably benign 0.00
R1607:Cnot10 UTSW 9 114,458,163 (GRCm39) nonsense probably null
R1721:Cnot10 UTSW 9 114,444,067 (GRCm39) missense probably benign
R1741:Cnot10 UTSW 9 114,426,892 (GRCm39) missense possibly damaging 0.87
R2116:Cnot10 UTSW 9 114,455,504 (GRCm39) missense probably damaging 1.00
R4073:Cnot10 UTSW 9 114,452,015 (GRCm39) missense possibly damaging 0.91
R4074:Cnot10 UTSW 9 114,452,015 (GRCm39) missense possibly damaging 0.91
R4075:Cnot10 UTSW 9 114,452,015 (GRCm39) missense possibly damaging 0.91
R4365:Cnot10 UTSW 9 114,460,949 (GRCm39) nonsense probably null
R4383:Cnot10 UTSW 9 114,460,949 (GRCm39) nonsense probably null
R4385:Cnot10 UTSW 9 114,460,949 (GRCm39) nonsense probably null
R4398:Cnot10 UTSW 9 114,460,949 (GRCm39) nonsense probably null
R4423:Cnot10 UTSW 9 114,446,988 (GRCm39) missense probably damaging 1.00
R4859:Cnot10 UTSW 9 114,456,532 (GRCm39) missense probably damaging 1.00
R4916:Cnot10 UTSW 9 114,458,202 (GRCm39) missense possibly damaging 0.72
R4927:Cnot10 UTSW 9 114,447,012 (GRCm39) missense probably damaging 1.00
R5153:Cnot10 UTSW 9 114,442,803 (GRCm39) missense probably damaging 1.00
R5677:Cnot10 UTSW 9 114,458,161 (GRCm39) missense probably damaging 1.00
R5790:Cnot10 UTSW 9 114,454,985 (GRCm39) splice site probably null
R6190:Cnot10 UTSW 9 114,461,791 (GRCm39) missense probably damaging 1.00
R6353:Cnot10 UTSW 9 114,426,614 (GRCm39) missense probably damaging 1.00
R6463:Cnot10 UTSW 9 114,454,970 (GRCm39) missense probably damaging 1.00
R6819:Cnot10 UTSW 9 114,444,123 (GRCm39) missense probably benign 0.10
R6849:Cnot10 UTSW 9 114,461,004 (GRCm39) missense probably benign 0.01
R6875:Cnot10 UTSW 9 114,444,175 (GRCm39) missense probably benign 0.00
R7071:Cnot10 UTSW 9 114,446,787 (GRCm39) splice site probably null
R7408:Cnot10 UTSW 9 114,460,894 (GRCm39) missense probably benign 0.33
R7412:Cnot10 UTSW 9 114,454,971 (GRCm39) missense probably damaging 1.00
R7645:Cnot10 UTSW 9 114,442,705 (GRCm39) missense probably benign
R7706:Cnot10 UTSW 9 114,422,506 (GRCm39) missense probably damaging 0.98
R7926:Cnot10 UTSW 9 114,446,883 (GRCm39) missense probably damaging 1.00
R8187:Cnot10 UTSW 9 114,426,556 (GRCm39) nonsense probably null
R8322:Cnot10 UTSW 9 114,456,537 (GRCm39) missense probably damaging 0.99
R8412:Cnot10 UTSW 9 114,439,738 (GRCm39) missense probably benign 0.11
R8904:Cnot10 UTSW 9 114,430,423 (GRCm39) missense probably benign 0.06
R9340:Cnot10 UTSW 9 114,460,897 (GRCm39) missense probably benign 0.01
R9691:Cnot10 UTSW 9 114,420,715 (GRCm39) missense probably damaging 1.00
X0062:Cnot10 UTSW 9 114,444,202 (GRCm39) splice site probably null
Predicted Primers PCR Primer
(F):5'- CTATGTGTGTACAAAGGTGTGC -3'
(R):5'- CATTCTGCCCGGATTGTTTCAG -3'

Sequencing Primer
(F):5'- CATCAGATCTTGTCAGAGTGAGC -3'
(R):5'- AGGTCCACTCGGCTGTTGAAG -3'
Posted On 2017-01-03