Incidental Mutation 'R5703:Wars1'
ID 451807
Institutional Source Beutler Lab
Gene Symbol Wars1
Ensembl Gene ENSMUSG00000021266
Gene Name tryptophanyl-tRNA synthetase1
Synonyms Wars
MMRRC Submission 043183-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5703 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 108825956-108860095 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 108841047 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 244 (Y244N)
Ref Sequence ENSEMBL: ENSMUSP00000125320 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000109848] [ENSMUST00000160477] [ENSMUST00000161154] [ENSMUST00000161410] [ENSMUST00000162748]
AlphaFold P32921
Predicted Effect probably damaging
Transcript: ENSMUST00000109848
AA Change: Y244N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105474
Gene: ENSMUSG00000021266
AA Change: Y244N

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000160477
Predicted Effect probably damaging
Transcript: ENSMUST00000161154
AA Change: Y244N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124625
Gene: ENSMUSG00000021266
AA Change: Y244N

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 446 1.4e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000161410
AA Change: Y244N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000125320
Gene: ENSMUSG00000021266
AA Change: Y244N

DomainStartEndE-ValueType
WHEP-TRS 16 72 3.01e-23 SMART
Pfam:tRNA-synt_1b 155 447 5.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000162748
SMART Domains Protein: ENSMUSP00000125102
Gene: ENSMUSG00000021266

DomainStartEndE-ValueType
PDB:2QUK|A 4 37 1e-8 PDB
SCOP:d1fyja_ 14 37 8e-7 SMART
Blast:WHEP 16 37 3e-7 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162952
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221779
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb3 T A 1: 25,459,640 (GRCm39) N605I probably damaging Het
Btd C T 14: 31,389,004 (GRCm39) R242* probably null Het
Cdc42bpg A G 19: 6,372,703 (GRCm39) D1502G possibly damaging Het
Chst2 A G 9: 95,286,985 (GRCm39) F454L probably damaging Het
Col16a1 G A 4: 129,947,092 (GRCm39) A146T probably damaging Het
Cyp3a11 A T 5: 145,797,183 (GRCm39) S399T probably benign Het
Dspp C T 5: 104,324,917 (GRCm39) H427Y possibly damaging Het
Dtx4 A T 19: 12,459,574 (GRCm39) M410K possibly damaging Het
Ecpas A T 4: 58,877,171 (GRCm39) probably null Het
Epb41l2 C T 10: 25,317,665 (GRCm39) R61W probably damaging Het
Gbp6 T C 5: 105,421,147 (GRCm39) K553E probably benign Het
Git1 CCG C 11: 77,395,494 (GRCm39) probably null Het
Gm13199 C T 2: 5,867,259 (GRCm39) probably benign Het
Gramd2a G A 9: 59,615,299 (GRCm39) G13R probably benign Het
Hoxa2 G T 6: 52,140,243 (GRCm39) Q248K probably damaging Het
Hycc1 A T 5: 24,185,577 (GRCm39) probably null Het
Krt33b T C 11: 99,916,374 (GRCm39) T228A probably benign Het
Loxhd1 A G 18: 77,444,573 (GRCm39) E324G probably damaging Het
Map3k20 A G 2: 72,232,514 (GRCm39) N390S probably benign Het
Mroh7 A G 4: 106,565,757 (GRCm39) Y126H possibly damaging Het
Muc4 G A 16: 32,555,059 (GRCm39) W15* probably null Het
Ndrg2 T A 14: 52,147,579 (GRCm39) probably null Het
Ntsr1 T C 2: 180,142,226 (GRCm39) S6P probably damaging Het
Or5m10 T C 2: 85,717,783 (GRCm39) I213T probably benign Het
Or5p70 G A 7: 107,994,707 (GRCm39) V127I probably benign Het
Pcdhb6 A T 18: 37,467,753 (GRCm39) T225S probably benign Het
Rfng C A 11: 120,672,842 (GRCm39) V294L probably benign Het
Scml4 C T 10: 42,741,566 (GRCm39) probably benign Het
Slc5a2 A G 7: 127,869,787 (GRCm39) I407V possibly damaging Het
Strc T C 2: 121,201,295 (GRCm39) T1267A probably benign Het
Tanc1 T C 2: 59,626,341 (GRCm39) V566A probably damaging Het
Tas1r2 T C 4: 139,394,647 (GRCm39) S468P probably damaging Het
Tenm2 T A 11: 35,914,626 (GRCm39) T2304S probably benign Het
Tirap A T 9: 35,100,054 (GRCm39) L210Q probably damaging Het
Vav3 A T 3: 109,248,557 (GRCm39) Q68L probably benign Het
Vmn2r54 C T 7: 12,363,594 (GRCm39) S433N probably benign Het
Zc3h6 A G 2: 128,835,372 (GRCm39) probably benign Het
Other mutations in Wars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01961:Wars1 APN 12 108,832,096 (GRCm39) missense probably damaging 1.00
IGL02327:Wars1 APN 12 108,832,227 (GRCm39) critical splice acceptor site probably null
IGL02864:Wars1 APN 12 108,848,791 (GRCm39) missense probably benign
IGL02962:Wars1 APN 12 108,841,706 (GRCm39) missense probably damaging 0.99
R0271:Wars1 UTSW 12 108,841,119 (GRCm39) missense probably benign
R0485:Wars1 UTSW 12 108,841,083 (GRCm39) missense probably damaging 1.00
R0669:Wars1 UTSW 12 108,831,944 (GRCm39) missense probably benign 0.00
R1144:Wars1 UTSW 12 108,854,291 (GRCm39) nonsense probably null
R1581:Wars1 UTSW 12 108,841,635 (GRCm39) nonsense probably null
R1730:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1783:Wars1 UTSW 12 108,841,667 (GRCm39) missense probably damaging 1.00
R1990:Wars1 UTSW 12 108,854,359 (GRCm39) missense possibly damaging 0.94
R5382:Wars1 UTSW 12 108,848,706 (GRCm39) missense probably benign
R6299:Wars1 UTSW 12 108,827,309 (GRCm39) missense probably benign 0.00
R7186:Wars1 UTSW 12 108,846,982 (GRCm39) missense probably damaging 0.99
R7508:Wars1 UTSW 12 108,848,801 (GRCm39) missense probably benign 0.01
R7919:Wars1 UTSW 12 108,847,030 (GRCm39) missense probably benign 0.11
R8530:Wars1 UTSW 12 108,848,818 (GRCm39) missense probably damaging 0.99
R9132:Wars1 UTSW 12 108,827,199 (GRCm39) missense probably benign 0.41
Predicted Primers PCR Primer
(F):5'- CATGACAACACGGCTTCATG -3'
(R):5'- ACAGGATGTGTTCAATGTGCC -3'

Sequencing Primer
(F):5'- GACAACACGGCTTCATGTTTATG -3'
(R):5'- CAATGTGCCTTTGGTCATCCAGATG -3'
Posted On 2017-01-03