Incidental Mutation 'R5704:Nrp2'
| ID |
451817 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nrp2
|
| Ensembl Gene |
ENSMUSG00000025969 |
| Gene Name |
neuropilin 2 |
| Synonyms |
1110048P06Rik, NP-2, Npn-2, NP2, Npn2 |
| MMRRC Submission |
043329-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.951)
|
| Stock # |
R5704 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
62742476-62857851 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 62824267 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 791
(I791L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109794
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027112]
[ENSMUST00000063594]
[ENSMUST00000075144]
[ENSMUST00000102822]
[ENSMUST00000114155]
[ENSMUST00000114157]
|
| AlphaFold |
O35375 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027112
AA Change: I791L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000027112
Gene: ENSMUSG00000025969
AA Change: I791L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
822 |
906 |
1.4e-35 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063594
AA Change: I791L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000069379
Gene: ENSMUSG00000025969
AA Change: I791L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
low complexity region
|
816 |
831 |
N/A |
INTRINSIC |
|
Pfam:DUF3481
|
839 |
923 |
1.6e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075144
AA Change: I791L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000074642
Gene: ENSMUSG00000025969
AA Change: I791L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
827 |
911 |
2.3e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102822
AA Change: I791L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000099886
Gene: ENSMUSG00000025969
AA Change: I791L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
822 |
906 |
2.3e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114155
AA Change: I791L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000109792
Gene: ENSMUSG00000025969
AA Change: I791L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
817 |
901 |
9.4e-36 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114157
AA Change: I791L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000109794
Gene: ENSMUSG00000025969
AA Change: I791L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
low complexity region
|
821 |
836 |
N/A |
INTRINSIC |
|
Pfam:DUF3481
|
844 |
928 |
2.4e-25 |
PFAM |
|
| Meta Mutation Damage Score |
0.0772 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.7%
|
| Validation Efficiency |
98% (85/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcg3 |
G |
A |
5: 105,116,036 (GRCm39) |
A266V |
probably damaging |
Het |
| Acad10 |
A |
G |
5: 121,769,606 (GRCm39) |
S617P |
probably benign |
Het |
| Ahi1 |
A |
C |
10: 20,950,326 (GRCm39) |
M126L |
probably benign |
Het |
| Alk |
T |
C |
17: 72,910,115 (GRCm39) |
E197G |
probably damaging |
Het |
| Alyref2 |
A |
T |
1: 171,331,547 (GRCm39) |
Y108F |
probably damaging |
Het |
| Ankrd26 |
T |
G |
6: 118,500,843 (GRCm39) |
H876P |
probably damaging |
Het |
| Arfgef1 |
T |
C |
1: 10,229,808 (GRCm39) |
T1298A |
probably damaging |
Het |
| Arhgap33 |
T |
A |
7: 30,219,045 (GRCm39) |
|
probably benign |
Het |
| Arhgef17 |
A |
G |
7: 100,530,548 (GRCm39) |
S1413P |
probably damaging |
Het |
| Arid1a |
A |
T |
4: 133,409,050 (GRCm39) |
V1819E |
unknown |
Het |
| Asprv1 |
A |
G |
6: 86,605,532 (GRCm39) |
N126S |
probably damaging |
Het |
| Atg16l2 |
T |
C |
7: 100,949,418 (GRCm39) |
Y43C |
probably damaging |
Het |
| Atp13a3 |
G |
T |
16: 30,140,697 (GRCm39) |
T1160K |
probably benign |
Het |
| Atp1a3 |
T |
C |
7: 24,696,736 (GRCm39) |
T272A |
probably damaging |
Het |
| Bpifa3 |
G |
T |
2: 153,979,562 (GRCm39) |
|
probably null |
Het |
| Bri3 |
T |
C |
5: 144,192,716 (GRCm39) |
V80A |
probably damaging |
Het |
| Ccdc28a |
T |
A |
10: 18,106,320 (GRCm39) |
E2V |
probably damaging |
Het |
| Ccdc7a |
T |
A |
8: 129,706,577 (GRCm39) |
|
probably benign |
Het |
| Cds2 |
G |
A |
2: 132,135,249 (GRCm39) |
V47I |
probably benign |
Het |
| Cela2a |
G |
A |
4: 141,553,299 (GRCm39) |
|
probably benign |
Het |
| Ckap5 |
A |
G |
2: 91,406,548 (GRCm39) |
Y783C |
probably damaging |
Het |
| Cmtr1 |
G |
C |
17: 29,882,217 (GRCm39) |
A23P |
possibly damaging |
Het |
| Crym |
C |
A |
7: 119,801,163 (GRCm39) |
|
probably null |
Het |
| Def6 |
T |
G |
17: 28,447,200 (GRCm39) |
D610E |
probably benign |
Het |
| Dnajc15 |
T |
C |
14: 78,063,898 (GRCm39) |
Y130C |
probably damaging |
Het |
| Dock8 |
G |
A |
19: 25,151,586 (GRCm39) |
V1560I |
probably damaging |
Het |
| Eif4g3 |
T |
C |
4: 137,918,003 (GRCm39) |
V1501A |
probably damaging |
Het |
| Esyt1 |
A |
G |
10: 128,347,379 (GRCm39) |
S1049P |
probably damaging |
Het |
| Gm4952 |
G |
T |
19: 12,604,275 (GRCm39) |
R229L |
probably damaging |
Het |
| Golga5 |
T |
A |
12: 102,455,707 (GRCm39) |
H548Q |
probably benign |
Het |
| Gspt1 |
A |
T |
16: 11,046,057 (GRCm39) |
D449E |
possibly damaging |
Het |
| Gtf3c2 |
T |
A |
5: 31,316,454 (GRCm39) |
D732V |
probably damaging |
Het |
| Hax1 |
T |
A |
3: 89,903,403 (GRCm39) |
Q168L |
probably damaging |
Het |
| Hectd2 |
T |
A |
19: 36,576,291 (GRCm39) |
S91T |
possibly damaging |
Het |
| Igfbp2 |
T |
A |
1: 72,891,303 (GRCm39) |
H300Q |
probably benign |
Het |
| Il12rb2 |
T |
C |
6: 67,269,197 (GRCm39) |
N538S |
possibly damaging |
Het |
| Insr |
G |
A |
8: 3,235,122 (GRCm39) |
P124L |
possibly damaging |
Het |
| Irak3 |
C |
A |
10: 119,981,594 (GRCm39) |
R437L |
probably benign |
Het |
| Jhy |
C |
T |
9: 40,808,734 (GRCm39) |
V676I |
probably damaging |
Het |
| Kcns3 |
G |
A |
12: 11,142,328 (GRCm39) |
R124C |
probably benign |
Het |
| Lactb |
G |
A |
9: 66,863,058 (GRCm39) |
R519* |
probably null |
Het |
| Mdfic |
G |
A |
6: 15,770,291 (GRCm39) |
G94D |
probably damaging |
Het |
| Mospd3 |
A |
G |
5: 137,598,613 (GRCm39) |
V42A |
possibly damaging |
Het |
| Mov10 |
A |
G |
3: 104,706,912 (GRCm39) |
V666A |
probably benign |
Het |
| Mucl1 |
T |
C |
15: 103,785,663 (GRCm39) |
I15V |
probably benign |
Het |
| Mug1 |
T |
A |
6: 121,828,392 (GRCm39) |
V268D |
possibly damaging |
Het |
| Myo5c |
T |
A |
9: 75,180,185 (GRCm39) |
S709T |
probably benign |
Het |
| Nol11 |
T |
A |
11: 107,064,195 (GRCm39) |
E519V |
probably benign |
Het |
| Nudt19 |
A |
G |
7: 35,250,972 (GRCm39) |
Y256H |
probably benign |
Het |
| Nudt8 |
C |
T |
19: 4,050,777 (GRCm39) |
R42C |
probably damaging |
Het |
| Or5ac16 |
A |
G |
16: 59,022,369 (GRCm39) |
L140P |
probably damaging |
Het |
| Or6c213 |
T |
A |
10: 129,574,685 (GRCm39) |
I34F |
probably benign |
Het |
| Pcdhga12 |
A |
G |
18: 37,900,422 (GRCm39) |
Y418C |
probably damaging |
Het |
| Pds5a |
A |
G |
5: 65,784,422 (GRCm39) |
|
probably null |
Het |
| Pdzd2 |
T |
C |
15: 12,385,761 (GRCm39) |
D1003G |
probably benign |
Het |
| Pglyrp4 |
T |
A |
3: 90,647,581 (GRCm39) |
|
probably null |
Het |
| Phip |
T |
C |
9: 82,753,408 (GRCm39) |
N1779D |
probably damaging |
Het |
| Postn |
G |
T |
3: 54,279,527 (GRCm39) |
C335F |
probably damaging |
Het |
| Ppp4r3a |
T |
C |
12: 101,049,619 (GRCm39) |
|
probably benign |
Het |
| Prrt2 |
C |
T |
7: 126,618,590 (GRCm39) |
V292M |
probably damaging |
Het |
| Rpl18 |
T |
C |
7: 45,370,146 (GRCm39) |
V138A |
possibly damaging |
Het |
| Rps14 |
G |
A |
18: 60,910,205 (GRCm39) |
|
probably benign |
Het |
| Sbno1 |
A |
G |
5: 124,533,956 (GRCm39) |
|
probably null |
Het |
| Siah2 |
T |
G |
3: 58,583,821 (GRCm39) |
K155T |
probably damaging |
Het |
| Slc22a30 |
G |
A |
19: 8,321,757 (GRCm39) |
Q436* |
probably null |
Het |
| Slc25a39 |
T |
A |
11: 102,294,220 (GRCm39) |
|
probably benign |
Het |
| Slco1a7 |
T |
C |
6: 141,658,980 (GRCm39) |
M539V |
probably benign |
Het |
| Smok2b |
T |
A |
17: 13,455,231 (GRCm39) |
C464S |
probably damaging |
Het |
| Spata31 |
G |
A |
13: 65,069,855 (GRCm39) |
V668I |
probably benign |
Het |
| Tbxas1 |
C |
A |
6: 38,998,067 (GRCm39) |
H212N |
probably benign |
Het |
| Tenm1 |
A |
G |
X: 42,163,572 (GRCm39) |
V107A |
possibly damaging |
Het |
| Thada |
C |
T |
17: 84,538,329 (GRCm39) |
A1560T |
probably benign |
Het |
| Tmem241 |
G |
C |
18: 12,197,263 (GRCm39) |
F65L |
probably damaging |
Het |
| Ttc16 |
C |
G |
2: 32,659,137 (GRCm39) |
E321Q |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,748,929 (GRCm39) |
L4040H |
possibly damaging |
Het |
| Tyw1 |
G |
A |
5: 130,310,863 (GRCm39) |
W437* |
probably null |
Het |
| Unc79 |
T |
A |
12: 102,968,202 (GRCm39) |
Y143N |
probably damaging |
Het |
| Urb2 |
C |
T |
8: 124,764,921 (GRCm39) |
R1310W |
probably damaging |
Het |
| Vmn2r4 |
T |
C |
3: 64,317,370 (GRCm39) |
I34V |
probably benign |
Het |
| Zfp513 |
C |
T |
5: 31,358,010 (GRCm39) |
C121Y |
possibly damaging |
Het |
| Zfp606 |
T |
G |
7: 12,227,456 (GRCm39) |
W468G |
probably damaging |
Het |
| Zfyve16 |
C |
T |
13: 92,640,979 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Nrp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00765:Nrp2
|
APN |
1 |
62,743,410 (GRCm39) |
nonsense |
probably null |
|
|
IGL01912:Nrp2
|
APN |
1 |
62,810,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01996:Nrp2
|
APN |
1 |
62,788,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02184:Nrp2
|
APN |
1 |
62,758,099 (GRCm39) |
nonsense |
probably null |
|
|
IGL02682:Nrp2
|
APN |
1 |
62,810,996 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02928:Nrp2
|
APN |
1 |
62,854,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03024:Nrp2
|
APN |
1 |
62,810,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Euphorbia
|
UTSW |
1 |
62,801,972 (GRCm39) |
missense |
probably benign |
0.02 |
|
Sabra
|
UTSW |
1 |
62,822,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0068:Nrp2
|
UTSW |
1 |
62,784,536 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0068:Nrp2
|
UTSW |
1 |
62,784,536 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0683:Nrp2
|
UTSW |
1 |
62,783,477 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0789:Nrp2
|
UTSW |
1 |
62,784,609 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1418:Nrp2
|
UTSW |
1 |
62,822,491 (GRCm39) |
nonsense |
probably null |
|
|
R1468:Nrp2
|
UTSW |
1 |
62,777,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Nrp2
|
UTSW |
1 |
62,777,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1544:Nrp2
|
UTSW |
1 |
62,802,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1645:Nrp2
|
UTSW |
1 |
62,824,283 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1677:Nrp2
|
UTSW |
1 |
62,822,479 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1752:Nrp2
|
UTSW |
1 |
62,777,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1840:Nrp2
|
UTSW |
1 |
62,777,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1916:Nrp2
|
UTSW |
1 |
62,801,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1962:Nrp2
|
UTSW |
1 |
62,758,090 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2108:Nrp2
|
UTSW |
1 |
62,783,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2164:Nrp2
|
UTSW |
1 |
62,783,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2216:Nrp2
|
UTSW |
1 |
62,802,077 (GRCm39) |
nonsense |
probably null |
|
|
R2679:Nrp2
|
UTSW |
1 |
62,824,237 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4349:Nrp2
|
UTSW |
1 |
62,777,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4351:Nrp2
|
UTSW |
1 |
62,777,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4352:Nrp2
|
UTSW |
1 |
62,777,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4353:Nrp2
|
UTSW |
1 |
62,777,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4811:Nrp2
|
UTSW |
1 |
62,758,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5362:Nrp2
|
UTSW |
1 |
62,808,221 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5387:Nrp2
|
UTSW |
1 |
62,801,972 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5461:Nrp2
|
UTSW |
1 |
62,786,370 (GRCm39) |
nonsense |
probably null |
|
|
R6143:Nrp2
|
UTSW |
1 |
62,799,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6303:Nrp2
|
UTSW |
1 |
62,784,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6304:Nrp2
|
UTSW |
1 |
62,784,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6376:Nrp2
|
UTSW |
1 |
62,758,176 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6945:Nrp2
|
UTSW |
1 |
62,799,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7347:Nrp2
|
UTSW |
1 |
62,784,663 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7393:Nrp2
|
UTSW |
1 |
62,784,583 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7593:Nrp2
|
UTSW |
1 |
62,758,203 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7881:Nrp2
|
UTSW |
1 |
62,810,990 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7882:Nrp2
|
UTSW |
1 |
62,822,680 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7948:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7958:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7959:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7960:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7961:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8009:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8012:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8014:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8015:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8068:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Nrp2
|
UTSW |
1 |
62,784,567 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8206:Nrp2
|
UTSW |
1 |
62,786,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8791:Nrp2
|
UTSW |
1 |
62,788,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9090:Nrp2
|
UTSW |
1 |
62,784,670 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9271:Nrp2
|
UTSW |
1 |
62,784,670 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9287:Nrp2
|
UTSW |
1 |
62,835,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9469:Nrp2
|
UTSW |
1 |
62,804,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9646:Nrp2
|
UTSW |
1 |
62,777,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9752:Nrp2
|
UTSW |
1 |
62,851,726 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTTCAAGAGATGGAGCCATGTGG -3'
(R):5'- AAAACCTTCACCTCATGTCTTAGTC -3'
Sequencing Primer
(F):5'- GTCCACAGATGTGTATGTACCAG -3'
(R):5'- ACCTCATGTCTTAGTCTTACCCC -3'
|
| Posted On |
2017-01-03 |
Incidental Mutation