Mutagenetix > Incidental Mutation

Incidental Mutation 'R5708:Dchs1'

452083

Institutional Source

Beutler Lab

Gene Symbol

Dchs1

Ensembl Gene

ENSMUSG00000036862

Gene Name

dachsous cadherin related 1

Synonyms

3110041P15Rik, C130033F22Rik

MMRRC Submission

043333-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R5708 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

105752990-105787654 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 105772809 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Proline to Serine at position 135 (P135S)

Ref Sequence

ENSEMBL: ENSMUSP00000077574 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078482]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000078482
AA Change: P135S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000077574
Gene: ENSMUSG00000036862
AA Change: P135S

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
CA	58	135	5.2e-11	SMART
CA	159	247	6.1e-17	SMART
CA	271	354	2.6e-30	SMART
CA	382	464	7.8e-26	SMART
CA	489	570	1.2e-34	SMART
CA	594	677	1.9e-27	SMART
CA	701	782	5.3e-11	SMART
CA	806	886	1e-12	SMART
CA	910	990	3.3e-14	SMART
CA	1016	1097	3.6e-18	SMART
CA	1121	1203	3.1e-34	SMART
CA	1233	1307	8.8e-16	SMART
low complexity region	1323	1335	N/A	INTRINSIC
CA	1344	1427	9.9e-9	SMART
CA	1451	1537	1.5e-23	SMART
CA	1560	1640	7.2e-32	SMART
CA	1664	1742	1.8e-31	SMART
CA	1765	1846	7.8e-30	SMART
CA	1870	1951	3.7e-26	SMART
low complexity region	1957	1965	N/A	INTRINSIC
CA	1979	2059	1.1e-6	SMART
CA	2083	2162	2.7e-18	SMART
CA	2186	2268	2.2e-26	SMART
CA	2291	2367	1e-18	SMART
CA	2391	2473	1.8e-23	SMART
CA	2497	2593	3.5e-21	SMART
CA	2617	2697	1.2e-25	SMART
CA	2721	2804	1.9e-18	SMART
CA	2828	2919	3e-3	SMART
transmembrane domain	2932	2954	N/A	INTRINSIC
low complexity region	3001	3017	N/A	INTRINSIC
low complexity region	3046	3055	N/A	INTRINSIC
low complexity region	3088	3097	N/A	INTRINSIC
low complexity region	3185	3196	N/A	INTRINSIC
low complexity region	3237	3259	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000131504

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154659

Meta Mutation Damage Score

0.8040

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 95.2%

Validation Efficiency

98% (65/66)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 53 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700067K01Rik	A	G	8: 84,002,998 (GRCm38)	K101R	probably benign	Het
4933430I17Rik	T	C	4: 62,525,869 (GRCm38)	S18P	probably benign	Het
Adgb	C	T	10: 10,391,757 (GRCm38)	V940I	probably damaging	Het
Aox4	G	T	1: 58,245,873 (GRCm38)	A595S	possibly damaging	Het
Asxl2	T	A	12: 3,500,603 (GRCm38)	S782T	possibly damaging	Het
C1s2	A	T	6: 124,625,743 (GRCm38)	L503*	probably null	Het
C7	A	G	15: 5,015,401 (GRCm38)	V385A	possibly damaging	Het
Cdh20	T	C	1: 104,984,910 (GRCm38)	F630L	probably damaging	Het
Cdk14	A	C	5: 5,266,036 (GRCm38)		probably benign	Het
Cdkl4	T	C	17: 80,539,522 (GRCm38)	I239M	possibly damaging	Het
Cfap299	A	T	5: 98,737,707 (GRCm38)	M158L	probably benign	Het
Col11a1	A	G	3: 114,097,094 (GRCm38)	N360S	unknown	Het
D630003M21Rik	A	G	2: 158,220,392 (GRCm38)		probably null	Het
Dpysl2	A	G	14: 66,813,146 (GRCm38)	S421P	probably benign	Het
Edn1	A	T	13: 42,303,667 (GRCm38)	M59L	probably benign	Het
EU599041	A	G	7: 43,225,887 (GRCm38)		noncoding transcript	Het
Furin	A	G	7: 80,397,855 (GRCm38)		probably benign	Het
Gkn2	T	C	6: 87,377,436 (GRCm38)	L94P	probably damaging	Het
Gmeb2	A	T	2: 181,264,989 (GRCm38)	C117S	probably damaging	Het
Greb1	T	A	12: 16,673,842 (GRCm38)	I1869F	probably benign	Het
Heg1	A	G	16: 33,742,404 (GRCm38)	E1119G	probably damaging	Het
Hmgcs2	T	A	3: 98,291,162 (GRCm38)	L127Q	probably damaging	Het
Insyn2a	C	A	7: 134,918,796 (GRCm38)	V2F	probably damaging	Het
Kcnh6	A	G	11: 106,020,256 (GRCm38)	R493G	probably benign	Het
Kcnj11	C	T	7: 46,099,818 (GRCm38)	R27H	probably benign	Het
Klra14-ps	A	G	6: 130,157,788 (GRCm38)		noncoding transcript	Het
Lgmn	A	T	12: 102,404,328 (GRCm38)	N114K	possibly damaging	Het
Lipg	C	T	18: 74,955,434 (GRCm38)	M148I	possibly damaging	Het
Megf8	G	T	7: 25,334,597 (GRCm38)	R607L	probably benign	Het
Mks1	A	G	11: 87,856,839 (GRCm38)	T183A	probably benign	Het
Mllt11	A	G	3: 95,220,204 (GRCm38)	V85A	probably benign	Het
Mpo	A	T	11: 87,801,755 (GRCm38)		probably null	Het
Muc4	A	T	16: 32,754,769 (GRCm38)		probably benign	Het
Myoz3	T	C	18: 60,579,032 (GRCm38)	Y158C	probably damaging	Het
Or11g25	A	T	14: 50,485,995 (GRCm38)	D179V	probably damaging	Het
Or4k41	A	G	2: 111,450,009 (GRCm38)	R290G	probably damaging	Het
Or5ae1	A	G	7: 84,916,183 (GRCm38)	I135V	possibly damaging	Het
Polq	T	A	16: 37,061,018 (GRCm38)	S902R	probably damaging	Het
Rarb	T	C	14: 16,548,545 (GRCm38)	T93A	probably damaging	Het
Rgs12	A	G	5: 34,966,352 (GRCm38)	D493G	probably benign	Het
Sec31b	T	A	19: 44,523,144 (GRCm38)	D606V	probably damaging	Het
Setd2	T	C	9: 110,548,823 (GRCm38)	F569L	possibly damaging	Het
Sil1	T	C	18: 35,341,117 (GRCm38)	E149G	probably benign	Het
Spata13	T	G	14: 60,692,003 (GRCm38)	S337A	probably damaging	Het
Srfbp1	T	A	18: 52,488,946 (GRCm38)	L360M	probably damaging	Het
Tecta	A	T	9: 42,338,926 (GRCm38)	C1852S	probably damaging	Het
Tgfbr3l	A	G	8: 4,250,360 (GRCm38)	T208A	probably damaging	Het
Tmem38b	G	C	4: 53,849,051 (GRCm38)		probably null	Het
Tnfrsf11a	T	A	1: 105,813,820 (GRCm38)		probably null	Het
Tnik	T	A	3: 28,611,971 (GRCm38)		probably null	Het
Tsc1	A	T	2: 28,665,185 (GRCm38)		probably benign	Het
Zfp930	T	C	8: 69,226,461 (GRCm38)	V41A	probably benign	Het
Zscan18	A	T	7: 12,774,456 (GRCm38)	D372E	probably benign	Het

Other mutations in Dchs1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00235:Dchs1	APN	7	105,758,743 (GRCm38)	missense	probably damaging	1.00
IGL00422:Dchs1	APN	7	105,758,029 (GRCm38)	missense	possibly damaging	0.88
IGL00427:Dchs1	APN	7	105,758,424 (GRCm38)	missense	probably damaging	0.98
IGL00469:Dchs1	APN	7	105,755,261 (GRCm38)	missense	probably damaging	1.00
IGL00470:Dchs1	APN	7	105,758,207 (GRCm38)	missense	probably damaging	1.00
IGL00534:Dchs1	APN	7	105,757,943 (GRCm38)	missense	probably benign
IGL01292:Dchs1	APN	7	105,760,891 (GRCm38)	missense	probably damaging	0.98
IGL01380:Dchs1	APN	7	105,762,211 (GRCm38)	missense	probably damaging	1.00
IGL01396:Dchs1	APN	7	105,772,283 (GRCm38)	missense	probably damaging	1.00
IGL01448:Dchs1	APN	7	105,771,927 (GRCm38)	missense	probably damaging	0.98
IGL01759:Dchs1	APN	7	105,755,302 (GRCm38)	missense	probably benign	0.00
IGL01829:Dchs1	APN	7	105,755,397 (GRCm38)	missense	probably damaging	0.99
IGL01946:Dchs1	APN	7	105,759,105 (GRCm38)	missense	probably damaging	1.00
IGL01955:Dchs1	APN	7	105,757,591 (GRCm38)	missense	probably benign	0.00
IGL02012:Dchs1	APN	7	105,764,297 (GRCm38)	missense	probably damaging	0.98
IGL02222:Dchs1	APN	7	105,764,887 (GRCm38)	missense	probably damaging	1.00
IGL02261:Dchs1	APN	7	105,772,569 (GRCm38)	missense	probably damaging	1.00
IGL02365:Dchs1	APN	7	105,755,188 (GRCm38)	missense	probably benign	0.22
IGL02430:Dchs1	APN	7	105,771,971 (GRCm38)	missense	probably benign	0.34
IGL02500:Dchs1	APN	7	105,755,806 (GRCm38)	missense	probably benign
IGL02741:Dchs1	APN	7	105,757,323 (GRCm38)	missense	probably damaging	1.00
IGL02890:Dchs1	APN	7	105,756,491 (GRCm38)	missense	probably damaging	1.00
IGL03213:Dchs1	APN	7	105,755,072 (GRCm38)	missense	probably damaging	1.00
G1patch:Dchs1	UTSW	7	105,758,793 (GRCm38)	missense	probably damaging	0.99
P0026:Dchs1	UTSW	7	105,758,405 (GRCm38)	missense	probably damaging	0.99
PIT4377001:Dchs1	UTSW	7	105,757,588 (GRCm38)	missense	probably damaging	1.00
PIT4791001:Dchs1	UTSW	7	105,758,971 (GRCm38)	missense	probably damaging	1.00
R0013:Dchs1	UTSW	7	105,755,836 (GRCm38)	missense	possibly damaging	0.90
R0090:Dchs1	UTSW	7	105,755,932 (GRCm38)	missense	probably benign	0.18
R0091:Dchs1	UTSW	7	105,766,094 (GRCm38)	splice site	probably benign
R0193:Dchs1	UTSW	7	105,764,983 (GRCm38)	missense	probably benign	0.40
R0395:Dchs1	UTSW	7	105,758,538 (GRCm38)	missense	probably damaging	1.00
R0448:Dchs1	UTSW	7	105,765,927 (GRCm38)	missense	probably benign	0.00
R0480:Dchs1	UTSW	7	105,771,489 (GRCm38)	missense	probably benign	0.14
R0485:Dchs1	UTSW	7	105,772,727 (GRCm38)	missense	probably benign	0.00
R0566:Dchs1	UTSW	7	105,759,195 (GRCm38)	missense	probably benign	0.00
R0571:Dchs1	UTSW	7	105,771,996 (GRCm38)	missense	probably damaging	1.00
R0573:Dchs1	UTSW	7	105,758,778 (GRCm38)	missense	probably damaging	0.98
R0577:Dchs1	UTSW	7	105,764,255 (GRCm38)	missense	possibly damaging	0.78
R0622:Dchs1	UTSW	7	105,763,449 (GRCm38)	missense	probably damaging	1.00
R0654:Dchs1	UTSW	7	105,772,349 (GRCm38)	missense	probably damaging	1.00
R0677:Dchs1	UTSW	7	105,764,984 (GRCm38)	missense	probably damaging	1.00
R1171:Dchs1	UTSW	7	105,757,714 (GRCm38)	missense	probably benign
R1241:Dchs1	UTSW	7	105,758,178 (GRCm38)	missense	probably damaging	1.00
R1389:Dchs1	UTSW	7	105,755,571 (GRCm38)	missense	probably benign	0.40
R1427:Dchs1	UTSW	7	105,766,191 (GRCm38)	missense	probably benign	0.06
R1458:Dchs1	UTSW	7	105,755,244 (GRCm38)	missense	probably damaging	1.00
R1513:Dchs1	UTSW	7	105,772,071 (GRCm38)	nonsense	probably null
R1524:Dchs1	UTSW	7	105,764,525 (GRCm38)	missense	probably damaging	1.00
R1525:Dchs1	UTSW	7	105,758,931 (GRCm38)	missense	probably damaging	1.00
R1534:Dchs1	UTSW	7	105,772,040 (GRCm38)	missense	probably damaging	0.98
R1567:Dchs1	UTSW	7	105,771,861 (GRCm38)	missense	probably benign	0.01
R1577:Dchs1	UTSW	7	105,765,955 (GRCm38)	missense	probably damaging	1.00
R1603:Dchs1	UTSW	7	105,762,770 (GRCm38)	missense	probably benign	0.24
R1676:Dchs1	UTSW	7	105,754,921 (GRCm38)	missense	probably benign	0.40
R1794:Dchs1	UTSW	7	105,771,720 (GRCm38)	missense	probably benign	0.02
R1826:Dchs1	UTSW	7	105,757,627 (GRCm38)	missense	probably damaging	1.00
R1892:Dchs1	UTSW	7	105,764,156 (GRCm38)	missense	probably benign	0.00
R1924:Dchs1	UTSW	7	105,772,280 (GRCm38)	missense	possibly damaging	0.81
R1932:Dchs1	UTSW	7	105,765,902 (GRCm38)	missense	probably damaging	1.00
R1962:Dchs1	UTSW	7	105,764,201 (GRCm38)	missense	probably damaging	1.00
R1985:Dchs1	UTSW	7	105,772,398 (GRCm38)	missense	possibly damaging	0.72
R1993:Dchs1	UTSW	7	105,762,548 (GRCm38)	missense	probably benign	0.00
R2007:Dchs1	UTSW	7	105,755,325 (GRCm38)	missense	probably damaging	1.00
R2316:Dchs1	UTSW	7	105,764,204 (GRCm38)	missense	possibly damaging	0.71
R2351:Dchs1	UTSW	7	105,754,094 (GRCm38)	missense	probably benign
R2474:Dchs1	UTSW	7	105,755,074 (GRCm38)	missense	probably benign	0.37
R2474:Dchs1	UTSW	7	105,772,838 (GRCm38)	missense	probably damaging	1.00
R3429:Dchs1	UTSW	7	105,756,504 (GRCm38)	missense	possibly damaging	0.85
R3430:Dchs1	UTSW	7	105,756,504 (GRCm38)	missense	possibly damaging	0.85
R3737:Dchs1	UTSW	7	105,762,316 (GRCm38)	missense	possibly damaging	0.88
R3767:Dchs1	UTSW	7	105,757,085 (GRCm38)	missense	possibly damaging	0.67
R3874:Dchs1	UTSW	7	105,761,635 (GRCm38)	missense	probably damaging	1.00
R3883:Dchs1	UTSW	7	105,762,563 (GRCm38)	missense	probably damaging	1.00
R4105:Dchs1	UTSW	7	105,765,140 (GRCm38)	missense	probably damaging	1.00
R4209:Dchs1	UTSW	7	105,766,190 (GRCm38)	missense	probably damaging	0.99
R4329:Dchs1	UTSW	7	105,753,759 (GRCm38)	missense	probably damaging	1.00
R4516:Dchs1	UTSW	7	105,754,852 (GRCm38)	missense	probably damaging	1.00
R4579:Dchs1	UTSW	7	105,758,973 (GRCm38)	missense	probably benign
R4579:Dchs1	UTSW	7	105,754,765 (GRCm38)	missense	probably damaging	1.00
R4588:Dchs1	UTSW	7	105,756,041 (GRCm38)	missense	probably benign
R4613:Dchs1	UTSW	7	105,772,724 (GRCm38)	missense	probably damaging	1.00
R4632:Dchs1	UTSW	7	105,754,355 (GRCm38)	missense	probably benign	0.02
R4696:Dchs1	UTSW	7	105,764,627 (GRCm38)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,765,552 (GRCm38)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,755,253 (GRCm38)	missense	probably damaging	0.98
R4738:Dchs1	UTSW	7	105,758,673 (GRCm38)	missense	probably damaging	0.96
R4768:Dchs1	UTSW	7	105,771,620 (GRCm38)	missense	possibly damaging	0.96
R4784:Dchs1	UTSW	7	105,765,926 (GRCm38)	missense	probably damaging	1.00
R4864:Dchs1	UTSW	7	105,755,253 (GRCm38)	missense	probably damaging	0.98
R4880:Dchs1	UTSW	7	105,755,730 (GRCm38)	missense	probably benign	0.00
R4909:Dchs1	UTSW	7	105,766,255 (GRCm38)	missense	probably damaging	1.00
R5102:Dchs1	UTSW	7	105,772,177 (GRCm38)	missense	probably benign	0.09
R5109:Dchs1	UTSW	7	105,765,014 (GRCm38)	missense	probably benign
R5126:Dchs1	UTSW	7	105,753,517 (GRCm38)	missense	probably damaging	1.00
R5149:Dchs1	UTSW	7	105,755,658 (GRCm38)	missense	probably damaging	0.98
R5330:Dchs1	UTSW	7	105,754,602 (GRCm38)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,772,055 (GRCm38)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,758,029 (GRCm38)	missense	probably damaging	1.00
R5386:Dchs1	UTSW	7	105,758,029 (GRCm38)	missense	probably damaging	1.00
R5622:Dchs1	UTSW	7	105,755,293 (GRCm38)	missense	probably benign	0.11
R5623:Dchs1	UTSW	7	105,772,769 (GRCm38)	missense	probably damaging	1.00
R5718:Dchs1	UTSW	7	105,755,748 (GRCm38)	missense	probably benign	0.01
R5743:Dchs1	UTSW	7	105,771,596 (GRCm38)	missense	probably benign
R5759:Dchs1	UTSW	7	105,764,176 (GRCm38)	missense	probably damaging	0.99
R5772:Dchs1	UTSW	7	105,773,040 (GRCm38)	missense	probably damaging	1.00
R5860:Dchs1	UTSW	7	105,772,035 (GRCm38)	missense	probably damaging	1.00
R5916:Dchs1	UTSW	7	105,759,166 (GRCm38)	missense	probably damaging	1.00
R5965:Dchs1	UTSW	7	105,755,925 (GRCm38)	missense	probably damaging	1.00
R5997:Dchs1	UTSW	7	105,754,095 (GRCm38)	missense	probably benign	0.08
R6065:Dchs1	UTSW	7	105,755,421 (GRCm38)	missense	probably damaging	1.00
R6136:Dchs1	UTSW	7	105,760,925 (GRCm38)	missense	probably benign
R6137:Dchs1	UTSW	7	105,765,106 (GRCm38)	missense	probably damaging	0.99
R6324:Dchs1	UTSW	7	105,764,938 (GRCm38)	missense	probably benign	0.05
R6363:Dchs1	UTSW	7	105,758,472 (GRCm38)	missense	probably benign	0.12
R6466:Dchs1	UTSW	7	105,764,541 (GRCm38)	missense	probably benign	0.09
R6544:Dchs1	UTSW	7	105,758,178 (GRCm38)	missense	probably damaging	1.00
R6572:Dchs1	UTSW	7	105,758,806 (GRCm38)	missense	possibly damaging	0.94
R6579:Dchs1	UTSW	7	105,762,913 (GRCm38)	missense	probably benign	0.17
R6632:Dchs1	UTSW	7	105,761,878 (GRCm38)	missense	probably damaging	1.00
R6725:Dchs1	UTSW	7	105,758,793 (GRCm38)	missense	probably damaging	0.99
R6789:Dchs1	UTSW	7	105,757,003 (GRCm38)	missense	possibly damaging	0.61
R6868:Dchs1	UTSW	7	105,763,503 (GRCm38)	missense	possibly damaging	0.91
R7058:Dchs1	UTSW	7	105,757,021 (GRCm38)	missense	probably benign
R7064:Dchs1	UTSW	7	105,763,185 (GRCm38)	missense	probably damaging	0.99
R7076:Dchs1	UTSW	7	105,761,871 (GRCm38)	missense	probably benign	0.04
R7191:Dchs1	UTSW	7	105,765,439 (GRCm38)	missense	possibly damaging	0.89
R7298:Dchs1	UTSW	7	105,755,131 (GRCm38)	nonsense	probably null
R7380:Dchs1	UTSW	7	105,758,628 (GRCm38)	missense	probably benign	0.35
R7438:Dchs1	UTSW	7	105,754,948 (GRCm38)	missense	probably benign	0.30
R7496:Dchs1	UTSW	7	105,761,859 (GRCm38)	missense	probably damaging	1.00
R7534:Dchs1	UTSW	7	105,772,373 (GRCm38)	missense	probably benign	0.00
R7604:Dchs1	UTSW	7	105,765,982 (GRCm38)	missense	probably damaging	1.00
R7631:Dchs1	UTSW	7	105,759,238 (GRCm38)	missense	probably benign
R7821:Dchs1	UTSW	7	105,765,145 (GRCm38)	missense	probably benign	0.00
R7834:Dchs1	UTSW	7	105,765,567 (GRCm38)	missense	probably benign	0.39
R7841:Dchs1	UTSW	7	105,762,973 (GRCm38)	missense	probably benign
R7913:Dchs1	UTSW	7	105,759,228 (GRCm38)	missense	possibly damaging	0.61
R8041:Dchs1	UTSW	7	105,755,188 (GRCm38)	missense	probably benign	0.45
R8076:Dchs1	UTSW	7	105,761,982 (GRCm38)	missense	probably damaging	1.00
R8076:Dchs1	UTSW	7	105,755,921 (GRCm38)	missense	possibly damaging	0.52
R8087:Dchs1	UTSW	7	105,753,499 (GRCm38)	missense	probably benign	0.41
R8125:Dchs1	UTSW	7	105,764,882 (GRCm38)	missense	possibly damaging	0.91
R8223:Dchs1	UTSW	7	105,762,617 (GRCm38)	missense	possibly damaging	0.81
R8239:Dchs1	UTSW	7	105,765,511 (GRCm38)	missense	probably benign	0.22
R8476:Dchs1	UTSW	7	105,758,808 (GRCm38)	missense	probably benign	0.05
R8497:Dchs1	UTSW	7	105,758,961 (GRCm38)	missense	probably damaging	1.00
R8770:Dchs1	UTSW	7	105,771,738 (GRCm38)	missense	probably damaging	1.00
R8856:Dchs1	UTSW	7	105,760,857 (GRCm38)	missense	probably damaging	1.00
R8866:Dchs1	UTSW	7	105,755,390 (GRCm38)	missense	probably benign	0.00
R8948:Dchs1	UTSW	7	105,759,005 (GRCm38)	missense	probably benign	0.30
R8950:Dchs1	UTSW	7	105,759,005 (GRCm38)	missense	probably benign	0.30
R9029:Dchs1	UTSW	7	105,753,712 (GRCm38)	missense	probably benign	0.13
R9039:Dchs1	UTSW	7	105,756,008 (GRCm38)	missense	probably benign	0.11
R9081:Dchs1	UTSW	7	105,754,429 (GRCm38)	missense	probably benign	0.00
R9134:Dchs1	UTSW	7	105,755,703 (GRCm38)	missense	probably damaging	0.96
R9159:Dchs1	UTSW	7	105,765,919 (GRCm38)	missense	probably benign
R9162:Dchs1	UTSW	7	105,765,525 (GRCm38)	missense	probably damaging	1.00
R9169:Dchs1	UTSW	7	105,772,907 (GRCm38)	missense	probably damaging	1.00
R9262:Dchs1	UTSW	7	105,755,626 (GRCm38)	missense	probably damaging	1.00
R9292:Dchs1	UTSW	7	105,753,913 (GRCm38)	missense	probably damaging	1.00
R9325:Dchs1	UTSW	7	105,766,195 (GRCm38)	missense	possibly damaging	0.51
R9376:Dchs1	UTSW	7	105,765,774 (GRCm38)	critical splice donor site	probably null
R9392:Dchs1	UTSW	7	105,772,662 (GRCm38)	missense	probably benign	0.09
R9619:Dchs1	UTSW	7	105,764,455 (GRCm38)	missense	probably benign	0.07
R9680:Dchs1	UTSW	7	105,762,418 (GRCm38)	missense	probably damaging	1.00
R9687:Dchs1	UTSW	7	105,757,984 (GRCm38)	missense	probably damaging	0.99
R9747:Dchs1	UTSW	7	105,763,475 (GRCm38)	missense	probably damaging	1.00
Z1177:Dchs1	UTSW	7	105,758,551 (GRCm38)	missense	probably benign	0.00
Z1177:Dchs1	UTSW	7	105,757,693 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CATGTAGTGTGAGCGGTTCTCC -3'
(R):5'- CTTCATCTCTGCCCAGGAAG -3'

Sequencing Primer
(F):5'- GTTCTCCGGCAATCACCAG -3'
(R):5'- CCAGGAAGGCAGTGGCGTAG -3'

Posted On

2017-01-03