|Institutional Source||Beutler Lab|
|Gene Name||zinc fingers and homeoboxes 2|
|Synonyms||Afr1, Raf, Afr-1|
|Is this an essential gene?||Possibly non essential (E-score: 0.284)|
|Stock #||R5710 (G1)|
|Chromosomal Location||57694665-57839832 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||T to A at 57821470 bp|
|Amino Acid Change||Tyrosine to Stop codon at position 78 (Y78*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000094164 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000096430]|
|Predicted Effect||probably null
AA Change: Y78*
AA Change: Y78*
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
PHENOTYPE: Alpha-fetoprotein levels in plasma decline precipitously after birth. This gene regulates a difference in adult level and rate of neonatal decrease of AFP. The BALB/cJ substrain carries a genetic variant allele determining a slow rate of decline to adultlevel. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Zhx2||
(F):5'- TGGCAAGCAAACGGAAATCTAC -3'
(R):5'- CCGGATGGAACTTGGAGTTG -3'
(F):5'- CATGGTTCGGACATCACAGGTAC -3'
(R):5'- ACTTGGAGTTGTGGTCAGACAAG -3'