Incidental Mutation 'R5725:Eif3m'
ID 452419
Institutional Source Beutler Lab
Gene Symbol Eif3m
Ensembl Gene ENSMUSG00000027170
Gene Name eukaryotic translation initiation factor 3, subunit M
Synonyms Tango7, Pcid1, Ga17
MMRRC Submission 043343-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5725 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 104830001-104847372 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 104844186 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 73 (I73T)
Ref Sequence ENSEMBL: ENSMUSP00000028592 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028592] [ENSMUST00000111110]
AlphaFold Q99JX4
Predicted Effect probably damaging
Transcript: ENSMUST00000028592
AA Change: I73T

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000028592
Gene: ENSMUSG00000027170
AA Change: I73T

DomainStartEndE-ValueType
Blast:HDc 119 209 1e-12 BLAST
PINT 268 357 6.42e-26 SMART
low complexity region 358 372 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000111110
SMART Domains Protein: ENSMUSP00000106739
Gene: ENSMUSG00000027170

DomainStartEndE-ValueType
Blast:HDc 13 77 7e-8 BLAST
PINT 136 225 6.42e-26 SMART
low complexity region 226 240 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130611
Predicted Effect probably benign
Transcript: ENSMUST00000144358
SMART Domains Protein: ENSMUSP00000114374
Gene: ENSMUSG00000045106

DomainStartEndE-ValueType
Pfam:CCDC73 1 182 3.1e-77 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
PHENOTYPE: Mice homozygous for a targeted allele exhibit embryonic lethality. Mice heterozygous for this allele exhibit decreased body weight and altered organ weights. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G A 12: 71,240,093 (GRCm39) R1301H probably benign Het
6030468B19Rik G T 11: 117,696,883 (GRCm39) S201I probably damaging Het
Abca13 G A 11: 9,527,181 (GRCm39) M4531I probably benign Het
Abca2 A G 2: 25,329,412 (GRCm39) M1058V probably damaging Het
Agrn T A 4: 156,258,332 (GRCm39) T938S probably benign Het
Aloxe3 A T 11: 69,019,480 (GRCm39) D131V probably null Het
Angptl7 C A 4: 148,580,965 (GRCm39) A277S possibly damaging Het
Ap5z1 T C 5: 142,454,731 (GRCm39) M244T probably damaging Het
Aplp2 T C 9: 31,069,110 (GRCm39) D573G probably damaging Het
Arid5a G T 1: 36,358,211 (GRCm39) E176* probably null Het
Atp8b4 A T 2: 126,275,856 (GRCm39) N125K probably benign Het
Auts2 A G 5: 131,468,584 (GRCm39) V911A probably benign Het
Bahcc1 G A 11: 120,165,714 (GRCm39) R990H probably benign Het
Cd84 T C 1: 171,700,928 (GRCm39) F230L probably benign Het
Dtnb T A 12: 3,823,566 (GRCm39) L584H probably damaging Het
Dync2h1 A C 9: 7,169,528 (GRCm39) S316R probably benign Het
Emilin3 A T 2: 160,750,410 (GRCm39) C399* probably null Het
Fam118a A G 15: 84,929,822 (GRCm39) K17E probably damaging Het
Fat4 A G 3: 38,943,774 (GRCm39) N889S probably damaging Het
Hmcn2 G A 2: 31,273,827 (GRCm39) probably null Het
Hyls1 G A 9: 35,472,480 (GRCm39) S312F probably benign Het
Igsf21 T C 4: 139,762,054 (GRCm39) D208G probably benign Het
Itgax A G 7: 127,747,033 (GRCm39) T945A possibly damaging Het
Itsn2 T A 12: 4,680,767 (GRCm39) probably benign Het
Kcna4 A G 2: 107,127,221 (GRCm39) T652A possibly damaging Het
Kir3dl1 G A X: 135,427,231 (GRCm39) D56N probably damaging Het
Lrp4 A G 2: 91,325,240 (GRCm39) Y1355C probably damaging Het
Mmp9 C A 2: 164,791,256 (GRCm39) A142E possibly damaging Het
Mpeg1 T C 19: 12,440,000 (GRCm39) V486A probably benign Het
Mrgprb3 A T 7: 48,293,548 (GRCm39) M1K probably null Het
Mrtfb A T 16: 13,202,174 (GRCm39) K146* probably null Het
Nacad T C 11: 6,551,643 (GRCm39) E516G probably benign Het
Or5k15 G A 16: 58,710,250 (GRCm39) T111I possibly damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pappa T A 4: 65,107,647 (GRCm39) V686E probably damaging Het
Polr3a A T 14: 24,515,455 (GRCm39) probably null Het
Ppp1r3a A G 6: 14,719,348 (GRCm39) V522A probably benign Het
Rab6b T A 9: 103,041,061 (GRCm39) F152I probably damaging Het
Sacs G A 14: 61,448,559 (GRCm39) R3535Q probably damaging Het
Septin14 T C 5: 129,766,630 (GRCm39) D317G probably damaging Het
Sin3b T C 8: 73,452,320 (GRCm39) probably null Het
Sis G A 3: 72,872,931 (GRCm39) P69L probably damaging Het
Slc12a3 G T 8: 95,057,074 (GRCm39) V116L probably benign Het
Slc16a12 A T 19: 34,652,227 (GRCm39) F306L probably damaging Het
Slc39a12 T C 2: 14,394,075 (GRCm39) probably benign Het
Smg6 A G 11: 74,821,439 (GRCm39) Q570R probably benign Het
Sptb G A 12: 76,669,888 (GRCm39) A480V probably benign Het
Srsf4 C A 4: 131,628,262 (GRCm39) probably benign Het
Topors T C 4: 40,261,952 (GRCm39) D444G probably damaging Het
Trav19 A C 14: 54,082,999 (GRCm39) T25P possibly damaging Het
Trim3 A G 7: 105,266,947 (GRCm39) probably null Het
Ugt2a2 T C 5: 87,622,755 (GRCm39) N281S probably damaging Het
Vmn1r12 A G 6: 57,136,694 (GRCm39) I264V probably benign Het
Vmn2r94 T A 17: 18,476,489 (GRCm39) I403F possibly damaging Het
Zzef1 G A 11: 72,746,308 (GRCm39) R870Q possibly damaging Het
Other mutations in Eif3m
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02003:Eif3m APN 2 104,843,188 (GRCm39) intron probably benign
IGL02661:Eif3m APN 2 104,835,314 (GRCm39) missense probably damaging 0.98
IGL02932:Eif3m APN 2 104,845,214 (GRCm39) missense probably damaging 1.00
R0039:Eif3m UTSW 2 104,836,217 (GRCm39) missense probably damaging 1.00
R0373:Eif3m UTSW 2 104,835,345 (GRCm39) missense probably benign 0.06
R1452:Eif3m UTSW 2 104,837,122 (GRCm39) missense probably damaging 1.00
R1695:Eif3m UTSW 2 104,847,298 (GRCm39) missense probably damaging 0.98
R1934:Eif3m UTSW 2 104,831,624 (GRCm39) missense probably damaging 1.00
R2115:Eif3m UTSW 2 104,837,141 (GRCm39) missense probably damaging 1.00
R2416:Eif3m UTSW 2 104,844,178 (GRCm39) missense probably benign
R4610:Eif3m UTSW 2 104,843,633 (GRCm39) missense probably benign 0.08
R4713:Eif3m UTSW 2 104,837,184 (GRCm39) splice site probably null
R5373:Eif3m UTSW 2 104,843,277 (GRCm39) missense probably damaging 0.99
R5374:Eif3m UTSW 2 104,843,277 (GRCm39) missense probably damaging 0.99
R7996:Eif3m UTSW 2 104,831,694 (GRCm39) missense probably benign 0.22
R8983:Eif3m UTSW 2 104,830,139 (GRCm39) missense possibly damaging 0.70
R9082:Eif3m UTSW 2 104,836,217 (GRCm39) missense probably damaging 1.00
R9227:Eif3m UTSW 2 104,831,705 (GRCm39) missense probably damaging 1.00
R9230:Eif3m UTSW 2 104,831,705 (GRCm39) missense probably damaging 1.00
Z1088:Eif3m UTSW 2 104,843,601 (GRCm39) missense probably damaging 1.00
Z1177:Eif3m UTSW 2 104,831,619 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAACATCCCTCTGAATGCTGTATC -3'
(R):5'- TGTTCTCTAACTTTCACAGTAGGC -3'

Sequencing Primer
(F):5'- AGCCATCTGACACGAGTGTTG -3'
(R):5'- CTTTCACAGTAGGCAAGCTATG -3'
Posted On 2017-01-03