Incidental Mutation 'R5727:Vmn2r2'
ID 452546
Institutional Source Beutler Lab
Gene Symbol Vmn2r2
Ensembl Gene ENSMUSG00000043897
Gene Name vomeronasal 2, receptor 2
Synonyms
MMRRC Submission 043190-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R5727 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 64022699-64049349 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 64024608 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 658 (I658V)
Ref Sequence ENSEMBL: ENSMUSP00000135110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077958] [ENSMUST00000177151]
AlphaFold L7N2E9
Predicted Effect probably benign
Transcript: ENSMUST00000077958
AA Change: I574V

PolyPhen 2 Score 0.410 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000077109
Gene: ENSMUSG00000043897
AA Change: I574V

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 4.5e-80 PFAM
Pfam:NCD3G 458 511 8.3e-18 PFAM
Pfam:7tm_3 542 779 1.3e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000177151
AA Change: I658V

PolyPhen 2 Score 0.410 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000135110
Gene: ENSMUSG00000043897
AA Change: I658V

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 83 500 1.6e-84 PFAM
Pfam:NCD3G 542 595 2.6e-17 PFAM
Pfam:7tm_3 628 862 1.9e-47 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 C A 14: 29,712,838 (GRCm39) L494M probably benign Het
Ahnak G T 19: 8,994,111 (GRCm39) A5132S probably damaging Het
Cadps G A 14: 12,486,525 (GRCm38) Q882* probably null Het
Cdhr2 G A 13: 54,872,121 (GRCm39) V662M possibly damaging Het
Cdyl2 T A 8: 117,309,907 (GRCm39) I350F probably damaging Het
Cfap44 T G 16: 44,255,805 (GRCm39) F966V probably damaging Het
Cpxm1 G A 2: 130,232,883 (GRCm39) R704* probably null Het
Dnah11 A T 12: 118,090,841 (GRCm39) F1034L probably damaging Het
Dpep2 A G 8: 106,713,075 (GRCm39) V440A probably benign Het
Ehmt2 A T 17: 35,125,008 (GRCm39) M11L possibly damaging Het
Eml2 C T 7: 18,924,685 (GRCm39) H185Y probably damaging Het
Gm10845 T A 14: 80,100,770 (GRCm39) noncoding transcript Het
Gm8122 T G 14: 43,091,477 (GRCm39) N97T unknown Het
Gnb1 A G 4: 155,639,559 (GRCm39) T263A probably benign Het
Hyls1 G A 9: 35,472,480 (GRCm39) S312F probably benign Het
Ier5l A G 2: 30,363,171 (GRCm39) C285R possibly damaging Het
Kif21b A G 1: 136,097,747 (GRCm39) N1336D probably damaging Het
Kl A G 5: 150,915,003 (GRCm39) N910S possibly damaging Het
Lama1 A G 17: 68,122,219 (GRCm39) H2722R possibly damaging Het
Mdm2 A G 10: 117,538,212 (GRCm39) M13T possibly damaging Het
Micall1 T A 15: 79,014,678 (GRCm39) Y685N possibly damaging Het
Mthfd1l T G 10: 4,053,302 (GRCm39) S884A possibly damaging Het
Nkiras2 A G 11: 100,515,853 (GRCm39) Y60C probably damaging Het
Oc90 T G 15: 65,753,388 (GRCm39) R342S possibly damaging Het
Or11h23 C A 14: 50,947,817 (GRCm39) T10K possibly damaging Het
Or1j4 T C 2: 36,740,544 (GRCm39) L162P possibly damaging Het
Or4k35 T A 2: 111,100,197 (GRCm39) R172* probably null Het
Or4p20 T A 2: 88,253,791 (GRCm39) I193F probably benign Het
Or9s13 A G 1: 92,547,900 (GRCm39) N91D probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Parp9 G T 16: 35,784,467 (GRCm39) E507* probably null Het
Pex13 A G 11: 23,605,705 (GRCm39) I175T probably benign Het
Phf12 A G 11: 77,914,370 (GRCm39) E604G probably damaging Het
Ppfia4 A T 1: 134,251,815 (GRCm39) probably null Het
Rragc T C 4: 123,813,828 (GRCm39) Y141H possibly damaging Het
Slc35g3 A G 11: 69,651,280 (GRCm39) V257A probably benign Het
Snx5 T C 2: 144,102,674 (GRCm39) T80A probably benign Het
Sorcs2 G A 5: 36,188,630 (GRCm39) A826V possibly damaging Het
Sptb G A 12: 76,669,888 (GRCm39) A480V probably benign Het
Tmem161b T A 13: 84,434,909 (GRCm39) S302R possibly damaging Het
Ube2o A T 11: 116,430,496 (GRCm39) F1081I probably damaging Het
Vwa3b T G 1: 37,174,600 (GRCm39) L672V probably benign Het
Wscd2 T C 5: 113,715,411 (GRCm39) F417S possibly damaging Het
Other mutations in Vmn2r2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00326:Vmn2r2 APN 3 64,041,319 (GRCm39) splice site probably benign
IGL00980:Vmn2r2 APN 3 64,024,601 (GRCm39) missense probably benign 0.11
IGL01389:Vmn2r2 APN 3 64,024,430 (GRCm39) missense probably damaging 0.97
IGL01804:Vmn2r2 APN 3 64,041,677 (GRCm39) missense possibly damaging 0.91
IGL02750:Vmn2r2 APN 3 64,024,823 (GRCm39) missense probably damaging 1.00
IGL02829:Vmn2r2 APN 3 64,026,172 (GRCm39) splice site probably benign
IGL03036:Vmn2r2 APN 3 64,024,321 (GRCm39) missense probably benign 0.01
IGL03174:Vmn2r2 APN 3 64,024,544 (GRCm39) nonsense probably null
PIT4151001:Vmn2r2 UTSW 3 64,024,334 (GRCm39) missense possibly damaging 0.67
R0029:Vmn2r2 UTSW 3 64,024,365 (GRCm39) missense probably benign 0.00
R0310:Vmn2r2 UTSW 3 64,042,039 (GRCm39) missense probably damaging 1.00
R0357:Vmn2r2 UTSW 3 64,041,320 (GRCm39) splice site probably null
R0637:Vmn2r2 UTSW 3 64,033,999 (GRCm39) missense probably benign 0.00
R1626:Vmn2r2 UTSW 3 64,041,921 (GRCm39) missense possibly damaging 0.61
R1662:Vmn2r2 UTSW 3 64,024,551 (GRCm39) missense probably benign 0.00
R1710:Vmn2r2 UTSW 3 64,024,820 (GRCm39) missense probably benign 0.19
R1797:Vmn2r2 UTSW 3 64,042,128 (GRCm39) missense probably benign 0.00
R1862:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
R1971:Vmn2r2 UTSW 3 64,034,121 (GRCm39) missense probably damaging 1.00
R2051:Vmn2r2 UTSW 3 64,024,766 (GRCm39) missense possibly damaging 0.77
R2099:Vmn2r2 UTSW 3 64,024,474 (GRCm39) missense probably damaging 1.00
R2275:Vmn2r2 UTSW 3 64,023,930 (GRCm39) missense probably benign 0.00
R3078:Vmn2r2 UTSW 3 64,042,053 (GRCm39) missense probably benign 0.22
R3418:Vmn2r2 UTSW 3 64,024,320 (GRCm39) missense probably benign 0.00
R3419:Vmn2r2 UTSW 3 64,024,320 (GRCm39) missense probably benign 0.00
R3959:Vmn2r2 UTSW 3 64,047,947 (GRCm39) missense probably benign
R4230:Vmn2r2 UTSW 3 64,041,912 (GRCm39) missense probably benign 0.00
R4258:Vmn2r2 UTSW 3 64,042,118 (GRCm39) missense probably damaging 1.00
R4810:Vmn2r2 UTSW 3 64,044,883 (GRCm39) missense probably damaging 1.00
R4822:Vmn2r2 UTSW 3 64,041,960 (GRCm39) missense probably damaging 0.99
R4919:Vmn2r2 UTSW 3 64,024,578 (GRCm39) missense possibly damaging 0.56
R4925:Vmn2r2 UTSW 3 64,044,892 (GRCm39) start codon destroyed probably null 0.03
R4954:Vmn2r2 UTSW 3 64,047,905 (GRCm39) missense probably benign 0.00
R5071:Vmn2r2 UTSW 3 64,024,321 (GRCm39) missense probably benign 0.01
R5315:Vmn2r2 UTSW 3 64,024,377 (GRCm39) missense probably benign 0.37
R5450:Vmn2r2 UTSW 3 64,034,011 (GRCm39) missense probably benign
R5577:Vmn2r2 UTSW 3 64,024,416 (GRCm39) missense probably benign 0.00
R5595:Vmn2r2 UTSW 3 64,034,036 (GRCm39) missense possibly damaging 0.74
R5810:Vmn2r2 UTSW 3 64,024,815 (GRCm39) missense probably damaging 1.00
R5919:Vmn2r2 UTSW 3 64,044,723 (GRCm39) missense probably benign 0.39
R6052:Vmn2r2 UTSW 3 64,024,782 (GRCm39) missense possibly damaging 0.56
R6084:Vmn2r2 UTSW 3 64,024,467 (GRCm39) missense probably benign 0.01
R6299:Vmn2r2 UTSW 3 64,024,074 (GRCm39) nonsense probably null
R6762:Vmn2r2 UTSW 3 64,041,870 (GRCm39) missense probably damaging 1.00
R6858:Vmn2r2 UTSW 3 64,044,915 (GRCm39) missense probably damaging 1.00
R6889:Vmn2r2 UTSW 3 64,024,688 (GRCm39) missense probably damaging 0.99
R6990:Vmn2r2 UTSW 3 64,024,608 (GRCm39) missense probably benign 0.02
R7195:Vmn2r2 UTSW 3 64,023,900 (GRCm39) missense probably benign 0.01
R7269:Vmn2r2 UTSW 3 64,033,998 (GRCm39) missense probably benign 0.32
R7699:Vmn2r2 UTSW 3 64,024,536 (GRCm39) missense possibly damaging 0.69
R7717:Vmn2r2 UTSW 3 64,042,019 (GRCm39) missense possibly damaging 0.95
R7798:Vmn2r2 UTSW 3 64,041,518 (GRCm39) missense possibly damaging 0.60
R7914:Vmn2r2 UTSW 3 64,041,526 (GRCm39) missense probably benign 0.20
R7974:Vmn2r2 UTSW 3 64,024,808 (GRCm39) missense probably damaging 0.99
R8394:Vmn2r2 UTSW 3 64,044,858 (GRCm39) missense probably damaging 1.00
R8478:Vmn2r2 UTSW 3 64,024,257 (GRCm39) missense possibly damaging 0.87
R8731:Vmn2r2 UTSW 3 64,024,404 (GRCm39) missense probably benign 0.16
R9035:Vmn2r2 UTSW 3 64,024,172 (GRCm39) missense probably damaging 1.00
R9182:Vmn2r2 UTSW 3 64,044,802 (GRCm39) missense probably damaging 1.00
R9225:Vmn2r2 UTSW 3 64,034,021 (GRCm39) missense probably benign 0.00
R9266:Vmn2r2 UTSW 3 64,024,057 (GRCm39) missense probably damaging 0.98
R9427:Vmn2r2 UTSW 3 64,041,945 (GRCm39) missense probably damaging 1.00
R9659:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
R9666:Vmn2r2 UTSW 3 64,023,870 (GRCm39) missense probably benign 0.08
R9771:Vmn2r2 UTSW 3 64,042,079 (GRCm39) missense possibly damaging 0.88
R9788:Vmn2r2 UTSW 3 64,041,942 (GRCm39) missense possibly damaging 0.79
X0024:Vmn2r2 UTSW 3 64,044,707 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCCAACACCAAGTATGCTGC -3'
(R):5'- AGTGTGTGCCAAAGCTTGTG -3'

Sequencing Primer
(F):5'- CGCAGACCAGTACAATTAGTTTTCG -3'
(R):5'- GCCAAAGCTTGTGGAATTCC -3'
Posted On 2017-01-03