Incidental Mutation 'R5727:Or11h23'
ID 452574
Institutional Source Beutler Lab
Gene Symbol Or11h23
Ensembl Gene ENSMUSG00000060084
Gene Name olfactory receptor family 11 subfamily G member 23
Synonyms GA_x6K02T2PMLR-6454789-6455712, Olfr748, MOR106-9P
MMRRC Submission 043190-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R5727 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 50947789-50948712 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 50947817 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 10 (T10K)
Ref Sequence ENSEMBL: ENSMUSP00000149491 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073561] [ENSMUST00000213101]
AlphaFold E9Q9Z0
Predicted Effect possibly damaging
Transcript: ENSMUST00000073561
AA Change: T10K

PolyPhen 2 Score 0.744 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000073251
Gene: ENSMUSG00000060084
AA Change: T10K

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.6e-52 PFAM
Pfam:7tm_1 41 290 2.8e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213101
AA Change: T10K

PolyPhen 2 Score 0.744 (Sensitivity: 0.85; Specificity: 0.92)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr8 C A 14: 29,712,838 (GRCm39) L494M probably benign Het
Ahnak G T 19: 8,994,111 (GRCm39) A5132S probably damaging Het
Cadps G A 14: 12,486,525 (GRCm38) Q882* probably null Het
Cdhr2 G A 13: 54,872,121 (GRCm39) V662M possibly damaging Het
Cdyl2 T A 8: 117,309,907 (GRCm39) I350F probably damaging Het
Cfap44 T G 16: 44,255,805 (GRCm39) F966V probably damaging Het
Cpxm1 G A 2: 130,232,883 (GRCm39) R704* probably null Het
Dnah11 A T 12: 118,090,841 (GRCm39) F1034L probably damaging Het
Dpep2 A G 8: 106,713,075 (GRCm39) V440A probably benign Het
Ehmt2 A T 17: 35,125,008 (GRCm39) M11L possibly damaging Het
Eml2 C T 7: 18,924,685 (GRCm39) H185Y probably damaging Het
Gm10845 T A 14: 80,100,770 (GRCm39) noncoding transcript Het
Gm8122 T G 14: 43,091,477 (GRCm39) N97T unknown Het
Gnb1 A G 4: 155,639,559 (GRCm39) T263A probably benign Het
Hyls1 G A 9: 35,472,480 (GRCm39) S312F probably benign Het
Ier5l A G 2: 30,363,171 (GRCm39) C285R possibly damaging Het
Kif21b A G 1: 136,097,747 (GRCm39) N1336D probably damaging Het
Kl A G 5: 150,915,003 (GRCm39) N910S possibly damaging Het
Lama1 A G 17: 68,122,219 (GRCm39) H2722R possibly damaging Het
Mdm2 A G 10: 117,538,212 (GRCm39) M13T possibly damaging Het
Micall1 T A 15: 79,014,678 (GRCm39) Y685N possibly damaging Het
Mthfd1l T G 10: 4,053,302 (GRCm39) S884A possibly damaging Het
Nkiras2 A G 11: 100,515,853 (GRCm39) Y60C probably damaging Het
Oc90 T G 15: 65,753,388 (GRCm39) R342S possibly damaging Het
Or1j4 T C 2: 36,740,544 (GRCm39) L162P possibly damaging Het
Or4k35 T A 2: 111,100,197 (GRCm39) R172* probably null Het
Or4p20 T A 2: 88,253,791 (GRCm39) I193F probably benign Het
Or9s13 A G 1: 92,547,900 (GRCm39) N91D probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Parp9 G T 16: 35,784,467 (GRCm39) E507* probably null Het
Pex13 A G 11: 23,605,705 (GRCm39) I175T probably benign Het
Phf12 A G 11: 77,914,370 (GRCm39) E604G probably damaging Het
Ppfia4 A T 1: 134,251,815 (GRCm39) probably null Het
Rragc T C 4: 123,813,828 (GRCm39) Y141H possibly damaging Het
Slc35g3 A G 11: 69,651,280 (GRCm39) V257A probably benign Het
Snx5 T C 2: 144,102,674 (GRCm39) T80A probably benign Het
Sorcs2 G A 5: 36,188,630 (GRCm39) A826V possibly damaging Het
Sptb G A 12: 76,669,888 (GRCm39) A480V probably benign Het
Tmem161b T A 13: 84,434,909 (GRCm39) S302R possibly damaging Het
Ube2o A T 11: 116,430,496 (GRCm39) F1081I probably damaging Het
Vmn2r2 T C 3: 64,024,608 (GRCm39) I658V probably benign Het
Vwa3b T G 1: 37,174,600 (GRCm39) L672V probably benign Het
Wscd2 T C 5: 113,715,411 (GRCm39) F417S possibly damaging Het
Other mutations in Or11h23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01368:Or11h23 APN 14 50,948,450 (GRCm39) missense possibly damaging 0.95
IGL02965:Or11h23 APN 14 50,948,653 (GRCm39) missense probably damaging 1.00
R0576:Or11h23 UTSW 14 50,948,661 (GRCm39) missense probably damaging 0.98
R1184:Or11h23 UTSW 14 50,948,071 (GRCm39) missense probably benign 0.01
R2129:Or11h23 UTSW 14 50,948,093 (GRCm39) missense probably damaging 0.99
R2895:Or11h23 UTSW 14 50,947,973 (GRCm39) missense probably damaging 0.99
R2896:Or11h23 UTSW 14 50,947,973 (GRCm39) missense probably damaging 0.99
R4017:Or11h23 UTSW 14 50,948,333 (GRCm39) missense probably benign 0.03
R5053:Or11h23 UTSW 14 50,947,968 (GRCm39) nonsense probably null
R5057:Or11h23 UTSW 14 50,948,669 (GRCm39) missense probably damaging 1.00
R5113:Or11h23 UTSW 14 50,948,371 (GRCm39) missense probably benign 0.00
R5294:Or11h23 UTSW 14 50,948,236 (GRCm39) missense probably benign 0.01
R5294:Or11h23 UTSW 14 50,947,900 (GRCm39) missense possibly damaging 0.95
R5499:Or11h23 UTSW 14 50,948,324 (GRCm39) missense probably damaging 1.00
R5582:Or11h23 UTSW 14 50,948,425 (GRCm39) missense probably damaging 1.00
R6797:Or11h23 UTSW 14 50,948,563 (GRCm39) missense probably damaging 1.00
R7685:Or11h23 UTSW 14 50,948,215 (GRCm39) missense possibly damaging 0.95
R7717:Or11h23 UTSW 14 50,948,219 (GRCm39) missense probably damaging 1.00
R7778:Or11h23 UTSW 14 50,947,928 (GRCm39) missense possibly damaging 0.60
R8276:Or11h23 UTSW 14 50,948,287 (GRCm39) missense probably benign 0.28
R8839:Or11h23 UTSW 14 50,947,957 (GRCm39) missense possibly damaging 0.73
R9322:Or11h23 UTSW 14 50,948,507 (GRCm39) missense probably damaging 1.00
R9358:Or11h23 UTSW 14 50,947,802 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGGAGCCAAAGGGACATACTC -3'
(R):5'- GCATGTTGGGAACTGTGCAG -3'

Sequencing Primer
(F):5'- GCCAAAGGGACATACTCAGAAATAG -3'
(R):5'- TCACGTACCAGATTTCTAGGAAGG -3'
Posted On 2017-01-03