Incidental Mutation 'R5729:Lats2'
ID 452678
Institutional Source Beutler Lab
Gene Symbol Lats2
Ensembl Gene ENSMUSG00000021959
Gene Name large tumor suppressor 2
Synonyms
MMRRC Submission 043346-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5729 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 57927119-57983669 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 57960192 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 151 (C151S)
Ref Sequence ENSEMBL: ENSMUSP00000038982 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022531] [ENSMUST00000038381] [ENSMUST00000077981] [ENSMUST00000173990] [ENSMUST00000174166] [ENSMUST00000174213] [ENSMUST00000174694]
AlphaFold Q7TSJ6
Predicted Effect probably benign
Transcript: ENSMUST00000022531
SMART Domains Protein: ENSMUSP00000022531
Gene: ENSMUSG00000021959

DomainStartEndE-ValueType
PDB:2COS|A 91 138 3e-20 PDB
low complexity region 210 223 N/A INTRINSIC
low complexity region 401 408 N/A INTRINSIC
low complexity region 437 444 N/A INTRINSIC
low complexity region 471 482 N/A INTRINSIC
low complexity region 517 529 N/A INTRINSIC
S_TKc 626 931 2.94e-94 SMART
S_TK_X 932 1002 1.21e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000038381
AA Change: C151S

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect probably benign
Transcript: ENSMUST00000077981
Predicted Effect probably benign
Transcript: ENSMUST00000173990
SMART Domains Protein: ENSMUSP00000133976
Gene: ENSMUSG00000021959

DomainStartEndE-ValueType
PDB:2COS|A 91 138 8e-22 PDB
low complexity region 210 223 N/A INTRINSIC
low complexity region 401 408 N/A INTRINSIC
low complexity region 437 444 N/A INTRINSIC
low complexity region 471 482 N/A INTRINSIC
low complexity region 517 529 N/A INTRINSIC
S_TKc 626 893 7.75e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000174166
SMART Domains Protein: ENSMUSP00000133379
Gene: ENSMUSG00000021959

DomainStartEndE-ValueType
PDB:2COS|A 91 114 5e-7 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000174213
SMART Domains Protein: ENSMUSP00000134321
Gene: ENSMUSG00000021959

DomainStartEndE-ValueType
PDB:2COS|A 91 114 2e-6 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000174694
SMART Domains Protein: ENSMUSP00000133680
Gene: ENSMUSG00000114942

DomainStartEndE-ValueType
PDB:2COS|A 91 138 7e-22 PDB
low complexity region 210 223 N/A INTRINSIC
low complexity region 401 408 N/A INTRINSIC
low complexity region 437 444 N/A INTRINSIC
low complexity region 471 482 N/A INTRINSIC
low complexity region 517 529 N/A INTRINSIC
Pfam:Pkinase 626 792 2.2e-38 PFAM
Pfam:Pkinase_Tyr 626 795 2.8e-21 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 97% (62/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice display embryonic lethality with decreased cell proliferation, chromosomal instability, atrial hyperplasia, ventricular hypoplasia, delayed embryonic development, an irregular kinked neural tube, and hemorrhages. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adss2 A T 1: 177,623,824 (GRCm39) V46E possibly damaging Het
Aldoart2 T C 12: 55,612,690 (GRCm39) V205A probably benign Het
Atp1a2 A G 1: 172,120,938 (GRCm39) S45P probably damaging Het
Atp4a A G 7: 30,411,851 (GRCm39) K29E possibly damaging Het
AU040320 T A 4: 126,724,208 (GRCm39) D428E probably damaging Het
Bend7 T C 2: 4,768,085 (GRCm39) L347P probably damaging Het
Cacna2d1 T A 5: 16,140,037 (GRCm39) L9* probably null Het
Ccdc103 A T 11: 102,773,904 (GRCm39) I50F probably damaging Het
Cdc5l T C 17: 45,737,495 (GRCm39) I88V probably benign Het
Cracr2a T C 6: 127,584,199 (GRCm39) V86A possibly damaging Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Dgkd C T 1: 87,864,054 (GRCm39) Q90* probably null Het
Dnajc21 A T 15: 10,449,682 (GRCm39) D446E probably benign Het
Fam13a T G 6: 58,916,292 (GRCm39) R648S probably damaging Het
Gabrg2 A G 11: 41,858,450 (GRCm39) V226A probably damaging Het
Gm5499 A T 17: 87,385,944 (GRCm39) noncoding transcript Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Irf2bp1 G T 7: 18,739,172 (GRCm39) E271* probably null Het
Krt86 T G 15: 101,374,429 (GRCm39) V274G probably benign Het
Mapk3 A T 7: 126,363,979 (GRCm39) T254S probably benign Het
Mat2b A T 11: 40,573,373 (GRCm39) M202K probably damaging Het
Mos A G 4: 3,870,971 (GRCm39) Y282H probably benign Het
Myo3b A G 2: 69,936,083 (GRCm39) K108R probably damaging Het
Naa16 A G 14: 79,593,220 (GRCm39) Y417H probably damaging Het
Oat A T 7: 132,159,984 (GRCm39) I412N probably damaging Het
Or4d11 A T 19: 12,013,272 (GRCm39) I278N probably damaging Het
Pcdh1 A T 18: 38,335,999 (GRCm39) V73D probably damaging Het
Pigv A T 4: 133,392,134 (GRCm39) Y345* probably null Het
Pitpnc1 G T 11: 107,228,264 (GRCm39) F34L probably benign Het
Plxnd1 A G 6: 115,942,838 (GRCm39) L1282P probably damaging Het
Ppp1r3a T C 6: 14,719,762 (GRCm39) D384G probably benign Het
Ppp2ca G A 11: 52,008,856 (GRCm39) E119K probably damaging Het
Psg29 A T 7: 16,944,459 (GRCm39) N323I probably damaging Het
Rasa4 T C 5: 136,122,016 (GRCm39) V108A probably benign Het
Rbm14 A G 19: 4,852,577 (GRCm39) probably benign Het
Rfc1 A T 5: 65,434,795 (GRCm39) V657E probably damaging Het
Rhcg A T 7: 79,250,371 (GRCm39) N237K probably damaging Het
Rpgrip1 A G 14: 52,397,617 (GRCm39) Q1302R probably benign Het
Rragc A G 4: 123,818,645 (GRCm39) M287V possibly damaging Het
Scn7a A G 2: 66,572,301 (GRCm39) probably null Het
Sema6a C T 18: 47,414,410 (GRCm39) C506Y probably damaging Het
Senp1 G T 15: 97,964,412 (GRCm39) H267Q possibly damaging Het
Skor2 A G 18: 76,946,578 (GRCm39) E100G unknown Het
Slc38a11 A T 2: 65,147,365 (GRCm39) C371S probably benign Het
Snai3 G A 8: 123,181,629 (GRCm39) A276V probably benign Het
Sp110 C G 1: 85,516,839 (GRCm39) E219D probably damaging Het
Spag6 C T 2: 18,720,525 (GRCm39) T99I probably benign Het
Spop A G 11: 95,376,675 (GRCm39) I243V possibly damaging Het
Sra1 A T 18: 36,800,496 (GRCm39) probably benign Het
Stag3 T A 5: 138,288,485 (GRCm39) S140T possibly damaging Het
Stx16 G A 2: 173,935,292 (GRCm39) G156R probably damaging Het
Tbc1d2b G C 9: 90,089,925 (GRCm39) A868G probably benign Het
Tead2 A G 7: 44,870,166 (GRCm39) probably benign Het
Tmem53 C A 4: 117,125,669 (GRCm39) H261N probably damaging Het
Ube4a A T 9: 44,844,627 (GRCm39) S932T probably damaging Het
Usp9y A T Y: 1,381,339 (GRCm39) D827E probably damaging Het
Vmn2r53 T C 7: 12,334,733 (GRCm39) E309G probably damaging Het
Wrn T C 8: 33,758,806 (GRCm39) S1026G probably benign Het
Zfp646 G A 7: 127,484,626 (GRCm39) A1760T probably damaging Het
Other mutations in Lats2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00272:Lats2 APN 14 57,929,026 (GRCm39) missense probably benign 0.09
IGL02104:Lats2 APN 14 57,971,469 (GRCm39) missense probably damaging 1.00
IGL02173:Lats2 APN 14 57,934,717 (GRCm39) missense probably damaging 1.00
IGL02377:Lats2 APN 14 57,929,052 (GRCm39) missense probably damaging 1.00
IGL02995:Lats2 APN 14 57,937,805 (GRCm39) missense probably damaging 1.00
Morpheus UTSW 14 57,933,591 (GRCm39) missense probably damaging 1.00
PIT4472001:Lats2 UTSW 14 57,936,814 (GRCm39) nonsense probably null
R0653:Lats2 UTSW 14 57,937,653 (GRCm39) nonsense probably null
R0780:Lats2 UTSW 14 57,928,753 (GRCm39) missense probably damaging 1.00
R1129:Lats2 UTSW 14 57,937,790 (GRCm39) missense possibly damaging 0.71
R1851:Lats2 UTSW 14 57,934,912 (GRCm39) missense probably damaging 1.00
R1882:Lats2 UTSW 14 57,934,811 (GRCm39) missense probably damaging 1.00
R2184:Lats2 UTSW 14 57,929,016 (GRCm39) missense probably damaging 0.99
R3498:Lats2 UTSW 14 57,959,923 (GRCm39) missense possibly damaging 0.95
R3692:Lats2 UTSW 14 57,928,998 (GRCm39) missense probably damaging 1.00
R4212:Lats2 UTSW 14 57,933,712 (GRCm39) missense possibly damaging 0.82
R4357:Lats2 UTSW 14 57,936,840 (GRCm39) missense probably damaging 1.00
R4962:Lats2 UTSW 14 57,937,049 (GRCm39) missense probably damaging 1.00
R5394:Lats2 UTSW 14 57,928,810 (GRCm39) missense probably benign 0.10
R5477:Lats2 UTSW 14 57,937,010 (GRCm39) missense probably benign 0.00
R5802:Lats2 UTSW 14 57,931,875 (GRCm39) missense probably damaging 0.99
R5931:Lats2 UTSW 14 57,933,588 (GRCm39) missense probably damaging 1.00
R6016:Lats2 UTSW 14 57,971,632 (GRCm39) missense probably damaging 1.00
R6376:Lats2 UTSW 14 57,959,966 (GRCm39) missense probably benign 0.00
R6624:Lats2 UTSW 14 57,931,769 (GRCm39) critical splice donor site probably null
R6638:Lats2 UTSW 14 57,936,822 (GRCm39) missense probably damaging 1.00
R6846:Lats2 UTSW 14 57,933,591 (GRCm39) missense probably damaging 1.00
R7198:Lats2 UTSW 14 57,934,582 (GRCm39) missense probably damaging 1.00
R7233:Lats2 UTSW 14 57,960,151 (GRCm39) splice site probably null
R7883:Lats2 UTSW 14 57,934,657 (GRCm39) missense probably damaging 1.00
R8081:Lats2 UTSW 14 57,937,968 (GRCm39) missense probably damaging 1.00
R8356:Lats2 UTSW 14 57,934,867 (GRCm39) missense probably damaging 1.00
R8508:Lats2 UTSW 14 57,960,162 (GRCm39) missense probably benign 0.08
R8536:Lats2 UTSW 14 57,940,495 (GRCm39) missense probably damaging 1.00
R8767:Lats2 UTSW 14 57,931,781 (GRCm39) missense probably damaging 1.00
R9579:Lats2 UTSW 14 57,937,191 (GRCm39) missense probably damaging 1.00
R9643:Lats2 UTSW 14 57,936,875 (GRCm39) missense possibly damaging 0.94
Predicted Primers PCR Primer
(F):5'- GGAAATAAAGAAATCTGCCTCAAGC -3'
(R):5'- AACAGAGGGATGGTGGCTTC -3'

Sequencing Primer
(F):5'- CAAGGGAAAATGAGAACTAATACCC -3'
(R):5'- GACAGTCTGTGCCCTTAACTATGAG -3'
Posted On 2017-01-03