Incidental Mutation 'R5729:Naa16'
ID 452679
Institutional Source Beutler Lab
Gene Symbol Naa16
Ensembl Gene ENSMUSG00000022020
Gene Name N(alpha)-acetyltransferase 16, NatA auxiliary subunit
Synonyms 1300019C06Rik, Narg1l
MMRRC Submission 043346-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R5729 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 79571947-79628228 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 79593220 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 417 (Y417H)
Ref Sequence ENSEMBL: ENSMUSP00000131268 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022597] [ENSMUST00000163486]
AlphaFold Q9DBB4
Predicted Effect probably damaging
Transcript: ENSMUST00000022597
AA Change: Y451H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: Y451H

DomainStartEndE-ValueType
TPR 46 79 2.99e1 SMART
TPR 80 113 2.98e-3 SMART
Blast:TPR 224 257 1e-10 BLAST
TPR 374 407 9.96e0 SMART
TPR 408 441 7.47e0 SMART
low complexity region 616 633 N/A INTRINSIC
Blast:TPR 672 705 3e-12 BLAST
low complexity region 830 841 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000163486
AA Change: Y417H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000131268
Gene: ENSMUSG00000022020
AA Change: Y417H

DomainStartEndE-ValueType
TPR 12 45 2.99e1 SMART
TPR 46 79 2.98e-3 SMART
Blast:TPR 190 223 3e-10 BLAST
TPR 340 373 9.96e0 SMART
TPR 374 407 7.47e0 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227775
Meta Mutation Damage Score 0.5541 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 97% (62/64)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adss2 A T 1: 177,623,824 (GRCm39) V46E possibly damaging Het
Aldoart2 T C 12: 55,612,690 (GRCm39) V205A probably benign Het
Atp1a2 A G 1: 172,120,938 (GRCm39) S45P probably damaging Het
Atp4a A G 7: 30,411,851 (GRCm39) K29E possibly damaging Het
AU040320 T A 4: 126,724,208 (GRCm39) D428E probably damaging Het
Bend7 T C 2: 4,768,085 (GRCm39) L347P probably damaging Het
Cacna2d1 T A 5: 16,140,037 (GRCm39) L9* probably null Het
Ccdc103 A T 11: 102,773,904 (GRCm39) I50F probably damaging Het
Cdc5l T C 17: 45,737,495 (GRCm39) I88V probably benign Het
Cracr2a T C 6: 127,584,199 (GRCm39) V86A possibly damaging Het
Cybb C G X: 9,316,989 (GRCm39) D246H probably benign Het
Dgkd C T 1: 87,864,054 (GRCm39) Q90* probably null Het
Dnajc21 A T 15: 10,449,682 (GRCm39) D446E probably benign Het
Fam13a T G 6: 58,916,292 (GRCm39) R648S probably damaging Het
Gabrg2 A G 11: 41,858,450 (GRCm39) V226A probably damaging Het
Gm5499 A T 17: 87,385,944 (GRCm39) noncoding transcript Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Irf2bp1 G T 7: 18,739,172 (GRCm39) E271* probably null Het
Krt86 T G 15: 101,374,429 (GRCm39) V274G probably benign Het
Lats2 A T 14: 57,960,192 (GRCm39) C151S probably benign Het
Mapk3 A T 7: 126,363,979 (GRCm39) T254S probably benign Het
Mat2b A T 11: 40,573,373 (GRCm39) M202K probably damaging Het
Mos A G 4: 3,870,971 (GRCm39) Y282H probably benign Het
Myo3b A G 2: 69,936,083 (GRCm39) K108R probably damaging Het
Oat A T 7: 132,159,984 (GRCm39) I412N probably damaging Het
Or4d11 A T 19: 12,013,272 (GRCm39) I278N probably damaging Het
Pcdh1 A T 18: 38,335,999 (GRCm39) V73D probably damaging Het
Pigv A T 4: 133,392,134 (GRCm39) Y345* probably null Het
Pitpnc1 G T 11: 107,228,264 (GRCm39) F34L probably benign Het
Plxnd1 A G 6: 115,942,838 (GRCm39) L1282P probably damaging Het
Ppp1r3a T C 6: 14,719,762 (GRCm39) D384G probably benign Het
Ppp2ca G A 11: 52,008,856 (GRCm39) E119K probably damaging Het
Psg29 A T 7: 16,944,459 (GRCm39) N323I probably damaging Het
Rasa4 T C 5: 136,122,016 (GRCm39) V108A probably benign Het
Rbm14 A G 19: 4,852,577 (GRCm39) probably benign Het
Rfc1 A T 5: 65,434,795 (GRCm39) V657E probably damaging Het
Rhcg A T 7: 79,250,371 (GRCm39) N237K probably damaging Het
Rpgrip1 A G 14: 52,397,617 (GRCm39) Q1302R probably benign Het
Rragc A G 4: 123,818,645 (GRCm39) M287V possibly damaging Het
Scn7a A G 2: 66,572,301 (GRCm39) probably null Het
Sema6a C T 18: 47,414,410 (GRCm39) C506Y probably damaging Het
Senp1 G T 15: 97,964,412 (GRCm39) H267Q possibly damaging Het
Skor2 A G 18: 76,946,578 (GRCm39) E100G unknown Het
Slc38a11 A T 2: 65,147,365 (GRCm39) C371S probably benign Het
Snai3 G A 8: 123,181,629 (GRCm39) A276V probably benign Het
Sp110 C G 1: 85,516,839 (GRCm39) E219D probably damaging Het
Spag6 C T 2: 18,720,525 (GRCm39) T99I probably benign Het
Spop A G 11: 95,376,675 (GRCm39) I243V possibly damaging Het
Sra1 A T 18: 36,800,496 (GRCm39) probably benign Het
Stag3 T A 5: 138,288,485 (GRCm39) S140T possibly damaging Het
Stx16 G A 2: 173,935,292 (GRCm39) G156R probably damaging Het
Tbc1d2b G C 9: 90,089,925 (GRCm39) A868G probably benign Het
Tead2 A G 7: 44,870,166 (GRCm39) probably benign Het
Tmem53 C A 4: 117,125,669 (GRCm39) H261N probably damaging Het
Ube4a A T 9: 44,844,627 (GRCm39) S932T probably damaging Het
Usp9y A T Y: 1,381,339 (GRCm39) D827E probably damaging Het
Vmn2r53 T C 7: 12,334,733 (GRCm39) E309G probably damaging Het
Wrn T C 8: 33,758,806 (GRCm39) S1026G probably benign Het
Zfp646 G A 7: 127,484,626 (GRCm39) A1760T probably damaging Het
Other mutations in Naa16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00551:Naa16 APN 14 79,593,169 (GRCm39) missense probably damaging 1.00
IGL01025:Naa16 APN 14 79,622,196 (GRCm39) missense probably damaging 1.00
IGL01155:Naa16 APN 14 79,622,155 (GRCm39) missense probably damaging 0.98
IGL01335:Naa16 APN 14 79,582,556 (GRCm39) splice site probably benign
IGL01981:Naa16 APN 14 79,618,956 (GRCm39) missense probably benign 0.05
IGL02230:Naa16 APN 14 79,614,801 (GRCm39) splice site probably benign
IGL02313:Naa16 APN 14 79,622,108 (GRCm39) missense probably damaging 1.00
IGL02418:Naa16 APN 14 79,620,806 (GRCm39) missense probably damaging 1.00
IGL02544:Naa16 APN 14 79,573,260 (GRCm39) missense probably damaging 1.00
IGL03051:Naa16 APN 14 79,606,522 (GRCm39) missense probably benign 0.01
IGL03064:Naa16 APN 14 79,577,068 (GRCm39) missense probably damaging 0.98
IGL03205:Naa16 APN 14 79,593,952 (GRCm39) missense possibly damaging 0.89
PIT4508001:Naa16 UTSW 14 79,606,527 (GRCm39) missense probably benign 0.15
R0651:Naa16 UTSW 14 79,588,832 (GRCm39) missense probably damaging 1.00
R1429:Naa16 UTSW 14 79,596,967 (GRCm39) missense probably benign 0.01
R1674:Naa16 UTSW 14 79,624,497 (GRCm39) start codon destroyed probably null 0.65
R1693:Naa16 UTSW 14 79,588,896 (GRCm39) missense probably damaging 1.00
R1874:Naa16 UTSW 14 79,593,183 (GRCm39) missense possibly damaging 0.62
R1992:Naa16 UTSW 14 79,593,931 (GRCm39) missense probably damaging 1.00
R2015:Naa16 UTSW 14 79,582,499 (GRCm39) missense probably damaging 1.00
R2391:Naa16 UTSW 14 79,607,489 (GRCm39) missense probably benign 0.16
R2847:Naa16 UTSW 14 79,573,323 (GRCm39) missense probably damaging 1.00
R2848:Naa16 UTSW 14 79,573,323 (GRCm39) missense probably damaging 1.00
R2877:Naa16 UTSW 14 79,580,738 (GRCm39) missense probably benign 0.00
R3884:Naa16 UTSW 14 79,580,702 (GRCm39) missense probably damaging 0.98
R4001:Naa16 UTSW 14 79,580,561 (GRCm39) splice site probably null
R4199:Naa16 UTSW 14 79,593,311 (GRCm39) missense probably damaging 1.00
R4638:Naa16 UTSW 14 79,577,473 (GRCm39) splice site probably null
R4676:Naa16 UTSW 14 79,573,788 (GRCm39) unclassified probably benign
R4690:Naa16 UTSW 14 79,582,497 (GRCm39) missense probably damaging 1.00
R4952:Naa16 UTSW 14 79,582,525 (GRCm39) missense probably damaging 1.00
R5087:Naa16 UTSW 14 79,614,855 (GRCm39) missense possibly damaging 0.68
R5104:Naa16 UTSW 14 79,622,140 (GRCm39) nonsense probably null
R6178:Naa16 UTSW 14 79,620,780 (GRCm39) missense possibly damaging 0.93
R6960:Naa16 UTSW 14 79,596,911 (GRCm39) missense possibly damaging 0.65
R7794:Naa16 UTSW 14 79,614,934 (GRCm39) missense probably damaging 1.00
R7936:Naa16 UTSW 14 79,578,486 (GRCm39) missense possibly damaging 0.47
R8356:Naa16 UTSW 14 79,596,915 (GRCm39) missense probably benign 0.00
R8456:Naa16 UTSW 14 79,596,915 (GRCm39) missense probably benign 0.00
R8892:Naa16 UTSW 14 79,628,016 (GRCm39) missense probably benign 0.32
R8931:Naa16 UTSW 14 79,582,395 (GRCm39) missense probably damaging 1.00
R9010:Naa16 UTSW 14 79,607,482 (GRCm39) missense probably benign 0.01
R9068:Naa16 UTSW 14 79,612,289 (GRCm39) missense probably benign 0.18
R9360:Naa16 UTSW 14 79,593,943 (GRCm39) missense probably benign 0.05
R9688:Naa16 UTSW 14 79,573,309 (GRCm39) nonsense probably null
X0064:Naa16 UTSW 14 79,588,829 (GRCm39) missense probably damaging 1.00
Z1177:Naa16 UTSW 14 79,582,419 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAATTTTGCAGCCAGGAGC -3'
(R):5'- GATACAATCATGTCAAACTGGAACC -3'

Sequencing Primer
(F):5'- GCCATAGTTAGAACACAGATTAATGG -3'
(R):5'- TGTCAAACTGGAACCCATTTTTATAC -3'
Posted On 2017-01-03