Mutagenetix > Incidental Mutation

Incidental Mutation 'R5730:Vmn1r64'

452714

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r64

Ensembl Gene

ENSMUSG00000058399

Gene Name

vomeronasal 1 receptor 64

Synonyms

V1rd11

MMRRC Submission

043191-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.053) question?

Stock #

R5730 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

5886579-5887541 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 5887522 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 7 (T7I)

Ref Sequence

ENSEMBL: ENSMUSP00000077568 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078475]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000078475
AA Change: T7I

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000077568
Gene: ENSMUSG00000058399
AA Change: T7I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	3.3e-13	PFAM
Pfam:V1R	41	296	1.5e-19	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 95.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ahnak	T	C	19: 8,987,617 (GRCm39)	V2967A	possibly damaging	Het
Apaf1	A	T	10: 90,856,633 (GRCm39)	I858K	possibly damaging	Het
Baiap3	T	C	17: 25,466,498 (GRCm39)	T466A	probably benign	Het
Brca2	T	A	5: 150,492,470 (GRCm39)	S3162T	possibly damaging	Het
Brd1	T	G	15: 88,601,248 (GRCm39)	N462T	probably benign	Het
Carm1	G	A	9: 21,491,636 (GRCm39)	R235H	probably benign	Het
Cd80	T	C	16: 38,303,097 (GRCm39)		probably null	Het
Clip4	A	G	17: 72,117,954 (GRCm39)	Y333C	probably damaging	Het
Col7a1	T	C	9: 108,801,310 (GRCm39)		probably null	Het
Csmd1	G	A	8: 16,235,206 (GRCm39)	Q1206*	probably null	Het
Cyp17a1	A	G	19: 46,661,095 (GRCm39)	I63T	possibly damaging	Het
Diaph1	A	G	18: 38,036,829 (GRCm39)	Y119H	unknown	Het
Dst	T	G	1: 34,156,607 (GRCm39)		probably null	Het
Fgfr1	A	G	8: 26,063,827 (GRCm39)	T785A	probably damaging	Het
Gm1553	A	G	10: 82,323,945 (GRCm39)	F94S	unknown	Het
Gpbar1	A	G	1: 74,318,195 (GRCm39)	N146S	probably damaging	Het
Gpc5	A	G	14: 116,025,726 (GRCm39)	T588A	possibly damaging	Het
Gramd2a	A	G	9: 59,618,489 (GRCm39)	H9R	probably damaging	Het
Klk1b11	G	A	7: 43,424,199 (GRCm39)	S6N	probably benign	Het
Lrp1	A	G	10: 127,419,703 (GRCm39)	S969P	probably benign	Het
Lyz2	G	T	10: 117,114,587 (GRCm39)	A114E	probably damaging	Het
Madd	T	C	2: 90,988,454 (GRCm39)	D1193G	probably damaging	Het
Mrpl39	C	T	16: 84,529,322 (GRCm39)	G107R	probably damaging	Het
Mthfd2	C	T	6: 83,294,441 (GRCm39)	R24H	probably benign	Het
Or2q1	C	T	6: 42,795,094 (GRCm39)	R230*	probably null	Het
Or4a68	T	C	2: 89,269,780 (GRCm39)	N281S	probably damaging	Het
Ovch2	A	G	7: 107,392,606 (GRCm39)	C246R	probably damaging	Het
Phf14	A	T	6: 11,953,319 (GRCm39)	I353F	possibly damaging	Het
Ppp2r5a	C	T	1: 191,104,732 (GRCm39)	V105I	probably benign	Het
Prr14l	T	C	5: 32,950,947 (GRCm39)	T1949A	probably damaging	Het
Prss48	T	G	3: 85,904,563 (GRCm39)	M212L	possibly damaging	Het
Pstk	A	T	7: 130,975,503 (GRCm39)	D152V	probably damaging	Het
Scn2a	C	A	2: 65,512,882 (GRCm39)	S214*	probably null	Het
Scn3a	T	G	2: 65,325,604 (GRCm39)	N971T	probably benign	Het
Syne3	T	C	12: 104,927,713 (GRCm39)	I250V	probably benign	Het
Synpo2	T	C	3: 122,907,768 (GRCm39)	D516G	probably benign	Het
Tcea3	T	C	4: 135,992,204 (GRCm39)	V209A	probably benign	Het
Tnr	A	G	1: 159,715,892 (GRCm39)	S885G	probably benign	Het
Trak2	T	C	1: 58,960,966 (GRCm39)	D188G	probably damaging	Het
Tubb1	A	G	2: 174,299,562 (GRCm39)	I415V	probably benign	Het
Virma	T	A	4: 11,542,154 (GRCm39)	M1580K	probably benign	Het
Vmn1r120	A	T	7: 20,786,934 (GRCm39)	I259N	possibly damaging	Het

Other mutations in Vmn1r64

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Vmn1r64	APN	7	5,886,827 (GRCm39)	missense	probably damaging	0.98
IGL01070:Vmn1r64	APN	7	5,886,941 (GRCm39)	missense	probably benign	0.04
IGL01817:Vmn1r64	APN	7	5,887,222 (GRCm39)	missense	probably damaging	1.00
IGL02026:Vmn1r64	APN	7	5,886,649 (GRCm39)	missense	possibly damaging	0.84
IGL02657:Vmn1r64	APN	7	5,886,727 (GRCm39)	missense	probably benign	0.33
IGL03352:Vmn1r64	APN	7	5,887,070 (GRCm39)	missense	probably benign	0.12
R0200:Vmn1r64	UTSW	7	5,886,817 (GRCm39)	missense	probably benign	0.38
R0540:Vmn1r64	UTSW	7	5,887,096 (GRCm39)	missense	probably damaging	1.00
R0655:Vmn1r64	UTSW	7	5,887,207 (GRCm39)	missense	probably benign	0.25
R1212:Vmn1r64	UTSW	7	5,887,210 (GRCm39)	missense	probably damaging	1.00
R1579:Vmn1r64	UTSW	7	5,886,803 (GRCm39)	missense	probably damaging	1.00
R2034:Vmn1r64	UTSW	7	5,886,988 (GRCm39)	missense	probably benign	0.09
R2221:Vmn1r64	UTSW	7	5,887,448 (GRCm39)	missense	probably benign	0.00
R2240:Vmn1r64	UTSW	7	5,887,369 (GRCm39)	nonsense	probably null
R2305:Vmn1r64	UTSW	7	5,887,535 (GRCm39)	missense	probably benign	0.04
R3019:Vmn1r64	UTSW	7	5,887,226 (GRCm39)	missense	probably damaging	1.00
R4256:Vmn1r64	UTSW	7	5,886,895 (GRCm39)	missense	probably benign	0.05
R4666:Vmn1r64	UTSW	7	5,887,357 (GRCm39)	missense	probably damaging	0.99
R4996:Vmn1r64	UTSW	7	5,887,052 (GRCm39)	missense	probably benign	0.03
R5682:Vmn1r64	UTSW	7	5,886,622 (GRCm39)	missense	possibly damaging	0.79
R7397:Vmn1r64	UTSW	7	5,887,013 (GRCm39)	missense	possibly damaging	0.87
R9697:Vmn1r64	UTSW	7	5,886,859 (GRCm39)	missense	probably benign	0.04
X0063:Vmn1r64	UTSW	7	5,887,349 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GGCTTCCTGGGAACAAAATCAATC -3'
(R):5'- AATTCTCCTGTAGTGTGCTAAAGC -3'

Sequencing Primer
(F):5'- TTCCTGGGAACAAAATCAATCAGGTC -3'
(R):5'- GCTAAAGCAGTGCCACCTTTTC -3'

Posted On

2017-01-03