Incidental Mutation 'IGL03055:Wnt6'
ID 453363
Institutional Source Beutler Lab
Gene Symbol Wnt6
Ensembl Gene ENSMUSG00000033227
Gene Name wingless-type MMTV integration site family, member 6
Synonyms Wnt-6
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL03055 (G1)
Quality Score 122
Status Validated
Chromosome 1
Chromosomal Location 74811051-74824481 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 74822013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 198 (R198H)
Ref Sequence ENSEMBL: ENSMUSP00000006716 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006716]
AlphaFold P22727
Predicted Effect probably damaging
Transcript: ENSMUST00000006716
AA Change: R198H

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000006716
Gene: ENSMUSG00000033227
AA Change: R198H

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
WNT1 42 364 6.06e-197 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189544
Meta Mutation Damage Score 0.5728 question?
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 98% (58/59)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line. The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired decidualization with reduced uterine stromal cell proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900041M22Rik T A 11: 117,503,072 (GRCm39) noncoding transcript Het
4933416I08Rik TCC TCCC X: 52,692,862 (GRCm39) noncoding transcript Het
A430005L14Rik T A 4: 154,045,092 (GRCm39) S40R probably benign Het
Aire A G 10: 77,878,903 (GRCm39) L48P probably damaging Het
Alkbh8 T C 9: 3,345,882 (GRCm39) probably benign Het
Aqp7 A G 4: 41,045,326 (GRCm39) M18T probably benign Het
Cchcr1 T A 17: 35,837,516 (GRCm39) M406K probably benign Het
Cdhr1 A T 14: 36,817,054 (GRCm39) D102E probably benign Het
Cilp TGGG TGG 9: 65,187,412 (GRCm39) probably null Het
Clec16a T A 16: 10,559,645 (GRCm39) S973T probably damaging Het
Crb1 CG C 1: 139,164,824 (GRCm39) probably null Het
Csmd1 A G 8: 16,145,515 (GRCm39) Y1471H probably damaging Het
Dnah12 A G 14: 26,594,697 (GRCm39) Y3489C probably damaging Het
Ect2 T C 3: 27,191,211 (GRCm39) E464G probably damaging Het
Enpp2 C A 15: 54,729,481 (GRCm39) probably null Het
Erich2 G T 2: 70,339,529 (GRCm39) C28F possibly damaging Het
Fam135b A T 15: 71,493,883 (GRCm39) H15Q possibly damaging Het
Fcna G C 2: 25,520,693 (GRCm39) probably benign Het
Gfral T A 9: 76,115,831 (GRCm39) T48S probably benign Het
Itga10 A G 3: 96,557,836 (GRCm39) E293G probably damaging Het
Lrp2 A T 2: 69,288,792 (GRCm39) N3691K probably damaging Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Nefm T C 14: 68,360,358 (GRCm39) T371A probably damaging Het
Nkain3 C A 4: 20,778,308 (GRCm39) C3F probably benign Het
Nol4l G C 2: 153,278,190 (GRCm39) silent Het
Nprl3 C A 11: 32,198,230 (GRCm39) probably benign Het
Or52p1 A T 7: 104,267,413 (GRCm39) I176F probably damaging Het
Pate2 T C 9: 35,523,069 (GRCm39) probably benign Het
Pde4d A G 13: 110,071,879 (GRCm39) K128R probably damaging Het
Ptprt A G 2: 161,375,533 (GRCm39) L1329P probably damaging Het
Rapgef3 T C 15: 97,647,370 (GRCm39) probably benign Het
Rassf5 T C 1: 131,172,732 (GRCm39) I46V probably benign Het
Rin1 C T 19: 5,103,187 (GRCm39) T481I probably benign Het
Samd4b A G 7: 28,104,971 (GRCm39) L524P possibly damaging Het
Speer4c1 A C 5: 15,919,214 (GRCm39) probably benign Het
Srebf1 T C 11: 60,097,902 (GRCm39) silent Het
Ssh2 C T 11: 77,299,021 (GRCm39) Q123* probably null Het
St18 G T 1: 6,872,959 (GRCm39) L231F probably damaging Het
Stk11 A C 10: 79,963,920 (GRCm39) D96A probably damaging Het
Svil A G 18: 5,108,615 (GRCm39) T1918A probably damaging Het
Thrap3 G A 4: 126,059,335 (GRCm39) probably null Het
Tlr1 C A 5: 65,083,939 (GRCm39) V213F probably benign Het
Trappc10 C T 10: 78,050,520 (GRCm39) R307Q probably damaging Het
Ugt1a1 AT A 1: 88,140,093 (GRCm39) probably null Het
Yipf2 A T 9: 21,501,019 (GRCm39) V98E probably benign Het
Zc3h15 A G 2: 83,491,515 (GRCm39) T248A possibly damaging Het
Zc3hav1 C T 6: 38,293,251 (GRCm39) probably null Het
Zfp697 T G 3: 98,332,810 (GRCm39) C79G possibly damaging Het
Other mutations in Wnt6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1467:Wnt6 UTSW 1 74,821,434 (GRCm39) missense probably damaging 1.00
R1467:Wnt6 UTSW 1 74,821,434 (GRCm39) missense probably damaging 1.00
R3778:Wnt6 UTSW 1 74,821,941 (GRCm39) missense possibly damaging 0.87
R4865:Wnt6 UTSW 1 74,821,788 (GRCm39) missense probably damaging 0.99
R4927:Wnt6 UTSW 1 74,823,296 (GRCm39) critical splice acceptor site probably null
R4927:Wnt6 UTSW 1 74,823,295 (GRCm39) splice site probably null
R5133:Wnt6 UTSW 1 74,823,755 (GRCm39) missense probably damaging 1.00
R7714:Wnt6 UTSW 1 74,823,422 (GRCm39) missense probably damaging 0.99
R8706:Wnt6 UTSW 1 74,821,947 (GRCm39) missense possibly damaging 0.46
RF024:Wnt6 UTSW 1 74,821,980 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAGTGTGGTTGTCAGGCAC -3'
(R):5'- ACGTATATCTGTGTGCCCGC -3'

Sequencing Primer
(F):5'- GTTGTCAGGCACCCCGC -3'
(R):5'- GCCCCAGCCTTCCCAAATTG -3'
Posted On 2017-02-03