Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03055:Fcna'

453368

Institutional Source

Beutler Lab

Gene Symbol

Fcna

Ensembl Gene

ENSMUSG00000026938

Gene Name

ficolin A

Synonyms

Fcn1, ficolin A

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03055 (G1)

Quality Score

160

Status

Validated

Chromosome

Chromosomal Location

25624666-25628030 bp(-) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

G to C at 25630681 bp

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000028307 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028307]

Predicted Effect

probably benign
Transcript: ENSMUST00000028307

SMART Domains

Protein: ENSMUSP00000028307
Gene: ENSMUSG00000026938

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:Collagen	48	108	2e-10	PFAM
FBG	121	334	2.18e-110	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000127642

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000135799

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000142371

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000155684

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000163217

Coding Region Coverage

1x: 0.0%
3x: 0.0%
10x: 0.0%
20x: 0.0%

Validation Efficiency

98% (58/59)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal collagen antibody-induced arthritis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2900041M22Rik	T	A	11: 117,612,246		noncoding transcript	Het
4933416I08Rik	TCC	TCCC	X: 53,690,895		noncoding transcript	Het
A430005L14Rik	T	A	4: 153,960,635	S40R	probably benign	Het
Aire	A	G	10: 78,043,069	L48P	probably damaging	Het
Alkbh8	T	C	9: 3,345,882		probably benign	Het
Aqp7	A	G	4: 41,045,326	M18T	probably benign	Het
Cchcr1	T	A	17: 35,526,619	M406K	probably benign	Het
Cdhr1	A	T	14: 37,095,097	D102E	probably benign	Het
Cilp	TGGG	TGG	9: 65,280,130		probably null	Het
Clec16a	T	A	16: 10,741,781	S973T	probably damaging	Het
Crb1	CG	C	1: 139,237,086		probably null	Het
Csmd1	A	G	8: 16,095,501	Y1471H	probably damaging	Het
Dnah12	A	G	14: 26,872,740	Y3489C	probably damaging	Het
Ect2	T	C	3: 27,137,062	E464G	probably damaging	Het
Enpp2	C	A	15: 54,866,085		probably null	Het
Erich2	G	T	2: 70,509,185	C28F	possibly damaging	Het
Fam135b	A	T	15: 71,622,034	H15Q	possibly damaging	Het
Gfral	T	A	9: 76,208,549	T48S	probably benign	Het
Itga10	A	G	3: 96,650,520	E293G	probably damaging	Het
Lrp2	A	T	2: 69,458,448	N3691K	probably damaging	Het
Mmp1a	TG	TGG	9: 7,465,083		probably null	Het
Nefm	T	C	14: 68,122,909	T371A	probably damaging	Het
Nkain3	C	A	4: 20,778,308	C3F	probably benign	Het
Nol4l	G	C	2: 153,436,270		silent	Het
Nprl3	C	A	11: 32,248,230		probably benign	Het
Olfr656	A	T	7: 104,618,206	I176F	probably damaging	Het
Pate2	T	C	9: 35,611,773		probably benign	Het
Pde4d	A	G	13: 109,935,345	K128R	probably damaging	Het
Ptprt	A	G	2: 161,533,613	L1329P	probably damaging	Het
Rapgef3	T	C	15: 97,749,489		probably benign	Het
Rassf5	T	C	1: 131,244,995	I46V	probably benign	Het
Rin1	C	T	19: 5,053,159	T481I	probably benign	Het
Samd4b	A	G	7: 28,405,546	L524P	possibly damaging	Het
Speer4c	A	C	5: 15,714,216		probably benign	Het
Srebf1	T	C	11: 60,207,076		silent	Het
Ssh2	C	T	11: 77,408,195	Q123*	probably null	Het
St18	G	T	1: 6,802,735	L231F	probably damaging	Het
Stk11	A	C	10: 80,128,086	D96A	probably damaging	Het
Svil	A	G	18: 5,108,615	T1918A	probably damaging	Het
Thrap3	G	A	4: 126,165,542		probably null	Het
Tlr1	C	A	5: 64,926,596	V213F	probably benign	Het
Trappc10	C	T	10: 78,214,686	R307Q	probably damaging	Het
Ugt1a1	AT	A	1: 88,212,371		probably null	Het
Wnt6	G	A	1: 74,782,854	R198H	probably damaging	Het
Yipf2	A	T	9: 21,589,723	V98E	probably benign	Het
Zc3h15	A	G	2: 83,661,171	T248A	possibly damaging	Het
Zc3hav1	C	T	6: 38,316,316		probably null	Het
Zfp697	T	G	3: 98,425,494	C79G	possibly damaging	Het

Other mutations in Fcna

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01945:Fcna	APN	2	25627835	start codon destroyed	probably null	0.53
IGL02479:Fcna	APN	2	25625260	missense	probably benign	0.02
IGL02488:Fcna	APN	2	25625211	critical splice donor site	probably null
IGL02984:Fcna	UTSW	2	25630681	unclassified	probably benign
IGL02988:Fcna	UTSW	2	25630681	unclassified	probably benign
IGL02991:Fcna	UTSW	2	25630681	unclassified	probably benign
IGL03014:Fcna	UTSW	2	25630681	unclassified	probably benign
IGL03046:Fcna	UTSW	2	25630681	unclassified	probably benign
IGL03048:Fcna	UTSW	2	25630681	unclassified	probably benign
IGL03052:Fcna	UTSW	2	25630681	unclassified	probably benign
IGL03138:Fcna	UTSW	2	25630681	unclassified	probably benign
R0318:Fcna	UTSW	2	25625059	missense	probably benign
R0455:Fcna	UTSW	2	25625508	missense	probably damaging	1.00
R2212:Fcna	UTSW	2	25627493	missense	probably damaging	1.00
R3413:Fcna	UTSW	2	25627493	missense	probably damaging	1.00
R3414:Fcna	UTSW	2	25627493	missense	probably damaging	1.00
R3854:Fcna	UTSW	2	25627772	missense	possibly damaging	0.76
R4007:Fcna	UTSW	2	25626006	splice site	probably null
R4448:Fcna	UTSW	2	25625476	missense	probably damaging	1.00
R4782:Fcna	UTSW	2	25625326	missense	probably damaging	1.00
R4831:Fcna	UTSW	2	25625341	missense	probably benign	0.11
R7255:Fcna	UTSW	2	25626028	missense	probably damaging	0.99
R7920:Fcna	UTSW	2	25626286	missense	probably benign	0.04
R8386:Fcna	UTSW	2	25626015	nonsense	probably null
R8417:Fcna	UTSW	2	25624851	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTTTCTGCTCACATTGTCAATTATTT -3'
(R):5'- GAGGAAATGTATATAAGAACACCCC -3'

Sequencing Primer
(F):5'- GGCTGTCCCAGAACTACCTATGTAG -3'
(R):5'- AGGTAGATCCCTGACCTCGATG -3'

Posted On

2017-02-03