Incidental Mutation 'IGL03055:Fcna'
ID453368
Institutional Source Beutler Lab
Gene Symbol Fcna
Ensembl Gene ENSMUSG00000026938
Gene Nameficolin A
SynonymsFcn1, ficolin A
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03055 (G1)
Quality Score160
Status Validated
Chromosome2
Chromosomal Location25624666-25628030 bp(-) (GRCm38)
Type of Mutationunclassified
DNA Base Change (assembly) G to C at 25630681 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000028307 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028307]
Predicted Effect probably benign
Transcript: ENSMUST00000028307
SMART Domains Protein: ENSMUSP00000028307
Gene: ENSMUSG00000026938

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:Collagen 48 108 2e-10 PFAM
FBG 121 334 2.18e-110 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127642
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135799
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142371
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155684
Predicted Effect noncoding transcript
Transcript: ENSMUST00000163217
Coding Region Coverage
  • 1x: 0.0%
  • 3x: 0.0%
  • 10x: 0.0%
  • 20x: 0.0%
Validation Efficiency 98% (58/59)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal collagen antibody-induced arthritis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900041M22Rik T A 11: 117,612,246 noncoding transcript Het
4933416I08Rik TCC TCCC X: 53,690,895 noncoding transcript Het
A430005L14Rik T A 4: 153,960,635 S40R probably benign Het
Aire A G 10: 78,043,069 L48P probably damaging Het
Alkbh8 T C 9: 3,345,882 probably benign Het
Aqp7 A G 4: 41,045,326 M18T probably benign Het
Cchcr1 T A 17: 35,526,619 M406K probably benign Het
Cdhr1 A T 14: 37,095,097 D102E probably benign Het
Cilp TGGG TGG 9: 65,280,130 probably null Het
Clec16a T A 16: 10,741,781 S973T probably damaging Het
Crb1 CG C 1: 139,237,086 probably null Het
Csmd1 A G 8: 16,095,501 Y1471H probably damaging Het
Dnah12 A G 14: 26,872,740 Y3489C probably damaging Het
Ect2 T C 3: 27,137,062 E464G probably damaging Het
Enpp2 C A 15: 54,866,085 probably null Het
Erich2 G T 2: 70,509,185 C28F possibly damaging Het
Fam135b A T 15: 71,622,034 H15Q possibly damaging Het
Gfral T A 9: 76,208,549 T48S probably benign Het
Itga10 A G 3: 96,650,520 E293G probably damaging Het
Lrp2 A T 2: 69,458,448 N3691K probably damaging Het
Mmp1a TG TGG 9: 7,465,083 probably null Het
Nefm T C 14: 68,122,909 T371A probably damaging Het
Nkain3 C A 4: 20,778,308 C3F probably benign Het
Nol4l G C 2: 153,436,270 silent Het
Nprl3 C A 11: 32,248,230 probably benign Het
Olfr656 A T 7: 104,618,206 I176F probably damaging Het
Pate2 T C 9: 35,611,773 probably benign Het
Pde4d A G 13: 109,935,345 K128R probably damaging Het
Ptprt A G 2: 161,533,613 L1329P probably damaging Het
Rapgef3 T C 15: 97,749,489 probably benign Het
Rassf5 T C 1: 131,244,995 I46V probably benign Het
Rin1 C T 19: 5,053,159 T481I probably benign Het
Samd4b A G 7: 28,405,546 L524P possibly damaging Het
Speer4c A C 5: 15,714,216 probably benign Het
Srebf1 T C 11: 60,207,076 silent Het
Ssh2 C T 11: 77,408,195 Q123* probably null Het
St18 G T 1: 6,802,735 L231F probably damaging Het
Stk11 A C 10: 80,128,086 D96A probably damaging Het
Svil A G 18: 5,108,615 T1918A probably damaging Het
Thrap3 G A 4: 126,165,542 probably null Het
Tlr1 C A 5: 64,926,596 V213F probably benign Het
Trappc10 C T 10: 78,214,686 R307Q probably damaging Het
Ugt1a1 AT A 1: 88,212,371 probably null Het
Wnt6 G A 1: 74,782,854 R198H probably damaging Het
Yipf2 A T 9: 21,589,723 V98E probably benign Het
Zc3h15 A G 2: 83,661,171 T248A possibly damaging Het
Zc3hav1 C T 6: 38,316,316 probably null Het
Zfp697 T G 3: 98,425,494 C79G possibly damaging Het
Other mutations in Fcna
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01945:Fcna APN 2 25627835 start codon destroyed probably null 0.53
IGL02479:Fcna APN 2 25625260 missense probably benign 0.02
IGL02488:Fcna APN 2 25625211 critical splice donor site probably null
IGL02984:Fcna UTSW 2 25630681 unclassified probably benign
IGL02988:Fcna UTSW 2 25630681 unclassified probably benign
IGL02991:Fcna UTSW 2 25630681 unclassified probably benign
IGL03014:Fcna UTSW 2 25630681 unclassified probably benign
IGL03046:Fcna UTSW 2 25630681 unclassified probably benign
IGL03048:Fcna UTSW 2 25630681 unclassified probably benign
IGL03052:Fcna UTSW 2 25630681 unclassified probably benign
IGL03138:Fcna UTSW 2 25630681 unclassified probably benign
R0318:Fcna UTSW 2 25625059 missense probably benign
R0455:Fcna UTSW 2 25625508 missense probably damaging 1.00
R2212:Fcna UTSW 2 25627493 missense probably damaging 1.00
R3413:Fcna UTSW 2 25627493 missense probably damaging 1.00
R3414:Fcna UTSW 2 25627493 missense probably damaging 1.00
R3854:Fcna UTSW 2 25627772 missense possibly damaging 0.76
R4007:Fcna UTSW 2 25626006 splice site probably null
R4448:Fcna UTSW 2 25625476 missense probably damaging 1.00
R4782:Fcna UTSW 2 25625326 missense probably damaging 1.00
R4831:Fcna UTSW 2 25625341 missense probably benign 0.11
R7255:Fcna UTSW 2 25626028 missense probably damaging 0.99
R7920:Fcna UTSW 2 25626286 missense probably benign 0.04
R8386:Fcna UTSW 2 25626015 nonsense probably null
R8417:Fcna UTSW 2 25624851 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTTCTGCTCACATTGTCAATTATTT -3'
(R):5'- GAGGAAATGTATATAAGAACACCCC -3'

Sequencing Primer
(F):5'- GGCTGTCCCAGAACTACCTATGTAG -3'
(R):5'- AGGTAGATCCCTGACCTCGATG -3'
Posted On2017-02-03