Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00402:Zfp207'

4534

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp207

Ensembl Gene

ENSMUSG00000017421

Gene Name

zinc finger protein 207

Synonyms

Zep, 8430401D15Rik

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00402

Quality Score

Status

Chromosome

Chromosomal Location

80274105-80296559 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 80283911 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 277 (M277K)

Ref Sequence

ENSEMBL: ENSMUSP00000103851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017567] [ENSMUST00000053740] [ENSMUST00000108216] [ENSMUST00000153824] [ENSMUST00000165565] [ENSMUST00000178665] [ENSMUST00000188489]

AlphaFold

Q9JMD0

Predicted Effect

probably benign
Transcript: ENSMUST00000017567

SMART Domains

Protein: ENSMUSP00000017567
Gene: ENSMUSG00000017421

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	274	286	N/A	INTRINSIC
low complexity region	295	310	N/A	INTRINSIC
low complexity region	312	350	N/A	INTRINSIC
low complexity region	379	424	N/A	INTRINSIC
low complexity region	429	458	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000053740
AA Change: M277K

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000054168
Gene: ENSMUSG00000017421
AA Change: M277K

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	283	300	N/A	INTRINSIC
low complexity region	306	313	N/A	INTRINSIC
low complexity region	326	341	N/A	INTRINSIC
low complexity region	343	381	N/A	INTRINSIC
low complexity region	410	455	N/A	INTRINSIC
low complexity region	460	489	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108216
AA Change: M277K

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000103851
Gene: ENSMUSG00000017421
AA Change: M277K

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	283	300	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000123726
AA Change: M123K

Predicted Effect

probably benign
Transcript: ENSMUST00000153824

SMART Domains

Protein: ENSMUSP00000115924
Gene: ENSMUSG00000017421

Domain	Start	End	E-Value	Type
ZnF_C2H2	3	23	1.34e2	SMART
ZnF_C2H2	24	47	2.29e0	SMART
low complexity region	87	115	N/A	INTRINSIC
low complexity region	134	173	N/A	INTRINSIC
low complexity region	189	226	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000165565
AA Change: M261K

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000132968
Gene: ENSMUSG00000017421
AA Change: M261K

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	221	N/A	INTRINSIC
low complexity region	236	253	N/A	INTRINSIC
low complexity region	267	284	N/A	INTRINSIC
low complexity region	290	297	N/A	INTRINSIC
low complexity region	310	325	N/A	INTRINSIC
low complexity region	327	365	N/A	INTRINSIC
low complexity region	394	439	N/A	INTRINSIC
low complexity region	444	473	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000178665

SMART Domains

Protein: ENSMUSP00000136727
Gene: ENSMUSG00000017421

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	274	286	N/A	INTRINSIC
low complexity region	295	310	N/A	INTRINSIC
low complexity region	312	350	N/A	INTRINSIC
low complexity region	379	424	N/A	INTRINSIC
low complexity region	429	458	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000188489

SMART Domains

Protein: ENSMUSP00000139653
Gene: ENSMUSG00000017421

Domain	Start	End	E-Value	Type
ZnF_C2H2	11	34	3.29e1	SMART
ZnF_C2H2	35	58	2.29e0	SMART
low complexity region	98	126	N/A	INTRINSIC
low complexity region	145	184	N/A	INTRINSIC
low complexity region	200	237	N/A	INTRINSIC
low complexity region	252	269	N/A	INTRINSIC
low complexity region	274	286	N/A	INTRINSIC
low complexity region	295	310	N/A	INTRINSIC
low complexity region	312	350	N/A	INTRINSIC
low complexity region	379	424	N/A	INTRINSIC
low complexity region	429	458	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca17	A	T	17: 24,514,165 (GRCm39)	L846H	probably benign	Het
Abca6	A	T	11: 110,075,535 (GRCm39)	L1319I	probably damaging	Het
Apob	C	T	12: 8,043,065 (GRCm39)		probably benign	Het
Atg16l2	A	C	7: 100,945,360 (GRCm39)	S268R	probably benign	Het
Atp1b3	T	C	9: 96,215,756 (GRCm39)		probably benign	Het
Atxn7	T	G	14: 14,096,324 (GRCm38)		probably benign	Het
Birc6	G	A	17: 74,880,558 (GRCm39)		probably benign	Het
C4b	G	A	17: 34,953,402 (GRCm39)	T1027I	probably damaging	Het
Caskin1	T	C	17: 24,722,863 (GRCm39)	I577T	probably damaging	Het
Cbx6	A	G	15: 79,713,130 (GRCm39)	V99A	possibly damaging	Het
Ccr9	A	C	9: 123,609,109 (GRCm39)	I252L	probably benign	Het
Cdh8	A	T	8: 100,006,322 (GRCm39)	D88E	probably damaging	Het
Cep135	T	C	5: 76,749,306 (GRCm39)	S258P	probably damaging	Het
Cep57l1	T	G	10: 41,597,547 (GRCm39)		probably benign	Het
Cip2a	T	A	16: 48,822,178 (GRCm39)	H234Q	probably damaging	Het
Col12a1	T	C	9: 79,588,819 (GRCm39)	T1099A	possibly damaging	Het
Col4a4	C	T	1: 82,469,362 (GRCm39)	G802D	unknown	Het
Ddx41	T	C	13: 55,679,212 (GRCm39)	T545A	probably damaging	Het
Disc1	A	T	8: 125,815,014 (GRCm39)	T293S	probably benign	Het
Fam13b	A	T	18: 34,587,771 (GRCm39)	V509D	probably damaging	Het
Ffar4	C	T	19: 38,095,837 (GRCm39)	P192L	probably benign	Het
Fn1	C	A	1: 71,680,322 (GRCm39)	C461F	probably damaging	Het
Gm14226	G	T	2: 154,867,078 (GRCm39)	S345I	probably damaging	Het
Gopc	T	C	10: 52,225,326 (GRCm39)	K308E	probably damaging	Het
Hapln2	A	T	3: 87,931,641 (GRCm39)	N28K	possibly damaging	Het
Hectd1	T	C	12: 51,815,891 (GRCm39)	S1394G	possibly damaging	Het
Hectd1	T	C	12: 51,806,215 (GRCm39)	H1807R	probably benign	Het
Ifnl2	A	T	7: 28,208,290 (GRCm39)	V193D	possibly damaging	Het
Il1rap	T	A	16: 26,541,151 (GRCm39)	M464K	possibly damaging	Het
Krtap16-1	A	T	11: 99,876,557 (GRCm39)	C282*	probably null	Het
Ltv1	C	T	10: 13,066,327 (GRCm39)	V100I	probably benign	Het
Mcf2l	T	C	8: 13,050,857 (GRCm39)	S308P	probably damaging	Het
Narf	G	A	11: 121,129,344 (GRCm39)		probably null	Het
Nmd3	T	A	3: 69,652,573 (GRCm39)	N386K	possibly damaging	Het
Noxo1	C	T	17: 24,917,910 (GRCm39)		probably benign	Het
Or1e30	T	A	11: 73,678,406 (GRCm39)	I214N	probably damaging	Het
Ppic	C	T	18: 53,542,366 (GRCm39)	G114D	probably damaging	Het
Ppp4r1	T	C	17: 66,123,014 (GRCm39)	S339P	probably benign	Het
Ptprg	T	A	14: 12,215,992 (GRCm38)	L1147Q	probably damaging	Het
Qser1	A	G	2: 104,617,326 (GRCm39)	V1072A	probably benign	Het
Rad54l2	T	A	9: 106,577,760 (GRCm39)	M1054L	probably benign	Het
Scara5	A	C	14: 65,975,864 (GRCm39)		probably benign	Het
Smtnl2	C	T	11: 72,294,085 (GRCm39)		probably benign	Het
Spink8	A	T	9: 109,648,287 (GRCm39)	I25F	probably benign	Het
Vit	G	A	17: 78,909,336 (GRCm39)		probably null	Het
Vps13b	A	G	15: 35,926,372 (GRCm39)	D3891G	possibly damaging	Het
Zp2	T	C	7: 119,732,623 (GRCm39)	D641G	probably benign	Het

Other mutations in Zfp207

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00331:Zfp207	APN	11	80,279,828 (GRCm39)	missense	probably benign	0.42
IGL01610:Zfp207	APN	11	80,276,796 (GRCm39)	missense	probably damaging	1.00
R0440:Zfp207	UTSW	11	80,286,333 (GRCm39)	unclassified	probably benign
R1926:Zfp207	UTSW	11	80,286,253 (GRCm39)	nonsense	probably null
R4614:Zfp207	UTSW	11	80,286,016 (GRCm39)	unclassified	probably benign
R5103:Zfp207	UTSW	11	80,282,736 (GRCm39)	missense	probably damaging	1.00
R5647:Zfp207	UTSW	11	80,283,959 (GRCm39)	missense	possibly damaging	0.72
R6845:Zfp207	UTSW	11	80,286,317 (GRCm39)	unclassified	probably benign
R6919:Zfp207	UTSW	11	80,286,329 (GRCm39)	unclassified	probably benign
R7131:Zfp207	UTSW	11	80,286,354 (GRCm39)	missense	unknown
R7216:Zfp207	UTSW	11	80,286,004 (GRCm39)	missense	unknown
R7672:Zfp207	UTSW	11	80,280,116 (GRCm39)	missense	probably benign	0.27
R7836:Zfp207	UTSW	11	80,282,726 (GRCm39)	missense	probably damaging	1.00
R8913:Zfp207	UTSW	11	80,276,744 (GRCm39)	missense	probably damaging	0.98
R9662:Zfp207	UTSW	11	80,286,029 (GRCm39)	missense	unknown

Posted On

2012-04-20