Incidental Mutation 'R5847:Ccdc158'
ID 453663
Institutional Source Beutler Lab
Gene Symbol Ccdc158
Ensembl Gene ENSMUSG00000050050
Gene Name coiled-coil domain containing 158
Synonyms 4932413O14Rik
MMRRC Submission 044065-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.197) question?
Stock # R5847 (G1)
Quality Score 210
Status Validated
Chromosome 5
Chromosomal Location 92756096-92823327 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 92775339 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 955 (N955K)
Ref Sequence ENSEMBL: ENSMUSP00000063050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060930]
AlphaFold Q8CDI6
Predicted Effect probably benign
Transcript: ENSMUST00000060930
AA Change: N955K

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000063050
Gene: ENSMUSG00000050050
AA Change: N955K

DomainStartEndE-ValueType
Pfam:CCDC158 1 1109 N/A PFAM
Meta Mutation Damage Score 0.0625 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.4%
Validation Efficiency 100% (62/62)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg6 T A 10: 14,302,521 (GRCm39) Y964F probably damaging Het
Akap3 T A 6: 126,842,521 (GRCm39) L380Q probably damaging Het
Alpk1 A G 3: 127,473,723 (GRCm39) I760T probably benign Het
Aoc1l2 T A 6: 48,910,412 (GRCm39) F701L probably damaging Het
Arhgap20 G A 9: 51,736,276 (GRCm39) probably benign Het
Cacng3 T C 7: 122,361,532 (GRCm39) F113S possibly damaging Het
Ccdc63 T A 5: 122,254,908 (GRCm39) M368L possibly damaging Het
Cnot2 T C 10: 116,363,851 (GRCm39) T18A probably damaging Het
Ctnna2 A T 6: 76,950,820 (GRCm39) D550E possibly damaging Het
Cyp2c37 C T 19: 40,000,176 (GRCm39) R433W probably damaging Het
Dact2 A G 17: 14,419,450 (GRCm39) S103P probably damaging Het
Dek A G 13: 47,255,077 (GRCm39) probably benign Het
Dnah9 CAGTTGCTTAAA CA 11: 65,986,066 (GRCm39) probably null Het
Dock4 A G 12: 40,671,250 (GRCm39) Y23C probably damaging Het
Edar T A 10: 58,439,001 (GRCm39) S344C probably damaging Het
Epg5 T C 18: 78,073,270 (GRCm39) V2431A probably benign Het
Evc2 C T 5: 37,562,068 (GRCm39) probably benign Het
Idh3b A T 2: 130,125,948 (GRCm39) D41E probably benign Het
Igkv8-24 A T 6: 70,193,956 (GRCm39) V84D probably damaging Het
Iqca1l A T 5: 24,749,164 (GRCm39) L778Q probably benign Het
Mgam T C 6: 40,660,989 (GRCm39) I1118T probably benign Het
Mtmr3 A G 11: 4,432,925 (GRCm39) V1116A probably damaging Het
Myoc A G 1: 162,466,936 (GRCm39) Y35C probably damaging Het
Ncr1 A T 7: 4,347,573 (GRCm39) D246V probably benign Het
Nphp3 A G 9: 103,880,236 (GRCm39) E86G probably damaging Het
Or2l13b A T 16: 19,349,076 (GRCm39) V198E probably damaging Het
Or52e5 A T 7: 104,719,064 (GRCm39) Y130F probably benign Het
Or8h7 A C 2: 86,720,676 (GRCm39) V281G probably damaging Het
Pbld1 A T 10: 62,912,193 (GRCm39) I275L probably benign Het
Pde12 A G 14: 26,386,786 (GRCm39) V574A possibly damaging Het
Pdxk G T 10: 78,280,872 (GRCm39) D189E probably benign Het
Pkhd1 C A 1: 20,444,960 (GRCm39) E2276* probably null Het
Ppp1r10 A G 17: 36,237,739 (GRCm39) N237S possibly damaging Het
Rheb T A 5: 25,012,067 (GRCm39) Y131F probably benign Het
Rpgrip1l T C 8: 92,031,613 (GRCm39) D88G probably damaging Het
Scgb2b33 T C 7: 32,812,239 (GRCm39) noncoding transcript Het
Snx9 C A 17: 5,974,896 (GRCm39) N461K possibly damaging Het
Tbc1d2b C A 9: 90,091,777 (GRCm39) V842F probably damaging Het
Tgfbi G A 13: 56,784,418 (GRCm39) E615K possibly damaging Het
Tmem51 A G 4: 141,759,346 (GRCm39) M134T probably damaging Het
Tox4 A G 14: 52,524,241 (GRCm39) D125G probably damaging Het
Trappc3 A T 4: 126,167,771 (GRCm39) N110I probably damaging Het
Trim11 T A 11: 58,881,419 (GRCm39) D437E probably damaging Het
Ttc23l T C 15: 10,537,682 (GRCm39) N196S probably benign Het
Wnk1 C A 6: 119,969,369 (GRCm39) G362V probably damaging Het
Wwc1 A G 11: 35,758,153 (GRCm39) F731S probably damaging Het
Wwp1 A T 4: 19,662,174 (GRCm39) D140E possibly damaging Het
Zfp24 G A 18: 24,151,095 (GRCm39) P17L possibly damaging Het
Zfp354b T C 11: 50,814,043 (GRCm39) E294G probably damaging Het
Zfp853 C T 5: 143,274,424 (GRCm39) V399M unknown Het
Zfp868 T C 8: 70,064,303 (GRCm39) H344R probably damaging Het
Other mutations in Ccdc158
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Ccdc158 APN 5 92,805,740 (GRCm39) missense probably benign 0.01
IGL00926:Ccdc158 APN 5 92,798,626 (GRCm39) missense probably damaging 0.98
IGL01533:Ccdc158 APN 5 92,757,815 (GRCm39) splice site probably null
IGL01551:Ccdc158 APN 5 92,814,620 (GRCm39) missense probably damaging 0.96
IGL01591:Ccdc158 APN 5 92,809,900 (GRCm39) missense probably benign 0.28
IGL01722:Ccdc158 APN 5 92,810,598 (GRCm39) missense possibly damaging 0.93
IGL02250:Ccdc158 APN 5 92,756,337 (GRCm39) missense probably damaging 1.00
IGL02457:Ccdc158 APN 5 92,797,907 (GRCm39) missense probably damaging 1.00
IGL02570:Ccdc158 APN 5 92,796,885 (GRCm39) missense possibly damaging 0.81
IGL02951:Ccdc158 APN 5 92,797,865 (GRCm39) missense probably damaging 1.00
IGL03275:Ccdc158 APN 5 92,777,491 (GRCm39) missense probably benign 0.00
R0238:Ccdc158 UTSW 5 92,809,977 (GRCm39) missense probably benign 0.31
R0238:Ccdc158 UTSW 5 92,809,977 (GRCm39) missense probably benign 0.31
R0747:Ccdc158 UTSW 5 92,781,156 (GRCm39) missense probably benign 0.00
R1219:Ccdc158 UTSW 5 92,802,040 (GRCm39) splice site probably benign
R1480:Ccdc158 UTSW 5 92,796,903 (GRCm39) missense probably damaging 1.00
R1926:Ccdc158 UTSW 5 92,798,647 (GRCm39) missense probably benign 0.41
R2172:Ccdc158 UTSW 5 92,780,367 (GRCm39) missense probably damaging 1.00
R2245:Ccdc158 UTSW 5 92,757,811 (GRCm39) unclassified probably benign
R3004:Ccdc158 UTSW 5 92,796,929 (GRCm39) missense probably damaging 1.00
R3147:Ccdc158 UTSW 5 92,805,822 (GRCm39) missense probably damaging 1.00
R3693:Ccdc158 UTSW 5 92,757,904 (GRCm39) missense probably damaging 1.00
R3694:Ccdc158 UTSW 5 92,757,904 (GRCm39) missense probably damaging 1.00
R3735:Ccdc158 UTSW 5 92,780,283 (GRCm39) missense possibly damaging 0.60
R3736:Ccdc158 UTSW 5 92,780,283 (GRCm39) missense possibly damaging 0.60
R3912:Ccdc158 UTSW 5 92,796,794 (GRCm39) missense possibly damaging 0.90
R4026:Ccdc158 UTSW 5 92,791,666 (GRCm39) missense probably benign 0.07
R4080:Ccdc158 UTSW 5 92,771,255 (GRCm39) missense probably benign 0.00
R4463:Ccdc158 UTSW 5 92,782,159 (GRCm39) missense probably null 0.99
R4483:Ccdc158 UTSW 5 92,781,187 (GRCm39) missense probably benign 0.01
R4859:Ccdc158 UTSW 5 92,781,262 (GRCm39) missense probably damaging 0.99
R5016:Ccdc158 UTSW 5 92,805,751 (GRCm39) missense probably benign 0.01
R5050:Ccdc158 UTSW 5 92,814,738 (GRCm39) missense probably benign 0.01
R5372:Ccdc158 UTSW 5 92,780,419 (GRCm39) missense possibly damaging 0.55
R5427:Ccdc158 UTSW 5 92,796,821 (GRCm39) missense probably damaging 1.00
R5966:Ccdc158 UTSW 5 92,797,908 (GRCm39) missense probably damaging 1.00
R6106:Ccdc158 UTSW 5 92,775,325 (GRCm39) missense probably benign
R6185:Ccdc158 UTSW 5 92,814,713 (GRCm39) missense possibly damaging 0.73
R6562:Ccdc158 UTSW 5 92,810,581 (GRCm39) missense probably damaging 0.99
R6743:Ccdc158 UTSW 5 92,810,005 (GRCm39) missense probably benign 0.08
R6815:Ccdc158 UTSW 5 92,760,345 (GRCm39) missense probably damaging 0.99
R6914:Ccdc158 UTSW 5 92,809,929 (GRCm39) missense probably benign 0.00
R6975:Ccdc158 UTSW 5 92,814,579 (GRCm39) nonsense probably null
R7252:Ccdc158 UTSW 5 92,798,647 (GRCm39) missense probably benign 0.41
R7477:Ccdc158 UTSW 5 92,798,555 (GRCm39) missense probably damaging 0.96
R7782:Ccdc158 UTSW 5 92,793,373 (GRCm39) missense probably benign 0.00
R8014:Ccdc158 UTSW 5 92,796,889 (GRCm39) missense probably damaging 1.00
R8018:Ccdc158 UTSW 5 92,771,260 (GRCm39) missense possibly damaging 0.64
R8028:Ccdc158 UTSW 5 92,782,110 (GRCm39) missense probably damaging 1.00
X0025:Ccdc158 UTSW 5 92,809,871 (GRCm39) missense probably benign
Z1176:Ccdc158 UTSW 5 92,756,350 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TATTCCATGGGCCTAGGACAG -3'
(R):5'- ACAGCCCTGGGTTCAATTCC -3'

Sequencing Primer
(F):5'- GCCTAGGACAGCACATTTGGTAC -3'
(R):5'- TCAAGACAGGGTCTCACTATGTAGC -3'
Posted On 2017-02-10