Incidental Mutation 'R5847:Cyp2c37'
ID 453703
Institutional Source Beutler Lab
Gene Symbol Cyp2c37
Ensembl Gene ENSMUSG00000042248
Gene Name cytochrome P450, family 2. subfamily c, polypeptide 37
Synonyms
MMRRC Submission 044065-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R5847 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 39980868-40000687 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 40000176 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Tryptophan at position 433 (R433W)
Ref Sequence ENSEMBL: ENSMUSP00000045362 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049178]
AlphaFold P56654
Predicted Effect probably damaging
Transcript: ENSMUST00000049178
AA Change: R433W

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000045362
Gene: ENSMUSG00000042248
AA Change: R433W

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:p450 30 487 5e-160 PFAM
Meta Mutation Damage Score 0.1992 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.8%
  • 20x: 93.4%
Validation Efficiency 100% (62/62)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg6 T A 10: 14,302,521 (GRCm39) Y964F probably damaging Het
Akap3 T A 6: 126,842,521 (GRCm39) L380Q probably damaging Het
Alpk1 A G 3: 127,473,723 (GRCm39) I760T probably benign Het
Aoc1l2 T A 6: 48,910,412 (GRCm39) F701L probably damaging Het
Arhgap20 G A 9: 51,736,276 (GRCm39) probably benign Het
Cacng3 T C 7: 122,361,532 (GRCm39) F113S possibly damaging Het
Ccdc158 G T 5: 92,775,339 (GRCm39) N955K probably benign Het
Ccdc63 T A 5: 122,254,908 (GRCm39) M368L possibly damaging Het
Cnot2 T C 10: 116,363,851 (GRCm39) T18A probably damaging Het
Ctnna2 A T 6: 76,950,820 (GRCm39) D550E possibly damaging Het
Dact2 A G 17: 14,419,450 (GRCm39) S103P probably damaging Het
Dek A G 13: 47,255,077 (GRCm39) probably benign Het
Dnah9 CAGTTGCTTAAA CA 11: 65,986,066 (GRCm39) probably null Het
Dock4 A G 12: 40,671,250 (GRCm39) Y23C probably damaging Het
Edar T A 10: 58,439,001 (GRCm39) S344C probably damaging Het
Epg5 T C 18: 78,073,270 (GRCm39) V2431A probably benign Het
Evc2 C T 5: 37,562,068 (GRCm39) probably benign Het
Idh3b A T 2: 130,125,948 (GRCm39) D41E probably benign Het
Igkv8-24 A T 6: 70,193,956 (GRCm39) V84D probably damaging Het
Iqca1l A T 5: 24,749,164 (GRCm39) L778Q probably benign Het
Mgam T C 6: 40,660,989 (GRCm39) I1118T probably benign Het
Mtmr3 A G 11: 4,432,925 (GRCm39) V1116A probably damaging Het
Myoc A G 1: 162,466,936 (GRCm39) Y35C probably damaging Het
Ncr1 A T 7: 4,347,573 (GRCm39) D246V probably benign Het
Nphp3 A G 9: 103,880,236 (GRCm39) E86G probably damaging Het
Or2l13b A T 16: 19,349,076 (GRCm39) V198E probably damaging Het
Or52e5 A T 7: 104,719,064 (GRCm39) Y130F probably benign Het
Or8h7 A C 2: 86,720,676 (GRCm39) V281G probably damaging Het
Pbld1 A T 10: 62,912,193 (GRCm39) I275L probably benign Het
Pde12 A G 14: 26,386,786 (GRCm39) V574A possibly damaging Het
Pdxk G T 10: 78,280,872 (GRCm39) D189E probably benign Het
Pkhd1 C A 1: 20,444,960 (GRCm39) E2276* probably null Het
Ppp1r10 A G 17: 36,237,739 (GRCm39) N237S possibly damaging Het
Rheb T A 5: 25,012,067 (GRCm39) Y131F probably benign Het
Rpgrip1l T C 8: 92,031,613 (GRCm39) D88G probably damaging Het
Scgb2b33 T C 7: 32,812,239 (GRCm39) noncoding transcript Het
Snx9 C A 17: 5,974,896 (GRCm39) N461K possibly damaging Het
Tbc1d2b C A 9: 90,091,777 (GRCm39) V842F probably damaging Het
Tgfbi G A 13: 56,784,418 (GRCm39) E615K possibly damaging Het
Tmem51 A G 4: 141,759,346 (GRCm39) M134T probably damaging Het
Tox4 A G 14: 52,524,241 (GRCm39) D125G probably damaging Het
Trappc3 A T 4: 126,167,771 (GRCm39) N110I probably damaging Het
Trim11 T A 11: 58,881,419 (GRCm39) D437E probably damaging Het
Ttc23l T C 15: 10,537,682 (GRCm39) N196S probably benign Het
Wnk1 C A 6: 119,969,369 (GRCm39) G362V probably damaging Het
Wwc1 A G 11: 35,758,153 (GRCm39) F731S probably damaging Het
Wwp1 A T 4: 19,662,174 (GRCm39) D140E possibly damaging Het
Zfp24 G A 18: 24,151,095 (GRCm39) P17L possibly damaging Het
Zfp354b T C 11: 50,814,043 (GRCm39) E294G probably damaging Het
Zfp853 C T 5: 143,274,424 (GRCm39) V399M unknown Het
Zfp868 T C 8: 70,064,303 (GRCm39) H344R probably damaging Het
Other mutations in Cyp2c37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00465:Cyp2c37 APN 19 39,990,441 (GRCm39) missense probably benign 0.00
IGL01307:Cyp2c37 APN 19 39,981,023 (GRCm39) missense probably benign 0.00
IGL01959:Cyp2c37 APN 19 39,984,277 (GRCm39) nonsense probably null
IGL02580:Cyp2c37 APN 19 39,982,942 (GRCm39) missense probably damaging 1.00
IGL02611:Cyp2c37 APN 19 39,982,309 (GRCm39) missense probably benign 0.00
R0124:Cyp2c37 UTSW 19 39,982,546 (GRCm39) missense probably damaging 1.00
R0391:Cyp2c37 UTSW 19 39,982,950 (GRCm39) missense probably damaging 1.00
R0420:Cyp2c37 UTSW 19 39,984,238 (GRCm39) missense probably benign 0.00
R0782:Cyp2c37 UTSW 19 39,982,269 (GRCm39) missense probably benign 0.00
R1413:Cyp2c37 UTSW 19 39,982,542 (GRCm39) missense probably benign 0.21
R1637:Cyp2c37 UTSW 19 39,990,426 (GRCm39) nonsense probably null
R1688:Cyp2c37 UTSW 19 39,982,887 (GRCm39) splice site probably null
R2258:Cyp2c37 UTSW 19 39,984,303 (GRCm39) missense possibly damaging 0.49
R4353:Cyp2c37 UTSW 19 39,988,989 (GRCm39) missense possibly damaging 0.66
R4640:Cyp2c37 UTSW 19 40,000,276 (GRCm39) missense possibly damaging 0.67
R4965:Cyp2c37 UTSW 19 40,000,206 (GRCm39) missense possibly damaging 0.79
R5053:Cyp2c37 UTSW 19 39,990,331 (GRCm39) missense probably benign 0.00
R5645:Cyp2c37 UTSW 19 39,982,596 (GRCm39) missense probably benign 0.04
R6487:Cyp2c37 UTSW 19 39,983,025 (GRCm39) missense probably benign
R6631:Cyp2c37 UTSW 19 39,998,287 (GRCm39) missense probably damaging 1.00
R7062:Cyp2c37 UTSW 19 39,983,990 (GRCm39) splice site probably null
R7937:Cyp2c37 UTSW 19 39,982,202 (GRCm39) missense probably damaging 1.00
R9640:Cyp2c37 UTSW 19 40,000,180 (GRCm39) missense probably benign 0.01
R9779:Cyp2c37 UTSW 19 39,998,323 (GRCm39) missense probably benign 0.09
R9784:Cyp2c37 UTSW 19 39,988,943 (GRCm39) missense possibly damaging 0.85
Predicted Primers PCR Primer
(F):5'- TGTCAACTTGCCTAATAGGGTATC -3'
(R):5'- AAGCCTCAGGGTGATCACAG -3'

Sequencing Primer
(F):5'- AATAGGGTATCTTCTCAGCCATTCG -3'
(R):5'- TGATCACAGAAGATGTCCCAGCTG -3'
Posted On 2017-02-10