Incidental Mutation 'R5860:Senp7'
ID 453870
Institutional Source Beutler Lab
Gene Symbol Senp7
Ensembl Gene ENSMUSG00000052917
Gene Name SUMO1/sentrin specific peptidase 7
Synonyms 2900036C23Rik, 6030449K19Rik, 2410152H17Rik, 2810413I22Rik
MMRRC Submission 044072-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.246) question?
Stock # R5860 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 55869306-56010394 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 55975722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glutamic Acid at position 476 (A476E)
Ref Sequence ENSEMBL: ENSMUSP00000086779 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089360] [ENSMUST00000089362]
AlphaFold Q8BUH8
Predicted Effect probably benign
Transcript: ENSMUST00000089360
AA Change: A449E

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000086776
Gene: ENSMUSG00000052917
AA Change: A449E

DomainStartEndE-ValueType
low complexity region 165 181 N/A INTRINSIC
low complexity region 352 376 N/A INTRINSIC
low complexity region 386 395 N/A INTRINSIC
low complexity region 639 646 N/A INTRINSIC
Pfam:Peptidase_C48 734 999 7.8e-36 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000089362
AA Change: A476E

PolyPhen 2 Score 0.485 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000086779
Gene: ENSMUSG00000052917
AA Change: A476E

DomainStartEndE-ValueType
low complexity region 192 208 N/A INTRINSIC
low complexity region 379 403 N/A INTRINSIC
low complexity region 413 422 N/A INTRINSIC
low complexity region 666 673 N/A INTRINSIC
Pfam:Peptidase_C48 761 1026 8.5e-36 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.1%
  • 20x: 90.8%
Validation Efficiency 97% (75/77)
MGI Phenotype FUNCTION: This gene encodes a SUMO deconjugating enzyme of the Sentrin/SUMO-specific protease (SENP) family. The encoded protein is a protease that exhibits deSUMOylating activity towards proteins involved in chromatin remodeling and promotes chromatin relaxation for DNA repair or transcription. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568A12Rik A G 1: 34,524,661 (GRCm39) noncoding transcript Het
A2ml1 T C 6: 128,518,024 (GRCm39) T1421A probably benign Het
Actr8 T A 14: 29,708,242 (GRCm39) Y150* probably null Het
Adamts1 A G 16: 85,595,432 (GRCm39) C249R probably damaging Het
Adgre1 T A 17: 57,752,034 (GRCm39) I594N probably damaging Het
Atf6 A T 1: 170,669,344 (GRCm39) L119H probably damaging Het
Atf6 G A 1: 170,669,345 (GRCm39) L119F possibly damaging Het
B3gat2 G A 1: 23,854,400 (GRCm39) W33* probably null Het
Bach2 A G 4: 32,580,268 (GRCm39) D831G probably damaging Het
Ccnk A T 12: 108,153,466 (GRCm39) I76F probably damaging Het
Cdyl A C 13: 36,042,066 (GRCm39) K368T possibly damaging Het
Chi3l1 A G 1: 134,112,909 (GRCm39) T114A probably benign Het
Cnppd1 A G 1: 75,113,131 (GRCm39) V379A probably benign Het
Col11a2 C A 17: 34,283,159 (GRCm39) probably benign Het
Creb3l1 T C 2: 91,854,399 (GRCm39) S18G probably benign Het
Crybg3 A C 16: 59,385,632 (GRCm39) D197E probably damaging Het
Cryga T C 1: 65,142,527 (GRCm39) probably benign Het
Cthrc1 T C 15: 38,950,080 (GRCm39) C146R probably damaging Het
Cyp2c39 A T 19: 39,525,270 (GRCm39) D191V probably damaging Het
Dchs1 C T 7: 105,421,242 (GRCm39) A393T probably damaging Het
Dhx30 G A 9: 109,913,645 (GRCm39) T1126I probably damaging Het
Dock2 C T 11: 34,206,562 (GRCm39) G1345R probably damaging Het
Dsc1 T C 18: 20,228,081 (GRCm39) E425G probably damaging Het
Dynlt2b A G 16: 32,247,614 (GRCm39) Y143C probably damaging Het
Exosc8 C T 3: 54,642,463 (GRCm39) probably benign Het
Fat1 C T 8: 45,504,166 (GRCm39) A4553V probably benign Het
Flnb T A 14: 7,931,135 (GRCm38) L2119Q probably damaging Het
Fnbp4 T A 2: 90,587,826 (GRCm39) D401E probably benign Het
Glyctk T C 9: 106,032,906 (GRCm39) E369G possibly damaging Het
Gm14149 C A 2: 151,066,225 (GRCm39) noncoding transcript Het
Golga4 T C 9: 118,387,174 (GRCm39) L1432P probably damaging Het
Gtpbp4 A T 13: 9,023,196 (GRCm39) S623T probably benign Het
Insc A C 7: 114,390,383 (GRCm39) S85R probably damaging Het
Lgr4 G A 2: 109,821,496 (GRCm39) R126H probably damaging Het
M1ap T A 6: 82,980,795 (GRCm39) L227Q probably damaging Het
Marchf7 T C 2: 60,067,187 (GRCm39) I569T probably damaging Het
Mbd1 C A 18: 74,409,768 (GRCm39) C339* probably null Het
Moxd2 T A 6: 40,857,341 (GRCm39) Y473F probably damaging Het
Mrgpra6 T C 7: 46,839,099 (GRCm39) H2R probably benign Het
Mtus1 T G 8: 41,529,303 (GRCm39) L742F probably damaging Het
Nek11 A G 9: 105,270,160 (GRCm39) Y21H probably benign Het
Notch4 G T 17: 34,801,392 (GRCm39) C1080F probably damaging Het
Nsd3 C A 8: 26,156,107 (GRCm39) P558Q probably damaging Het
Oas1e A T 5: 120,930,015 (GRCm39) S168T probably benign Het
Ogfr T C 2: 180,234,285 (GRCm39) S119P probably damaging Het
Or2y15 A G 11: 49,350,563 (GRCm39) D19G probably damaging Het
Or8g20 T A 9: 39,395,767 (GRCm39) M261L probably benign Het
Pde4dip A G 3: 97,631,504 (GRCm39) I1135T possibly damaging Het
Prex1 G A 2: 166,486,604 (GRCm39) probably benign Het
Ptprf T C 4: 118,068,486 (GRCm39) probably benign Het
Rapsn T C 2: 90,875,859 (GRCm39) V359A probably damaging Het
Ric1 A G 19: 29,577,245 (GRCm39) S1050G possibly damaging Het
Rnft2 A G 5: 118,366,868 (GRCm39) I290T possibly damaging Het
Serpinh1 G A 7: 98,995,571 (GRCm39) S337L probably damaging Het
Slc5a12 C A 2: 110,427,969 (GRCm39) A8D probably benign Het
Smg5 T A 3: 88,250,214 (GRCm39) C109S probably damaging Het
Speer4b T C 5: 27,705,226 (GRCm39) H49R possibly damaging Het
Tas2r109 T C 6: 132,957,664 (GRCm39) I89V probably benign Het
Tet1 A G 10: 62,648,399 (GRCm39) probably null Het
Tmed6 G T 8: 107,790,786 (GRCm39) T87K probably damaging Het
Tpgs1 G A 10: 79,505,545 (GRCm39) G101D probably damaging Het
Trim13 T G 14: 61,842,188 (GRCm39) S68R probably damaging Het
Vwf A G 6: 125,620,053 (GRCm39) N1577S Het
Vwf G T 6: 125,656,228 (GRCm39) probably benign Het
Xpr1 T C 1: 155,207,868 (GRCm39) probably benign Het
Ylpm1 C T 12: 85,087,660 (GRCm39) P1148L probably damaging Het
Zftraf1 A T 15: 76,532,391 (GRCm39) I239N probably damaging Het
Zftraf1 T C 15: 76,540,615 (GRCm39) Y101C probably damaging Het
Zscan29 G T 2: 120,994,518 (GRCm39) T489N probably damaging Het
Other mutations in Senp7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00895:Senp7 APN 16 55,902,740 (GRCm39) missense probably damaging 0.96
IGL01610:Senp7 APN 16 55,996,186 (GRCm39) missense possibly damaging 0.94
IGL01627:Senp7 APN 16 55,992,219 (GRCm39) missense probably damaging 1.00
IGL02748:Senp7 APN 16 56,006,457 (GRCm39) missense probably damaging 1.00
IGL03031:Senp7 APN 16 55,996,249 (GRCm39) missense probably damaging 1.00
IGL03083:Senp7 APN 16 55,992,228 (GRCm39) missense probably benign 0.28
R0034:Senp7 UTSW 16 55,973,933 (GRCm39) missense possibly damaging 0.63
R0200:Senp7 UTSW 16 55,944,236 (GRCm39) missense possibly damaging 0.66
R0242:Senp7 UTSW 16 55,999,884 (GRCm39) missense probably damaging 1.00
R0242:Senp7 UTSW 16 55,999,884 (GRCm39) missense probably damaging 1.00
R0547:Senp7 UTSW 16 55,996,189 (GRCm39) missense probably damaging 1.00
R0608:Senp7 UTSW 16 55,944,236 (GRCm39) missense possibly damaging 0.66
R1595:Senp7 UTSW 16 56,005,131 (GRCm39) missense probably damaging 1.00
R1737:Senp7 UTSW 16 55,944,162 (GRCm39) missense probably damaging 1.00
R1837:Senp7 UTSW 16 55,978,879 (GRCm39) missense probably benign 0.01
R1945:Senp7 UTSW 16 55,944,309 (GRCm39) missense probably damaging 0.98
R2143:Senp7 UTSW 16 55,990,169 (GRCm39) missense probably benign
R2275:Senp7 UTSW 16 56,005,146 (GRCm39) missense probably damaging 1.00
R2508:Senp7 UTSW 16 55,971,725 (GRCm39) missense probably benign 0.28
R3404:Senp7 UTSW 16 56,008,640 (GRCm39) missense probably damaging 1.00
R3405:Senp7 UTSW 16 56,008,640 (GRCm39) missense probably damaging 1.00
R3717:Senp7 UTSW 16 55,999,420 (GRCm39) splice site probably benign
R3885:Senp7 UTSW 16 56,006,442 (GRCm39) missense probably damaging 1.00
R4159:Senp7 UTSW 16 55,973,832 (GRCm39) missense possibly damaging 0.86
R4160:Senp7 UTSW 16 55,973,832 (GRCm39) missense possibly damaging 0.86
R4161:Senp7 UTSW 16 55,973,832 (GRCm39) missense possibly damaging 0.86
R4512:Senp7 UTSW 16 55,986,246 (GRCm39) missense probably damaging 1.00
R5291:Senp7 UTSW 16 56,006,542 (GRCm39) nonsense probably null
R5315:Senp7 UTSW 16 56,000,889 (GRCm39) missense probably benign 0.26
R5390:Senp7 UTSW 16 55,990,279 (GRCm39) missense probably benign
R5424:Senp7 UTSW 16 56,006,471 (GRCm39) missense possibly damaging 0.82
R5643:Senp7 UTSW 16 56,004,512 (GRCm39) splice site silent
R5644:Senp7 UTSW 16 56,004,512 (GRCm39) splice site silent
R5645:Senp7 UTSW 16 55,993,571 (GRCm39) missense possibly damaging 0.80
R5799:Senp7 UTSW 16 55,959,468 (GRCm39) splice site probably null
R5954:Senp7 UTSW 16 55,990,234 (GRCm39) missense probably benign 0.04
R6164:Senp7 UTSW 16 55,990,117 (GRCm39) missense probably damaging 1.00
R6280:Senp7 UTSW 16 55,982,738 (GRCm39) missense possibly damaging 0.62
R6647:Senp7 UTSW 16 55,993,618 (GRCm39) missense probably damaging 1.00
R6652:Senp7 UTSW 16 55,944,257 (GRCm39) missense probably benign 0.08
R7310:Senp7 UTSW 16 56,006,445 (GRCm39) missense probably benign 0.18
R7460:Senp7 UTSW 16 55,993,545 (GRCm39) missense possibly damaging 0.65
R7480:Senp7 UTSW 16 55,975,589 (GRCm39) missense possibly damaging 0.80
R7609:Senp7 UTSW 16 55,932,000 (GRCm39) missense probably benign 0.06
R7760:Senp7 UTSW 16 55,959,442 (GRCm39) missense probably benign
R8171:Senp7 UTSW 16 55,932,089 (GRCm39) missense probably damaging 1.00
R8290:Senp7 UTSW 16 55,974,000 (GRCm39) nonsense probably null
R8305:Senp7 UTSW 16 55,975,603 (GRCm39) missense probably damaging 1.00
R8353:Senp7 UTSW 16 56,008,691 (GRCm39) missense probably damaging 1.00
R8394:Senp7 UTSW 16 55,990,190 (GRCm39) missense possibly damaging 0.81
R8428:Senp7 UTSW 16 55,999,391 (GRCm39) missense probably damaging 1.00
R8453:Senp7 UTSW 16 56,008,691 (GRCm39) missense probably damaging 1.00
R8554:Senp7 UTSW 16 55,978,973 (GRCm39) missense probably benign 0.01
R8669:Senp7 UTSW 16 55,986,315 (GRCm39) missense probably damaging 0.97
R9153:Senp7 UTSW 16 56,006,486 (GRCm39) missense probably benign 0.34
R9521:Senp7 UTSW 16 55,992,144 (GRCm39) missense probably damaging 1.00
R9617:Senp7 UTSW 16 55,971,652 (GRCm39) missense probably benign 0.02
R9624:Senp7 UTSW 16 55,990,075 (GRCm39) missense probably damaging 1.00
R9631:Senp7 UTSW 16 55,975,631 (GRCm39) missense probably benign 0.45
R9657:Senp7 UTSW 16 55,944,295 (GRCm39) nonsense probably null
R9718:Senp7 UTSW 16 55,944,277 (GRCm39) missense probably damaging 0.98
R9727:Senp7 UTSW 16 55,990,169 (GRCm39) missense probably benign
U24488:Senp7 UTSW 16 56,005,182 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGGAAGCTGCTGTATAATAATGCTC -3'
(R):5'- CTATTAGCCAATAAGACTATTCTCCCG -3'

Sequencing Primer
(F):5'- GCTGCTGTATAATAATGCTCATATGG -3'
(R):5'- AATAAGACTATTCTCCCGGGGGC -3'
Posted On 2017-02-10