Mutagenetix > Incidental Mutations

Incidental Mutation 'R5861:Olfr1141'

453884

Institutional Source

Beutler Lab

Gene Symbol

Olfr1141

Ensembl Gene

ENSMUSG00000075148

Gene Name

olfactory receptor 1141

Synonyms

MOR177-10, GA_x6K02T2Q125-49257818-49256883

MMRRC Submission

044073-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.103) question?

Stock #

R5861 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

87753056-87753991 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 87753578 bp

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 138 (N138K)

Ref Sequence

ENSEMBL: ENSMUSP00000097433 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099846]

Predicted Effect

probably benign
Transcript: ENSMUST00000099846
AA Change: N138K

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000097433
Gene: ENSMUSG00000075148
AA Change: N138K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	2.8e-28	PFAM
Pfam:7tm_1	41	290	1.5e-6	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 97.3%
20x: 91.3%

Validation Efficiency

98% (81/83)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 67 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010111I01Rik	A	G	13: 63,298,812	D143G	probably damaging	Het
Abcc5	G	T	16: 20,399,894	T246N	probably damaging	Het
Arhgap10	C	T	8: 77,310,764	A612T	probably damaging	Het
Arsg	T	A	11: 109,563,188	F407I	probably damaging	Het
Asxl1	C	A	2: 153,399,390	A620D	probably damaging	Het
BC080695	G	T	4: 143,571,240	V77L	probably benign	Het
C2cd3	A	G	7: 100,444,475		probably benign	Het
Chn2	G	A	6: 54,290,374	V92I	probably damaging	Het
Cog2	T	C	8: 124,537,878	F332S	probably damaging	Het
Crhbp	G	A	13: 95,443,825	A82V	probably damaging	Het
Cyp2j6	A	G	4: 96,545,803	V90A	possibly damaging	Het
Dennd4c	A	T	4: 86,791,352	M397L	probably benign	Het
Dnajb8	A	G	6: 88,223,106	D208G	possibly damaging	Het
Ecm1	G	C	3: 95,736,597	L230V	probably damaging	Het
Ercc2	G	C	7: 19,394,141	A696P	possibly damaging	Het
Fkbpl	G	A	17: 34,645,329	A24T	probably benign	Het
Gm13035	A	G	4: 146,073,289		noncoding transcript	Het
Gm28042	T	C	2: 120,034,635	V247A	probably damaging	Het
Gm28455	T	A	7: 39,498,579		noncoding transcript	Het
Gpr150	A	T	13: 76,056,073	V251D	possibly damaging	Het
Grip1	C	T	10: 119,929,970	S69L	probably damaging	Het
Hs6st3	A	G	14: 119,138,853	I147V	possibly damaging	Het
Il5	G	A	11: 53,723,916	E102K	probably benign	Het
Kif1c	T	C	11: 70,703,795	F94L	probably damaging	Het
Lrrc63	T	C	14: 75,107,366	E427G	possibly damaging	Het
Man1b1	A	G	2: 25,348,054	T384A	probably benign	Het
Mapk15	C	A	15: 75,996,359		probably benign	Het
Mfsd10	T	C	5: 34,634,244		probably benign	Het
Mgat5	C	A	1: 127,387,392	A285E	probably damaging	Het
Mroh4	T	A	15: 74,606,607		probably benign	Het
Myf5	A	T	10: 107,484,208	C194S	probably benign	Het
Myh7	A	G	14: 54,988,890	V431A	possibly damaging	Het
Nadsyn1	A	C	7: 143,811,227	M247R	possibly damaging	Het
Nipsnap3b	A	G	4: 53,021,177	D166G	probably damaging	Het
Nqo2	A	T	13: 33,972,430	L42F	probably damaging	Het
Nt5dc3	A	T	10: 86,815,874	D180V	probably damaging	Het
Numa1	C	A	7: 102,009,287		probably null	Het
Olfm3	T	A	3: 115,122,403	L328Q	probably damaging	Het
Olfr1353	A	T	10: 78,969,931	Y94F	probably damaging	Het
Olfr1508	T	C	14: 52,463,496	Y171C	probably damaging	Het
Papolb	T	C	5: 142,529,237	N217S	possibly damaging	Het
Pcmtd2	C	A	2: 181,842,475	T26K	probably damaging	Het
Pld5	T	G	1: 176,090,005	N59H	probably damaging	Het
Ppm1d	T	C	11: 85,311,848	S126P	possibly damaging	Het
Ppp1r21	T	C	17: 88,582,509	L727P	probably damaging	Het
Prpsap2	C	T	11: 61,737,044	R202H	probably damaging	Het
Rara	T	A	11: 98,968,161	C148*	probably null	Het
Rexo2	A	T	9: 48,475,181	I83N	probably damaging	Het
Rnf213	A	G	11: 119,473,377	R4501G	probably damaging	Het
Rps5	T	A	7: 12,925,574	F97L	probably damaging	Het
Sigirr	G	A	7: 141,091,379	R397W	probably damaging	Het
Slc6a6	T	C	6: 91,741,033	Y318H	probably damaging	Het
Spam1	A	G	6: 24,796,571	T174A	probably benign	Het
Stam2	G	T	2: 52,742,104		probably benign	Het
Taar7a	T	C	10: 23,992,439	E348G	probably benign	Het
Taf11	T	C	17: 27,901,670	T209A	probably benign	Het
Tenm4	A	G	7: 96,843,217		probably benign	Het
Tmed6	G	T	8: 107,064,154	T87K	probably damaging	Het
Trim5	G	T	7: 104,279,519	H72N	probably benign	Het
Trim5	A	C	7: 104,279,521	L71R	probably benign	Het
Uevld	A	T	7: 46,926,356	S461T	probably benign	Het
Vmn2r6	T	A	3: 64,556,033	N460I	probably benign	Het
Ylpm1	C	T	12: 85,040,886	P1148L	probably damaging	Het
Zfp316	T	C	5: 143,263,340	Y180C	unknown	Het
Zfp941	A	G	7: 140,812,139	S436P	probably damaging	Het
Zfp979	G	A	4: 147,613,509	Q248*	probably null	Het
Zscan29	G	T	2: 121,164,037	T489N	probably damaging	Het

Other mutations in Olfr1141

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01143:Olfr1141	APN	2	87753934	missense	probably benign	0.00
IGL01412:Olfr1141	APN	2	87753117	missense	probably damaging	1.00
IGL01533:Olfr1141	APN	2	87753068	missense	probably benign	0.01
IGL02455:Olfr1141	APN	2	87753583	missense	possibly damaging	0.95
IGL02698:Olfr1141	APN	2	87753844	nonsense	probably null
PIT4480001:Olfr1141	UTSW	2	87753783	missense	possibly damaging	0.95
R0543:Olfr1141	UTSW	2	87753650	missense	probably damaging	1.00
R1542:Olfr1141	UTSW	2	87753318	missense	probably damaging	0.99
R1750:Olfr1141	UTSW	2	87753186	missense	probably damaging	0.97
R1844:Olfr1141	UTSW	2	87753990	start codon destroyed	probably null	1.00
R2248:Olfr1141	UTSW	2	87753943	missense	probably null	0.05
R4064:Olfr1141	UTSW	2	87753789	missense	probably damaging	1.00
R5193:Olfr1141	UTSW	2	87753104	missense	possibly damaging	0.59
R6146:Olfr1141	UTSW	2	87753258	missense	probably damaging	1.00
R6197:Olfr1141	UTSW	2	87753352	missense	probably benign	0.15
R6481:Olfr1141	UTSW	2	87753468	missense	probably damaging	1.00
R6857:Olfr1141	UTSW	2	87753487	missense	probably damaging	1.00
R6904:Olfr1141	UTSW	2	87753879	missense	probably benign	0.00
R6962:Olfr1141	UTSW	2	87753727	missense	probably benign
R7014:Olfr1141	UTSW	2	87753871	missense	probably benign	0.00
R8229:Olfr1141	UTSW	2	87753064	missense	probably benign	0.00
T0722:Olfr1141	UTSW	2	87753123	missense	probably damaging	1.00
Z1177:Olfr1141	UTSW	2	87753190	missense	possibly damaging	0.95

Predicted Primers

PCR Primer
(F):5'- CAAGGACTTCTGAAATAGTGCTC -3'
(R):5'- TGCAATTGGGTCCAAGATGTTG -3'

Sequencing Primer
(F):5'- GGACTTCTGAAATAGTGCTCAACTG -3'
(R):5'- CAATTGGGTCCAAGATGTTGATAGAC -3'

Posted On

2017-02-10