Incidental Mutation 'R5862:Zbtb10'
ID 453957
Institutional Source Beutler Lab
Gene Symbol Zbtb10
Ensembl Gene ENSMUSG00000069114
Gene Name zinc finger and BTB domain containing 10
Synonyms
MMRRC Submission 043231-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.442) question?
Stock # R5862 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 9315662-9350393 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 9330276 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 545 (S545T)
Ref Sequence ENSEMBL: ENSMUSP00000119386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000155203]
AlphaFold E9Q8X5
Predicted Effect probably damaging
Transcript: ENSMUST00000155203
AA Change: S545T

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000119386
Gene: ENSMUSG00000069114
AA Change: S545T

DomainStartEndE-ValueType
low complexity region 15 32 N/A INTRINSIC
low complexity region 38 54 N/A INTRINSIC
low complexity region 75 82 N/A INTRINSIC
low complexity region 96 111 N/A INTRINSIC
low complexity region 121 137 N/A INTRINSIC
low complexity region 180 222 N/A INTRINSIC
ZnF_TTF 239 321 7.92e-2 SMART
BTB 357 456 4.02e-20 SMART
internal_repeat_1 648 671 2.82e-12 PROSPERO
internal_repeat_1 672 695 2.82e-12 PROSPERO
ZnF_C2H2 714 736 6.78e-3 SMART
ZnF_C2H2 742 764 2.09e-3 SMART
low complexity region 765 777 N/A INTRINSIC
low complexity region 823 842 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahctf1 A G 1: 179,615,895 (GRCm39) Y326H probably damaging Het
Alpk2 T A 18: 65,440,360 (GRCm39) K811N probably damaging Het
Ap3b1 T A 13: 94,684,278 (GRCm39) M1014K unknown Het
Bphl G A 13: 34,247,967 (GRCm39) V247I possibly damaging Het
C6 A T 15: 4,764,745 (GRCm39) D147V possibly damaging Het
Clec18a G A 8: 111,808,190 (GRCm39) H71Y possibly damaging Het
Cse1l A G 2: 166,757,127 (GRCm39) T10A probably benign Het
Cyp2b9 G T 7: 25,887,232 (GRCm39) G214C probably benign Het
Dctn6 A T 8: 34,575,571 (GRCm39) probably null Het
Dnaja4 G T 9: 54,606,625 (GRCm39) probably benign Het
Dpp8 A T 9: 64,953,004 (GRCm39) S227C probably benign Het
Ecel1 T C 1: 87,077,318 (GRCm39) N630S probably benign Het
Etnppl T C 3: 130,425,473 (GRCm39) V426A possibly damaging Het
Golgb1 A T 16: 36,746,453 (GRCm39) silent Het
Hapln3 A T 7: 78,771,639 (GRCm39) H83Q possibly damaging Het
Hmgxb4 A G 8: 75,727,683 (GRCm39) K222R probably damaging Het
Hsf5 C A 11: 87,513,817 (GRCm39) T294K probably damaging Het
Ighv12-2 A G 12: 114,091,557 (GRCm39) noncoding transcript Het
Lrch3 A T 16: 32,816,179 (GRCm39) H587L probably damaging Het
Macroh2a1 T A 13: 56,222,084 (GRCm39) I359L probably damaging Het
Mboat1 C T 13: 30,419,680 (GRCm39) T339M probably damaging Het
Mief1 G A 15: 80,132,586 (GRCm39) R156Q probably benign Het
Ms4a6b T A 19: 11,499,167 (GRCm39) F94I probably benign Het
Neb T A 2: 52,069,554 (GRCm39) R307* probably null Het
Neu4 A G 1: 93,950,652 (GRCm39) I147V probably benign Het
Or5m9b T C 2: 85,905,990 (GRCm39) I302T probably benign Het
Pcyox1 A G 6: 86,368,656 (GRCm39) probably null Het
Pik3ap1 T A 19: 41,320,784 (GRCm39) D145V probably damaging Het
Pja2 T C 17: 64,604,821 (GRCm39) D454G probably benign Het
Plekhg1 C T 10: 3,887,914 (GRCm39) T281M probably damaging Het
Ptprq T C 10: 107,401,739 (GRCm39) I1918V probably benign Het
Rasgef1a A C 6: 118,057,405 (GRCm39) R35S probably benign Het
Rnf167 A G 11: 70,541,918 (GRCm39) T308A probably damaging Het
Sfmbt2 C T 2: 10,406,863 (GRCm39) T54I possibly damaging Het
Sh3bp5 C A 14: 31,099,452 (GRCm39) R265L probably benign Het
Shkbp1 G T 7: 27,042,829 (GRCm39) S536* probably null Het
Taf2 C A 15: 54,911,719 (GRCm39) V566L possibly damaging Het
Tmed6 G T 8: 107,790,786 (GRCm39) T87K probably damaging Het
Tyms A T 5: 30,268,408 (GRCm39) D97E probably damaging Het
Usp20 T A 2: 30,896,461 (GRCm39) L188* probably null Het
Zscan29 G T 2: 120,994,518 (GRCm39) T489N probably damaging Het
Other mutations in Zbtb10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02174:Zbtb10 APN 3 9,316,872 (GRCm39) missense probably damaging 0.96
IGL02207:Zbtb10 APN 3 9,345,525 (GRCm39) critical splice donor site probably null
IGL02499:Zbtb10 APN 3 9,316,800 (GRCm39) missense probably damaging 1.00
IGL02506:Zbtb10 APN 3 9,330,297 (GRCm39) missense probably damaging 0.99
IGL03294:Zbtb10 APN 3 9,346,047 (GRCm39) missense probably benign 0.18
R0510:Zbtb10 UTSW 3 9,329,728 (GRCm39) missense probably damaging 1.00
R1859:Zbtb10 UTSW 3 9,345,446 (GRCm39) missense possibly damaging 0.47
R2342:Zbtb10 UTSW 3 9,330,255 (GRCm39) missense possibly damaging 0.60
R3407:Zbtb10 UTSW 3 9,329,926 (GRCm39) missense probably damaging 1.00
R4161:Zbtb10 UTSW 3 9,345,356 (GRCm39) missense probably damaging 1.00
R4301:Zbtb10 UTSW 3 9,330,220 (GRCm39) missense probably damaging 0.96
R4698:Zbtb10 UTSW 3 9,329,610 (GRCm39) missense possibly damaging 0.87
R5184:Zbtb10 UTSW 3 9,329,731 (GRCm39) missense probably damaging 0.99
R5443:Zbtb10 UTSW 3 9,345,108 (GRCm39) missense probably benign
R5665:Zbtb10 UTSW 3 9,330,252 (GRCm39) missense probably damaging 0.99
R5744:Zbtb10 UTSW 3 9,329,623 (GRCm39) missense probably damaging 1.00
R5909:Zbtb10 UTSW 3 9,345,109 (GRCm39) missense probably benign 0.14
R6547:Zbtb10 UTSW 3 9,316,763 (GRCm39) missense probably benign 0.38
R6612:Zbtb10 UTSW 3 9,317,125 (GRCm39) missense possibly damaging 0.87
R7457:Zbtb10 UTSW 3 9,316,538 (GRCm39) missense possibly damaging 0.77
R8985:Zbtb10 UTSW 3 9,345,807 (GRCm39) missense probably damaging 1.00
R9191:Zbtb10 UTSW 3 9,330,295 (GRCm39) missense probably damaging 0.98
R9472:Zbtb10 UTSW 3 9,343,355 (GRCm39) missense probably benign 0.25
R9616:Zbtb10 UTSW 3 9,316,473 (GRCm39) missense probably benign 0.01
Z1177:Zbtb10 UTSW 3 9,343,391 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCCTCACGGGAACAGAAGATC -3'
(R):5'- CTGGACTGACAACCTTACCTG -3'

Sequencing Primer
(F):5'- AGAAGATCGCCAGCTTCTG -3'
(R):5'- ACCTGGCTCTTCCTTGATGAGTAAG -3'
Posted On 2017-02-10