Incidental Mutation 'R5863:Or8c20'
ID 454012
Institutional Source Beutler Lab
Gene Symbol Or8c20
Ensembl Gene ENSMUSG00000094588
Gene Name olfactory receptor family 8 subfamily C member 20
Synonyms GA_x6K02T2PVTD-32037624-32038565, MOR170-3, Olfr898
MMRRC Submission 043232-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.172) question?
Stock # R5863 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38260381-38261331 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38261083 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 235 (S235P)
Ref Sequence ENSEMBL: ENSMUSP00000075824 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076504] [ENSMUST00000216304] [ENSMUST00000217063]
AlphaFold L7N1Z5
Predicted Effect probably benign
Transcript: ENSMUST00000076504
AA Change: S235P

PolyPhen 2 Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000075824
Gene: ENSMUSG00000094588
AA Change: S235P

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 2.2e-47 PFAM
Pfam:7tm_1 47 313 1.7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216304
AA Change: S229P

PolyPhen 2 Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000217063
AA Change: S229P

PolyPhen 2 Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aacs T C 5: 125,580,287 (GRCm39) I204T possibly damaging Het
Abcc2 A G 19: 43,786,575 (GRCm39) I136V probably benign Het
Adam6a T C 12: 113,507,987 (GRCm39) I120T probably benign Het
Add3 C A 19: 53,222,301 (GRCm39) L303I probably benign Het
Anln A G 9: 22,249,280 (GRCm39) L149P probably damaging Het
Arhgef4 A G 1: 34,761,926 (GRCm39) E394G unknown Het
Asns G A 6: 7,675,443 (GRCm39) Q520* probably null Het
Auh T G 13: 53,052,694 (GRCm39) N141T probably benign Het
B3galt2 G A 1: 143,522,104 (GRCm39) R80Q probably benign Het
Bcl9 T C 3: 97,117,666 (GRCm39) T343A probably benign Het
C3 T A 17: 57,530,141 (GRCm39) I487F probably benign Het
Cast T C 13: 74,884,875 (GRCm39) K326E probably damaging Het
Ccdc185 T A 1: 182,576,122 (GRCm39) H189L possibly damaging Het
Cep112 A G 11: 108,497,058 (GRCm39) E51G probably damaging Het
Cpvl G A 6: 53,850,413 (GRCm39) P475S probably damaging Het
Cstf2t G T 19: 31,060,477 (GRCm39) L4F probably damaging Het
Dido1 A G 2: 180,303,566 (GRCm39) V1446A probably benign Het
Dlg2 T A 7: 91,360,987 (GRCm39) M35K probably benign Het
Dnah12 C T 14: 26,576,878 (GRCm39) L3043F probably damaging Het
Fam135a A G 1: 24,053,863 (GRCm39) S1225P possibly damaging Het
Fhod3 T C 18: 25,258,810 (GRCm39) F1443S probably benign Het
Flacc1 G T 1: 58,730,908 (GRCm39) H49Q probably benign Het
Gm14226 C A 2: 154,866,211 (GRCm39) T56N probably benign Het
Itgb4 C T 11: 115,881,748 (GRCm39) R766W probably damaging Het
Kcnj8 T A 6: 142,511,414 (GRCm39) I398F probably benign Het
Khdrbs1 G A 4: 129,616,493 (GRCm39) R284C probably damaging Het
Nog A G 11: 89,192,356 (GRCm39) L164P probably damaging Het
Or13a18 G A 7: 140,190,544 (GRCm39) G155D probably damaging Het
Pkhd1 T A 1: 20,590,434 (GRCm39) Q1771L possibly damaging Het
Prl3c1 T A 13: 27,387,593 (GRCm39) *193K probably null Het
Prpf4b T A 13: 35,083,111 (GRCm39) I829N possibly damaging Het
Rassf1 C T 9: 107,435,023 (GRCm39) P103S probably damaging Het
Rdh16f2 A C 10: 127,712,256 (GRCm39) I238L probably benign Het
Sdk2 G T 11: 113,725,810 (GRCm39) D1146E probably damaging Het
Slc16a3 T C 11: 120,848,779 (GRCm39) F412L probably benign Het
Slc24a1 T C 9: 64,835,824 (GRCm39) T768A unknown Het
Stk32a A G 18: 43,448,209 (GRCm39) N396S probably benign Het
Ston1 T C 17: 88,943,373 (GRCm39) S260P possibly damaging Het
Tmem135 A G 7: 88,797,176 (GRCm39) probably null Het
Tmem30c A G 16: 57,090,418 (GRCm39) V263A probably benign Het
Ttn T A 2: 76,587,102 (GRCm39) T21632S probably damaging Het
Ube2w A G 1: 16,655,531 (GRCm39) I141T probably damaging Het
Zbtb47 A G 9: 121,596,596 (GRCm39) S651G probably benign Het
Zscan20 A T 4: 128,480,141 (GRCm39) C783* probably null Het
Other mutations in Or8c20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01394:Or8c20 APN 9 38,261,101 (GRCm39) missense possibly damaging 0.95
IGL02477:Or8c20 APN 9 38,260,421 (GRCm39) missense probably benign 0.16
IGL02858:Or8c20 APN 9 38,260,469 (GRCm39) missense probably benign 0.04
PIT4362001:Or8c20 UTSW 9 38,260,494 (GRCm39) missense probably benign 0.34
R0060:Or8c20 UTSW 9 38,260,808 (GRCm39) missense probably benign 0.23
R0518:Or8c20 UTSW 9 38,260,499 (GRCm39) missense probably damaging 0.99
R0521:Or8c20 UTSW 9 38,260,499 (GRCm39) missense probably damaging 0.99
R0622:Or8c20 UTSW 9 38,260,667 (GRCm39) missense possibly damaging 0.74
R0898:Or8c20 UTSW 9 38,260,738 (GRCm39) missense probably damaging 0.97
R1562:Or8c20 UTSW 9 38,260,658 (GRCm39) nonsense probably null
R3903:Or8c20 UTSW 9 38,260,954 (GRCm39) nonsense probably null
R4375:Or8c20 UTSW 9 38,260,465 (GRCm39) missense probably benign
R4459:Or8c20 UTSW 9 38,261,288 (GRCm39) missense probably damaging 1.00
R4762:Or8c20 UTSW 9 38,260,577 (GRCm39) missense probably damaging 1.00
R4943:Or8c20 UTSW 9 38,260,924 (GRCm39) missense probably damaging 1.00
R5033:Or8c20 UTSW 9 38,260,924 (GRCm39) missense probably damaging 1.00
R5442:Or8c20 UTSW 9 38,261,158 (GRCm39) missense probably benign 0.06
R5988:Or8c20 UTSW 9 38,261,045 (GRCm39) missense probably benign 0.30
R7077:Or8c20 UTSW 9 38,261,266 (GRCm39) missense probably damaging 1.00
R7509:Or8c20 UTSW 9 38,260,868 (GRCm39) missense probably benign 0.26
R7709:Or8c20 UTSW 9 38,260,573 (GRCm39) missense probably benign 0.02
R9305:Or8c20 UTSW 9 38,260,381 (GRCm39) start codon destroyed probably benign 0.33
Predicted Primers PCR Primer
(F):5'- CAGGGTTTATGATCAGGCTCAG -3'
(R):5'- GTTCCTGAGGCTGTAAATGAGAG -3'

Sequencing Primer
(F):5'- TGATCAGGCTCAGTTTTTGTAATTC -3'
(R):5'- GCTGTAAATGAGAGGATTTAGCATG -3'
Posted On 2017-02-10