Mutagenetix > Incidental Mutation

Incidental Mutation 'R5868:Vmn2r23'

454272

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r23

Ensembl Gene

ENSMUSG00000091620

Gene Name

vomeronasal 2, receptor 23

Synonyms

EG435916

MMRRC Submission

044076-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R5868 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

123679780-123719198 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 123689901 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 259 (V259A)

Ref Sequence

ENSEMBL: ENSMUSP00000126682 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172391]

AlphaFold

E9PXI5

Predicted Effect

probably benign
Transcript: ENSMUST00000172391
AA Change: V259A

PolyPhen 2 Score 0.115 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000126682
Gene: ENSMUSG00000091620
AA Change: V259A

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	79	461	1.7e-31	PFAM
Pfam:NCD3G	513	566	1.2e-23	PFAM
Pfam:7tm_3	596	834	1.5e-55	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.2%
20x: 90.8%

Validation Efficiency

95% (58/61)

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2810408A11Rik	C	A	11: 69,788,401 (GRCm39)	K394N	possibly damaging	Het
Adamts18	T	A	8: 114,504,380 (GRCm39)	Q80L	possibly damaging	Het
Apbb2	T	A	5: 66,609,439 (GRCm39)	K69N	probably damaging	Het
Ascc3	C	T	10: 50,718,279 (GRCm39)	R1991*	probably null	Het
BC035947	T	A	1: 78,474,960 (GRCm39)	N524I	probably damaging	Het
Bpifa1	A	G	2: 153,985,796 (GRCm39)	N37S	unknown	Het
Cfap91	T	A	16: 38,152,604 (GRCm39)	D202V	probably damaging	Het
Crnkl1	A	T	2: 145,760,473 (GRCm39)	D648E	probably benign	Het
Cul5	C	A	9: 53,569,973 (GRCm39)	G86V	probably benign	Het
Cyfip1	A	C	7: 55,576,061 (GRCm39)	D1077A	probably damaging	Het
Dennd4a	T	C	9: 64,804,011 (GRCm39)	S1117P	probably benign	Het
Dnaaf8	T	C	16: 4,791,932 (GRCm39)		noncoding transcript	Het
Elmo2	A	T	2: 165,136,192 (GRCm39)	M618K	possibly damaging	Het
Fggy	A	G	4: 95,585,225 (GRCm39)	T35A	probably damaging	Het
Gad2	G	A	2: 22,575,079 (GRCm39)		probably null	Het
Gtf3c2	A	C	5: 31,325,425 (GRCm39)	F455V	possibly damaging	Het
H4c16	C	T	6: 136,781,292 (GRCm39)	G29D	probably damaging	Het
Hacl1	C	A	14: 31,341,873 (GRCm39)	A311S	probably damaging	Het
Kat6b	G	A	14: 21,684,547 (GRCm39)	D611N	probably damaging	Het
Kifap3	T	C	1: 163,693,041 (GRCm39)	I611T	probably damaging	Het
Lrba	A	G	3: 86,226,911 (GRCm39)	Y683C	probably damaging	Het
Mfsd14a	T	C	3: 116,427,399 (GRCm39)	N413S	probably benign	Het
Mtmr11	T	A	3: 96,078,518 (GRCm39)	D691E	possibly damaging	Het
Mzf1	A	T	7: 12,787,116 (GRCm39)	F64I	probably benign	Het
Neu2	G	T	1: 87,524,478 (GRCm39)	Q154H	probably damaging	Het
Nid1	T	C	13: 13,663,742 (GRCm39)		probably null	Het
Nod1	C	A	6: 54,916,312 (GRCm39)	K128N	probably damaging	Het
Noxred1	T	A	12: 87,270,976 (GRCm39)	Q215L	possibly damaging	Het
Npat	A	G	9: 53,481,424 (GRCm39)	E1044G	probably damaging	Het
Npr1	A	G	3: 90,366,800 (GRCm39)		probably benign	Het
Pdcd6	T	C	13: 74,452,133 (GRCm39)	D169G	probably damaging	Het
Pld3	G	T	7: 27,237,093 (GRCm39)	T262N	probably benign	Het
Plxna1	T	C	6: 89,299,704 (GRCm39)		probably benign	Het
Prh1	A	G	6: 132,549,174 (GRCm39)	Q227R	unknown	Het
Prtg	C	A	9: 72,716,999 (GRCm39)	Y113*	probably null	Het
Rbm27	T	A	18: 42,433,450 (GRCm39)	V242E	possibly damaging	Het
Ripor1	T	C	8: 106,342,636 (GRCm39)	L198P	probably damaging	Het
Rnpc3	T	C	3: 113,410,360 (GRCm39)		probably null	Het
Serpinf2	T	C	11: 75,324,065 (GRCm39)	T321A	probably benign	Het
Sh3gl1	T	C	17: 56,326,119 (GRCm39)	D129G	probably damaging	Het
Slc12a2	C	A	18: 58,077,068 (GRCm39)	P1189Q	probably damaging	Het
Slc16a9	T	C	10: 70,118,320 (GRCm39)	M213T	probably benign	Het
Spata31f3	A	T	4: 42,871,711 (GRCm39)	D221E	probably damaging	Het
Svil	G	A	18: 5,056,854 (GRCm39)		probably null	Het
Synpo	A	G	18: 60,737,118 (GRCm39)	L37P	probably damaging	Het
Tmprss9	A	G	10: 80,718,580 (GRCm39)	H87R	probably benign	Het
Tmtc1	A	T	6: 148,139,353 (GRCm39)	L885Q	probably damaging	Het
Ttc41	T	C	10: 86,586,128 (GRCm39)	S811P	possibly damaging	Het
Wwox	T	A	8: 115,406,586 (GRCm39)	H192Q	probably benign	Het

Other mutations in Vmn2r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00324:Vmn2r23	APN	6	123,706,684 (GRCm39)	missense	possibly damaging	0.89
IGL01012:Vmn2r23	APN	6	123,706,555 (GRCm39)	missense	probably benign
IGL01073:Vmn2r23	APN	6	123,689,759 (GRCm39)	missense	possibly damaging	0.82
IGL01547:Vmn2r23	APN	6	123,681,383 (GRCm39)	missense	possibly damaging	0.88
IGL01571:Vmn2r23	APN	6	123,681,366 (GRCm39)	missense	probably damaging	1.00
IGL01950:Vmn2r23	APN	6	123,718,845 (GRCm39)	missense	possibly damaging	0.80
IGL02028:Vmn2r23	APN	6	123,718,819 (GRCm39)	missense	probably damaging	1.00
IGL02248:Vmn2r23	APN	6	123,718,703 (GRCm39)	missense	probably damaging	0.96
IGL02318:Vmn2r23	APN	6	123,718,795 (GRCm39)	missense	probably benign	0.10
IGL02649:Vmn2r23	APN	6	123,681,437 (GRCm39)	missense	probably benign
IGL02831:Vmn2r23	APN	6	123,681,344 (GRCm39)	missense	probably benign	0.22
IGL02832:Vmn2r23	APN	6	123,681,355 (GRCm39)	missense	probably benign	0.00
IGL02865:Vmn2r23	APN	6	123,718,578 (GRCm39)	missense	probably damaging	1.00
IGL02964:Vmn2r23	APN	6	123,718,741 (GRCm39)	missense	possibly damaging	0.93
IGL03347:Vmn2r23	APN	6	123,681,333 (GRCm39)	missense	probably benign	0.01
IGL03396:Vmn2r23	APN	6	123,706,585 (GRCm39)	missense	probably damaging	1.00
PIT4472001:Vmn2r23	UTSW	6	123,689,936 (GRCm39)	missense	possibly damaging	0.62
R0597:Vmn2r23	UTSW	6	123,706,680 (GRCm39)	missense	probably benign	0.08
R0677:Vmn2r23	UTSW	6	123,690,410 (GRCm39)	missense	probably benign	0.00
R0904:Vmn2r23	UTSW	6	123,719,094 (GRCm39)	missense	probably damaging	1.00
R1330:Vmn2r23	UTSW	6	123,718,963 (GRCm39)	missense	probably damaging	1.00
R1424:Vmn2r23	UTSW	6	123,690,229 (GRCm39)	nonsense	probably null
R1629:Vmn2r23	UTSW	6	123,690,386 (GRCm39)	missense	probably benign	0.05
R1842:Vmn2r23	UTSW	6	123,706,649 (GRCm39)	missense	possibly damaging	0.77
R1867:Vmn2r23	UTSW	6	123,679,874 (GRCm39)	missense	probably damaging	1.00
R1919:Vmn2r23	UTSW	6	123,689,969 (GRCm39)	missense	possibly damaging	0.94
R2087:Vmn2r23	UTSW	6	123,718,458 (GRCm39)	missense	probably benign	0.00
R2338:Vmn2r23	UTSW	6	123,681,384 (GRCm39)	missense	possibly damaging	0.88
R2568:Vmn2r23	UTSW	6	123,719,147 (GRCm39)	nonsense	probably null
R2867:Vmn2r23	UTSW	6	123,690,123 (GRCm39)	missense	possibly damaging	0.94
R2867:Vmn2r23	UTSW	6	123,690,123 (GRCm39)	missense	possibly damaging	0.94
R3500:Vmn2r23	UTSW	6	123,690,129 (GRCm39)	missense	possibly damaging	0.81
R3789:Vmn2r23	UTSW	6	123,718,348 (GRCm39)	missense	probably damaging	1.00
R4164:Vmn2r23	UTSW	6	123,706,697 (GRCm39)	missense	probably benign
R4506:Vmn2r23	UTSW	6	123,679,884 (GRCm39)	missense	probably damaging	1.00
R4652:Vmn2r23	UTSW	6	123,718,689 (GRCm39)	missense	probably damaging	1.00
R4697:Vmn2r23	UTSW	6	123,718,785 (GRCm39)	missense	probably damaging	1.00
R4840:Vmn2r23	UTSW	6	123,690,033 (GRCm39)	missense	probably damaging	1.00
R4983:Vmn2r23	UTSW	6	123,710,308 (GRCm39)	missense	probably damaging	1.00
R5276:Vmn2r23	UTSW	6	123,689,936 (GRCm39)	missense	possibly damaging	0.62
R5392:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R5528:Vmn2r23	UTSW	6	123,689,961 (GRCm39)	missense	probably damaging	1.00
R5529:Vmn2r23	UTSW	6	123,690,410 (GRCm39)	missense	probably benign	0.00
R5664:Vmn2r23	UTSW	6	123,690,033 (GRCm39)	missense	probably damaging	1.00
R5749:Vmn2r23	UTSW	6	123,710,232 (GRCm39)	missense	probably benign
R5761:Vmn2r23	UTSW	6	123,689,718 (GRCm39)	missense	probably benign	0.39
R5762:Vmn2r23	UTSW	6	123,710,352 (GRCm39)	missense	probably damaging	1.00
R5935:Vmn2r23	UTSW	6	123,718,854 (GRCm39)	missense	possibly damaging	0.94
R6242:Vmn2r23	UTSW	6	123,681,359 (GRCm39)	missense	possibly damaging	0.82
R6416:Vmn2r23	UTSW	6	123,689,861 (GRCm39)	missense	probably damaging	1.00
R6524:Vmn2r23	UTSW	6	123,690,384 (GRCm39)	missense	probably damaging	1.00
R6576:Vmn2r23	UTSW	6	123,710,232 (GRCm39)	missense	probably benign
R6925:Vmn2r23	UTSW	6	123,681,512 (GRCm39)	missense	probably damaging	1.00
R7148:Vmn2r23	UTSW	6	123,689,981 (GRCm39)	missense	probably benign
R7215:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R7252:Vmn2r23	UTSW	6	123,718,540 (GRCm39)	missense	probably damaging	0.97
R7403:Vmn2r23	UTSW	6	123,681,538 (GRCm39)	missense	probably benign	0.01
R8015:Vmn2r23	UTSW	6	123,681,500 (GRCm39)	missense	probably benign	0.00
R8143:Vmn2r23	UTSW	6	123,718,312 (GRCm39)	missense	probably damaging	0.99
R8474:Vmn2r23	UTSW	6	123,681,599 (GRCm39)	missense	probably benign	0.36
R8520:Vmn2r23	UTSW	6	123,718,615 (GRCm39)	missense	probably damaging	0.99
R8679:Vmn2r23	UTSW	6	123,690,431 (GRCm39)	missense	probably damaging	0.99
R8713:Vmn2r23	UTSW	6	123,679,991 (GRCm39)	missense
R8966:Vmn2r23	UTSW	6	123,719,079 (GRCm39)	missense	possibly damaging	0.94
R9124:Vmn2r23	UTSW	6	123,719,038 (GRCm39)	missense	possibly damaging	0.57
R9163:Vmn2r23	UTSW	6	123,718,782 (GRCm39)	missense	probably damaging	1.00
R9189:Vmn2r23	UTSW	6	123,681,323 (GRCm39)	missense	probably benign	0.36
R9451:Vmn2r23	UTSW	6	123,710,352 (GRCm39)	missense	probably damaging	1.00
R9495:Vmn2r23	UTSW	6	123,689,672 (GRCm39)	missense	probably benign	0.30
R9514:Vmn2r23	UTSW	6	123,689,672 (GRCm39)	missense	probably benign	0.30
RF018:Vmn2r23	UTSW	6	123,690,075 (GRCm39)	missense	probably benign	0.00
T0975:Vmn2r23	UTSW	6	123,690,120 (GRCm39)	missense	probably benign	0.00
Z1088:Vmn2r23	UTSW	6	123,719,067 (GRCm39)	missense	probably damaging	0.98
Z1177:Vmn2r23	UTSW	6	123,706,684 (GRCm39)	frame shift	probably null

Predicted Primers

PCR Primer
(F):5'- AGTTTCCTGTGCACACCAC -3'
(R):5'- TCCTCCACCAAAGTATGTATAACCTAG -3'

Sequencing Primer
(F):5'- ACCACAGCTCTGTATCAGGG -3'
(R):5'- CAGACGTTGTGATCCAGAT -3'

Posted On

2017-02-10