Incidental Mutation 'R5880:Or10al4'
ID 454387
Institutional Source Beutler Lab
Gene Symbol Or10al4
Ensembl Gene ENSMUSG00000063994
Gene Name olfactory receptor family 10 subfamily AL member 4
Synonyms Olfr120, MOR263-3, GA_x6K02T2PSCP-2184981-2185946
MMRRC Submission 043235-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R5880 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 38036890-38037882 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38037545 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 219 (V219A)
Ref Sequence ENSEMBL: ENSMUSP00000094931 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077498] [ENSMUST00000207771]
AlphaFold Q8VFQ2
Predicted Effect probably benign
Transcript: ENSMUST00000077498
AA Change: V219A

PolyPhen 2 Score 0.085 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000094931
Gene: ENSMUSG00000063994
AA Change: V219A

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 50 320 1e-5 PFAM
Pfam:7tm_1 56 305 6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207771
AA Change: V210A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.2%
  • 10x: 93.4%
  • 20x: 74.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaa2 G A 18: 74,937,072 (GRCm39) V319M probably damaging Het
Actrt2 T A 4: 154,751,747 (GRCm39) T130S probably benign Het
Ap1g2 A G 14: 55,340,157 (GRCm39) S392P probably damaging Het
Cby2 C T 14: 75,821,243 (GRCm39) V119I probably benign Het
Cdh23 T A 10: 60,220,713 (GRCm39) N1344Y probably damaging Het
Cyp4x1 A T 4: 114,965,918 (GRCm39) H469Q possibly damaging Het
Dhodh T A 8: 110,321,409 (GRCm39) T326S probably benign Het
Ebf3 T G 7: 136,800,367 (GRCm39) N529T probably benign Het
Echdc2 A C 4: 108,030,097 (GRCm39) I133L possibly damaging Het
Fbn2 A T 18: 58,156,354 (GRCm39) C2488* probably null Het
Fndc3b T A 3: 27,483,052 (GRCm39) T1049S probably damaging Het
Igsf10 T C 3: 59,238,252 (GRCm39) Y643C probably damaging Het
Il15ra A G 2: 11,735,426 (GRCm39) *104W probably null Het
Iqgap3 T A 3: 88,024,509 (GRCm39) S628R possibly damaging Het
Lrp1b C T 2: 41,231,826 (GRCm39) V1215M probably benign Het
Mmp20 G A 9: 7,655,002 (GRCm39) R370Q probably benign Het
Or4d5 A T 9: 40,012,543 (GRCm39) M81K possibly damaging Het
Or4k6 A G 14: 50,476,172 (GRCm39) S57P possibly damaging Het
Patj A T 4: 98,299,382 (GRCm39) H168L probably damaging Het
Peak1 A T 9: 56,114,894 (GRCm39) I319N probably damaging Het
Rgs20 A T 1: 4,994,104 (GRCm39) C93S probably damaging Het
Sh3tc2 A T 18: 62,106,382 (GRCm39) H137L probably benign Het
Sycp2 A G 2: 178,016,263 (GRCm39) V733A possibly damaging Het
Tet3 G C 6: 83,347,532 (GRCm39) P1154R probably damaging Het
Other mutations in Or10al4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01402:Or10al4 APN 17 38,037,193 (GRCm39) missense probably benign 0.08
IGL01925:Or10al4 APN 17 38,037,002 (GRCm39) missense probably benign 0.18
IGL02901:Or10al4 APN 17 38,037,311 (GRCm39) missense probably damaging 1.00
PIT4687001:Or10al4 UTSW 17 38,037,082 (GRCm39) missense probably benign 0.01
R1645:Or10al4 UTSW 17 38,037,229 (GRCm39) missense probably benign 0.01
R2218:Or10al4 UTSW 17 38,037,145 (GRCm39) missense probably damaging 0.97
R2336:Or10al4 UTSW 17 38,037,689 (GRCm39) missense probably benign 0.07
R4613:Or10al4 UTSW 17 38,037,587 (GRCm39) missense probably damaging 1.00
R5237:Or10al4 UTSW 17 38,037,268 (GRCm39) missense probably damaging 1.00
R6187:Or10al4 UTSW 17 38,037,032 (GRCm39) missense probably damaging 0.99
R9083:Or10al4 UTSW 17 38,037,060 (GRCm39) missense probably damaging 1.00
R9479:Or10al4 UTSW 17 38,036,986 (GRCm39) missense probably damaging 0.99
R9647:Or10al4 UTSW 17 38,037,796 (GRCm39) missense probably damaging 1.00
Z1088:Or10al4 UTSW 17 38,036,983 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCAATAGTTTCATGGGGAATGG -3'
(R):5'- GTCACCGCGGTGTAGAAAAG -3'

Sequencing Primer
(F):5'- CAATAGTTTCATGGGGAATGGGATGC -3'
(R):5'- AGGGCCAAGAGTTTATCTATTCCTG -3'
Posted On 2017-02-10