Mutagenetix > Incidental Mutation

Incidental Mutation 'R5882:Zfp882'

454472

Institutional Source

Beutler Lab

Gene Symbol

Zfp882

Ensembl Gene

ENSMUSG00000089857

Gene Name

zinc finger protein 882

Synonyms

ENSMUSG00000052439

MMRRC Submission

043236-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.176) question?

Stock #

R5882 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

71908608-71916354 bp(+) (GRCm38)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

A to T at 71913459 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000119978 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110002] [ENSMUST00000125802] [ENSMUST00000126607] [ENSMUST00000131544]

AlphaFold

E9Q4R4

Predicted Effect

probably null
Transcript: ENSMUST00000110002

SMART Domains

Protein: ENSMUSP00000105629
Gene: ENSMUSG00000089857

Domain	Start	End	E-Value	Type
KRAB	4	61	8.58e-14	SMART
ZnF_C2H2	84	106	1.47e-3	SMART
ZnF_C2H2	168	190	8.47e-4	SMART
ZnF_C2H2	196	218	2.27e-4	SMART
ZnF_C2H2	224	246	6.31e1	SMART
ZnF_C2H2	251	273	1.16e-1	SMART
ZnF_C2H2	279	301	1.25e-1	SMART
ZnF_C2H2	307	329	5.42e-2	SMART
ZnF_C2H2	335	357	1.47e-3	SMART
ZnF_C2H2	363	385	7.26e-3	SMART
ZnF_C2H2	391	413	1.26e-2	SMART
ZnF_C2H2	419	441	3.29e1	SMART
ZnF_C2H2	447	469	2.67e-1	SMART
ZnF_C2H2	475	497	1.04e-3	SMART
ZnF_C2H2	503	525	4.11e-2	SMART
ZnF_C2H2	531	553	4.87e-4	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000118290

Predicted Effect

probably null
Transcript: ENSMUST00000125802

SMART Domains

Protein: ENSMUSP00000121316
Gene: ENSMUSG00000089857

Domain	Start	End	E-Value	Type
KRAB	12	69	8.58e-14	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000126607

SMART Domains

Protein: ENSMUSP00000119978
Gene: ENSMUSG00000089857

Domain	Start	End	E-Value	Type
KRAB	44	101	8.58e-14	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000131544

SMART Domains

Protein: ENSMUSP00000120213
Gene: ENSMUSG00000066880

Domain	Start	End	E-Value	Type
KRAB	4	56	1.08e-10	SMART
ZnF_C2H2	167	189	8.47e-4	SMART
ZnF_C2H2	195	217	8.34e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170898

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 96.5%
20x: 86.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apol7e	T	A	15: 77,718,247	H348Q	probably benign	Het
Cacna1g	T	A	11: 94,459,819	E400V	probably damaging	Het
Cyp2j6	T	A	4: 96,535,602	K176N	probably benign	Het
Dcaf4	T	C	12: 83,539,429	V377A	probably damaging	Het
Dennd1a	A	G	2: 37,961,663	L71P	probably damaging	Het
Dmbx1	G	T	4: 115,920,301	R117S	probably damaging	Het
Ep400	A	G	5: 110,755,587	V382A	probably benign	Het
Kars	G	A	8: 112,003,425	R107*	probably null	Het
Kif16b	C	T	2: 142,707,258		probably null	Het
Lrrc69	A	G	4: 14,708,690	F218S	probably damaging	Het
Myo15b	A	G	11: 115,869,596	Y1158C	probably damaging	Het
Myom1	G	C	17: 71,110,722	A1307P	probably damaging	Het
Nacad	C	T	11: 6,598,568	V1389I	possibly damaging	Het
Nit2	T	C	16: 57,159,466	D132G	probably benign	Het
Nln	G	T	13: 104,059,498	D60E	probably benign	Het
Oas1f	G	A	5: 120,848,253	E90K	probably damaging	Het
Obox3	A	G	7: 15,626,968	V82A	probably benign	Het
Olfr1277	A	T	2: 111,270,139	V76E	probably damaging	Het
Olfr874	C	T	9: 37,746,632	T166I	probably benign	Het
Pcdhb1	A	T	18: 37,267,177	Q727L	probably benign	Het
Phactr1	G	T	13: 42,709,851		probably null	Het
Prkg1	A	T	19: 31,585,697	N116K	probably damaging	Het
Scnn1g	A	T	7: 121,767,358	S593C	possibly damaging	Het
Serpina6	T	C	12: 103,654,235	N85S	probably benign	Het
Spock3	A	G	8: 63,143,931	T93A	probably benign	Het
St7	T	C	6: 17,846,249	L121P	probably damaging	Het
Stoml2	G	C	4: 43,031,003	R57G	probably damaging	Het
Tdrd1	C	T	19: 56,848,939	R532C	probably damaging	Het
Tmc5	A	G	7: 118,654,919	N660S	probably damaging	Het
Tmem38a	A	G	8: 72,585,887	H233R	probably damaging	Het
Trp53bp2	T	C	1: 182,442,212	V304A	possibly damaging	Het
Ush1g	C	A	11: 115,318,542	M275I	probably damaging	Het
Zim1	A	T	7: 6,682,738		probably null	Het

Other mutations in Zfp882

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00676:Zfp882	APN	8	71913827	missense	probably benign
R0244:Zfp882	UTSW	8	71913523	missense	possibly damaging	0.79
R0270:Zfp882	UTSW	8	71914615	missense	probably benign	0.05
R0636:Zfp882	UTSW	8	71914337	missense	probably benign	0.01
R0840:Zfp882	UTSW	8	71914686	nonsense	probably null
R1299:Zfp882	UTSW	8	71913473	missense	probably damaging	1.00
R4439:Zfp882	UTSW	8	71913609	missense	probably damaging	0.97
R4829:Zfp882	UTSW	8	71914389	missense	probably damaging	1.00
R5028:Zfp882	UTSW	8	71914654	missense	possibly damaging	0.70
R5296:Zfp882	UTSW	8	71914360	missense	probably damaging	1.00
R5974:Zfp882	UTSW	8	71913155	missense	probably damaging	1.00
R6052:Zfp882	UTSW	8	71914505	missense	probably benign	0.01
R6383:Zfp882	UTSW	8	71914640	missense	probably damaging	1.00
R6888:Zfp882	UTSW	8	71914286	missense	probably benign	0.01
R6987:Zfp882	UTSW	8	71914673	missense	probably benign	0.01
R7045:Zfp882	UTSW	8	71913249	critical splice donor site	probably null
R7780:Zfp882	UTSW	8	71914229	missense	possibly damaging	0.89
R7793:Zfp882	UTSW	8	71913141	missense	probably damaging	1.00
R8386:Zfp882	UTSW	8	71914118	missense	probably benign	0.00
R9452:Zfp882	UTSW	8	71914987	missense	probably damaging	1.00
R9694:Zfp882	UTSW	8	71914071	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- TGCCTTGTTTAGTCCATGAGAG -3'
(R):5'- TGTGTCTGCTAAAACTGTCTTCAG -3'

Sequencing Primer
(F):5'- CCAGTCATGATCTTATACCAG -3'
(R):5'- TCATATGTTCCAGAAAACTTTGGGG -3'

Posted On

2017-02-10