|Institutional Source||Beutler Lab|
|Gene Name||nectin cell adhesion molecule 2|
|Synonyms||MPH, nectin-2, Cd112, Pvs, Pvrl2|
|Is this an essential gene?||Probably non essential (E-score: 0.167)|
|Stock #||R0555 (G1)|
|Chromosomal Location||19716644-19750483 bp(-) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 19733223 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000104089 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000075447] [ENSMUST00000108450]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||100% (98/98)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for targeted null mutations exhibit male sterility associated with sperm head and midpiece malformation, impaired zona binding, and lack of oocyte penetration. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nectin2||
(F):5'- ACCATAGGCAAGGCAAGGTTTGGC -3'
(R):5'- CCATGCATCAGTCCCATGTGACATC -3'
(F):5'- ACGTGACCTTGACGCCATC -3'
(R):5'- ATAGTTTAACTGGCTGCCCAGAG -3'