Mutagenetix > Incidental Mutations

Incidental Mutation 'R5851:Pate2'

454679

Institutional Source

Beutler Lab

Gene Symbol

Pate2

Ensembl Gene

ENSMUSG00000074452

Gene Name

prostate and testis expressed 2

Synonyms

mANLP1, LOC330921

MMRRC Submission

044067-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5851 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

35570284-35690318 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 35670501 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 26 (Y26*)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098906] [ENSMUST00000118254]

Predicted Effect

probably null
Transcript: ENSMUST00000098906
AA Change: Y30*

SMART Domains

Protein: ENSMUSP00000096505
Gene: ENSMUSG00000074452
AA Change: Y30*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000118254
AA Change: Y30*

SMART Domains

Protein: ENSMUSP00000113239
Gene: ENSMUSG00000074452
AA Change: Y30*

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173488

Predicted Effect

probably null
Transcript: ENSMUST00000217565
AA Change: Y26*

Meta Mutation Damage Score

0.9665

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 98.0%
20x: 94.0%

Validation Efficiency

100% (75/75)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930404N11Rik	A	T	10: 81,364,877		probably null	Het
Abca2	A	G	2: 25,442,310	N1452D	possibly damaging	Het
Abhd15	T	C	11: 77,518,447	L329P	probably benign	Het
Add3	T	C	19: 53,236,774	S442P	probably damaging	Het
Arhgef18	T	C	8: 3,434,980	F228L	probably damaging	Het
Bptf	A	T	11: 107,110,862	Y475N	probably damaging	Het
C3	T	C	17: 57,211,612	N1257S	probably null	Het
Ccdc94	C	T	17: 55,967,582	S298F	probably damaging	Het
Cd163l1	C	T	7: 140,228,027	P704S	possibly damaging	Het
Cdkl1	A	T	12: 69,756,564	Y179*	probably null	Het
Ceacam1	T	C	7: 25,474,600	N210S	possibly damaging	Het
Celf3	T	A	3: 94,479,126	I7N	probably damaging	Het
Cmpk1	A	G	4: 114,986,970	V55A	possibly damaging	Het
Csrnp1	C	T	9: 119,973,078	G305D	possibly damaging	Het
Dnah3	A	G	7: 120,039,362	S1266P	possibly damaging	Het
Edc4	T	C	8: 105,890,867	L1077P	probably damaging	Het
Efcab1	T	A	16: 14,920,436	L155H	probably damaging	Het
Fam174a	G	A	1: 95,325,143	G157S	probably damaging	Het
Fubp3	T	A	2: 31,598,610	D159E	probably benign	Het
Garem2	C	T	5: 30,114,290	T250M	probably damaging	Het
H2-Eb1	C	T	17: 34,309,771	P92L	probably benign	Het
Ifnl3	G	T	7: 28,523,511	C69F	probably damaging	Het
Itga2b	C	A	11: 102,457,601		probably benign	Het
Klhl33	A	T	14: 50,892,878	D386E	probably damaging	Het
Lin9	T	A	1: 180,669,198	L351I	probably benign	Het
Lor	G	A	3: 92,080,539	A480V	unknown	Het
Msh3	G	T	13: 92,215,522	Q1041K	probably benign	Het
Myo1e	G	A	9: 70,383,804	G959E	probably benign	Het
Nfat5	G	T	8: 107,347,727	V338L	probably damaging	Het
Nrf1	A	G	6: 30,089,976	H18R	possibly damaging	Het
Nup160	A	G	2: 90,707,038	D752G	probably benign	Het
Obscn	A	T	11: 58,994,700	L2489*	probably null	Het
Olfr1184	A	G	2: 88,486,860	I43V	possibly damaging	Het
Olfr638	A	G	7: 104,003,452	E59G	probably benign	Het
Paip1	T	C	13: 119,440,765	S215P	possibly damaging	Het
Pcdhb10	A	G	18: 37,412,758	I296V	probably benign	Het
Pdzph1	T	G	17: 58,973,746	T514P	probably benign	Het
Pnlip	G	A	19: 58,673,792	W123*	probably null	Het
Prmt2	C	A	10: 76,236,740	C9F	possibly damaging	Het
Rbl1	T	A	2: 157,167,325	K763N	probably benign	Het
Rfk	C	T	19: 17,395,198	A28V	probably damaging	Het
Sdk1	G	A	5: 141,962,669	V590I	probably benign	Het
Sele	A	G	1: 164,049,574	K140E	probably benign	Het
Skiv2l2	G	A	13: 112,908,952	R349W	probably damaging	Het
Sla	G	A	15: 66,783,723	T189I	probably damaging	Het
Slc46a2	A	G	4: 59,913,906	V339A	probably damaging	Het
Slc5a9	A	G	4: 111,885,600	F432L	probably benign	Het
Slc6a19	A	G	13: 73,691,740	F141S	possibly damaging	Het
Tas2r123	T	C	6: 132,847,308	L56S	probably damaging	Het
Tmem245	T	C	4: 56,916,770	I53V	probably benign	Het
Tor2a	A	T	2: 32,761,607	Q278L	probably benign	Het
Trav6-3	A	G	14: 53,430,115	M15V	probably benign	Het
Ttc28	G	A	5: 111,235,469		probably benign	Het
Ubap2	G	A	4: 41,206,268	Q534*	probably null	Het
Zfp954	C	A	7: 7,115,625	E307*	probably null	Het
Zscan21	A	G	5: 138,126,478	K219E	probably benign	Het

Other mutations in Pate2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01475:Pate2	APN	9	35669702	start codon destroyed	probably null
IGL01729:Pate2	APN	9	35670592	missense	probably damaging	1.00
IGL03055:Pate2	APN	9	35611773	splice site	probably benign
foie_gras	UTSW	9	35670501	nonsense	probably null
PIT4576001:Pate2	UTSW	9	35670593	missense	probably damaging	1.00
R1229:Pate2	UTSW	9	35669695	missense	probably damaging	0.98
R1397:Pate2	UTSW	9	35669695	missense	probably damaging	0.98
R2393:Pate2	UTSW	9	35669740	splice site	probably benign
R2426:Pate2	UTSW	9	35670480	critical splice acceptor site	probably null
R3407:Pate2	UTSW	9	35670966	missense	probably damaging	0.99
R4323:Pate2	UTSW	9	35670471	splice site	probably benign
R4574:Pate2	UTSW	9	35685673	intron	probably benign
R4716:Pate2	UTSW	9	35685682	intron	probably benign
R5023:Pate2	UTSW	9	35686111	intron	probably benign
R5057:Pate2	UTSW	9	35686111	intron	probably benign
R5384:Pate2	UTSW	9	35670541	missense	probably damaging	0.98
R5574:Pate2	UTSW	9	35686115	intron	probably benign
R5593:Pate2	UTSW	9	35670482	missense	possibly damaging	0.76
R6510:Pate2	UTSW	9	35669722	missense	probably null	0.99
R6800:Pate2	UTSW	9	35685645	intron	probably benign
R6819:Pate2	UTSW	9	35670505	missense	probably damaging	1.00
R7531:Pate2	UTSW	9	35670712	intron	probably null
R7765:Pate2	UTSW	9	35669901	missense	probably benign	0.15

Predicted Primers

PCR Primer
(F):5'- AACTCGGACCTCCTTAAATGG -3'
(R):5'- TGAAAGGACCTGCTATTTAGAAGAG -3'

Sequencing Primer
(F):5'- TTAAGTTCTAGCCCAGCCAGG -3'
(R):5'- CCTGCTATTTAGAAGAGAAGGTGTG -3'

Posted On

2017-02-10