Incidental Mutation 'R5852:Zng1'
ID 454739
Institutional Source Beutler Lab
Gene Symbol Zng1
Ensembl Gene ENSMUSG00000024878
Gene Name Zn regulated GTPase metalloprotein activator 1
Synonyms Cbwd1, Zng1
MMRRC Submission 043227-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R5852 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 24897280-24938974 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 24932769 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 88 (V88A)
Ref Sequence ENSEMBL: ENSMUSP00000025815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025815]
AlphaFold Q8VEH6
Predicted Effect possibly damaging
Transcript: ENSMUST00000025815
AA Change: V88A

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000025815
Gene: ENSMUSG00000024878
AA Change: V88A

DomainStartEndE-ValueType
low complexity region 9 16 N/A INTRINSIC
Pfam:cobW 41 229 7.1e-51 PFAM
CobW_C 271 374 5.34e-1 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.3%
  • 20x: 95.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 T A 12: 118,891,139 (GRCm39) I453F probably damaging Het
Anpep C T 7: 79,488,720 (GRCm39) W402* probably null Het
Apcdd1 T C 18: 63,070,134 (GRCm39) S134P probably damaging Het
Ccdc154 T C 17: 25,382,183 (GRCm39) V34A probably benign Het
Cntn3 A T 6: 102,397,377 (GRCm39) N65K probably damaging Het
Cntn6 G T 6: 104,812,706 (GRCm39) V663F probably damaging Het
Crisp3 A T 17: 40,536,711 (GRCm39) C201* probably null Het
Dnhd1 T A 7: 105,344,955 (GRCm39) W2100R probably damaging Het
Dync2h1 A T 9: 7,011,290 (GRCm39) S3634R probably benign Het
Entrep2 T A 7: 64,425,579 (GRCm39) H171L probably damaging Het
Gucy1a2 T C 9: 3,865,460 (GRCm39) F645L probably damaging Het
Hs6st3 G T 14: 120,106,738 (GRCm39) R382L probably damaging Het
Il27 T A 7: 126,191,786 (GRCm39) T89S possibly damaging Het
Iqgap2 C T 13: 95,811,880 (GRCm39) R707H probably damaging Het
Klhl23 T A 2: 69,654,613 (GRCm39) I161N probably benign Het
Lrrk2 G A 15: 91,640,152 (GRCm39) E1566K probably damaging Het
Mia3 A G 1: 183,113,713 (GRCm39) V437A probably benign Het
Ncoa6 G T 2: 155,247,419 (GRCm39) H1962N possibly damaging Het
Nox4 C T 7: 86,988,172 (GRCm39) T361I probably damaging Het
Pappa2 T C 1: 158,544,584 (GRCm39) Y1748C probably damaging Het
Phyhip T C 14: 70,699,369 (GRCm39) probably null Het
Pkhd1 A G 1: 20,447,632 (GRCm39) F2254L probably benign Het
Plxnb1 A G 9: 108,935,518 (GRCm39) Y1018C probably damaging Het
Pnoc C T 14: 65,648,671 (GRCm39) V8I probably benign Het
Prss29 A G 17: 25,541,408 (GRCm39) D256G probably benign Het
Scrn3 T C 2: 73,161,349 (GRCm39) F312L probably damaging Het
Sephs1 A G 2: 4,904,339 (GRCm39) E239G possibly damaging Het
Tti1 A G 2: 157,842,593 (GRCm39) L812P probably damaging Het
Wdr1 A G 5: 38,694,518 (GRCm39) S62P probably benign Het
Zfp106 A G 2: 120,346,487 (GRCm39) S1659P probably damaging Het
Other mutations in Zng1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00720:Zng1 APN 19 24,898,495 (GRCm39) missense probably benign 0.01
IGL01618:Zng1 APN 19 24,918,140 (GRCm39) missense possibly damaging 0.83
IGL02351:Zng1 APN 19 24,909,026 (GRCm39) critical splice donor site probably null
IGL02358:Zng1 APN 19 24,909,026 (GRCm39) critical splice donor site probably null
IGL02628:Zng1 APN 19 24,935,269 (GRCm39) missense probably damaging 1.00
IGL03001:Zng1 APN 19 24,900,002 (GRCm39) missense probably benign 0.01
IGL03053:Zng1 APN 19 24,932,741 (GRCm39) missense probably damaging 1.00
IGL03409:Zng1 APN 19 24,900,130 (GRCm39) missense probably benign 0.01
R0544:Zng1 UTSW 19 24,926,575 (GRCm39) missense possibly damaging 0.79
R0655:Zng1 UTSW 19 24,930,684 (GRCm39) missense possibly damaging 0.90
R0833:Zng1 UTSW 19 24,918,203 (GRCm39) splice site probably benign
R1296:Zng1 UTSW 19 24,920,039 (GRCm39) splice site probably benign
R1723:Zng1 UTSW 19 24,925,458 (GRCm39) missense possibly damaging 0.89
R1888:Zng1 UTSW 19 24,932,769 (GRCm39) missense probably damaging 1.00
R1888:Zng1 UTSW 19 24,932,769 (GRCm39) missense probably damaging 1.00
R4526:Zng1 UTSW 19 24,935,328 (GRCm39) missense probably benign 0.20
R5092:Zng1 UTSW 19 24,898,383 (GRCm39) critical splice donor site probably null
R5238:Zng1 UTSW 19 24,897,994 (GRCm39) missense probably damaging 0.99
R7248:Zng1 UTSW 19 24,898,505 (GRCm39) missense probably damaging 0.99
R7699:Zng1 UTSW 19 24,920,045 (GRCm39) critical splice donor site probably null
R7700:Zng1 UTSW 19 24,920,045 (GRCm39) critical splice donor site probably null
R7733:Zng1 UTSW 19 24,918,158 (GRCm39) missense probably damaging 1.00
R8363:Zng1 UTSW 19 24,920,091 (GRCm39) missense probably benign 0.01
R8825:Zng1 UTSW 19 24,926,601 (GRCm39) missense probably benign 0.23
R8931:Zng1 UTSW 19 24,932,780 (GRCm39) missense probably damaging 1.00
R9118:Zng1 UTSW 19 24,920,048 (GRCm39) missense probably damaging 1.00
R9467:Zng1 UTSW 19 24,930,684 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- TGTATATCCTACCCCAAAATACAATGG -3'
(R):5'- TGAAGAGTCATCAGTATACTTCCTG -3'

Sequencing Primer
(F):5'- TACCCCAAAATACAATGGTATAAGC -3'
(R):5'- CAGCGGTTAAGAGCACTTTC -3'
Posted On 2017-02-10