Incidental Mutation 'R5855:Dcaf10'
ID 454853
Institutional Source Beutler Lab
Gene Symbol Dcaf10
Ensembl Gene ENSMUSG00000035572
Gene Name DDB1 and CUL4 associated factor 10
Synonyms Wdr32
MMRRC Submission 043229-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5855 (G1)
Quality Score 171
Status Not validated
Chromosome 4
Chromosomal Location 45342101-45379759 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 45342558 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 131 (F131L)
Ref Sequence ENSEMBL: ENSMUSP00000117082 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000155551]
AlphaFold A2AKB9
Predicted Effect noncoding transcript
Transcript: ENSMUST00000107798
Predicted Effect noncoding transcript
Transcript: ENSMUST00000117307
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130821
Predicted Effect probably benign
Transcript: ENSMUST00000152056
SMART Domains Protein: ENSMUSP00000115532
Gene: ENSMUSG00000028322

DomainStartEndE-ValueType
Blast:S1 24 93 8e-38 BLAST
Pfam:KH_6 109 145 8e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155551
AA Change: F131L

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000117082
Gene: ENSMUSG00000035572
AA Change: F131L

DomainStartEndE-ValueType
low complexity region 15 46 N/A INTRINSIC
low complexity region 80 107 N/A INTRINSIC
low complexity region 110 132 N/A INTRINSIC
WD40 166 203 1.71e1 SMART
WD40 206 245 7.85e-7 SMART
WD40 249 288 2.59e-7 SMART
WD40 295 334 2.05e1 SMART
low complexity region 352 374 N/A INTRINSIC
Blast:WD40 468 506 3e-10 BLAST
WD40 524 563 1.31e-3 SMART
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.4%
  • 10x: 96.8%
  • 20x: 89.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadsb T G 7: 131,026,328 (GRCm39) L57R probably damaging Het
Bmpr1b G A 3: 141,577,146 (GRCm39) T55M possibly damaging Het
Cep350 G A 1: 155,829,508 (GRCm39) T132I probably benign Het
Cops4 A T 5: 100,695,280 (GRCm39) M400L probably benign Het
Cul1 G A 6: 47,500,147 (GRCm39) D653N probably benign Het
Cyp3a13 C G 5: 137,917,318 (GRCm39) L36F probably damaging Het
Dgkh T C 14: 78,861,944 (GRCm39) probably null Het
Igll1 C T 16: 16,678,921 (GRCm39) V130M probably damaging Het
Kif2c C T 4: 117,039,739 (GRCm39) probably benign Het
Klra7 T C 6: 130,195,921 (GRCm39) D262G possibly damaging Het
Lrrc27 T C 7: 138,798,251 (GRCm39) probably benign Het
Maf A G 8: 116,432,531 (GRCm39) S358P probably benign Het
Map1a A G 2: 121,134,155 (GRCm39) D1419G possibly damaging Het
Map3k1 G A 13: 111,892,513 (GRCm39) A914V probably benign Het
Naa25 T G 5: 121,561,755 (GRCm39) L436R possibly damaging Het
Ndc1 T C 4: 107,240,904 (GRCm39) I294T probably damaging Het
Nek1 A C 8: 61,469,306 (GRCm39) D121A probably damaging Het
Nfil3 C T 13: 53,122,746 (GRCm39) G53R probably benign Het
Or10h28 T C 17: 33,488,310 (GRCm39) V204A possibly damaging Het
Parp14 A T 16: 35,661,297 (GRCm39) Y1550* probably null Het
Patl1 A G 19: 11,898,880 (GRCm39) I192V probably damaging Het
Pax3 G A 1: 78,098,288 (GRCm39) T367I probably damaging Het
Pla2g4a C T 1: 149,755,814 (GRCm39) V208M probably damaging Het
Prdm10 A T 9: 31,248,619 (GRCm39) K347M probably damaging Het
Prkd1 A T 12: 50,439,699 (GRCm39) M376K probably benign Het
Prkg1 C T 19: 30,872,094 (GRCm39) V219I possibly damaging Het
Rictor G A 15: 6,823,487 (GRCm39) E1555K probably benign Het
Scn3a T C 2: 65,295,074 (GRCm39) I1550V possibly damaging Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Sox4 T C 13: 29,136,979 (GRCm39) E9G probably damaging Het
Spon1 T A 7: 113,628,307 (GRCm39) D354E probably damaging Het
Stat2 T A 10: 128,119,363 (GRCm39) L450H probably damaging Het
Tek T A 4: 94,741,790 (GRCm39) M849K probably damaging Het
Tmem63c G A 12: 87,122,500 (GRCm39) D433N probably damaging Het
Tnpo3 G A 6: 29,589,032 (GRCm39) T106I probably damaging Het
Tns1 G T 1: 73,957,192 (GRCm39) A1674D possibly damaging Het
Trim8 T C 19: 46,503,849 (GRCm39) V467A possibly damaging Het
Trmo T A 4: 46,382,568 (GRCm39) H183L probably benign Het
Trpm1 C A 7: 63,918,710 (GRCm39) C683* probably null Het
Vsig10 T G 5: 117,476,335 (GRCm39) L263R probably damaging Het
Zfp874a A T 13: 67,590,812 (GRCm39) Y291N probably benign Het
Other mutations in Dcaf10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02431:Dcaf10 APN 4 45,342,630 (GRCm39) missense probably benign 0.01
IGL02660:Dcaf10 APN 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R0048:Dcaf10 UTSW 4 45,374,262 (GRCm39) nonsense probably null
R0550:Dcaf10 UTSW 4 45,372,753 (GRCm39) missense probably benign
R0611:Dcaf10 UTSW 4 45,373,011 (GRCm39) missense probably damaging 1.00
R2289:Dcaf10 UTSW 4 45,359,816 (GRCm39) missense probably damaging 1.00
R2973:Dcaf10 UTSW 4 45,373,957 (GRCm39) missense probably benign 0.04
R3610:Dcaf10 UTSW 4 45,372,962 (GRCm39) nonsense probably null
R3735:Dcaf10 UTSW 4 45,348,117 (GRCm39) missense probably benign 0.01
R4655:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4665:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4690:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4724:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4725:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4735:Dcaf10 UTSW 4 45,372,769 (GRCm39) missense possibly damaging 0.92
R4743:Dcaf10 UTSW 4 45,370,409 (GRCm39) missense probably damaging 0.98
R5220:Dcaf10 UTSW 4 45,373,909 (GRCm39) missense possibly damaging 0.94
R5254:Dcaf10 UTSW 4 45,370,415 (GRCm39) missense possibly damaging 0.94
R6833:Dcaf10 UTSW 4 45,373,043 (GRCm39) missense probably damaging 1.00
R7132:Dcaf10 UTSW 4 45,342,391 (GRCm39) missense probably benign
R7345:Dcaf10 UTSW 4 45,342,583 (GRCm39) missense probably damaging 0.98
R7366:Dcaf10 UTSW 4 45,373,919 (GRCm39) missense probably damaging 1.00
R7832:Dcaf10 UTSW 4 45,348,196 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGTCATGTTTCCCTTCGGGC -3'
(R):5'- TGGGGTGTAGGAGCTTACCC -3'

Sequencing Primer
(F):5'- AGCTTCCAGACCGCCCTC -3'
(R):5'- TTACCCGTCCGGAGAGTACTC -3'
Posted On 2017-02-10