Incidental Mutation 'R0555:Hecw1'
| ID |
45505 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hecw1
|
| Ensembl Gene |
ENSMUSG00000021301 |
| Gene Name |
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 |
| Synonyms |
NEDL1, E130207I19Rik |
| MMRRC Submission |
038747-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0555 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
14401023-14697813 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 14411526 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Asparagine
at position 1058
(T1058N)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000152215
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000110516]
[ENSMUST00000220718]
|
| AlphaFold |
Q8K4P8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110516
AA Change: T1485N
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000106145
Gene: ENSMUSG00000021301
AA Change: T1485N
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HECW_N
|
65 |
184 |
6.5e-62 |
PFAM |
|
C2
|
206 |
317 |
1.02e-12 |
SMART |
|
low complexity region
|
463 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
497 |
512 |
N/A |
INTRINSIC |
|
low complexity region
|
577 |
598 |
N/A |
INTRINSIC |
|
low complexity region
|
677 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
731 |
745 |
N/A |
INTRINSIC |
|
WW
|
827 |
859 |
8.66e-13 |
SMART |
|
coiled coil region
|
873 |
898 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
930 |
N/A |
INTRINSIC |
|
WW
|
1017 |
1049 |
5.59e-7 |
SMART |
|
Blast:HECTc
|
1137 |
1192 |
3e-26 |
BLAST |
|
low complexity region
|
1193 |
1208 |
N/A |
INTRINSIC |
|
low complexity region
|
1212 |
1223 |
N/A |
INTRINSIC |
|
HECTc
|
1267 |
1604 |
1.36e-185 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000220718
AA Change: T1058N
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| Meta Mutation Damage Score |
0.1052 |
| Coding Region Coverage |
- 1x: 99.6%
- 3x: 98.8%
- 10x: 96.9%
- 20x: 93.8%
|
| Validation Efficiency |
100% (98/98) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam10 |
T |
A |
9: 70,661,516 (GRCm39) |
I363N |
probably damaging |
Het |
| Ahcyl2 |
T |
C |
6: 29,890,670 (GRCm39) |
|
probably benign |
Het |
| Asap1 |
A |
G |
15: 63,966,213 (GRCm39) |
L941P |
probably damaging |
Het |
| Aurka |
G |
A |
2: 172,209,067 (GRCm39) |
R23C |
probably benign |
Het |
| Cacna1c |
C |
T |
6: 118,589,586 (GRCm39) |
R1446H |
probably damaging |
Het |
| Casp8ap2 |
T |
A |
4: 32,640,381 (GRCm39) |
H478Q |
probably damaging |
Het |
| Clcn4 |
C |
T |
7: 7,293,503 (GRCm39) |
A418T |
possibly damaging |
Het |
| Cplx3 |
T |
C |
9: 57,521,384 (GRCm39) |
T193A |
probably benign |
Het |
| Cpxm2 |
A |
T |
7: 131,645,772 (GRCm39) |
Y715* |
probably null |
Het |
| Csmd1 |
T |
C |
8: 16,235,287 (GRCm39) |
M1179V |
probably benign |
Het |
| Ddx21 |
A |
T |
10: 62,423,307 (GRCm39) |
F632I |
probably damaging |
Het |
| Dnai1 |
C |
A |
4: 41,625,335 (GRCm39) |
T433K |
possibly damaging |
Het |
| Dpyd |
G |
A |
3: 119,225,191 (GRCm39) |
G988D |
probably damaging |
Het |
| Dync1i2 |
AAAAGAAGAGGAAAGAAGAGGAAAG |
AAAAGAAGAGGAAAG |
2: 71,044,862 (GRCm39) |
|
probably null |
Het |
| Dync1li2 |
A |
T |
8: 105,147,297 (GRCm39) |
S466T |
probably benign |
Het |
| Ears2 |
T |
C |
7: 121,647,667 (GRCm39) |
T206A |
probably benign |
Het |
| Elmod1 |
A |
T |
9: 53,838,876 (GRCm39) |
|
probably benign |
Het |
| Eps8l3 |
C |
A |
3: 107,799,661 (GRCm39) |
D590E |
probably benign |
Het |
| Etfdh |
A |
T |
3: 79,513,112 (GRCm39) |
H370Q |
probably benign |
Het |
| Fam83g |
C |
A |
11: 61,598,489 (GRCm39) |
A792E |
probably benign |
Het |
| Ffar3 |
G |
T |
7: 30,554,962 (GRCm39) |
Y119* |
probably null |
Het |
| Fosb |
G |
T |
7: 19,041,138 (GRCm39) |
S118R |
possibly damaging |
Het |
| Foxn4 |
G |
A |
5: 114,401,175 (GRCm39) |
L3F |
probably damaging |
Het |
| Foxo4 |
A |
G |
X: 100,298,784 (GRCm39) |
K65E |
probably damaging |
Het |
| Frem2 |
A |
G |
3: 53,424,281 (GRCm39) |
L3052P |
probably damaging |
Het |
| Fubp3 |
G |
A |
2: 31,498,149 (GRCm39) |
R101H |
probably damaging |
Het |
| Gba2 |
C |
A |
4: 43,569,927 (GRCm39) |
G429C |
probably damaging |
Het |
| Gimap1 |
T |
C |
6: 48,718,363 (GRCm39) |
|
probably benign |
Het |
| Gnas |
A |
G |
2: 174,140,304 (GRCm39) |
T158A |
possibly damaging |
Het |
| Gpc5 |
T |
C |
14: 115,789,740 (GRCm39) |
V538A |
probably damaging |
Het |
| Greb1l |
T |
C |
18: 10,458,781 (GRCm39) |
|
probably benign |
Het |
| H2-M10.5 |
G |
A |
17: 37,085,620 (GRCm39) |
G260R |
probably damaging |
Het |
| Hbs1l |
A |
C |
10: 21,225,222 (GRCm39) |
Q412H |
probably benign |
Het |
| Heph |
A |
T |
X: 95,601,690 (GRCm39) |
T1027S |
probably damaging |
Het |
| Hoga1 |
A |
C |
19: 42,034,514 (GRCm39) |
E53A |
possibly damaging |
Het |
| Insrr |
T |
G |
3: 87,721,744 (GRCm39) |
|
probably benign |
Het |
| Ipo11 |
A |
T |
13: 107,028,969 (GRCm39) |
V328D |
probably damaging |
Het |
| Jakmip1 |
T |
C |
5: 37,276,217 (GRCm39) |
V509A |
probably damaging |
Het |
| Jmjd1c |
T |
C |
10: 67,061,568 (GRCm39) |
V1307A |
probably benign |
Het |
| Kmt2a |
T |
A |
9: 44,758,868 (GRCm39) |
S1027C |
probably damaging |
Het |
| Kprp |
G |
C |
3: 92,731,664 (GRCm39) |
P462R |
unknown |
Het |
| Lrit3 |
A |
T |
3: 129,584,945 (GRCm39) |
V271D |
probably damaging |
Het |
| Map4 |
T |
A |
9: 109,808,171 (GRCm39) |
|
probably benign |
Het |
| Mark4 |
A |
C |
7: 19,182,598 (GRCm39) |
|
probably benign |
Het |
| Mfsd14b |
A |
G |
13: 65,226,259 (GRCm39) |
V142A |
probably benign |
Het |
| Mis18bp1 |
A |
T |
12: 65,208,227 (GRCm39) |
I162N |
possibly damaging |
Het |
| Mrpl43 |
A |
T |
19: 44,994,391 (GRCm39) |
|
probably benign |
Het |
| Mrpl47 |
A |
G |
3: 32,790,842 (GRCm39) |
F16S |
probably benign |
Het |
| Myh2 |
G |
T |
11: 67,069,793 (GRCm39) |
G380C |
probably damaging |
Het |
| Myo15a |
T |
C |
11: 60,412,464 (GRCm39) |
Y3284H |
probably damaging |
Het |
| Nectin2 |
A |
G |
7: 19,467,148 (GRCm39) |
|
probably benign |
Het |
| Neu3 |
A |
G |
7: 99,463,390 (GRCm39) |
V111A |
probably damaging |
Het |
| Nol4l |
T |
C |
2: 153,259,604 (GRCm39) |
|
probably null |
Het |
| Nphp3 |
C |
A |
9: 103,900,633 (GRCm39) |
H510Q |
probably damaging |
Het |
| Nprl3 |
T |
A |
11: 32,183,118 (GRCm39) |
|
probably null |
Het |
| Or14c39 |
A |
G |
7: 86,344,516 (GRCm39) |
N284S |
probably damaging |
Het |
| Or4c58 |
T |
C |
2: 89,674,787 (GRCm39) |
T177A |
probably benign |
Het |
| Or52ab7 |
T |
C |
7: 102,978,170 (GRCm39) |
V159A |
probably benign |
Het |
| Or6c2 |
T |
C |
10: 129,362,765 (GRCm39) |
I223T |
possibly damaging |
Het |
| Pex1 |
A |
G |
5: 3,656,130 (GRCm39) |
E319G |
possibly damaging |
Het |
| Pgap6 |
T |
C |
17: 26,336,088 (GRCm39) |
L130S |
probably benign |
Het |
| Phtf1 |
C |
A |
3: 103,911,785 (GRCm39) |
T709K |
probably damaging |
Het |
| Plek2 |
A |
T |
12: 78,938,946 (GRCm39) |
L271Q |
probably damaging |
Het |
| Plekhg5 |
T |
A |
4: 152,191,926 (GRCm39) |
C421* |
probably null |
Het |
| Polk |
A |
C |
13: 96,620,687 (GRCm39) |
C525W |
probably damaging |
Het |
| Ppfibp2 |
T |
C |
7: 107,328,381 (GRCm39) |
S471P |
probably damaging |
Het |
| Prickle2 |
A |
T |
6: 92,435,546 (GRCm39) |
F74L |
probably benign |
Het |
| Prl7d1 |
A |
T |
13: 27,896,038 (GRCm39) |
V113D |
probably benign |
Het |
| Prr14 |
C |
T |
7: 127,071,267 (GRCm39) |
|
probably benign |
Het |
| Ptpro |
T |
A |
6: 137,420,592 (GRCm39) |
V1007D |
probably damaging |
Het |
| Ret |
A |
G |
6: 118,155,571 (GRCm39) |
V375A |
probably damaging |
Het |
| Rora |
T |
C |
9: 69,269,028 (GRCm39) |
F41S |
probably damaging |
Het |
| Sall1 |
T |
C |
8: 89,758,386 (GRCm39) |
T573A |
probably benign |
Het |
| Shb |
A |
G |
4: 45,458,321 (GRCm39) |
V281A |
possibly damaging |
Het |
| Slc25a26 |
A |
T |
6: 94,569,391 (GRCm39) |
|
probably null |
Het |
| Sltm |
T |
C |
9: 70,493,363 (GRCm39) |
F769L |
probably damaging |
Het |
| Snx9 |
T |
A |
17: 5,968,688 (GRCm39) |
M328K |
probably damaging |
Het |
| Stk25 |
G |
T |
1: 93,552,313 (GRCm39) |
Q356K |
probably benign |
Het |
| Svep1 |
T |
A |
4: 58,128,858 (GRCm39) |
Y613F |
possibly damaging |
Het |
| Syne4 |
G |
A |
7: 30,016,169 (GRCm39) |
A195T |
probably damaging |
Het |
| Tmem217b |
A |
T |
17: 29,738,545 (GRCm39) |
F74I |
probably benign |
Het |
| Trcg1 |
C |
T |
9: 57,149,616 (GRCm39) |
T396M |
probably damaging |
Het |
| Trim30b |
A |
G |
7: 104,006,505 (GRCm39) |
V117A |
possibly damaging |
Het |
| Trpc4 |
T |
C |
3: 54,209,511 (GRCm39) |
|
probably benign |
Het |
| Ttll4 |
A |
G |
1: 74,727,439 (GRCm39) |
H827R |
probably damaging |
Het |
| Tut7 |
A |
G |
13: 59,948,131 (GRCm39) |
V328A |
probably benign |
Het |
| Urgcp |
T |
C |
11: 5,667,477 (GRCm39) |
E287G |
probably damaging |
Het |
| Usp2 |
G |
T |
9: 44,004,081 (GRCm39) |
L319F |
probably damaging |
Het |
| Vmn1r167 |
A |
T |
7: 23,204,512 (GRCm39) |
V168D |
probably damaging |
Het |
| Vmn2r100 |
C |
A |
17: 19,742,382 (GRCm39) |
P252Q |
possibly damaging |
Het |
| Vmn2r61 |
A |
T |
7: 41,915,442 (GRCm39) |
I130F |
probably benign |
Het |
| Vmn2r63 |
A |
T |
7: 42,577,952 (GRCm39) |
Y195* |
probably null |
Het |
| Vmn2r81 |
T |
C |
10: 79,129,283 (GRCm39) |
S725P |
probably damaging |
Het |
| Wnt10b |
A |
G |
15: 98,670,818 (GRCm39) |
|
probably benign |
Het |
| Zfp292 |
T |
C |
4: 34,807,194 (GRCm39) |
E1950G |
probably damaging |
Het |
| Zfyve16 |
A |
G |
13: 92,653,028 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Hecw1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00591:Hecw1
|
APN |
13 |
14,440,565 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL00813:Hecw1
|
APN |
13 |
14,452,961 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL00843:Hecw1
|
APN |
13 |
14,422,158 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00942:Hecw1
|
APN |
13 |
14,515,325 (GRCm39) |
splice site |
probably benign |
|
|
IGL00976:Hecw1
|
APN |
13 |
14,493,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01289:Hecw1
|
APN |
13 |
14,438,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Hecw1
|
APN |
13 |
14,409,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01783:Hecw1
|
APN |
13 |
14,452,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01941:Hecw1
|
APN |
13 |
14,490,895 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02170:Hecw1
|
APN |
13 |
14,438,743 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02172:Hecw1
|
APN |
13 |
14,438,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02214:Hecw1
|
APN |
13 |
14,474,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Hecw1
|
APN |
13 |
14,422,923 (GRCm39) |
splice site |
probably null |
|
|
IGL02357:Hecw1
|
APN |
13 |
14,422,923 (GRCm39) |
splice site |
probably null |
|
|
IGL02372:Hecw1
|
APN |
13 |
14,438,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02591:Hecw1
|
APN |
13 |
14,531,821 (GRCm39) |
splice site |
probably benign |
|
|
IGL02718:Hecw1
|
APN |
13 |
14,481,520 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02795:Hecw1
|
APN |
13 |
14,497,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02941:Hecw1
|
APN |
13 |
14,552,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03256:Hecw1
|
APN |
13 |
14,455,070 (GRCm39) |
missense |
probably benign |
0.36 |
|
IGL03256:Hecw1
|
APN |
13 |
14,455,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03366:Hecw1
|
APN |
13 |
14,552,382 (GRCm39) |
missense |
probably damaging |
1.00 |
|
deflated
|
UTSW |
13 |
14,422,205 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Demoralized
|
UTSW |
13 |
14,491,403 (GRCm39) |
nonsense |
probably null |
|
|
Letdown
|
UTSW |
13 |
14,491,077 (GRCm39) |
missense |
probably benign |
0.40 |
|
BB001:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Hecw1
|
UTSW |
13 |
14,420,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Hecw1
|
UTSW |
13 |
14,552,368 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0617:Hecw1
|
UTSW |
13 |
14,455,027 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1476:Hecw1
|
UTSW |
13 |
14,480,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1479:Hecw1
|
UTSW |
13 |
14,491,077 (GRCm39) |
missense |
probably benign |
0.40 |
|
R1551:Hecw1
|
UTSW |
13 |
14,491,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1579:Hecw1
|
UTSW |
13 |
14,552,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Hecw1
|
UTSW |
13 |
14,515,328 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1735:Hecw1
|
UTSW |
13 |
14,552,350 (GRCm39) |
missense |
probably null |
0.09 |
|
R1872:Hecw1
|
UTSW |
13 |
14,455,034 (GRCm39) |
nonsense |
probably null |
|
|
R1897:Hecw1
|
UTSW |
13 |
14,552,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Hecw1
|
UTSW |
13 |
14,471,998 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2085:Hecw1
|
UTSW |
13 |
14,438,672 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2134:Hecw1
|
UTSW |
13 |
14,552,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2172:Hecw1
|
UTSW |
13 |
14,552,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2258:Hecw1
|
UTSW |
13 |
14,490,723 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2274:Hecw1
|
UTSW |
13 |
14,520,653 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2275:Hecw1
|
UTSW |
13 |
14,520,653 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2937:Hecw1
|
UTSW |
13 |
14,420,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3830:Hecw1
|
UTSW |
13 |
14,520,643 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3971:Hecw1
|
UTSW |
13 |
14,411,514 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Hecw1
|
UTSW |
13 |
14,491,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4066:Hecw1
|
UTSW |
13 |
14,491,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Hecw1
|
UTSW |
13 |
14,491,724 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4366:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4382:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4385:Hecw1
|
UTSW |
13 |
14,490,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4510:Hecw1
|
UTSW |
13 |
14,531,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4511:Hecw1
|
UTSW |
13 |
14,531,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4558:Hecw1
|
UTSW |
13 |
14,422,190 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4804:Hecw1
|
UTSW |
13 |
14,480,570 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4854:Hecw1
|
UTSW |
13 |
14,491,477 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5104:Hecw1
|
UTSW |
13 |
14,515,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5113:Hecw1
|
UTSW |
13 |
14,520,614 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5167:Hecw1
|
UTSW |
13 |
14,460,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5392:Hecw1
|
UTSW |
13 |
14,420,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Hecw1
|
UTSW |
13 |
14,497,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5504:Hecw1
|
UTSW |
13 |
14,515,487 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5764:Hecw1
|
UTSW |
13 |
14,497,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6038:Hecw1
|
UTSW |
13 |
14,520,647 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6038:Hecw1
|
UTSW |
13 |
14,520,647 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6228:Hecw1
|
UTSW |
13 |
14,520,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6247:Hecw1
|
UTSW |
13 |
14,409,010 (GRCm39) |
nonsense |
probably null |
|
|
R6252:Hecw1
|
UTSW |
13 |
14,446,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6291:Hecw1
|
UTSW |
13 |
14,697,592 (GRCm39) |
unclassified |
probably benign |
|
|
R6321:Hecw1
|
UTSW |
13 |
14,697,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6325:Hecw1
|
UTSW |
13 |
14,491,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6328:Hecw1
|
UTSW |
13 |
14,422,205 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6557:Hecw1
|
UTSW |
13 |
14,491,231 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6566:Hecw1
|
UTSW |
13 |
14,471,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Hecw1
|
UTSW |
13 |
14,491,403 (GRCm39) |
nonsense |
probably null |
|
|
R6821:Hecw1
|
UTSW |
13 |
14,438,719 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6914:Hecw1
|
UTSW |
13 |
14,491,423 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7078:Hecw1
|
UTSW |
13 |
14,609,044 (GRCm39) |
start codon destroyed |
probably null |
0.21 |
|
R7114:Hecw1
|
UTSW |
13 |
14,486,356 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7140:Hecw1
|
UTSW |
13 |
14,491,118 (GRCm39) |
missense |
probably benign |
|
|
R7150:Hecw1
|
UTSW |
13 |
14,609,045 (GRCm39) |
start codon destroyed |
probably benign |
|
|
R7288:Hecw1
|
UTSW |
13 |
14,490,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7447:Hecw1
|
UTSW |
13 |
14,531,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7479:Hecw1
|
UTSW |
13 |
14,515,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7552:Hecw1
|
UTSW |
13 |
14,490,835 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7590:Hecw1
|
UTSW |
13 |
14,438,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Hecw1
|
UTSW |
13 |
14,493,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7803:Hecw1
|
UTSW |
13 |
14,408,927 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7924:Hecw1
|
UTSW |
13 |
14,497,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7967:Hecw1
|
UTSW |
13 |
14,552,332 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8176:Hecw1
|
UTSW |
13 |
14,422,286 (GRCm39) |
splice site |
probably null |
|
|
R8195:Hecw1
|
UTSW |
13 |
14,480,692 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8252:Hecw1
|
UTSW |
13 |
14,515,425 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8696:Hecw1
|
UTSW |
13 |
14,531,743 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8827:Hecw1
|
UTSW |
13 |
14,438,720 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8867:Hecw1
|
UTSW |
13 |
14,422,275 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8914:Hecw1
|
UTSW |
13 |
14,422,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8942:Hecw1
|
UTSW |
13 |
14,481,395 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9126:Hecw1
|
UTSW |
13 |
14,546,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9185:Hecw1
|
UTSW |
13 |
14,491,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9203:Hecw1
|
UTSW |
13 |
14,491,243 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9236:Hecw1
|
UTSW |
13 |
14,490,643 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9291:Hecw1
|
UTSW |
13 |
14,491,522 (GRCm39) |
missense |
probably benign |
|
|
R9312:Hecw1
|
UTSW |
13 |
14,546,567 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9438:Hecw1
|
UTSW |
13 |
14,481,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9502:Hecw1
|
UTSW |
13 |
14,546,567 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9642:Hecw1
|
UTSW |
13 |
14,515,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF001:Hecw1
|
UTSW |
13 |
14,472,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0020:Hecw1
|
UTSW |
13 |
14,405,308 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
X0066:Hecw1
|
UTSW |
13 |
14,455,045 (GRCm39) |
missense |
probably benign |
0.13 |
|
Z1176:Hecw1
|
UTSW |
13 |
14,474,918 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCAAGGATTACTGTTGCCTGAAAAGA -3'
(R):5'- GCTGGGGATAAAGATTATAACATGCAAGTAGA -3'
Sequencing Primer
(F):5'- tcaaagaaggcagacacgag -3'
(R):5'- ATGTATTCAGACCGCTGCTATG -3'
|
| Posted On |
2013-06-11 |
Incidental Mutation