Incidental Mutation 'R5859:Cep162'
ID 455070
Institutional Source Beutler Lab
Gene Symbol Cep162
Ensembl Gene ENSMUSG00000056919
Gene Name centrosomal protein 162
Synonyms 4922501C03Rik
MMRRC Submission 044071-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R5859 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 87071630-87137589 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 87086145 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 1060 (A1060T)
Ref Sequence ENSEMBL: ENSMUSP00000091319 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000093802]
AlphaFold Q6ZQ06
Predicted Effect probably damaging
Transcript: ENSMUST00000093802
AA Change: A1060T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000091319
Gene: ENSMUSG00000056919
AA Change: A1060T

DomainStartEndE-ValueType
low complexity region 198 208 N/A INTRINSIC
low complexity region 528 539 N/A INTRINSIC
coiled coil region 630 674 N/A INTRINSIC
coiled coil region 695 899 N/A INTRINSIC
coiled coil region 953 1124 N/A INTRINSIC
coiled coil region 1235 1386 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139301
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157106
Meta Mutation Damage Score 0.0775 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.4%
  • 20x: 91.9%
Validation Efficiency 93% (70/75)
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam5 A T 8: 25,303,477 (GRCm39) V150E probably benign Het
Alg11 A G 8: 22,555,857 (GRCm39) K373E probably benign Het
Arl14ep C T 2: 106,799,398 (GRCm39) probably benign Het
Ascc2 G A 11: 4,608,284 (GRCm39) G227R probably benign Het
Ash1l C T 3: 88,976,300 (GRCm39) P2627S probably damaging Het
Btla T G 16: 45,059,402 (GRCm39) probably null Het
Btnl10 C T 11: 58,813,138 (GRCm39) P256S probably benign Het
Cfap54 T A 10: 92,852,386 (GRCm39) K907* probably null Het
Chpf A T 1: 75,452,072 (GRCm39) F461I probably damaging Het
Chrdl2 A G 7: 99,670,114 (GRCm39) Y79C probably damaging Het
Copb2 G A 9: 98,450,161 (GRCm39) C40Y probably benign Het
Cyfip1 T C 7: 55,574,929 (GRCm39) L1060P probably damaging Het
Drg1 G A 11: 3,209,273 (GRCm39) probably benign Het
Erich3 A G 3: 154,468,134 (GRCm39) D862G possibly damaging Het
Flii G T 11: 60,607,137 (GRCm39) Y946* probably null Het
Glt8d2 T C 10: 82,507,915 (GRCm39) M1V probably null Het
Gm21136 T A 7: 38,567,165 (GRCm39) noncoding transcript Het
Gramd1c T C 16: 43,812,454 (GRCm39) T393A possibly damaging Het
Gucy2d T A 7: 98,101,090 (GRCm39) I471N probably benign Het
Hps3 G A 3: 20,063,034 (GRCm39) T711M probably benign Het
Hs3st4 A T 7: 123,582,831 (GRCm39) D143V probably benign Het
Kif17 T A 4: 138,018,744 (GRCm39) M461K possibly damaging Het
Klhdc7a T A 4: 139,694,885 (GRCm39) S21C probably damaging Het
Klk15 G A 7: 43,587,800 (GRCm39) R76H probably benign Het
Lnpk G A 2: 74,399,372 (GRCm39) T57I possibly damaging Het
Ltbp2 A G 12: 84,840,837 (GRCm39) V999A possibly damaging Het
Ltbr T C 6: 125,289,771 (GRCm39) H141R probably damaging Het
Lvrn T C 18: 47,026,816 (GRCm39) F805L probably damaging Het
Ms4a13 A T 19: 11,161,280 (GRCm39) C86* probably null Het
Ncbp1 A G 4: 46,163,026 (GRCm39) N480S probably benign Het
Nelfcd T G 2: 174,268,856 (GRCm39) *592G probably null Het
Neurog2 T C 3: 127,427,664 (GRCm39) V96A probably benign Het
Nod1 A T 6: 54,907,162 (GRCm39) W902R probably benign Het
Or12d13 T C 17: 37,647,260 (GRCm39) I288V possibly damaging Het
Or4k15c T A 14: 50,321,484 (GRCm39) Y218F probably damaging Het
Or55b3 T C 7: 102,126,957 (GRCm39) Y40C possibly damaging Het
Or6d13 T C 6: 116,517,861 (GRCm39) L149P probably damaging Het
Pcdha11 A T 18: 37,140,336 (GRCm39) H655L probably damaging Het
Plpp7 A G 2: 31,985,996 (GRCm39) E58G probably benign Het
Psph A T 5: 129,867,685 (GRCm39) probably benign Het
Rab11fip1 A C 8: 27,644,748 (GRCm39) S346A probably damaging Het
Rreb1 C A 13: 38,131,384 (GRCm39) P1513T probably benign Het
Rreb1 C T 13: 38,131,385 (GRCm39) P1513L probably benign Het
Rsf1 C T 7: 97,334,766 (GRCm39) R1300C probably damaging Het
Scap A G 9: 110,203,115 (GRCm39) N263S probably benign Het
Sec24d A T 3: 123,072,961 (GRCm39) probably benign Het
Slain2 T C 5: 73,105,888 (GRCm39) probably benign Het
Slc6a18 G T 13: 73,816,278 (GRCm39) T367N probably benign Het
Slk T A 19: 47,597,481 (GRCm39) D96E probably benign Het
Spag5 G A 11: 78,204,360 (GRCm39) V514I probably benign Het
St8sia2 T C 7: 73,616,654 (GRCm39) D107G probably damaging Het
Tgfbr3 T A 5: 107,288,381 (GRCm39) I427F probably benign Het
Tlr2 T G 3: 83,743,810 (GRCm39) T758P possibly damaging Het
Tmem270 A G 5: 134,931,738 (GRCm39) V68A probably benign Het
Vmn2r106 T A 17: 20,505,583 (GRCm39) H37L possibly damaging Het
Vmn2r27 T G 6: 124,177,647 (GRCm39) R452S probably damaging Het
Wdr5 A G 2: 27,423,362 (GRCm39) Y252C probably damaging Het
Zswim9 C T 7: 12,995,371 (GRCm39) V262M probably damaging Het
Other mutations in Cep162
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Cep162 APN 9 87,109,220 (GRCm39) missense probably benign 0.24
IGL00584:Cep162 APN 9 87,103,143 (GRCm39) splice site probably benign
IGL01387:Cep162 APN 9 87,093,864 (GRCm39) missense probably benign 0.08
IGL01862:Cep162 APN 9 87,135,986 (GRCm39) missense possibly damaging 0.90
IGL02304:Cep162 APN 9 87,109,200 (GRCm39) splice site probably benign
IGL02558:Cep162 APN 9 87,107,779 (GRCm39) missense probably benign
IGL02558:Cep162 APN 9 87,107,786 (GRCm39) missense probably benign 0.04
IGL02602:Cep162 APN 9 87,128,206 (GRCm39) missense probably benign 0.19
IGL02636:Cep162 APN 9 87,130,432 (GRCm39) missense possibly damaging 0.90
IGL02680:Cep162 APN 9 87,128,797 (GRCm39) missense possibly damaging 0.64
IGL03195:Cep162 APN 9 87,107,839 (GRCm39) missense probably benign 0.00
circus UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
moscow UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
smiley UTSW 9 87,099,134 (GRCm39) nonsense probably null
PIT4378001:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
PIT4431001:Cep162 UTSW 9 87,126,398 (GRCm39) missense probably benign 0.00
PIT4434001:Cep162 UTSW 9 87,075,701 (GRCm39) missense probably damaging 1.00
R0060:Cep162 UTSW 9 87,119,878 (GRCm39) splice site probably benign
R0218:Cep162 UTSW 9 87,093,862 (GRCm39) missense possibly damaging 0.73
R0366:Cep162 UTSW 9 87,102,537 (GRCm39) missense probably damaging 0.96
R0468:Cep162 UTSW 9 87,075,750 (GRCm39) missense probably damaging 1.00
R0764:Cep162 UTSW 9 87,083,798 (GRCm39) missense probably damaging 1.00
R1386:Cep162 UTSW 9 87,103,255 (GRCm39) missense probably benign
R1614:Cep162 UTSW 9 87,094,985 (GRCm39) missense probably damaging 1.00
R1633:Cep162 UTSW 9 87,085,736 (GRCm39) missense probably benign 0.23
R1831:Cep162 UTSW 9 87,088,985 (GRCm39) missense probably damaging 1.00
R1847:Cep162 UTSW 9 87,086,133 (GRCm39) missense probably benign 0.06
R1941:Cep162 UTSW 9 87,082,048 (GRCm39) missense probably benign 0.14
R2228:Cep162 UTSW 9 87,126,384 (GRCm39) missense probably benign 0.05
R2256:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2257:Cep162 UTSW 9 87,088,967 (GRCm39) missense probably damaging 1.00
R2936:Cep162 UTSW 9 87,109,467 (GRCm39) missense probably benign
R3005:Cep162 UTSW 9 87,114,113 (GRCm39) missense probably benign 0.00
R3508:Cep162 UTSW 9 87,114,030 (GRCm39) critical splice donor site probably null
R3689:Cep162 UTSW 9 87,107,747 (GRCm39) nonsense probably null
R3743:Cep162 UTSW 9 87,099,230 (GRCm39) splice site probably benign
R4118:Cep162 UTSW 9 87,086,229 (GRCm39) missense probably benign 0.30
R4380:Cep162 UTSW 9 87,082,056 (GRCm39) missense probably damaging 0.99
R4450:Cep162 UTSW 9 87,107,861 (GRCm39) missense probably damaging 1.00
R4540:Cep162 UTSW 9 87,094,992 (GRCm39) missense probably damaging 1.00
R4598:Cep162 UTSW 9 87,085,848 (GRCm39) missense possibly damaging 0.95
R4700:Cep162 UTSW 9 87,088,915 (GRCm39) missense probably damaging 1.00
R4941:Cep162 UTSW 9 87,108,022 (GRCm39) intron probably benign
R5356:Cep162 UTSW 9 87,088,948 (GRCm39) missense probably damaging 1.00
R5468:Cep162 UTSW 9 87,109,290 (GRCm39) missense probably benign 0.00
R5579:Cep162 UTSW 9 87,085,724 (GRCm39) missense probably benign 0.26
R6114:Cep162 UTSW 9 87,085,763 (GRCm39) missense probably benign
R6143:Cep162 UTSW 9 87,094,904 (GRCm39) critical splice donor site probably null
R6422:Cep162 UTSW 9 87,114,069 (GRCm39) missense possibly damaging 0.92
R6517:Cep162 UTSW 9 87,104,227 (GRCm39) missense probably damaging 0.99
R6576:Cep162 UTSW 9 87,099,198 (GRCm39) missense probably benign 0.01
R6782:Cep162 UTSW 9 87,093,737 (GRCm39) missense probably benign 0.07
R6867:Cep162 UTSW 9 87,099,134 (GRCm39) nonsense probably null
R7293:Cep162 UTSW 9 87,085,836 (GRCm39) missense probably benign 0.01
R7355:Cep162 UTSW 9 87,136,008 (GRCm39) nonsense probably null
R7391:Cep162 UTSW 9 87,130,547 (GRCm39) nonsense probably null
R7426:Cep162 UTSW 9 87,074,819 (GRCm39) missense probably damaging 1.00
R7593:Cep162 UTSW 9 87,086,250 (GRCm39) missense probably benign 0.40
R7710:Cep162 UTSW 9 87,114,172 (GRCm39) missense probably damaging 1.00
R7841:Cep162 UTSW 9 87,126,369 (GRCm39) missense probably benign 0.00
R7949:Cep162 UTSW 9 87,088,901 (GRCm39) missense probably benign 0.04
R8351:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8451:Cep162 UTSW 9 87,074,903 (GRCm39) nonsense probably null
R8552:Cep162 UTSW 9 87,126,361 (GRCm39) missense probably benign 0.34
R8755:Cep162 UTSW 9 87,114,064 (GRCm39) missense probably benign 0.02
R8762:Cep162 UTSW 9 87,109,314 (GRCm39) missense probably benign 0.00
R9640:Cep162 UTSW 9 87,126,352 (GRCm39) missense probably benign 0.06
X0063:Cep162 UTSW 9 87,104,095 (GRCm39) critical splice donor site probably null
Z1177:Cep162 UTSW 9 87,082,033 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TCTGCCTCGACAGCATCATC -3'
(R):5'- TTTCCTCAGATTCAGTACGAACAG -3'

Sequencing Primer
(F):5'- TCGACAGCATCATCCTTCTC -3'
(R):5'- TTCAGTACGAACAGCGGCTAG -3'
Posted On 2017-02-10