Incidental Mutation 'R5870:Mobp'
ID 455136
Institutional Source Beutler Lab
Gene Symbol Mobp
Ensembl Gene ENSMUSG00000032517
Gene Name myelin-associated oligodendrocytic basic protein
Synonyms MOBP155
MMRRC Submission 044078-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R5870 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 119978773-120010550 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 119996919 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 17 (K17E)
Ref Sequence ENSEMBL: ENSMUSP00000149831 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068698] [ENSMUST00000093773] [ENSMUST00000111627] [ENSMUST00000174193] [ENSMUST00000214943] [ENSMUST00000215512]
AlphaFold Q9D2P8
Predicted Effect probably damaging
Transcript: ENSMUST00000068698
AA Change: K17E

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000071084
Gene: ENSMUSG00000032517
AA Change: K17E

DomainStartEndE-ValueType
Pfam:FYVE_2 1 75 6.4e-13 PFAM
low complexity region 82 99 N/A INTRINSIC
low complexity region 102 151 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000093773
AA Change: K17E

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000091287
Gene: ENSMUSG00000032517
AA Change: K17E

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111627
AA Change: K17E

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000107254
Gene: ENSMUSG00000032517
AA Change: K17E

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000174193
AA Change: K17E

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000134410
Gene: ENSMUSG00000032517
AA Change: K17E

DomainStartEndE-ValueType
Pfam:FYVE_2 1 77 3.8e-14 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214943
AA Change: K17E

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000215512
AA Change: K17E

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.1131 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.4%
  • 10x: 97.2%
  • 20x: 91.1%
Validation Efficiency 93% (84/90)
MGI Phenotype PHENOTYPE: Mice homozygous for one null allele show abnormal myelin arrangements but do not exhibit an overt behavorial phenotype. Mice homozygous for another allele have normal myelin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy9 A G 16: 4,236,232 (GRCm39) V156A probably damaging Het
Ak6 C A 13: 100,791,932 (GRCm39) P125Q probably damaging Het
Aqp4 A C 18: 15,532,946 (GRCm39) V49G probably damaging Het
Arfgef1 A G 1: 10,251,163 (GRCm39) I874T probably damaging Het
Arid1a T C 4: 133,408,387 (GRCm39) D2040G unknown Het
Atp1a3 T G 7: 24,697,003 (GRCm39) D220A probably benign Het
C2cd4c A T 10: 79,448,043 (GRCm39) I368N possibly damaging Het
Ccnt1 G A 15: 98,441,394 (GRCm39) Q625* probably null Het
Cd177 T A 7: 24,455,757 (GRCm39) H255L probably benign Het
Cdipt G A 7: 126,578,094 (GRCm39) V114M probably benign Het
Coro1b T A 19: 4,199,384 (GRCm39) H14Q probably damaging Het
Ctdp1 T A 18: 80,451,901 (GRCm39) D158V unknown Het
Cts7 A T 13: 61,503,545 (GRCm39) S140T probably damaging Het
Dlgap3 T A 4: 127,089,502 (GRCm39) L366* probably null Het
Dnah9 C T 11: 65,976,036 (GRCm39) A1338T probably benign Het
Dock7 T C 4: 98,952,199 (GRCm39) I424V probably benign Het
Dock8 G T 19: 25,109,490 (GRCm39) A891S probably benign Het
Dync2i1 A G 12: 116,219,865 (GRCm39) S26P possibly damaging Het
Elmod3 A G 6: 72,571,721 (GRCm39) probably null Het
Eps15 G A 4: 109,218,507 (GRCm39) E107K probably damaging Het
Esco1 A T 18: 10,593,744 (GRCm39) probably null Het
Fuz A G 7: 44,549,742 (GRCm39) T407A probably damaging Het
Galr1 A T 18: 82,424,197 (GRCm39) F27I probably benign Het
Glt1d1 A G 5: 127,754,344 (GRCm39) Y182C probably damaging Het
Gm37240 A T 3: 84,597,828 (GRCm39) probably benign Het
Gm37610 A G 6: 41,061,848 (GRCm39) noncoding transcript Het
Gm6658 G T 8: 91,635,020 (GRCm39) probably benign Het
Gm9376 A G 14: 118,504,789 (GRCm39) T74A possibly damaging Het
Hadha G A 5: 30,349,284 (GRCm39) S109F possibly damaging Het
Herc3 A T 6: 58,893,435 (GRCm39) Q899L probably benign Het
Ift172 C T 5: 31,434,284 (GRCm39) E485K probably benign Het
Lrrc8e A G 8: 4,285,725 (GRCm39) K650R possibly damaging Het
Ly6d A T 15: 74,635,381 (GRCm39) V10D possibly damaging Het
Med27 A G 2: 29,279,823 (GRCm39) probably null Het
Med29 A T 7: 28,091,922 (GRCm39) V56E probably damaging Het
Mrpl37 G A 4: 106,923,919 (GRCm39) T25I probably benign Het
Myh1 A G 11: 67,092,805 (GRCm39) D33G possibly damaging Het
Nrg3 T A 14: 39,194,586 (GRCm39) I58F possibly damaging Het
Or52e2 A G 7: 102,804,948 (GRCm39) I2T probably benign Het
Or7e176 A G 9: 20,171,874 (GRCm39) D246G probably benign Het
Padi1 T A 4: 140,553,892 (GRCm39) D359V probably benign Het
Pcdh7 T C 5: 57,877,753 (GRCm39) V436A possibly damaging Het
Pgm3 C A 9: 86,452,414 (GRCm39) K15N probably damaging Het
Phip A T 9: 82,790,730 (GRCm39) probably benign Het
Pot1a G A 6: 25,778,950 (GRCm39) T48I possibly damaging Het
Ppic T C 18: 53,542,333 (GRCm39) K125R probably benign Het
Ppm1j T C 3: 104,692,811 (GRCm39) V440A possibly damaging Het
Prg4 T A 1: 150,331,300 (GRCm39) K458* probably null Het
Rd3 A T 1: 191,717,261 (GRCm39) M244L probably benign Het
Rflnb A G 11: 75,912,864 (GRCm39) Y175H probably benign Het
Rnf157 T A 11: 116,237,900 (GRCm39) S574C probably benign Het
Sardh A G 2: 27,110,653 (GRCm39) probably null Het
Senp3 C T 11: 69,569,048 (GRCm39) probably null Het
Siglec1 G A 2: 130,914,767 (GRCm39) R1450C probably damaging Het
Sim2 A G 16: 93,924,193 (GRCm39) H446R probably damaging Het
Spon1 T C 7: 113,631,021 (GRCm39) I444T probably damaging Het
Srebf1 T A 11: 60,094,410 (GRCm39) Q568H possibly damaging Het
Stxbp4 A T 11: 90,428,782 (GRCm39) I441N possibly damaging Het
Sugt1 G A 14: 79,846,451 (GRCm39) V163I probably benign Het
Surf1 G T 2: 26,806,271 (GRCm39) probably benign Het
Synj2 A G 17: 6,088,128 (GRCm39) E1348G probably benign Het
Tc2n A T 12: 101,619,111 (GRCm39) V349D probably damaging Het
Ten1 A G 11: 116,105,751 (GRCm39) R112G possibly damaging Het
Tm9sf4 A G 2: 153,036,201 (GRCm39) D321G probably damaging Het
Ttll12 A T 15: 83,461,237 (GRCm39) M594K probably damaging Het
Ttn T A 2: 76,703,058 (GRCm39) probably benign Het
Usp28 C T 9: 48,937,285 (GRCm39) Q185* probably null Het
Vmn2r112 A G 17: 22,838,004 (GRCm39) I822V probably benign Het
Zc3hc1 A T 6: 30,382,682 (GRCm39) L88* probably null Het
Zfr T A 15: 12,160,701 (GRCm39) V758D probably damaging Het
Zfyve27 T G 19: 42,160,110 (GRCm39) L42R probably benign Het
Other mutations in Mobp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01155:Mobp APN 9 119,997,300 (GRCm39) missense probably benign 0.08
IGL01730:Mobp APN 9 119,996,992 (GRCm39) missense probably damaging 1.00
IGL02078:Mobp APN 9 119,996,980 (GRCm39) missense probably damaging 1.00
IGL02470:Mobp APN 9 119,997,072 (GRCm39) missense probably benign 0.18
P0041:Mobp UTSW 9 119,997,083 (GRCm39) utr 3 prime probably benign
R3794:Mobp UTSW 9 119,997,033 (GRCm39) nonsense probably null
R3890:Mobp UTSW 9 119,997,022 (GRCm39) missense probably damaging 1.00
R5173:Mobp UTSW 9 119,997,311 (GRCm39) missense possibly damaging 0.68
R5255:Mobp UTSW 9 119,997,419 (GRCm39) unclassified probably benign
R5549:Mobp UTSW 9 119,996,876 (GRCm39) missense probably damaging 1.00
R6128:Mobp UTSW 9 119,997,392 (GRCm39) unclassified probably benign
R7267:Mobp UTSW 9 119,996,914 (GRCm39) missense probably damaging 1.00
R9260:Mobp UTSW 9 119,997,572 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCTGCACCTTTGTTCTGCAGAG -3'
(R):5'- TCCTAACAGGGAGCTGACAGTC -3'

Sequencing Primer
(F):5'- AGAGCAGTGTCACCTGTGGAC -3'
(R):5'- AATGTGGTGTAGACCTGGCCC -3'
Posted On 2017-02-10