Incidental Mutation 'R5872:Vmn2r14'
| ID |
455237 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r14
|
| Ensembl Gene |
ENSMUSG00000091059 |
| Gene Name |
vomeronasal 2, receptor 14 |
| Synonyms |
EG231591 |
| MMRRC Submission |
044079-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.469)
|
| Stock # |
R5872 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
109362822-109372488 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 109369222 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 117
(I117T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128015
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170341]
|
| AlphaFold |
E9Q759 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170341
AA Change: I117T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000128015
Gene: ENSMUSG00000091059
AA Change: I117T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
76 |
466 |
8.3e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
561 |
1.1e-17 |
PFAM |
|
Pfam:7tm_3
|
594 |
829 |
1.2e-55 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 97.8%
- 20x: 93.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
A |
G |
14: 32,382,309 (GRCm39) |
S1219P |
possibly damaging |
Het |
| A2ml1 |
A |
G |
6: 128,538,489 (GRCm39) |
Y644H |
probably damaging |
Het |
| Abca9 |
T |
G |
11: 110,007,902 (GRCm39) |
R1232S |
possibly damaging |
Het |
| Acsf2 |
C |
T |
11: 94,463,975 (GRCm39) |
V70M |
probably benign |
Het |
| Ampd1 |
A |
G |
3: 102,986,446 (GRCm39) |
I42V |
probably benign |
Het |
| Arhgap10 |
A |
G |
8: 78,071,267 (GRCm39) |
|
probably null |
Het |
| Atp1a4 |
A |
T |
1: 172,071,975 (GRCm39) |
L432Q |
probably damaging |
Het |
| Bbs12 |
T |
A |
3: 37,374,598 (GRCm39) |
C349S |
possibly damaging |
Het |
| Bnc2 |
A |
G |
4: 84,211,007 (GRCm39) |
V479A |
possibly damaging |
Het |
| Cald1 |
A |
T |
6: 34,748,043 (GRCm39) |
K761* |
probably null |
Het |
| Cd177 |
C |
T |
7: 24,451,688 (GRCm39) |
G443R |
probably null |
Het |
| Cdc42bpb |
T |
C |
12: 111,292,410 (GRCm39) |
D375G |
probably damaging |
Het |
| Chsy3 |
T |
C |
18: 59,309,268 (GRCm39) |
Y174H |
probably damaging |
Het |
| Cmya5 |
T |
C |
13: 93,233,943 (GRCm39) |
M382V |
probably benign |
Het |
| Col1a2 |
G |
A |
6: 4,531,926 (GRCm39) |
S782N |
unknown |
Het |
| Crtac1 |
C |
T |
19: 42,297,629 (GRCm39) |
|
probably null |
Het |
| Csmd3 |
T |
A |
15: 47,445,923 (GRCm39) |
D3683V |
probably damaging |
Het |
| Ctrc |
A |
G |
4: 141,572,354 (GRCm39) |
L62P |
probably damaging |
Het |
| Cyp3a57 |
A |
T |
5: 145,307,867 (GRCm39) |
K208* |
probably null |
Het |
| Dnaaf2 |
A |
T |
12: 69,244,122 (GRCm39) |
L313Q |
probably damaging |
Het |
| Dtl |
A |
G |
1: 191,278,680 (GRCm39) |
L394P |
probably benign |
Het |
| Ehhadh |
T |
C |
16: 21,585,305 (GRCm39) |
E192G |
probably benign |
Het |
| Fads2 |
T |
C |
19: 10,059,997 (GRCm39) |
I226V |
probably benign |
Het |
| Fat2 |
T |
C |
11: 55,161,208 (GRCm39) |
E3174G |
probably damaging |
Het |
| Galnt14 |
C |
T |
17: 73,881,826 (GRCm39) |
R91Q |
probably damaging |
Het |
| Hdhd5 |
G |
T |
6: 120,487,252 (GRCm39) |
D368E |
probably benign |
Het |
| Hk3 |
T |
A |
13: 55,158,617 (GRCm39) |
I528F |
probably damaging |
Het |
| Il10ra |
A |
C |
9: 45,166,951 (GRCm39) |
S533R |
possibly damaging |
Het |
| Itpr3 |
G |
T |
17: 27,305,950 (GRCm39) |
K169N |
probably benign |
Het |
| Lrrc17 |
A |
G |
5: 21,780,264 (GRCm39) |
T413A |
probably benign |
Het |
| Mcm2 |
C |
T |
6: 88,861,053 (GRCm39) |
D882N |
probably benign |
Het |
| Met |
T |
C |
6: 17,562,197 (GRCm39) |
V1186A |
probably damaging |
Het |
| Msh5 |
C |
T |
17: 35,248,628 (GRCm39) |
|
probably null |
Het |
| Nav3 |
T |
C |
10: 109,600,648 (GRCm39) |
I1326M |
probably damaging |
Het |
| Nek10 |
A |
G |
14: 14,850,896 (GRCm38) |
I314V |
probably benign |
Het |
| Or10g1 |
A |
C |
14: 52,648,225 (GRCm39) |
F35V |
probably damaging |
Het |
| Or8b53 |
T |
A |
9: 38,667,412 (GRCm39) |
Y143N |
probably benign |
Het |
| Pim1 |
A |
G |
17: 29,712,720 (GRCm39) |
E211G |
probably damaging |
Het |
| Plaat1 |
T |
A |
16: 29,039,189 (GRCm39) |
Y90N |
probably benign |
Het |
| Ppp1r12b |
A |
T |
1: 134,704,144 (GRCm39) |
D903E |
probably benign |
Het |
| Ptpn14 |
T |
C |
1: 189,583,229 (GRCm39) |
L692P |
probably benign |
Het |
| Ptprt |
A |
G |
2: 161,977,138 (GRCm39) |
C387R |
probably damaging |
Het |
| Qrfprl |
A |
G |
6: 65,418,369 (GRCm39) |
|
probably benign |
Het |
| Scarb1 |
A |
G |
5: 125,381,341 (GRCm39) |
Y68H |
possibly damaging |
Het |
| Shisa6 |
T |
A |
11: 66,108,800 (GRCm39) |
D359V |
probably damaging |
Het |
| Shprh |
T |
C |
10: 11,063,817 (GRCm39) |
S1297P |
probably damaging |
Het |
| Sik1 |
T |
C |
17: 32,069,125 (GRCm39) |
D250G |
probably damaging |
Het |
| Slamf7 |
A |
G |
1: 171,466,635 (GRCm39) |
L190S |
probably damaging |
Het |
| Slc22a3 |
G |
A |
17: 12,652,355 (GRCm39) |
P423L |
probably damaging |
Het |
| Slc35e2 |
A |
T |
4: 155,697,137 (GRCm39) |
E217V |
probably damaging |
Het |
| Spocd1 |
A |
T |
4: 129,850,254 (GRCm39) |
N760I |
probably damaging |
Het |
| Tas2r136 |
G |
T |
6: 132,754,294 (GRCm39) |
P278T |
possibly damaging |
Het |
| Tchhl1 |
A |
T |
3: 93,377,836 (GRCm39) |
Q180L |
probably benign |
Het |
| Tmem151b |
T |
A |
17: 45,858,010 (GRCm39) |
T79S |
probably benign |
Het |
| Tomm70a |
T |
A |
16: 56,965,105 (GRCm39) |
C430S |
probably benign |
Het |
| Trbv16 |
T |
A |
6: 41,128,936 (GRCm39) |
L40Q |
probably damaging |
Het |
| Trmt1l |
T |
G |
1: 151,316,594 (GRCm39) |
I32S |
probably damaging |
Het |
| Ubr4 |
A |
G |
4: 139,152,641 (GRCm39) |
T2011A |
probably damaging |
Het |
| Urb1 |
C |
T |
16: 90,569,652 (GRCm39) |
W1358* |
probably null |
Het |
| Usp31 |
T |
G |
7: 121,248,698 (GRCm39) |
H915P |
probably benign |
Het |
| Vmn2r10 |
A |
T |
5: 109,151,377 (GRCm39) |
M79K |
possibly damaging |
Het |
| Vps13b |
A |
G |
15: 35,869,497 (GRCm39) |
H2667R |
possibly damaging |
Het |
| Vwa5b1 |
G |
A |
4: 138,305,962 (GRCm39) |
T912M |
possibly damaging |
Het |
| Zfp709 |
G |
A |
8: 72,643,363 (GRCm39) |
C264Y |
probably benign |
Het |
| Zkscan5 |
A |
G |
5: 145,156,898 (GRCm39) |
I467V |
probably benign |
Het |
| Zxdc |
A |
T |
6: 90,347,281 (GRCm39) |
D214V |
probably damaging |
Het |
|
| Other mutations in Vmn2r14 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01472:Vmn2r14
|
APN |
5 |
109,364,180 (GRCm39) |
nonsense |
probably null |
|
|
IGL01504:Vmn2r14
|
APN |
5 |
109,369,285 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01828:Vmn2r14
|
APN |
5 |
109,372,443 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL02093:Vmn2r14
|
APN |
5 |
109,368,275 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02103:Vmn2r14
|
APN |
5 |
109,372,349 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02123:Vmn2r14
|
APN |
5 |
109,367,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02145:Vmn2r14
|
APN |
5 |
109,368,454 (GRCm39) |
nonsense |
probably null |
|
|
IGL02676:Vmn2r14
|
APN |
5 |
109,367,882 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02720:Vmn2r14
|
APN |
5 |
109,369,305 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02877:Vmn2r14
|
APN |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02974:Vmn2r14
|
APN |
5 |
109,369,292 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL03151:Vmn2r14
|
APN |
5 |
109,364,260 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03297:Vmn2r14
|
APN |
5 |
109,363,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03386:Vmn2r14
|
APN |
5 |
109,368,350 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03394:Vmn2r14
|
APN |
5 |
109,367,702 (GRCm39) |
missense |
probably null |
0.83 |
|
ANU74:Vmn2r14
|
UTSW |
5 |
109,366,910 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0316:Vmn2r14
|
UTSW |
5 |
109,366,762 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0755:Vmn2r14
|
UTSW |
5 |
109,364,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1219:Vmn2r14
|
UTSW |
5 |
109,372,440 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1321:Vmn2r14
|
UTSW |
5 |
109,364,117 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1465:Vmn2r14
|
UTSW |
5 |
109,368,195 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R1509:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1551:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1628:Vmn2r14
|
UTSW |
5 |
109,367,838 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1668:Vmn2r14
|
UTSW |
5 |
109,366,913 (GRCm39) |
nonsense |
probably null |
|
|
R2013:Vmn2r14
|
UTSW |
5 |
109,369,109 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2201:Vmn2r14
|
UTSW |
5 |
109,366,698 (GRCm39) |
splice site |
probably null |
|
|
R2417:Vmn2r14
|
UTSW |
5 |
109,372,329 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3029:Vmn2r14
|
UTSW |
5 |
109,363,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3120:Vmn2r14
|
UTSW |
5 |
109,372,431 (GRCm39) |
missense |
probably null |
0.00 |
|
R3729:Vmn2r14
|
UTSW |
5 |
109,364,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3762:Vmn2r14
|
UTSW |
5 |
109,368,033 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3943:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vmn2r14
|
UTSW |
5 |
109,363,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4224:Vmn2r14
|
UTSW |
5 |
109,364,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4239:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4240:Vmn2r14
|
UTSW |
5 |
109,364,277 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4782:Vmn2r14
|
UTSW |
5 |
109,369,370 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4832:Vmn2r14
|
UTSW |
5 |
109,363,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4884:Vmn2r14
|
UTSW |
5 |
109,369,384 (GRCm39) |
splice site |
probably null |
|
|
R4896:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5004:Vmn2r14
|
UTSW |
5 |
109,368,246 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5117:Vmn2r14
|
UTSW |
5 |
109,363,961 (GRCm39) |
missense |
probably benign |
0.16 |
|
R5285:Vmn2r14
|
UTSW |
5 |
109,365,442 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5413:Vmn2r14
|
UTSW |
5 |
109,369,154 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5569:Vmn2r14
|
UTSW |
5 |
109,368,261 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5701:Vmn2r14
|
UTSW |
5 |
109,367,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5726:Vmn2r14
|
UTSW |
5 |
109,365,486 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5763:Vmn2r14
|
UTSW |
5 |
109,363,724 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5985:Vmn2r14
|
UTSW |
5 |
109,368,082 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6268:Vmn2r14
|
UTSW |
5 |
109,369,283 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6273:Vmn2r14
|
UTSW |
5 |
109,369,133 (GRCm39) |
missense |
probably benign |
0.44 |
|
R6409:Vmn2r14
|
UTSW |
5 |
109,364,096 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,364,140 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6944:Vmn2r14
|
UTSW |
5 |
109,363,925 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7608:Vmn2r14
|
UTSW |
5 |
109,369,276 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7740:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7768:Vmn2r14
|
UTSW |
5 |
109,368,086 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7804:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7872:Vmn2r14
|
UTSW |
5 |
109,369,219 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7993:Vmn2r14
|
UTSW |
5 |
109,363,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8006:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8007:Vmn2r14
|
UTSW |
5 |
109,368,324 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8187:Vmn2r14
|
UTSW |
5 |
109,368,420 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8369:Vmn2r14
|
UTSW |
5 |
109,369,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8463:Vmn2r14
|
UTSW |
5 |
109,369,340 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8968:Vmn2r14
|
UTSW |
5 |
109,365,533 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9008:Vmn2r14
|
UTSW |
5 |
109,367,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9030:Vmn2r14
|
UTSW |
5 |
109,368,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9039:Vmn2r14
|
UTSW |
5 |
109,367,902 (GRCm39) |
nonsense |
probably null |
|
|
R9150:Vmn2r14
|
UTSW |
5 |
109,367,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9164:Vmn2r14
|
UTSW |
5 |
109,364,087 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Vmn2r14
|
UTSW |
5 |
109,369,112 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9225:Vmn2r14
|
UTSW |
5 |
109,369,288 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Vmn2r14
|
UTSW |
5 |
109,368,176 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9342:Vmn2r14
|
UTSW |
5 |
109,368,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9472:Vmn2r14
|
UTSW |
5 |
109,367,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9678:Vmn2r14
|
UTSW |
5 |
109,364,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Vmn2r14
|
UTSW |
5 |
109,369,126 (GRCm39) |
missense |
probably benign |
0.07 |
|
Z1177:Vmn2r14
|
UTSW |
5 |
109,367,741 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTGTAGGCACATGTAAATGGAC -3'
(R):5'- GTAATCTAGTTCAAGGTTGGCATTC -3'
Sequencing Primer
(F):5'- GAGTTCAATTCCCAGTAACCATGTGG -3'
(R):5'- GTTCAAGGTTGGCATTCAATAAAAC -3'
|
| Posted On |
2017-02-10 |
Incidental Mutation