Incidental Mutation 'R5873:Or2y6'
ID 455325
Institutional Source Beutler Lab
Gene Symbol Or2y6
Ensembl Gene ENSMUSG00000060170
Gene Name olfactory receptor family 2 subfamily Y member 6
Synonyms GA_x6K02T2QP88-3214035-3214970, MOR256-58, Olfr1371
MMRRC Submission 044080-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R5873 (G1)
Quality Score 192
Status Not validated
Chromosome 11
Chromosomal Location 52103879-52104814 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 52104180 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 212 (L212Q)
Ref Sequence ENSEMBL: ENSMUSP00000075241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075844]
AlphaFold Q7TQT7
Predicted Effect probably damaging
Transcript: ENSMUST00000075844
AA Change: L212Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000075241
Gene: ENSMUSG00000060170
AA Change: L212Q

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.9e-48 PFAM
Pfam:7tm_1 41 289 5.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181262
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T A 18: 6,630,167 (GRCm39) probably null Het
4930505A04Rik T A 11: 30,376,220 (GRCm39) K216* probably null Het
5330417H12Rik T C 7: 107,223,975 (GRCm39) probably benign Het
Abcc4 G T 14: 118,763,702 (GRCm39) D1044E probably benign Het
Adgre4 A G 17: 56,159,282 (GRCm39) T656A probably benign Het
Ankk1 T C 9: 49,327,196 (GRCm39) N661S probably benign Het
Asah2 A G 19: 31,981,082 (GRCm39) probably null Het
Asxl3 A G 18: 22,649,142 (GRCm39) D377G probably benign Het
C3ar1 A G 6: 122,827,381 (GRCm39) S279P probably benign Het
C7 A G 15: 5,034,717 (GRCm39) V610A probably damaging Het
Cacna2d3 C A 14: 29,442,891 (GRCm39) A48S probably benign Het
Card11 T A 5: 140,894,393 (GRCm39) I79F probably damaging Het
Casc3 A G 11: 98,712,270 (GRCm39) Y103C unknown Het
Cass4 G T 2: 172,268,688 (GRCm39) V259L probably benign Het
Col14a1 A G 15: 55,309,182 (GRCm39) probably benign Het
Cox10 A G 11: 63,962,512 (GRCm39) S110P probably benign Het
Cpt1b T C 15: 89,304,931 (GRCm39) Y439C probably damaging Het
Crybb2 C T 5: 113,213,759 (GRCm39) probably null Het
Cyp2b23 C T 7: 26,374,431 (GRCm39) R271H probably benign Het
Dnah17 T C 11: 117,947,723 (GRCm39) I3039V probably benign Het
Dnpep T C 1: 75,291,787 (GRCm39) D242G probably damaging Het
Dock10 T A 1: 80,551,855 (GRCm39) N660I probably damaging Het
Esco2 T C 14: 66,061,640 (GRCm39) D471G probably benign Het
Evpl A T 11: 116,125,258 (GRCm39) L97H probably damaging Het
Exoc3l4 A T 12: 111,389,850 (GRCm39) I142F probably damaging Het
Fry C A 5: 150,302,350 (GRCm39) P519Q probably damaging Het
Gal3st2 T A 1: 93,801,472 (GRCm39) F92I probably benign Het
Galm A G 17: 80,445,532 (GRCm39) E94G probably benign Het
Gfy T G 7: 44,827,004 (GRCm39) H364P probably damaging Het
Helz2 A G 2: 180,875,821 (GRCm39) S1558P possibly damaging Het
Hmmr T A 11: 40,598,527 (GRCm39) Q600L probably damaging Het
Hnrnph3 A G 10: 62,855,170 (GRCm39) probably null Het
Igkv4-90 T A 6: 68,784,453 (GRCm39) N21I probably benign Het
Kpna1 A G 16: 35,834,598 (GRCm39) probably benign Het
Krt28 A C 11: 99,257,716 (GRCm39) L375R probably damaging Het
Lrrn1 T C 6: 107,545,936 (GRCm39) V578A probably damaging Het
Lta4h T C 10: 93,305,052 (GRCm39) probably null Het
Matk T A 10: 81,095,963 (GRCm39) V166E probably benign Het
Muc4 C A 16: 32,570,113 (GRCm39) T391K possibly damaging Het
Mybl1 T A 1: 9,755,890 (GRCm39) T220S possibly damaging Het
Nrp1 T C 8: 129,194,858 (GRCm39) V438A probably damaging Het
Or6p1 T A 1: 174,258,348 (GRCm39) M118K possibly damaging Het
Pdia4 A T 6: 47,785,110 (GRCm39) W86R probably damaging Het
Pdzd7 T A 19: 45,016,388 (GRCm39) D911V probably damaging Het
Pkd1 A G 17: 24,788,804 (GRCm39) Q854R probably benign Het
Ppl A G 16: 4,923,913 (GRCm39) probably null Het
Ppp1r26 A G 2: 28,341,617 (GRCm39) T416A probably benign Het
Prdm15 T C 16: 97,609,889 (GRCm39) D585G probably damaging Het
Rbak A G 5: 143,159,466 (GRCm39) V529A probably benign Het
Rc3h1 C T 1: 160,787,071 (GRCm39) T822I probably damaging Het
Slc25a18 A T 6: 120,763,242 (GRCm39) probably null Het
Taf2 T C 15: 54,901,818 (GRCm39) N792S probably benign Het
Tat T C 8: 110,718,581 (GRCm39) probably null Het
Tbx21 A T 11: 97,005,474 (GRCm39) probably null Het
Txndc11 A G 16: 10,893,069 (GRCm39) L887P probably damaging Het
Usp10 A G 8: 120,673,831 (GRCm39) T399A possibly damaging Het
Vmn2r26 A T 6: 124,038,633 (GRCm39) H736L probably benign Het
Vstm2a T A 11: 16,208,044 (GRCm39) F13I probably damaging Het
Zkscan5 A G 5: 145,157,204 (GRCm39) R496G possibly damaging Het
Zranb2 C T 3: 157,242,020 (GRCm39) R36* probably null Het
Other mutations in Or2y6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0513:Or2y6 UTSW 11 52,104,576 (GRCm39) missense possibly damaging 0.94
R4462:Or2y6 UTSW 11 52,104,801 (GRCm39) missense probably damaging 1.00
R4567:Or2y6 UTSW 11 52,104,291 (GRCm39) missense probably damaging 1.00
R4621:Or2y6 UTSW 11 52,104,706 (GRCm39) missense probably benign 0.26
R5846:Or2y6 UTSW 11 52,103,881 (GRCm39) makesense probably null
R8181:Or2y6 UTSW 11 52,104,096 (GRCm39) missense probably damaging 1.00
Z1177:Or2y6 UTSW 11 52,104,237 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GGCAAGAAATTTCCCCTCCTTC -3'
(R):5'- GCAGAGCATTGGTTGTATTCTCC -3'

Sequencing Primer
(F):5'- CTTCTCAGAATACCTGTGGACAG -3'
(R):5'- GGCCTTGTGAACTCTCTGATCCAG -3'
Posted On 2017-02-10