Incidental Mutation 'R5876:Cbr4'
ID455535
Institutional Source Beutler Lab
Gene Symbol Cbr4
Ensembl Gene ENSMUSG00000031641
Gene Namecarbonyl reductase 4
Synonyms
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.733) question?
Stock #R5876 (G1)
Quality Score225
Status Not validated
Chromosome8
Chromosomal Location61487734-61506694 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 61490593 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Arginine at position 91 (G91R)
Ref Sequence ENSEMBL: ENSMUSP00000117069 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034058] [ENSMUST00000126575]
Predicted Effect probably benign
Transcript: ENSMUST00000034058
SMART Domains Protein: ENSMUSP00000034058
Gene: ENSMUSG00000031641

DomainStartEndE-ValueType
Pfam:adh_short 3 192 2.4e-54 PFAM
Pfam:KR 4 182 6.5e-18 PFAM
Pfam:adh_short_C2 9 233 4.4e-33 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000126575
AA Change: G91R

PolyPhen 2 Score 0.780 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000117069
Gene: ENSMUSG00000031641
AA Change: G91R

DomainStartEndE-ValueType
Pfam:adh_short 3 108 9.4e-20 PFAM
Pfam:KR 4 92 3.1e-10 PFAM
Pfam:adh_short_C2 9 110 1.1e-8 PFAM
low complexity region 117 128 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130495
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150932
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155442
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156535
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034E13Rik A G 18: 52,663,582 D64G possibly damaging Het
Ano2 T A 6: 126,039,279 M925K possibly damaging Het
Arnt2 T C 7: 84,347,512 T69A probably damaging Het
Asap2 T A 12: 21,212,809 N229K possibly damaging Het
Atp13a3 T A 16: 30,362,734 N23Y probably benign Het
Cdc27 A T 11: 104,515,418 C624S probably benign Het
Cdc42bpg T A 19: 6,310,815 I201N probably damaging Het
Cdh5 A G 8: 104,142,577 Y645C probably damaging Het
Celsr2 C T 3: 108,413,943 V518I probably damaging Het
Clca4b T C 3: 144,912,060 T761A possibly damaging Het
Cpne4 C A 9: 104,925,770 S204R probably damaging Het
Dcaf1 T C 9: 106,863,650 W1279R probably damaging Het
Dennd4a C T 9: 64,911,755 P1731S probably damaging Het
Dmxl1 T A 18: 49,870,984 V892D possibly damaging Het
Fam131b A G 6: 42,321,248 probably null Het
Fam83b T A 9: 76,491,850 D657V possibly damaging Het
Fam83e T A 7: 45,722,363 probably null Het
Fbxo4 A T 15: 3,977,819 I121N probably damaging Het
Gabrg2 A G 11: 41,968,820 S202P probably damaging Het
Gm10471 T C 5: 26,084,718 E237G probably damaging Het
Grid2 T A 6: 64,663,162 I788N probably damaging Het
Grik4 T A 9: 42,688,023 N53Y probably damaging Het
Hipk2 A C 6: 38,730,867 probably null Het
Hps5 T C 7: 46,789,196 T38A probably damaging Het
Hs1bp3 A G 12: 8,341,843 D315G possibly damaging Het
Kdm4a C T 4: 118,138,876 M985I probably damaging Het
Kdm5d A G Y: 900,525 Y190C probably damaging Het
Krt86 T C 15: 101,476,610 S295P probably damaging Het
Matr3 T A 18: 35,587,738 D413E probably benign Het
Mbd5 T A 2: 49,274,645 F319L probably damaging Het
Mcoln1 T A 8: 3,510,910 Y411N probably damaging Het
Mpdz C A 4: 81,285,474 E1863* probably null Het
Mrps9 A G 1: 42,895,378 E173G probably damaging Het
Olfr8 A T 10: 78,955,357 I51F probably benign Het
Osmr T C 15: 6,821,047 T692A probably benign Het
Pkhd1l1 A T 15: 44,578,588 H3641L possibly damaging Het
Pml T C 9: 58,233,182 T421A possibly damaging Het
Podxl A G 6: 31,528,456 probably null Het
Ppargc1b C G 18: 61,309,093 D591H probably damaging Het
Prkag3 A G 1: 74,748,816 probably benign Het
Proz A G 8: 13,073,448 R240G probably benign Het
Ptpn13 C A 5: 103,476,960 D43E probably damaging Het
Rbm5 T G 9: 107,760,326 K135N probably damaging Het
Ska1 G A 18: 74,197,528 T201M probably damaging Het
Slc35f5 A C 1: 125,587,363 probably null Het
Slc9a3 T C 13: 74,161,723 L510P probably damaging Het
Svil A G 18: 5,082,828 K1231E probably damaging Het
Tanc2 T C 11: 105,922,613 S1628P possibly damaging Het
Tm9sf3 T A 19: 41,240,584 D260V probably damaging Het
Ttc9 G T 12: 81,631,622 R73L probably damaging Het
Vps13b A G 15: 35,917,061 I3684V probably damaging Het
Vps8 T C 16: 21,461,439 probably null Het
Vwa3b T A 1: 37,076,439 I328N probably damaging Het
Wdr1 C T 5: 38,530,023 V222M probably benign Het
Xpnpep1 T A 19: 52,997,008 T530S probably damaging Het
Zc3h6 C T 2: 128,993,277 S111F probably benign Het
Zfp768 G A 7: 127,344,546 P137S probably benign Het
Other mutations in Cbr4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01603:Cbr4 APN 8 61503211 makesense probably null
R0498:Cbr4 UTSW 8 61495073 missense probably benign 0.00
R0637:Cbr4 UTSW 8 61490706 splice site probably benign
R1609:Cbr4 UTSW 8 61503158 missense probably damaging 1.00
R4168:Cbr4 UTSW 8 61491521 intron probably benign
R4709:Cbr4 UTSW 8 61490027 missense possibly damaging 0.66
R4802:Cbr4 UTSW 8 61490079 intron probably benign
R5049:Cbr4 UTSW 8 61495204 critical splice donor site probably null
R6020:Cbr4 UTSW 8 61487853 missense probably benign 0.44
R7818:Cbr4 UTSW 8 61487942 missense probably benign 0.04
Predicted Primers
Posted On2017-02-10