Mutagenetix > Incidental Mutation

Incidental Mutation 'R5876:Dmxl1'

455561

Institutional Source

Beutler Lab

Gene Symbol

Dmxl1

Ensembl Gene

ENSMUSG00000037416

Gene Name

Dmx-like 1

Synonyms

C630007L23Rik

Accession Numbers

Essential gene?

Probably essential (E-score: 0.956) question?

Stock #

R5876 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

49965737-50098540 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 50004051 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 892 (V892D)

Ref Sequence

ENSEMBL: ENSMUSP00000045559 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000041772] [ENSMUST00000180611]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000041772
AA Change: V892D

PolyPhen 2 Score 0.699 (Sensitivity: 0.86; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000045559
Gene: ENSMUSG00000037416
AA Change: V892D

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
Pfam:Rav1p_C	1102	1877	4.3e-84	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2371	2385	N/A	INTRINSIC
low complexity region	2397	2410	N/A	INTRINSIC
low complexity region	2449	2466	N/A	INTRINSIC
WD40	2735	2770	1.07e1	SMART
WD40	2773	2813	3.7e0	SMART
WD40	2825	2867	1.07e0	SMART
WD40	2873	2912	1.05e-2	SMART
WD40	2915	2954	4.51e-7	SMART
Blast:WD40	2957	3005	9e-26	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000180611
AA Change: V892D

PolyPhen 2 Score 0.521 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000137871
Gene: ENSMUSG00000037416
AA Change: V892D

Domain	Start	End	E-Value	Type
WD40	100	136	8.22e1	SMART
WD40	156	195	2.88e-1	SMART
WD40	218	266	8.29e-1	SMART
low complexity region	367	378	N/A	INTRINSIC
WD40	464	505	1.53e2	SMART
Blast:WD40	719	772	1e-25	BLAST
WD40	957	999	1.1e1	SMART
low complexity region	1195	1206	N/A	INTRINSIC
low complexity region	1258	1271	N/A	INTRINSIC
Pfam:Rav1p_C	1287	1876	9.4e-72	PFAM
low complexity region	1922	1942	N/A	INTRINSIC
low complexity region	1966	1975	N/A	INTRINSIC
low complexity region	1993	2007	N/A	INTRINSIC
low complexity region	2147	2158	N/A	INTRINSIC
low complexity region	2385	2398	N/A	INTRINSIC
low complexity region	2437	2454	N/A	INTRINSIC
WD40	2723	2758	1.07e1	SMART
WD40	2761	2801	3.7e0	SMART
WD40	2813	2855	1.07e0	SMART
WD40	2861	2900	1.05e-2	SMART
WD40	2903	2942	4.51e-7	SMART
Blast:WD40	2945	2993	9e-26	BLAST

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the WD repeat superfamily of proteins, which have regulatory functions. This gene is expressed in many tissue types including several types of eye tissue, and it has been associated with ocular phenotypes. In addition, it is upregulated in cultured cells that overexpress growth factor independence 1B, a transcription factor that is essential for hematopoietic cell development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700034E13Rik	A	G	18: 52,796,654 (GRCm39)	D64G	possibly damaging	Het
Ano2	T	A	6: 126,016,242 (GRCm39)	M925K	possibly damaging	Het
Arnt2	T	C	7: 83,996,720 (GRCm39)	T69A	probably damaging	Het
Asap2	T	A	12: 21,262,810 (GRCm39)	N229K	possibly damaging	Het
Atp13a3	T	A	16: 30,181,552 (GRCm39)	N23Y	probably benign	Het
Cbr4	G	A	8: 61,943,627 (GRCm39)	G91R	possibly damaging	Het
Cdc27	A	T	11: 104,406,244 (GRCm39)	C624S	probably benign	Het
Cdc42bpg	T	A	19: 6,360,845 (GRCm39)	I201N	probably damaging	Het
Cdh5	A	G	8: 104,869,209 (GRCm39)	Y645C	probably damaging	Het
Celsr2	C	T	3: 108,321,259 (GRCm39)	V518I	probably damaging	Het
Clca4b	T	C	3: 144,617,821 (GRCm39)	T761A	possibly damaging	Het
Cpne4	C	A	9: 104,802,969 (GRCm39)	S204R	probably damaging	Het
Dcaf1	T	C	9: 106,740,849 (GRCm39)	W1279R	probably damaging	Het
Dennd4a	C	T	9: 64,819,037 (GRCm39)	P1731S	probably damaging	Het
Fam131b	A	G	6: 42,298,182 (GRCm39)		probably null	Het
Fam83b	T	A	9: 76,399,132 (GRCm39)	D657V	possibly damaging	Het
Fam83e	T	A	7: 45,371,787 (GRCm39)		probably null	Het
Fbxo4	A	T	15: 4,007,301 (GRCm39)	I121N	probably damaging	Het
Gabrg2	A	G	11: 41,859,647 (GRCm39)	S202P	probably damaging	Het
Grid2	T	A	6: 64,640,146 (GRCm39)	I788N	probably damaging	Het
Grik4	T	A	9: 42,599,319 (GRCm39)	N53Y	probably damaging	Het
Hipk2	A	C	6: 38,707,802 (GRCm39)		probably null	Het
Hps5	T	C	7: 46,438,620 (GRCm39)	T38A	probably damaging	Het
Hs1bp3	A	G	12: 8,391,843 (GRCm39)	D315G	possibly damaging	Het
Kdm4a	C	T	4: 117,996,073 (GRCm39)	M985I	probably damaging	Het
Kdm5d	A	G	Y: 900,525 (GRCm39)	Y190C	probably damaging	Het
Krt86	T	C	15: 101,374,491 (GRCm39)	S295P	probably damaging	Het
Matr3	T	A	18: 35,720,791 (GRCm39)	D413E	probably benign	Het
Mbd5	T	A	2: 49,164,657 (GRCm39)	F319L	probably damaging	Het
Mcoln1	T	A	8: 3,560,910 (GRCm39)	Y411N	probably damaging	Het
Mpdz	C	A	4: 81,203,711 (GRCm39)	E1863*	probably null	Het
Mrps9	A	G	1: 42,934,538 (GRCm39)	E173G	probably damaging	Het
Or7a42	A	T	10: 78,791,191 (GRCm39)	I51F	probably benign	Het
Osmr	T	C	15: 6,850,528 (GRCm39)	T692A	probably benign	Het
Pkhd1l1	A	T	15: 44,441,984 (GRCm39)	H3641L	possibly damaging	Het
Pml	T	C	9: 58,140,465 (GRCm39)	T421A	possibly damaging	Het
Podxl	A	G	6: 31,505,391 (GRCm39)		probably null	Het
Ppargc1b	C	G	18: 61,442,164 (GRCm39)	D591H	probably damaging	Het
Prkag3	A	G	1: 74,787,975 (GRCm39)		probably benign	Het
Proz	A	G	8: 13,123,448 (GRCm39)	R240G	probably benign	Het
Ptpn13	C	A	5: 103,624,826 (GRCm39)	D43E	probably damaging	Het
Rbm5	T	G	9: 107,637,525 (GRCm39)	K135N	probably damaging	Het
Ska1	G	A	18: 74,330,599 (GRCm39)	T201M	probably damaging	Het
Slc35f5	A	C	1: 125,515,100 (GRCm39)		probably null	Het
Slc9a3	T	C	13: 74,309,842 (GRCm39)	L510P	probably damaging	Het
Speer4a2	T	C	5: 26,289,716 (GRCm39)	E237G	probably damaging	Het
Svil	A	G	18: 5,082,828 (GRCm39)	K1231E	probably damaging	Het
Tanc2	T	C	11: 105,813,439 (GRCm39)	S1628P	possibly damaging	Het
Tm9sf3	T	A	19: 41,229,023 (GRCm39)	D260V	probably damaging	Het
Ttc9	G	T	12: 81,678,396 (GRCm39)	R73L	probably damaging	Het
Vps13b	A	G	15: 35,917,207 (GRCm39)	I3684V	probably damaging	Het
Vps8	T	C	16: 21,280,189 (GRCm39)		probably null	Het
Vwa3b	T	A	1: 37,115,520 (GRCm39)	I328N	probably damaging	Het
Wdr1	C	T	5: 38,687,366 (GRCm39)	V222M	probably benign	Het
Xpnpep1	T	A	19: 52,985,439 (GRCm39)	T530S	probably damaging	Het
Zc3h6	C	T	2: 128,835,197 (GRCm39)	S111F	probably benign	Het
Zfp768	G	A	7: 126,943,718 (GRCm39)	P137S	probably benign	Het

Other mutations in Dmxl1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00163:Dmxl1	APN	18	49,984,534 (GRCm39)	missense	probably damaging	1.00
IGL00668:Dmxl1	APN	18	50,072,620 (GRCm39)	missense	possibly damaging	0.64
IGL00740:Dmxl1	APN	18	50,050,735 (GRCm39)	missense	probably benign	0.00
IGL00969:Dmxl1	APN	18	50,045,792 (GRCm39)	missense	probably benign	0.02
IGL01113:Dmxl1	APN	18	50,045,818 (GRCm39)	missense	probably benign	0.01
IGL01384:Dmxl1	APN	18	49,990,401 (GRCm39)	missense	probably benign
IGL01475:Dmxl1	APN	18	50,004,781 (GRCm39)	missense	probably damaging	1.00
IGL01559:Dmxl1	APN	18	50,054,005 (GRCm39)	missense	probably damaging	0.99
IGL01578:Dmxl1	APN	18	50,095,272 (GRCm39)	missense	probably damaging	1.00
IGL01632:Dmxl1	APN	18	49,996,092 (GRCm39)	missense	probably damaging	0.99
IGL01814:Dmxl1	APN	18	49,997,935 (GRCm39)	missense	probably damaging	1.00
IGL01843:Dmxl1	APN	18	50,011,449 (GRCm39)	nonsense	probably null
IGL01933:Dmxl1	APN	18	50,010,852 (GRCm39)	missense	probably benign	0.17
IGL01952:Dmxl1	APN	18	50,023,721 (GRCm39)	missense	probably benign	0.11
IGL02120:Dmxl1	APN	18	50,027,245 (GRCm39)	missense	possibly damaging	0.83
IGL02162:Dmxl1	APN	18	50,094,230 (GRCm39)	missense	probably benign	0.00
IGL02213:Dmxl1	APN	18	50,010,741 (GRCm39)	splice site	probably benign
IGL02261:Dmxl1	APN	18	49,973,566 (GRCm39)	missense	possibly damaging	0.85
IGL02689:Dmxl1	APN	18	49,997,962 (GRCm39)	missense	probably damaging	1.00
IGL02892:Dmxl1	APN	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
IGL03232:Dmxl1	APN	18	50,011,247 (GRCm39)	missense	probably benign	0.01
IGL03258:Dmxl1	APN	18	50,053,960 (GRCm39)	missense	probably damaging	1.00
IGL03298:Dmxl1	APN	18	49,997,885 (GRCm39)	missense	probably benign
capture	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
carnivora	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
digestion	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
drowning	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
hibiscus	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
impound	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
pitcher	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
PIT4810001:Dmxl1	UTSW	18	50,065,030 (GRCm39)	missense	probably damaging	1.00
R0001:Dmxl1	UTSW	18	50,021,964 (GRCm39)	splice site	probably benign
R0027:Dmxl1	UTSW	18	50,090,362 (GRCm39)	splice site	probably benign
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0042:Dmxl1	UTSW	18	49,997,102 (GRCm39)	missense	probably benign	0.03
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0046:Dmxl1	UTSW	18	50,011,149 (GRCm39)	missense	probably benign	0.22
R0257:Dmxl1	UTSW	18	50,088,870 (GRCm39)	splice site	probably benign
R0349:Dmxl1	UTSW	18	50,012,349 (GRCm39)	missense	probably damaging	0.99
R0390:Dmxl1	UTSW	18	50,012,429 (GRCm39)	missense	probably benign	0.14
R0511:Dmxl1	UTSW	18	50,024,534 (GRCm39)	nonsense	probably null
R0539:Dmxl1	UTSW	18	49,990,497 (GRCm39)	splice site	probably benign
R0542:Dmxl1	UTSW	18	50,026,761 (GRCm39)	missense	probably benign	0.05
R0587:Dmxl1	UTSW	18	50,068,374 (GRCm39)	missense	probably benign	0.39
R0635:Dmxl1	UTSW	18	49,984,490 (GRCm39)	splice site	probably benign
R0744:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0836:Dmxl1	UTSW	18	49,966,215 (GRCm39)	missense	probably damaging	1.00
R0845:Dmxl1	UTSW	18	50,026,469 (GRCm39)	missense	probably damaging	1.00
R1218:Dmxl1	UTSW	18	50,026,678 (GRCm39)	missense	probably damaging	1.00
R1278:Dmxl1	UTSW	18	50,026,292 (GRCm39)	missense	probably benign
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1313:Dmxl1	UTSW	18	50,011,550 (GRCm39)	missense	probably damaging	1.00
R1349:Dmxl1	UTSW	18	50,021,920 (GRCm39)	missense	probably damaging	1.00
R1453:Dmxl1	UTSW	18	49,990,316 (GRCm39)	missense	probably benign	0.05
R1522:Dmxl1	UTSW	18	49,985,434 (GRCm39)	missense	probably benign	0.05
R1629:Dmxl1	UTSW	18	49,992,353 (GRCm39)	critical splice donor site	probably null
R1638:Dmxl1	UTSW	18	50,023,834 (GRCm39)	nonsense	probably null
R1646:Dmxl1	UTSW	18	50,095,328 (GRCm39)	missense	probably damaging	1.00
R1719:Dmxl1	UTSW	18	50,067,704 (GRCm39)	missense	probably damaging	1.00
R1732:Dmxl1	UTSW	18	50,036,055 (GRCm39)	missense	probably benign
R1732:Dmxl1	UTSW	18	50,026,511 (GRCm39)	nonsense	probably null
R1886:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1887:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R1895:Dmxl1	UTSW	18	50,088,981 (GRCm39)	splice site	probably null
R1911:Dmxl1	UTSW	18	50,011,230 (GRCm39)	missense	probably benign	0.00
R2020:Dmxl1	UTSW	18	50,022,625 (GRCm39)	nonsense	probably null
R2116:Dmxl1	UTSW	18	50,011,884 (GRCm39)	missense	probably damaging	1.00
R2196:Dmxl1	UTSW	18	50,050,698 (GRCm39)	missense	probably benign	0.00
R2206:Dmxl1	UTSW	18	50,027,161 (GRCm39)	missense	probably benign	0.12
R2216:Dmxl1	UTSW	18	50,026,990 (GRCm39)	missense	probably benign	0.00
R2255:Dmxl1	UTSW	18	49,979,706 (GRCm39)	missense	probably benign	0.34
R2333:Dmxl1	UTSW	18	50,053,043 (GRCm39)	splice site	probably null
R2343:Dmxl1	UTSW	18	50,023,745 (GRCm39)	missense	probably damaging	1.00
R2496:Dmxl1	UTSW	18	50,013,858 (GRCm39)	missense	possibly damaging	0.51
R3757:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3758:Dmxl1	UTSW	18	50,068,384 (GRCm39)	missense	probably damaging	0.98
R3783:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3786:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3787:Dmxl1	UTSW	18	49,998,189 (GRCm39)	missense	probably damaging	1.00
R3885:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3886:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3887:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3888:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R3889:Dmxl1	UTSW	18	50,011,326 (GRCm39)	missense	probably damaging	1.00
R4014:Dmxl1	UTSW	18	49,997,029 (GRCm39)	missense	probably benign
R4033:Dmxl1	UTSW	18	49,984,498 (GRCm39)	missense	possibly damaging	0.95
R4096:Dmxl1	UTSW	18	50,094,264 (GRCm39)	missense	probably damaging	1.00
R4366:Dmxl1	UTSW	18	50,011,084 (GRCm39)	nonsense	probably null
R4406:Dmxl1	UTSW	18	50,022,620 (GRCm39)	missense	probably damaging	1.00
R4412:Dmxl1	UTSW	18	49,981,828 (GRCm39)	missense	probably benign
R4454:Dmxl1	UTSW	18	50,026,399 (GRCm39)	missense	probably benign	0.01
R4459:Dmxl1	UTSW	18	50,094,283 (GRCm39)	missense	possibly damaging	0.80
R4569:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4570:Dmxl1	UTSW	18	49,985,427 (GRCm39)	missense	probably damaging	1.00
R4606:Dmxl1	UTSW	18	50,095,248 (GRCm39)	missense	probably damaging	0.98
R4649:Dmxl1	UTSW	18	50,011,698 (GRCm39)	missense	probably damaging	0.99
R4683:Dmxl1	UTSW	18	50,011,088 (GRCm39)	missense	probably damaging	1.00
R4782:Dmxl1	UTSW	18	49,996,059 (GRCm39)	missense	probably damaging	1.00
R4878:Dmxl1	UTSW	18	49,984,543 (GRCm39)	missense	probably damaging	1.00
R4879:Dmxl1	UTSW	18	50,022,534 (GRCm39)	missense	probably damaging	1.00
R4881:Dmxl1	UTSW	18	50,090,348 (GRCm39)	intron	probably benign
R4885:Dmxl1	UTSW	18	50,011,862 (GRCm39)	missense	probably damaging	0.99
R4916:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5022:Dmxl1	UTSW	18	50,028,194 (GRCm39)	missense	probably damaging	0.99
R5056:Dmxl1	UTSW	18	50,003,990 (GRCm39)	missense	probably benign	0.00
R5177:Dmxl1	UTSW	18	50,026,651 (GRCm39)	missense	probably damaging	0.99
R5342:Dmxl1	UTSW	18	50,084,302 (GRCm39)	missense	probably damaging	0.96
R5421:Dmxl1	UTSW	18	49,996,186 (GRCm39)	critical splice donor site	probably null
R5433:Dmxl1	UTSW	18	50,000,966 (GRCm39)	splice site	probably null
R5484:Dmxl1	UTSW	18	50,022,531 (GRCm39)	missense	probably damaging	1.00
R5598:Dmxl1	UTSW	18	49,997,545 (GRCm39)	missense	probably benign	0.04
R5633:Dmxl1	UTSW	18	50,010,764 (GRCm39)	missense	probably damaging	1.00
R5638:Dmxl1	UTSW	18	50,024,693 (GRCm39)	missense	possibly damaging	0.95
R5694:Dmxl1	UTSW	18	50,027,324 (GRCm39)	missense	probably damaging	1.00
R5696:Dmxl1	UTSW	18	50,065,008 (GRCm39)	nonsense	probably null
R5706:Dmxl1	UTSW	18	50,090,462 (GRCm39)	critical splice donor site	probably null
R5745:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R6054:Dmxl1	UTSW	18	49,990,453 (GRCm39)	missense	probably benign	0.00
R6145:Dmxl1	UTSW	18	50,045,833 (GRCm39)	missense	possibly damaging	0.90
R6189:Dmxl1	UTSW	18	50,026,402 (GRCm39)	missense	probably benign	0.33
R6213:Dmxl1	UTSW	18	49,996,082 (GRCm39)	missense	possibly damaging	0.93
R6219:Dmxl1	UTSW	18	50,035,434 (GRCm39)	missense	probably damaging	0.99
R6221:Dmxl1	UTSW	18	50,004,799 (GRCm39)	missense	probably damaging	0.96
R6276:Dmxl1	UTSW	18	49,979,653 (GRCm39)	missense	probably benign
R6319:Dmxl1	UTSW	18	49,985,367 (GRCm39)	missense	probably benign	0.00
R6426:Dmxl1	UTSW	18	49,997,645 (GRCm39)	missense	probably damaging	0.99
R6567:Dmxl1	UTSW	18	49,992,246 (GRCm39)	missense	probably damaging	0.99
R6739:Dmxl1	UTSW	18	50,011,313 (GRCm39)	missense	probably benign	0.03
R6743:Dmxl1	UTSW	18	50,013,847 (GRCm39)	missense	possibly damaging	0.95
R6776:Dmxl1	UTSW	18	50,027,041 (GRCm39)	missense	probably damaging	1.00
R6827:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6828:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6829:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6830:Dmxl1	UTSW	18	50,054,091 (GRCm39)	missense	probably damaging	1.00
R6833:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6834:Dmxl1	UTSW	18	50,088,890 (GRCm39)	missense	probably damaging	0.99
R6856:Dmxl1	UTSW	18	49,985,355 (GRCm39)	nonsense	probably null
R6857:Dmxl1	UTSW	18	49,997,902 (GRCm39)	missense	probably damaging	0.99
R6881:Dmxl1	UTSW	18	50,068,372 (GRCm39)	missense	probably benign	0.00
R6882:Dmxl1	UTSW	18	49,976,851 (GRCm39)	critical splice acceptor site	probably null
R6892:Dmxl1	UTSW	18	50,053,969 (GRCm39)	missense	probably damaging	0.98
R6897:Dmxl1	UTSW	18	49,996,124 (GRCm39)	missense	possibly damaging	0.51
R6897:Dmxl1	UTSW	18	49,984,562 (GRCm39)	missense	probably null	0.99
R6917:Dmxl1	UTSW	18	49,997,215 (GRCm39)	missense	probably damaging	1.00
R7192:Dmxl1	UTSW	18	50,088,920 (GRCm39)	missense	probably damaging	0.99
R7447:Dmxl1	UTSW	18	49,997,681 (GRCm39)	missense	probably damaging	0.99
R7460:Dmxl1	UTSW	18	50,011,679 (GRCm39)	missense	probably benign	0.00
R7570:Dmxl1	UTSW	18	50,027,024 (GRCm39)	missense	possibly damaging	0.82
R7626:Dmxl1	UTSW	18	50,035,861 (GRCm39)	missense	probably benign
R7629:Dmxl1	UTSW	18	49,992,337 (GRCm39)	missense	probably damaging	1.00
R7644:Dmxl1	UTSW	18	50,026,619 (GRCm39)	missense	probably benign
R7688:Dmxl1	UTSW	18	50,088,938 (GRCm39)	missense	probably benign	0.03
R7689:Dmxl1	UTSW	18	49,979,685 (GRCm39)	missense	probably benign	0.00
R7712:Dmxl1	UTSW	18	50,026,528 (GRCm39)	missense	probably damaging	0.99
R7808:Dmxl1	UTSW	18	50,011,382 (GRCm39)	missense	probably benign	0.00
R7834:Dmxl1	UTSW	18	50,054,044 (GRCm39)	missense	probably damaging	1.00
R7848:Dmxl1	UTSW	18	49,973,557 (GRCm39)	missense	possibly damaging	0.88
R7849:Dmxl1	UTSW	18	50,094,214 (GRCm39)	missense	probably benign	0.00
R7881:Dmxl1	UTSW	18	49,997,450 (GRCm39)	missense	probably damaging	0.99
R7884:Dmxl1	UTSW	18	50,026,474 (GRCm39)	missense	possibly damaging	0.65
R8073:Dmxl1	UTSW	18	50,011,500 (GRCm39)	missense	probably damaging	1.00
R8089:Dmxl1	UTSW	18	50,021,897 (GRCm39)	missense	probably damaging	0.99
R8266:Dmxl1	UTSW	18	49,976,878 (GRCm39)	missense	probably benign	0.17
R8371:Dmxl1	UTSW	18	50,031,781 (GRCm39)	missense	probably benign	0.08
R8402:Dmxl1	UTSW	18	50,011,409 (GRCm39)	missense	probably benign
R8402:Dmxl1	UTSW	18	50,011,393 (GRCm39)	nonsense	probably null
R8402:Dmxl1	UTSW	18	50,011,394 (GRCm39)	missense	probably benign	0.09
R8423:Dmxl1	UTSW	18	49,998,183 (GRCm39)	missense	probably damaging	1.00
R8678:Dmxl1	UTSW	18	50,004,759 (GRCm39)	nonsense	probably null
R8702:Dmxl1	UTSW	18	49,992,202 (GRCm39)	missense	probably benign	0.09
R8749:Dmxl1	UTSW	18	50,088,937 (GRCm39)	missense	probably damaging	1.00
R8813:Dmxl1	UTSW	18	50,090,406 (GRCm39)	missense	probably damaging	0.99
R8877:Dmxl1	UTSW	18	50,011,292 (GRCm39)	missense	possibly damaging	0.55
R8945:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	50,026,741 (GRCm39)	missense	probably damaging	1.00
R8971:Dmxl1	UTSW	18	49,997,575 (GRCm39)	missense	possibly damaging	0.96
R8978:Dmxl1	UTSW	18	50,055,679 (GRCm39)	missense	probably benign	0.37
R8987:Dmxl1	UTSW	18	50,026,919 (GRCm39)	missense
R9011:Dmxl1	UTSW	18	49,997,240 (GRCm39)	missense	probably damaging	1.00
R9124:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9131:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9132:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9156:Dmxl1	UTSW	18	50,072,639 (GRCm39)	missense	probably damaging	1.00
R9165:Dmxl1	UTSW	18	50,011,992 (GRCm39)	missense	probably damaging	1.00
R9244:Dmxl1	UTSW	18	50,026,316 (GRCm39)	missense	probably benign
R9254:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9262:Dmxl1	UTSW	18	49,976,919 (GRCm39)	missense	probably benign	0.03
R9335:Dmxl1	UTSW	18	49,992,187 (GRCm39)	missense	probably damaging	0.96
R9375:Dmxl1	UTSW	18	50,091,477 (GRCm39)	missense	probably damaging	1.00
R9379:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.67
R9434:Dmxl1	UTSW	18	50,010,788 (GRCm39)	missense	probably damaging	0.98
R9470:Dmxl1	UTSW	18	50,026,777 (GRCm39)	missense	possibly damaging	0.69
R9500:Dmxl1	UTSW	18	50,011,271 (GRCm39)	missense	probably damaging	1.00
R9507:Dmxl1	UTSW	18	50,024,567 (GRCm39)	missense	possibly damaging	0.94
R9617:Dmxl1	UTSW	18	49,998,228 (GRCm39)	missense	probably damaging	1.00
R9642:Dmxl1	UTSW	18	50,013,825 (GRCm39)	missense	probably damaging	1.00
RF009:Dmxl1	UTSW	18	50,026,461 (GRCm39)	missense	probably damaging	0.96
X0025:Dmxl1	UTSW	18	49,997,435 (GRCm39)	missense	probably damaging	0.98
X0066:Dmxl1	UTSW	18	50,052,966 (GRCm39)	missense	probably damaging	1.00
Z1088:Dmxl1	UTSW	18	50,054,032 (GRCm39)	missense	probably benign
Z1188:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96
Z1189:Dmxl1	UTSW	18	50,001,070 (GRCm39)	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- CATGTGCTAATGACCCATTCTG -3'
(R):5'- GGCCAAGTAACTATACACATATACG -3'

Sequencing Primer
(F):5'- GTGCTAATGACCCATTCTGTAATCTG -3'
(R):5'- GTTTCTCGGTTAAATATGTAGGAT -3'

Posted On

2017-02-10