Incidental Mutation 'R5877:Hdac11'
ID 455599
Institutional Source Beutler Lab
Gene Symbol Hdac11
Ensembl Gene ENSMUSG00000034245
Gene Name histone deacetylase 11
Synonyms
MMRRC Submission 044083-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.284) question?
Stock # R5877 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 91133652-91151674 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 91134524 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 50 (K50E)
Ref Sequence ENSEMBL: ENSMUSP00000121624 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041736] [ENSMUST00000143621]
AlphaFold Q91WA3
Predicted Effect probably benign
Transcript: ENSMUST00000041736
AA Change: K50E

PolyPhen 2 Score 0.123 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000043828
Gene: ENSMUSG00000034245
AA Change: K50E

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 24 321 1e-51 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127768
Predicted Effect probably damaging
Transcript: ENSMUST00000143621
AA Change: K50E

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000121624
Gene: ENSMUSG00000034245
AA Change: K50E

DomainStartEndE-ValueType
Pfam:Hist_deacetyl 23 141 1.6e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150544
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154389
Predicted Effect unknown
Transcript: ENSMUST00000155007
AA Change: K49E
SMART Domains Protein: ENSMUSP00000120923
Gene: ENSMUSG00000034245
AA Change: K49E

DomainStartEndE-ValueType
SCOP:d1c3pa_ 14 122 8e-16 SMART
low complexity region 124 140 N/A INTRINSIC
Meta Mutation Damage Score 0.1411 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.7%
Validation Efficiency 97% (68/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2009]
PHENOTYPE: Mice homozygous for a knockout allele exhibit increased IL10 secretion from peritoneal elicited macrophages stimulated with LPS, more suppressive myeloid-derived suppressive cell population and enhanced tumor growth of injected tumor cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b A T 12: 113,453,822 (GRCm39) H213L probably damaging Het
Alk A G 17: 72,274,521 (GRCm39) W597R probably damaging Het
Ark2n G T 18: 77,730,902 (GRCm39) probably null Het
Ash1l G A 3: 88,888,891 (GRCm39) V257I probably benign Het
Atp9b C T 18: 80,796,004 (GRCm39) V957I probably benign Het
Birc2 A C 9: 7,849,347 (GRCm39) C576G probably damaging Het
Brca2 T C 5: 150,466,686 (GRCm39) M2150T possibly damaging Het
C3ar1 T G 6: 122,827,581 (GRCm39) D212A probably benign Het
Cacna1s T C 1: 136,028,405 (GRCm39) F914S probably damaging Het
Camk1d T C 2: 5,570,476 (GRCm39) I62V probably benign Het
Caskin1 T C 17: 24,724,239 (GRCm39) M1009T possibly damaging Het
Casp2 A G 6: 42,253,571 (GRCm39) probably benign Het
Cd2bp2 T A 7: 126,793,971 (GRCm39) Y106F probably damaging Het
Celsr3 G A 9: 108,722,926 (GRCm39) C2763Y probably damaging Het
Cyp2g1 T G 7: 26,516,065 (GRCm39) L310V possibly damaging Het
Dusp22 G A 13: 30,891,944 (GRCm39) V99M probably damaging Het
Elp1 A T 4: 56,787,807 (GRCm39) W375R probably damaging Het
Fam131b G A 6: 42,297,913 (GRCm39) S92L probably benign Het
Fbxw10 A T 11: 62,748,542 (GRCm39) N390Y probably damaging Het
Flg2 A T 3: 93,110,756 (GRCm39) H928L unknown Het
Gapdhs T C 7: 30,431,772 (GRCm39) T280A probably damaging Het
Hif3a G T 7: 16,785,071 (GRCm39) A181E probably damaging Het
Itgb8 A G 12: 119,166,271 (GRCm39) S87P probably benign Het
Klhl12 T A 1: 134,411,558 (GRCm39) Y302* probably null Het
Lhx1 C A 11: 84,413,065 (GRCm39) D30Y probably damaging Het
Mrpl40 A G 16: 18,691,135 (GRCm39) Y148H probably damaging Het
Myh13 A T 11: 67,244,484 (GRCm39) H1007L possibly damaging Het
Nhlrc2 T C 19: 56,559,016 (GRCm39) I167T probably damaging Het
Nxpe3 A T 16: 55,686,564 (GRCm39) I148K probably damaging Het
Odf2l A G 3: 144,834,771 (GRCm39) probably null Het
Otud7b C T 3: 96,059,277 (GRCm39) R347* probably null Het
P3h4 G T 11: 100,304,843 (GRCm39) H181Q probably benign Het
P4htm T A 9: 108,460,932 (GRCm39) Y180F possibly damaging Het
Pcna-ps2 A G 19: 9,261,463 (GRCm39) I241V probably benign Het
Pcnx2 T C 8: 126,480,467 (GRCm39) S1947G probably damaging Het
Piezo2 T C 18: 63,247,005 (GRCm39) I336V probably benign Het
Plcd1 T C 9: 118,905,240 (GRCm39) D157G probably damaging Het
Plekhm2 A C 4: 141,367,004 (GRCm39) I212S probably damaging Het
Pmvk G T 3: 89,371,676 (GRCm39) C57F probably benign Het
Pole T C 5: 110,480,329 (GRCm39) S91P probably benign Het
Ppargc1b C G 18: 61,442,164 (GRCm39) D591H probably damaging Het
Ppp4r3b A T 11: 29,159,356 (GRCm39) D570V probably damaging Het
Pxdn T A 12: 30,053,045 (GRCm39) I1074N probably damaging Het
Ralgapa2 A T 2: 146,230,489 (GRCm39) D1025E probably damaging Het
Ralgps1 A G 2: 33,133,640 (GRCm39) probably benign Het
Rasal1 C T 5: 120,817,135 (GRCm39) probably benign Het
Rps2 A T 17: 24,939,890 (GRCm39) probably benign Het
Scn7a G C 2: 66,530,217 (GRCm39) Y709* probably null Het
Skint1 T A 4: 111,878,720 (GRCm39) C217* probably null Het
Slc50a1 T C 3: 89,176,460 (GRCm39) Y82C probably damaging Het
Slc9a4 T C 1: 40,651,423 (GRCm39) V567A probably benign Het
Snx27 A T 3: 94,410,270 (GRCm39) W469R probably damaging Het
Sos2 A G 12: 69,643,569 (GRCm39) L937P probably damaging Het
Ssh1 T C 5: 114,081,181 (GRCm39) T728A probably benign Het
Tnfrsf8 G A 4: 145,019,257 (GRCm39) R193C probably benign Het
Tut4 T C 4: 108,370,120 (GRCm39) V673A probably damaging Het
Usp33 T A 3: 152,085,113 (GRCm39) M583K possibly damaging Het
Usp33 G A 3: 152,085,233 (GRCm39) C623Y probably damaging Het
Wdfy3 T C 5: 102,017,855 (GRCm39) I2562V probably damaging Het
Wnk2 T C 13: 49,220,782 (GRCm39) D1175G probably damaging Het
Zfp341 G A 2: 154,474,209 (GRCm39) E338K probably damaging Het
Zfp398 A G 6: 47,817,638 (GRCm39) probably benign Het
Zp2 T A 7: 119,732,562 (GRCm39) K661N probably null Het
Other mutations in Hdac11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01452:Hdac11 APN 6 91,144,843 (GRCm39) missense probably damaging 1.00
IGL01556:Hdac11 APN 6 91,150,162 (GRCm39) missense probably benign 0.00
IGL02159:Hdac11 APN 6 91,150,084 (GRCm39) missense probably damaging 0.99
IGL03082:Hdac11 APN 6 91,150,085 (GRCm39) missense probably damaging 1.00
IGL03046:Hdac11 UTSW 6 91,145,827 (GRCm39) missense probably benign 0.02
R1791:Hdac11 UTSW 6 91,145,806 (GRCm39) missense probably benign
R5771:Hdac11 UTSW 6 91,146,364 (GRCm39) splice site probably null
R5974:Hdac11 UTSW 6 91,150,196 (GRCm39) missense probably benign
R6803:Hdac11 UTSW 6 91,143,247 (GRCm39) missense probably damaging 0.97
R7483:Hdac11 UTSW 6 91,136,214 (GRCm39) missense probably damaging 0.99
R7786:Hdac11 UTSW 6 91,150,158 (GRCm39) nonsense probably null
R8259:Hdac11 UTSW 6 91,149,210 (GRCm39) missense probably damaging 1.00
R8990:Hdac11 UTSW 6 91,145,799 (GRCm39) nonsense probably null
R9681:Hdac11 UTSW 6 91,150,068 (GRCm39) missense probably benign 0.11
Z1177:Hdac11 UTSW 6 91,144,816 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- TCCACAAGGAGGCTGTTGTC -3'
(R):5'- CCTTTAACAGCAAGGCAGAAG -3'

Sequencing Primer
(F):5'- CACAAGGAGGCTGTTGTCCATATG -3'
(R):5'- AGGTCTGAGGAGGTAGTATG -3'
Posted On 2017-02-10