Incidental Mutation 'R5877:Wnk2'
ID 455620
Institutional Source Beutler Lab
Gene Symbol Wnk2
Ensembl Gene ENSMUSG00000037989
Gene Name WNK lysine deficient protein kinase 2
Synonyms X83337, ESTM15, 1810073P09Rik
MMRRC Submission 044083-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.287) question?
Stock # R5877 (G1)
Quality Score 181
Status Validated
Chromosome 13
Chromosomal Location 49189779-49301490 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 49220782 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 1175 (D1175G)
Ref Sequence ENSEMBL: ENSMUSP00000105723 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035538] [ENSMUST00000049265] [ENSMUST00000091623] [ENSMUST00000110096] [ENSMUST00000110097] [ENSMUST00000159559] [ENSMUST00000160087] [ENSMUST00000162403] [ENSMUST00000162581]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000035538
AA Change: D1273G

PolyPhen 2 Score 0.215 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000047231
Gene: ENSMUSG00000037989
AA Change: D1273G

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.5e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.6e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 6.72e-6 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
low complexity region 2033 2053 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000049265
AA Change: D1273G

PolyPhen 2 Score 0.119 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000049327
Gene: ENSMUSG00000037989
AA Change: D1273G

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
S_TKc 195 453 3.3e-19 SMART
Pfam:OSR1_C 474 511 5.6e-19 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 9.51e-6 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
internal_repeat_2 1611 1703 2.12e-5 PROSPERO
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
internal_repeat_2 1923 2023 2.12e-5 PROSPERO
low complexity region 2069 2089 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000091623
AA Change: D1273G

PolyPhen 2 Score 0.716 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000089212
Gene: ENSMUSG00000037989
AA Change: D1273G

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 1.6e-41 PFAM
Pfam:Pkinase 195 453 1e-54 PFAM
Pfam:OSR1_C 474 511 4e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 1.52e-5 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
internal_repeat_2 1611 1713 7.41e-5 PROSPERO
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
internal_repeat_2 1923 2027 7.41e-5 PROSPERO
low complexity region 2117 2137 N/A INTRINSIC
low complexity region 2191 2202 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000110096
AA Change: D1175G

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000105723
Gene: ENSMUSG00000037989
AA Change: D1175G

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.6e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.6e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 1015 1038 N/A INTRINSIC
internal_repeat_1 1064 1087 2.89e-5 PROSPERO
low complexity region 1177 1194 N/A INTRINSIC
low complexity region 1219 1255 N/A INTRINSIC
low complexity region 1331 1343 N/A INTRINSIC
low complexity region 1351 1359 N/A INTRINSIC
low complexity region 1366 1391 N/A INTRINSIC
low complexity region 1489 1498 N/A INTRINSIC
low complexity region 1721 1732 N/A INTRINSIC
coiled coil region 1737 1768 N/A INTRINSIC
low complexity region 2018 2038 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110097
AA Change: D1273G

PolyPhen 2 Score 0.446 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000105724
Gene: ENSMUSG00000037989
AA Change: D1273G

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.7e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.8e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 1.16e-5 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
internal_repeat_2 1611 1713 5.74e-5 PROSPERO
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
internal_repeat_2 1923 2027 5.74e-5 PROSPERO
low complexity region 2117 2137 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000159559
AA Change: D1261G

PolyPhen 2 Score 0.740 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000123915
Gene: ENSMUSG00000037989
AA Change: D1261G

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.7e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.8e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 736 N/A INTRINSIC
low complexity region 759 791 N/A INTRINSIC
low complexity region 809 819 N/A INTRINSIC
low complexity region 828 842 N/A INTRINSIC
low complexity region 863 878 N/A INTRINSIC
low complexity region 926 942 N/A INTRINSIC
low complexity region 971 1002 N/A INTRINSIC
low complexity region 1009 1036 N/A INTRINSIC
low complexity region 1101 1124 N/A INTRINSIC
internal_repeat_1 1150 1173 7.19e-6 PROSPERO
low complexity region 1263 1280 N/A INTRINSIC
low complexity region 1305 1341 N/A INTRINSIC
low complexity region 1417 1429 N/A INTRINSIC
low complexity region 1437 1445 N/A INTRINSIC
low complexity region 1452 1477 N/A INTRINSIC
low complexity region 1575 1585 N/A INTRINSIC
internal_repeat_2 1599 1701 3.66e-5 PROSPERO
low complexity region 1808 1819 N/A INTRINSIC
coiled coil region 1824 1855 N/A INTRINSIC
internal_repeat_2 1911 2015 3.66e-5 PROSPERO
low complexity region 2105 2125 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000160087
AA Change: D415G

PolyPhen 2 Score 0.954 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124614
Gene: ENSMUSG00000037989
AA Change: D415G

DomainStartEndE-ValueType
low complexity region 61 71 N/A INTRINSIC
low complexity region 80 94 N/A INTRINSIC
low complexity region 115 130 N/A INTRINSIC
low complexity region 178 194 N/A INTRINSIC
low complexity region 255 278 N/A INTRINSIC
low complexity region 417 434 N/A INTRINSIC
low complexity region 459 495 N/A INTRINSIC
low complexity region 571 583 N/A INTRINSIC
low complexity region 591 599 N/A INTRINSIC
low complexity region 606 631 N/A INTRINSIC
low complexity region 729 738 N/A INTRINSIC
low complexity region 961 972 N/A INTRINSIC
coiled coil region 977 1008 N/A INTRINSIC
low complexity region 1258 1278 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162403
AA Change: D1163G

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000125539
Gene: ENSMUSG00000037989
AA Change: D1163G

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.3e-42 PFAM
Pfam:Pkinase 195 453 1.6e-56 PFAM
Pfam:OSR1_C 474 511 5.3e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 736 N/A INTRINSIC
low complexity region 759 791 N/A INTRINSIC
low complexity region 809 819 N/A INTRINSIC
low complexity region 828 842 N/A INTRINSIC
low complexity region 863 878 N/A INTRINSIC
low complexity region 926 942 N/A INTRINSIC
low complexity region 1003 1026 N/A INTRINSIC
internal_repeat_1 1052 1075 1.05e-5 PROSPERO
low complexity region 1165 1182 N/A INTRINSIC
low complexity region 1207 1243 N/A INTRINSIC
low complexity region 1319 1331 N/A INTRINSIC
low complexity region 1339 1347 N/A INTRINSIC
low complexity region 1354 1379 N/A INTRINSIC
low complexity region 1477 1487 N/A INTRINSIC
internal_repeat_2 1501 1593 2.32e-5 PROSPERO
low complexity region 1710 1721 N/A INTRINSIC
coiled coil region 1726 1757 N/A INTRINSIC
internal_repeat_2 1813 1913 2.32e-5 PROSPERO
low complexity region 1959 1979 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162581
AA Change: D1273G

PolyPhen 2 Score 0.215 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000125448
Gene: ENSMUSG00000037989
AA Change: D1273G

DomainStartEndE-ValueType
low complexity region 2 9 N/A INTRINSIC
low complexity region 66 78 N/A INTRINSIC
low complexity region 88 116 N/A INTRINSIC
low complexity region 124 136 N/A INTRINSIC
low complexity region 171 182 N/A INTRINSIC
Pfam:Pkinase_Tyr 195 451 4.5e-42 PFAM
Pfam:Pkinase 195 453 1.7e-56 PFAM
Pfam:OSR1_C 474 511 5.6e-22 PFAM
low complexity region 582 593 N/A INTRINSIC
low complexity region 626 642 N/A INTRINSIC
low complexity region 678 693 N/A INTRINSIC
low complexity region 707 724 N/A INTRINSIC
low complexity region 771 803 N/A INTRINSIC
low complexity region 821 831 N/A INTRINSIC
low complexity region 840 854 N/A INTRINSIC
low complexity region 875 890 N/A INTRINSIC
low complexity region 938 954 N/A INTRINSIC
low complexity region 983 1014 N/A INTRINSIC
low complexity region 1021 1048 N/A INTRINSIC
low complexity region 1113 1136 N/A INTRINSIC
internal_repeat_1 1162 1185 6.72e-6 PROSPERO
low complexity region 1275 1292 N/A INTRINSIC
low complexity region 1317 1353 N/A INTRINSIC
low complexity region 1429 1441 N/A INTRINSIC
low complexity region 1449 1457 N/A INTRINSIC
low complexity region 1464 1489 N/A INTRINSIC
low complexity region 1587 1597 N/A INTRINSIC
low complexity region 1820 1831 N/A INTRINSIC
coiled coil region 1836 1867 N/A INTRINSIC
low complexity region 2033 2053 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000159633
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.2%
  • 20x: 94.7%
Validation Efficiency 97% (68/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam6b A T 12: 113,453,822 (GRCm39) H213L probably damaging Het
Alk A G 17: 72,274,521 (GRCm39) W597R probably damaging Het
Ark2n G T 18: 77,730,902 (GRCm39) probably null Het
Ash1l G A 3: 88,888,891 (GRCm39) V257I probably benign Het
Atp9b C T 18: 80,796,004 (GRCm39) V957I probably benign Het
Birc2 A C 9: 7,849,347 (GRCm39) C576G probably damaging Het
Brca2 T C 5: 150,466,686 (GRCm39) M2150T possibly damaging Het
C3ar1 T G 6: 122,827,581 (GRCm39) D212A probably benign Het
Cacna1s T C 1: 136,028,405 (GRCm39) F914S probably damaging Het
Camk1d T C 2: 5,570,476 (GRCm39) I62V probably benign Het
Caskin1 T C 17: 24,724,239 (GRCm39) M1009T possibly damaging Het
Casp2 A G 6: 42,253,571 (GRCm39) probably benign Het
Cd2bp2 T A 7: 126,793,971 (GRCm39) Y106F probably damaging Het
Celsr3 G A 9: 108,722,926 (GRCm39) C2763Y probably damaging Het
Cyp2g1 T G 7: 26,516,065 (GRCm39) L310V possibly damaging Het
Dusp22 G A 13: 30,891,944 (GRCm39) V99M probably damaging Het
Elp1 A T 4: 56,787,807 (GRCm39) W375R probably damaging Het
Fam131b G A 6: 42,297,913 (GRCm39) S92L probably benign Het
Fbxw10 A T 11: 62,748,542 (GRCm39) N390Y probably damaging Het
Flg2 A T 3: 93,110,756 (GRCm39) H928L unknown Het
Gapdhs T C 7: 30,431,772 (GRCm39) T280A probably damaging Het
Hdac11 A G 6: 91,134,524 (GRCm39) K50E probably damaging Het
Hif3a G T 7: 16,785,071 (GRCm39) A181E probably damaging Het
Itgb8 A G 12: 119,166,271 (GRCm39) S87P probably benign Het
Klhl12 T A 1: 134,411,558 (GRCm39) Y302* probably null Het
Lhx1 C A 11: 84,413,065 (GRCm39) D30Y probably damaging Het
Mrpl40 A G 16: 18,691,135 (GRCm39) Y148H probably damaging Het
Myh13 A T 11: 67,244,484 (GRCm39) H1007L possibly damaging Het
Nhlrc2 T C 19: 56,559,016 (GRCm39) I167T probably damaging Het
Nxpe3 A T 16: 55,686,564 (GRCm39) I148K probably damaging Het
Odf2l A G 3: 144,834,771 (GRCm39) probably null Het
Otud7b C T 3: 96,059,277 (GRCm39) R347* probably null Het
P3h4 G T 11: 100,304,843 (GRCm39) H181Q probably benign Het
P4htm T A 9: 108,460,932 (GRCm39) Y180F possibly damaging Het
Pcna-ps2 A G 19: 9,261,463 (GRCm39) I241V probably benign Het
Pcnx2 T C 8: 126,480,467 (GRCm39) S1947G probably damaging Het
Piezo2 T C 18: 63,247,005 (GRCm39) I336V probably benign Het
Plcd1 T C 9: 118,905,240 (GRCm39) D157G probably damaging Het
Plekhm2 A C 4: 141,367,004 (GRCm39) I212S probably damaging Het
Pmvk G T 3: 89,371,676 (GRCm39) C57F probably benign Het
Pole T C 5: 110,480,329 (GRCm39) S91P probably benign Het
Ppargc1b C G 18: 61,442,164 (GRCm39) D591H probably damaging Het
Ppp4r3b A T 11: 29,159,356 (GRCm39) D570V probably damaging Het
Pxdn T A 12: 30,053,045 (GRCm39) I1074N probably damaging Het
Ralgapa2 A T 2: 146,230,489 (GRCm39) D1025E probably damaging Het
Ralgps1 A G 2: 33,133,640 (GRCm39) probably benign Het
Rasal1 C T 5: 120,817,135 (GRCm39) probably benign Het
Rps2 A T 17: 24,939,890 (GRCm39) probably benign Het
Scn7a G C 2: 66,530,217 (GRCm39) Y709* probably null Het
Skint1 T A 4: 111,878,720 (GRCm39) C217* probably null Het
Slc50a1 T C 3: 89,176,460 (GRCm39) Y82C probably damaging Het
Slc9a4 T C 1: 40,651,423 (GRCm39) V567A probably benign Het
Snx27 A T 3: 94,410,270 (GRCm39) W469R probably damaging Het
Sos2 A G 12: 69,643,569 (GRCm39) L937P probably damaging Het
Ssh1 T C 5: 114,081,181 (GRCm39) T728A probably benign Het
Tnfrsf8 G A 4: 145,019,257 (GRCm39) R193C probably benign Het
Tut4 T C 4: 108,370,120 (GRCm39) V673A probably damaging Het
Usp33 T A 3: 152,085,113 (GRCm39) M583K possibly damaging Het
Usp33 G A 3: 152,085,233 (GRCm39) C623Y probably damaging Het
Wdfy3 T C 5: 102,017,855 (GRCm39) I2562V probably damaging Het
Zfp341 G A 2: 154,474,209 (GRCm39) E338K probably damaging Het
Zfp398 A G 6: 47,817,638 (GRCm39) probably benign Het
Zp2 T A 7: 119,732,562 (GRCm39) K661N probably null Het
Other mutations in Wnk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01518:Wnk2 APN 13 49,221,668 (GRCm39) missense possibly damaging 0.89
IGL01575:Wnk2 APN 13 49,300,152 (GRCm39) missense probably damaging 1.00
IGL01601:Wnk2 APN 13 49,230,038 (GRCm39) missense probably damaging 1.00
IGL01775:Wnk2 APN 13 49,224,586 (GRCm39) missense probably damaging 1.00
IGL02013:Wnk2 APN 13 49,235,510 (GRCm39) missense possibly damaging 0.46
IGL02016:Wnk2 APN 13 49,210,381 (GRCm39) missense probably damaging 1.00
IGL02167:Wnk2 APN 13 49,224,601 (GRCm39) critical splice acceptor site probably null
IGL02174:Wnk2 APN 13 49,210,643 (GRCm39) missense probably damaging 1.00
IGL02210:Wnk2 APN 13 49,244,345 (GRCm39) missense probably damaging 0.98
IGL02228:Wnk2 APN 13 49,210,416 (GRCm39) missense probably damaging 1.00
IGL02282:Wnk2 APN 13 49,221,601 (GRCm39) missense probably damaging 1.00
IGL02319:Wnk2 APN 13 49,214,914 (GRCm39) missense possibly damaging 0.73
IGL02394:Wnk2 APN 13 49,235,375 (GRCm39) splice site probably null
IGL02624:Wnk2 APN 13 49,256,278 (GRCm39) missense probably damaging 1.00
IGL02743:Wnk2 APN 13 49,248,920 (GRCm39) missense probably damaging 1.00
IGL03012:Wnk2 APN 13 49,197,865 (GRCm39) missense probably damaging 0.99
IGL03166:Wnk2 APN 13 49,224,520 (GRCm39) nonsense probably null
R0034:Wnk2 UTSW 13 49,221,556 (GRCm39) missense possibly damaging 0.64
R0385:Wnk2 UTSW 13 49,221,604 (GRCm39) missense probably damaging 1.00
R0423:Wnk2 UTSW 13 49,248,894 (GRCm39) missense possibly damaging 0.91
R0504:Wnk2 UTSW 13 49,238,872 (GRCm39) missense probably damaging 1.00
R0504:Wnk2 UTSW 13 49,238,870 (GRCm39) missense possibly damaging 0.92
R0653:Wnk2 UTSW 13 49,210,492 (GRCm39) missense possibly damaging 0.85
R1135:Wnk2 UTSW 13 49,230,034 (GRCm39) missense probably damaging 1.00
R1445:Wnk2 UTSW 13 49,224,586 (GRCm39) missense probably damaging 1.00
R1464:Wnk2 UTSW 13 49,235,451 (GRCm39) missense probably damaging 1.00
R1464:Wnk2 UTSW 13 49,235,451 (GRCm39) missense probably damaging 1.00
R1468:Wnk2 UTSW 13 49,235,571 (GRCm39) missense probably damaging 0.99
R1468:Wnk2 UTSW 13 49,235,571 (GRCm39) missense probably damaging 0.99
R1480:Wnk2 UTSW 13 49,210,708 (GRCm39) missense probably damaging 1.00
R1605:Wnk2 UTSW 13 49,214,370 (GRCm39) missense probably damaging 1.00
R1719:Wnk2 UTSW 13 49,214,202 (GRCm39) missense possibly damaging 0.76
R1891:Wnk2 UTSW 13 49,206,200 (GRCm39) nonsense probably null
R1966:Wnk2 UTSW 13 49,192,487 (GRCm39) missense probably damaging 0.96
R2001:Wnk2 UTSW 13 49,232,158 (GRCm39) missense possibly damaging 0.61
R2310:Wnk2 UTSW 13 49,204,053 (GRCm39) missense probably damaging 0.97
R2356:Wnk2 UTSW 13 49,192,644 (GRCm39) nonsense probably null
R2406:Wnk2 UTSW 13 49,214,964 (GRCm39) missense possibly damaging 0.86
R2519:Wnk2 UTSW 13 49,224,505 (GRCm39) missense probably damaging 0.99
R3962:Wnk2 UTSW 13 49,224,453 (GRCm39) missense probably damaging 1.00
R4160:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4161:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4226:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4227:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4234:Wnk2 UTSW 13 49,214,604 (GRCm39) missense probably benign 0.33
R4304:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4308:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4584:Wnk2 UTSW 13 49,244,313 (GRCm39) missense probably damaging 1.00
R4655:Wnk2 UTSW 13 49,210,359 (GRCm39) missense probably damaging 1.00
R4715:Wnk2 UTSW 13 49,300,708 (GRCm39) start codon destroyed unknown
R4887:Wnk2 UTSW 13 49,224,478 (GRCm39) missense probably damaging 1.00
R4888:Wnk2 UTSW 13 49,224,478 (GRCm39) missense probably damaging 1.00
R4945:Wnk2 UTSW 13 49,210,722 (GRCm39) missense probably damaging 1.00
R5182:Wnk2 UTSW 13 49,214,637 (GRCm39) missense possibly damaging 0.92
R5243:Wnk2 UTSW 13 49,226,054 (GRCm39) missense possibly damaging 0.51
R5370:Wnk2 UTSW 13 49,256,437 (GRCm39) missense probably damaging 1.00
R5771:Wnk2 UTSW 13 49,256,276 (GRCm39) missense probably damaging 1.00
R5900:Wnk2 UTSW 13 49,256,308 (GRCm39) missense probably damaging 1.00
R5905:Wnk2 UTSW 13 49,229,821 (GRCm39) missense probably damaging 0.99
R5912:Wnk2 UTSW 13 49,214,250 (GRCm39) missense probably damaging 1.00
R5915:Wnk2 UTSW 13 49,231,561 (GRCm39) missense probably damaging 0.99
R6028:Wnk2 UTSW 13 49,229,821 (GRCm39) missense probably damaging 0.99
R6074:Wnk2 UTSW 13 49,204,875 (GRCm39) missense probably damaging 1.00
R6171:Wnk2 UTSW 13 49,214,308 (GRCm39) missense probably damaging 1.00
R6368:Wnk2 UTSW 13 49,214,814 (GRCm39) missense probably damaging 0.99
R6467:Wnk2 UTSW 13 49,300,081 (GRCm39) missense probably damaging 1.00
R6501:Wnk2 UTSW 13 49,300,159 (GRCm39) missense probably damaging 1.00
R6849:Wnk2 UTSW 13 49,220,834 (GRCm39) missense probably damaging 1.00
R6898:Wnk2 UTSW 13 49,224,557 (GRCm39) missense probably damaging 1.00
R6949:Wnk2 UTSW 13 49,254,616 (GRCm39) missense probably damaging 1.00
R7011:Wnk2 UTSW 13 49,224,567 (GRCm39) missense probably damaging 0.99
R7097:Wnk2 UTSW 13 49,256,314 (GRCm39) missense possibly damaging 0.86
R7121:Wnk2 UTSW 13 49,300,653 (GRCm39) missense probably benign 0.26
R7123:Wnk2 UTSW 13 49,235,462 (GRCm39) missense possibly damaging 0.90
R7423:Wnk2 UTSW 13 49,191,608 (GRCm39) missense probably benign 0.07
R7502:Wnk2 UTSW 13 49,300,720 (GRCm39) splice site probably null
R7529:Wnk2 UTSW 13 49,254,457 (GRCm39) missense possibly damaging 0.50
R7751:Wnk2 UTSW 13 49,231,493 (GRCm39) missense unknown
R7979:Wnk2 UTSW 13 49,248,884 (GRCm39) missense probably damaging 1.00
R8118:Wnk2 UTSW 13 49,244,459 (GRCm39) missense probably damaging 0.99
R8121:Wnk2 UTSW 13 49,214,415 (GRCm39) nonsense probably null
R8155:Wnk2 UTSW 13 49,192,577 (GRCm39) missense unknown
R8329:Wnk2 UTSW 13 49,248,914 (GRCm39) missense probably damaging 1.00
R8334:Wnk2 UTSW 13 49,203,958 (GRCm39) critical splice donor site probably null
R8872:Wnk2 UTSW 13 49,210,960 (GRCm39) missense probably benign 0.00
R8919:Wnk2 UTSW 13 49,221,711 (GRCm39) missense possibly damaging 0.86
R9091:Wnk2 UTSW 13 49,224,505 (GRCm39) missense probably benign 0.41
R9234:Wnk2 UTSW 13 49,224,274 (GRCm39) missense probably damaging 0.99
R9262:Wnk2 UTSW 13 49,221,430 (GRCm39) missense probably benign 0.12
R9268:Wnk2 UTSW 13 49,235,507 (GRCm39) missense possibly damaging 0.82
R9270:Wnk2 UTSW 13 49,224,505 (GRCm39) missense probably benign 0.41
R9386:Wnk2 UTSW 13 49,220,822 (GRCm39) missense probably damaging 0.98
R9582:Wnk2 UTSW 13 49,210,975 (GRCm39) missense probably benign 0.01
R9617:Wnk2 UTSW 13 49,192,453 (GRCm39) missense unknown
R9625:Wnk2 UTSW 13 49,254,445 (GRCm39) missense probably benign 0.20
R9794:Wnk2 UTSW 13 49,229,674 (GRCm39) missense probably benign 0.02
RF023:Wnk2 UTSW 13 49,300,255 (GRCm39) missense probably benign 0.00
X0025:Wnk2 UTSW 13 49,214,418 (GRCm39) missense probably damaging 0.99
X0063:Wnk2 UTSW 13 49,192,453 (GRCm39) missense unknown
Z1176:Wnk2 UTSW 13 49,191,537 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- GAAGTGGTAACTTGGCCTGCAG -3'
(R):5'- TAAGAGGGAGCTTGAGTCCC -3'

Sequencing Primer
(F):5'- TGACAGTATGGGTCAGCAGC -3'
(R):5'- AGCTTGAGTCCCTGCTCACAG -3'
Posted On 2017-02-10