Mutagenetix > Incidental Mutation

Incidental Mutation 'R5878:Itpr3'

455682

Institutional Source

Beutler Lab

Gene Symbol

Itpr3

Ensembl Gene

ENSMUSG00000042644

Gene Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

tf, Ip3r3, Itpr-3

MMRRC Submission

044084-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5878 (G1)

Quality Score

156

Status

Validated

Chromosome

Chromosomal Location

27057304-27122223 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 27110862 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 1543 (D1543E)

Ref Sequence

ENSEMBL: ENSMUSP00000038150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049308]

AlphaFold

P70227

PDB Structure

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor [X-RAY DIFFRACTION]

Predicted Effect

probably benign
Transcript: ENSMUST00000049308
AA Change: D1543E

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000038150
Gene: ENSMUSG00000042644
AA Change: D1543E

Domain	Start	End	E-Value	Type
MIR	113	167	7.75e-6	SMART
MIR	174	224	1.16e-4	SMART
MIR	232	288	1.21e-7	SMART
MIR	295	402	9.38e-14	SMART
Pfam:RYDR_ITPR	473	670	7.8e-64	PFAM
low complexity region	881	889	N/A	INTRINSIC
Pfam:RYDR_ITPR	1175	1333	5.8e-16	PFAM
low complexity region	1549	1567	N/A	INTRINSIC
low complexity region	1831	1851	N/A	INTRINSIC
Pfam:RIH_assoc	1863	1973	2.6e-34	PFAM
transmembrane domain	2203	2225	N/A	INTRINSIC
Pfam:Ion_trans	2235	2527	8.1e-20	PFAM
coiled coil region	2631	2660	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.7%

Validation Efficiency

99% (66/67)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca12	A	T	1: 71,346,633 (GRCm38)	N275K	possibly damaging	Het
Abhd6	G	A	14: 8,028,286 (GRCm38)	V6I	probably benign	Het
Afap1l2	T	C	19: 56,915,675 (GRCm38)	T727A	probably benign	Het
Aggf1	T	C	13: 95,369,557 (GRCm38)	E174G	probably benign	Het
Ahnak	T	G	19: 9,008,342 (GRCm38)	L2330R	probably damaging	Het
Arb2a	T	A	13: 77,952,067 (GRCm38)	V129E	probably damaging	Het
Arfgef2	A	G	2: 166,870,217 (GRCm38)	T1205A	probably benign	Het
Ccdc3	T	C	2: 5,229,016 (GRCm38)	L217P	probably benign	Het
Cfap54	T	C	10: 92,964,561 (GRCm38)	D1595G	probably benign	Het
Cps1	G	T	1: 67,157,878 (GRCm38)		probably null	Het
Fam120b	A	G	17: 15,402,240 (GRCm38)	D160G	probably damaging	Het
Fezf1	C	A	6: 23,247,581 (GRCm38)	R165L	possibly damaging	Het
Fkbp15	A	T	4: 62,306,908 (GRCm38)	L838H	probably benign	Het
Frmd3	G	A	4: 74,153,610 (GRCm38)	G243D	probably damaging	Het
Gldc	A	T	19: 30,143,467 (GRCm38)		probably null	Het
Gm10188	T	C	1: 132,229,202 (GRCm38)		probably benign	Het
Gm5190	T	A	12: 113,397,239 (GRCm38)		noncoding transcript	Het
Gria1	T	C	11: 57,317,802 (GRCm38)		probably null	Het
Hdhd5	A	G	6: 120,514,524 (GRCm38)	L206P	probably damaging	Het
Herc2	A	G	7: 56,124,248 (GRCm38)	N1149S	probably benign	Het
Inca1	G	A	11: 70,695,982 (GRCm38)		probably benign	Het
Iqch	G	A	9: 63,547,990 (GRCm38)	S175F	probably damaging	Het
Khk	T	A	5: 30,930,875 (GRCm38)		probably null	Het
Kiz	C	T	2: 146,889,601 (GRCm38)	S337L	probably damaging	Het
Lzts3	G	A	2: 130,636,539 (GRCm38)	T213I	probably damaging	Het
Mab21l2	T	A	3: 86,546,718 (GRCm38)	D325V	probably damaging	Het
Mctp2	A	G	7: 72,214,108 (GRCm38)	S336P	probably benign	Het
Me3	T	A	7: 89,848,006 (GRCm38)	L405Q	probably benign	Het
Mgst2	A	T	3: 51,661,230 (GRCm38)		probably benign	Het
Myh2	A	G	11: 67,192,504 (GRCm38)	E1431G	probably damaging	Het
Naip6	A	G	13: 100,299,673 (GRCm38)	S781P	probably damaging	Het
Nr3c2	A	G	8: 76,908,268 (GRCm38)		probably null	Het
Or10ab5	A	T	7: 108,645,739 (GRCm38)	L279Q	probably damaging	Het
Or6s1	A	G	14: 51,070,992 (GRCm38)	Y134H	probably damaging	Het
Or6x1	C	T	9: 40,187,571 (GRCm38)	T152I	probably benign	Het
Otop1	G	T	5: 38,277,822 (GRCm38)	R132L	possibly damaging	Het
Parg	T	A	14: 32,217,662 (GRCm38)	D548E	possibly damaging	Het
Pcdhga4	G	T	18: 37,687,686 (GRCm38)	G763W	probably benign	Het
Pde10a	A	G	17: 8,949,372 (GRCm38)	N9S	possibly damaging	Het
Pi4k2a	T	C	19: 42,100,641 (GRCm38)	I147T	probably benign	Het
Polh	T	A	17: 46,194,325 (GRCm38)	T122S	probably damaging	Het
Ptpn13	T	C	5: 103,477,118 (GRCm38)	V96A	possibly damaging	Het
Ptpn6	C	A	6: 124,728,785 (GRCm38)	C132F	probably damaging	Het
Rbm19	T	A	5: 120,132,867 (GRCm38)	V585E	probably damaging	Het
Relch	T	A	1: 105,692,960 (GRCm38)	S387T	probably benign	Het
Rp1l1	C	T	14: 64,028,906 (GRCm38)	P647L	probably benign	Het
Rrp1b	A	G	17: 32,047,675 (GRCm38)	E72G	probably damaging	Het
Shcbp1	A	T	8: 4,748,742 (GRCm38)	H392Q	probably benign	Het
Skic2	C	T	17: 34,846,117 (GRCm38)	R371Q	possibly damaging	Het
Slc13a5	G	A	11: 72,253,391 (GRCm38)	T287I	possibly damaging	Het
Slc22a27	T	A	19: 7,926,757 (GRCm38)	E5V	probably benign	Het
Slc38a2	A	G	15: 96,692,584 (GRCm38)	V293A	probably damaging	Het
Slco6d1	T	A	1: 98,463,836 (GRCm38)		probably benign	Het
Sri	G	C	5: 8,059,353 (GRCm38)	D46H	probably damaging	Het
Tango6	A	G	8: 106,689,168 (GRCm38)	D207G	possibly damaging	Het
Tigd4	T	C	3: 84,594,442 (GRCm38)	M222T	probably benign	Het
Tmem229a	T	C	6: 24,955,173 (GRCm38)	D194G	probably benign	Het
Trank1	T	C	9: 111,366,685 (GRCm38)	V1259A	possibly damaging	Het
Trdv5	T	C	14: 54,148,798 (GRCm38)	D70G	probably benign	Het
Trim52	T	A	14: 106,106,941 (GRCm38)	M11K	probably damaging	Het
Wdr62	A	G	7: 30,241,347 (GRCm38)	M882T	probably benign	Het
Ybx3	A	G	6: 131,367,763 (GRCm38)		probably null	Het
Zfand2b	A	G	1: 75,170,510 (GRCm38)		probably benign	Het
Zfp91	T	A	19: 12,770,320 (GRCm38)	T480S	possibly damaging	Het

Other mutations in Itpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Itpr3	APN	17	27,083,629 (GRCm38)	missense	probably benign	0.05
IGL00980:Itpr3	APN	17	27,110,956 (GRCm38)	missense	probably benign
IGL01151:Itpr3	APN	17	27,091,529 (GRCm38)	missense	probably damaging	1.00
IGL01289:Itpr3	APN	17	27,099,765 (GRCm38)	missense	probably damaging	0.99
IGL01403:Itpr3	APN	17	27,118,595 (GRCm38)	missense	probably damaging	0.97
IGL01666:Itpr3	APN	17	27,117,178 (GRCm38)	missense	probably benign	0.02
IGL01897:Itpr3	APN	17	27,111,262 (GRCm38)	missense	probably damaging	1.00
IGL02003:Itpr3	APN	17	27,121,475 (GRCm38)	missense	probably damaging	1.00
IGL02012:Itpr3	APN	17	27,104,095 (GRCm38)	missense	probably benign
IGL02063:Itpr3	APN	17	27,120,023 (GRCm38)	missense	probably benign	0.01
IGL02146:Itpr3	APN	17	27,117,275 (GRCm38)	missense	probably damaging	1.00
IGL02158:Itpr3	APN	17	27,098,442 (GRCm38)	missense	probably damaging	1.00
IGL02177:Itpr3	APN	17	27,099,614 (GRCm38)	missense	possibly damaging	0.74
IGL02247:Itpr3	APN	17	27,098,179 (GRCm38)	missense	probably damaging	1.00
IGL02606:Itpr3	APN	17	27,114,512 (GRCm38)	splice site	probably benign
IGL02651:Itpr3	APN	17	27,106,398 (GRCm38)	missense	probably damaging	0.99
IGL02902:Itpr3	APN	17	27,104,556 (GRCm38)	missense	probably benign	0.21
IGL03001:Itpr3	APN	17	27,089,612 (GRCm38)	splice site	probably benign
IGL03004:Itpr3	APN	17	27,097,978 (GRCm38)	missense	possibly damaging	0.90
IGL03065:Itpr3	APN	17	27,091,933 (GRCm38)	missense	probably damaging	1.00
IGL03117:Itpr3	APN	17	27,119,266 (GRCm38)	missense	probably damaging	1.00
IGL03181:Itpr3	APN	17	27,111,268 (GRCm38)	missense	probably benign
IGL03404:Itpr3	APN	17	27,091,518 (GRCm38)	missense	probably damaging	1.00
Allure	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
alopecia	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98
Beauty	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
Opuesto	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
Paradox	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
Pulchritude	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R0010:Itpr3	UTSW	17	27,120,977 (GRCm38)	missense	probably damaging	1.00
R0055:Itpr3	UTSW	17	27,098,322 (GRCm38)	missense	probably damaging	1.00
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0104:Itpr3	UTSW	17	27,095,992 (GRCm38)	missense	probably benign	0.01
R0195:Itpr3	UTSW	17	27,114,114 (GRCm38)	missense	probably damaging	1.00
R0212:Itpr3	UTSW	17	27,089,319 (GRCm38)	missense	probably damaging	1.00
R0454:Itpr3	UTSW	17	27,113,819 (GRCm38)	missense	probably benign
R0485:Itpr3	UTSW	17	27,111,929 (GRCm38)	missense	probably damaging	0.98
R0501:Itpr3	UTSW	17	27,107,289 (GRCm38)	missense	probably benign	0.09
R0781:Itpr3	UTSW	17	27,110,555 (GRCm38)	missense	probably benign	0.00
R0890:Itpr3	UTSW	17	27,089,011 (GRCm38)	nonsense	probably null
R1028:Itpr3	UTSW	17	27,091,369 (GRCm38)	missense	probably benign	0.04
R1144:Itpr3	UTSW	17	27,114,923 (GRCm38)	missense	probably benign	0.01
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1458:Itpr3	UTSW	17	27,118,372 (GRCm38)	missense	probably benign	0.01
R1463:Itpr3	UTSW	17	27,117,154 (GRCm38)	splice site	probably benign
R1472:Itpr3	UTSW	17	27,114,225 (GRCm38)	missense	probably benign	0.09
R1529:Itpr3	UTSW	17	27,105,485 (GRCm38)	splice site	probably null
R1533:Itpr3	UTSW	17	27,095,560 (GRCm38)	missense	possibly damaging	0.71
R1537:Itpr3	UTSW	17	27,114,147 (GRCm38)	missense	possibly damaging	0.96
R1618:Itpr3	UTSW	17	27,116,607 (GRCm38)	critical splice acceptor site	probably null
R1672:Itpr3	UTSW	17	27,089,013 (GRCm38)	missense	probably benign
R1726:Itpr3	UTSW	17	27,111,690 (GRCm38)	missense	probably damaging	0.96
R1865:Itpr3	UTSW	17	27,120,023 (GRCm38)	missense	probably benign	0.01
R1940:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R2023:Itpr3	UTSW	17	27,102,811 (GRCm38)	missense	possibly damaging	0.76
R2063:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2064:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2065:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2067:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2068:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2219:Itpr3	UTSW	17	27,115,053 (GRCm38)	missense	probably benign
R2248:Itpr3	UTSW	17	27,115,059 (GRCm38)	missense	probably damaging	1.00
R2291:Itpr3	UTSW	17	27,113,579 (GRCm38)	missense	possibly damaging	0.92
R2320:Itpr3	UTSW	17	27,095,915 (GRCm38)	missense	probably benign
R2864:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R2865:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R3778:Itpr3	UTSW	17	27,095,472 (GRCm38)	missense	possibly damaging	0.57
R3881:Itpr3	UTSW	17	27,113,840 (GRCm38)	missense	probably benign	0.01
R3979:Itpr3	UTSW	17	27,091,572 (GRCm38)	missense	probably damaging	1.00
R3979:Itpr3	UTSW	17	27,085,131 (GRCm38)	missense	probably benign	0.23
R4224:Itpr3	UTSW	17	27,107,258 (GRCm38)	missense	probably damaging	1.00
R4259:Itpr3	UTSW	17	27,106,324 (GRCm38)	missense	probably damaging	1.00
R4321:Itpr3	UTSW	17	27,111,974 (GRCm38)	missense	probably benign	0.00
R4466:Itpr3	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
R4493:Itpr3	UTSW	17	27,104,612 (GRCm38)	missense	probably damaging	1.00
R4597:Itpr3	UTSW	17	27,093,283 (GRCm38)	missense	probably damaging	1.00
R4823:Itpr3	UTSW	17	27,085,147 (GRCm38)	missense	probably benign	0.30
R4921:Itpr3	UTSW	17	27,098,005 (GRCm38)	missense	probably damaging	1.00
R4974:Itpr3	UTSW	17	27,083,608 (GRCm38)	missense	probably damaging	0.96
R5063:Itpr3	UTSW	17	27,089,911 (GRCm38)	missense	possibly damaging	0.94
R5079:Itpr3	UTSW	17	27,098,423 (GRCm38)	missense	probably damaging	1.00
R5303:Itpr3	UTSW	17	27,116,689 (GRCm38)	missense	probably benign	0.38
R5518:Itpr3	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
R5521:Itpr3	UTSW	17	27,107,334 (GRCm38)	missense	probably benign	0.09
R5566:Itpr3	UTSW	17	27,115,952 (GRCm38)	missense	possibly damaging	0.71
R5567:Itpr3	UTSW	17	27,103,906 (GRCm38)	missense	possibly damaging	0.66
R5579:Itpr3	UTSW	17	27,113,519 (GRCm38)	missense	probably damaging	1.00
R5610:Itpr3	UTSW	17	27,118,566 (GRCm38)	missense	probably benign	0.42
R5658:Itpr3	UTSW	17	27,107,878 (GRCm38)	missense	possibly damaging	0.74
R5856:Itpr3	UTSW	17	27,106,405 (GRCm38)	missense	probably damaging	1.00
R5872:Itpr3	UTSW	17	27,086,976 (GRCm38)	missense	probably benign	0.02
R5889:Itpr3	UTSW	17	27,115,065 (GRCm38)	missense	probably damaging	0.99
R5907:Itpr3	UTSW	17	27,117,893 (GRCm38)	missense	probably damaging	1.00
R5930:Itpr3	UTSW	17	27,110,921 (GRCm38)	missense	possibly damaging	0.49
R5987:Itpr3	UTSW	17	27,104,601 (GRCm38)	missense	probably damaging	1.00
R6029:Itpr3	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
R6195:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6213:Itpr3	UTSW	17	27,111,200 (GRCm38)	missense	probably benign	0.03
R6233:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6376:Itpr3	UTSW	17	27,095,475 (GRCm38)	missense	possibly damaging	0.94
R6514:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6515:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6516:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6955:Itpr3	UTSW	17	27,121,467 (GRCm38)	missense	probably damaging	1.00
R7002:Itpr3	UTSW	17	27,110,580 (GRCm38)	missense	probably benign	0.00
R7064:Itpr3	UTSW	17	27,089,295 (GRCm38)	missense	probably damaging	1.00
R7257:Itpr3	UTSW	17	27,118,561 (GRCm38)	missense	probably benign	0.00
R7349:Itpr3	UTSW	17	27,107,812 (GRCm38)	splice site	probably null
R7469:Itpr3	UTSW	17	27,121,054 (GRCm38)	missense	possibly damaging	0.74
R7493:Itpr3	UTSW	17	27,094,800 (GRCm38)	missense	probably benign	0.09
R7510:Itpr3	UTSW	17	27,089,039 (GRCm38)	missense	probably damaging	0.97
R7565:Itpr3	UTSW	17	27,110,888 (GRCm38)	missense	probably benign	0.01
R7616:Itpr3	UTSW	17	27,088,977 (GRCm38)	missense	probably damaging	1.00
R7728:Itpr3	UTSW	17	27,098,114 (GRCm38)	missense	probably damaging	1.00
R7779:Itpr3	UTSW	17	27,096,063 (GRCm38)	missense	probably damaging	1.00
R7788:Itpr3	UTSW	17	27,118,597 (GRCm38)	nonsense	probably null
R7871:Itpr3	UTSW	17	27,117,179 (GRCm38)	missense	probably damaging	1.00
R7889:Itpr3	UTSW	17	27,116,777 (GRCm38)	missense	probably damaging	1.00
R7966:Itpr3	UTSW	17	27,112,028 (GRCm38)	critical splice donor site	probably null
R8065:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8067:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8230:Itpr3	UTSW	17	27,107,737 (GRCm38)	critical splice donor site	probably null
R8263:Itpr3	UTSW	17	27,115,913 (GRCm38)	nonsense	probably null
R8264:Itpr3	UTSW	17	27,104,112 (GRCm38)	synonymous	silent
R8269:Itpr3	UTSW	17	27,093,284 (GRCm38)	missense	possibly damaging	0.60
R8271:Itpr3	UTSW	17	27,087,648 (GRCm38)	missense	probably damaging	1.00
R8316:Itpr3	UTSW	17	27,106,225 (GRCm38)	missense	possibly damaging	0.50
R8354:Itpr3	UTSW	17	27,115,919 (GRCm38)	missense	possibly damaging	0.74
R8413:Itpr3	UTSW	17	27,111,926 (GRCm38)	missense	probably damaging	1.00
R8437:Itpr3	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
R8676:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8679:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8846:Itpr3	UTSW	17	27,112,022 (GRCm38)	missense	probably damaging	1.00
R8884:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8885:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8886:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8887:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8888:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8891:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8896:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8975:Itpr3	UTSW	17	27,116,654 (GRCm38)	missense	possibly damaging	0.56
R9025:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9026:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9063:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9087:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9088:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9089:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9090:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9091:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9200:Itpr3	UTSW	17	27,107,662 (GRCm38)	missense	probably damaging	0.99
R9270:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9271:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9294:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R9389:Itpr3	UTSW	17	27,095,925 (GRCm38)	missense	possibly damaging	0.84
R9433:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9434:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9443:Itpr3	UTSW	17	27,105,549 (GRCm38)	missense	probably damaging	1.00
R9472:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9474:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9475:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9476:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9477:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9507:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9508:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9511:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9694:Itpr3	UTSW	17	27,115,953 (GRCm38)	missense	probably damaging	0.99
R9789:Itpr3	UTSW	17	27,089,941 (GRCm38)	missense	probably benign	0.15
V7732:Itpr3	UTSW	17	27,111,026 (GRCm38)	splice site	probably null
V7732:Itpr3	UTSW	17	27,111,024 (GRCm38)	splice site	probably benign
Z1088:Itpr3	UTSW	17	27,113,528 (GRCm38)	missense	possibly damaging	0.50
Z1177:Itpr3	UTSW	17	27,119,987 (GRCm38)	missense	probably damaging	1.00
Z1177:Itpr3	UTSW	17	27,114,929 (GRCm38)	missense	probably damaging	1.00
Z31818:Itpr3	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CTGACTGCAAAGGATCAGGCAG -3'
(R):5'- GTGTCCAACCAAGAAGCAGC -3'

Sequencing Primer
(F):5'- CAAAGGATCAGGCAGGAAGC -3'
(R):5'- CGTGTATCGGGCCTTCC -3'

Posted On

2017-02-10