Incidental Mutation 'R5879:Olfml2a'
ID 455696
Institutional Source Beutler Lab
Gene Symbol Olfml2a
Ensembl Gene ENSMUSG00000046618
Gene Name olfactomedin-like 2A
Synonyms photomedin-1, 4932431K08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R5879 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 38821992-38850597 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38850242 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 653 (T653S)
Ref Sequence ENSEMBL: ENSMUSP00000058761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057279]
AlphaFold Q8BHP7
Predicted Effect probably damaging
Transcript: ENSMUST00000057279
AA Change: T653S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000058761
Gene: ENSMUSG00000046618
AA Change: T653S

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
internal_repeat_1 39 66 2.55e-7 PROSPERO
internal_repeat_1 78 105 2.55e-7 PROSPERO
coiled coil region 168 189 N/A INTRINSIC
low complexity region 212 228 N/A INTRINSIC
low complexity region 252 271 N/A INTRINSIC
low complexity region 302 320 N/A INTRINSIC
low complexity region 367 407 N/A INTRINSIC
OLF 426 681 8.73e-69 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh16a1 C T 7: 44,796,930 (GRCm39) W66* probably null Het
Arhgap39 T C 15: 76,636,007 (GRCm39) D76G probably damaging Het
Arhgef2 G A 3: 88,550,924 (GRCm39) probably null Het
C1qtnf2 T C 11: 43,376,835 (GRCm39) M99T probably damaging Het
Cyren A G 6: 34,851,593 (GRCm39) L87P probably damaging Het
Eml3 G A 19: 8,912,379 (GRCm39) C392Y possibly damaging Het
Ephb4 C A 5: 137,358,678 (GRCm39) P287Q probably benign Het
Fat4 G T 3: 38,941,485 (GRCm39) R126L probably benign Het
Flt3 T C 5: 147,271,719 (GRCm39) M858V probably damaging Het
Gprin3 A C 6: 59,331,698 (GRCm39) I203R probably benign Het
Insr G T 8: 3,248,173 (GRCm39) Y457* probably null Het
Ipo13 G A 4: 117,760,400 (GRCm39) T649I possibly damaging Het
Krba1 A G 6: 48,392,678 (GRCm39) D818G possibly damaging Het
Llgl1 G A 11: 60,603,806 (GRCm39) G1016R probably benign Het
Loxl4 A G 19: 42,596,066 (GRCm39) V142A probably benign Het
Mthfd1 A G 12: 76,340,992 (GRCm39) I464V probably benign Het
Mycs C A X: 5,380,131 (GRCm39) K316N probably damaging Het
Ncor2 A G 5: 125,103,839 (GRCm39) probably benign Het
Nlrc3 A G 16: 3,781,909 (GRCm39) F516S probably damaging Het
Oacyl A G 18: 65,882,743 (GRCm39) S540G probably damaging Het
Or8s16 C T 15: 98,211,369 (GRCm39) V21I probably benign Het
Pcnx2 A T 8: 126,500,685 (GRCm39) N1468K probably damaging Het
Plbd1 A G 6: 136,611,503 (GRCm39) I258T probably damaging Het
Ppargc1b C G 18: 61,442,164 (GRCm39) D591H probably damaging Het
Pramel21 A T 4: 143,344,161 (GRCm39) Y487F possibly damaging Het
Prop1 C T 11: 50,844,153 (GRCm39) V27M probably damaging Het
Rfx4 T G 10: 84,650,625 (GRCm39) probably null Het
Rgs11 C T 17: 26,422,437 (GRCm39) probably benign Het
Slc6a5 T A 7: 49,595,260 (GRCm39) F541I probably damaging Het
Srgap3 A T 6: 112,699,807 (GRCm39) V1057E possibly damaging Het
Synpo2 A T 3: 122,907,946 (GRCm39) W457R probably damaging Het
Tet2 T A 3: 133,193,721 (GRCm39) N238Y possibly damaging Het
Tiam2 T A 17: 3,487,540 (GRCm39) M687K probably damaging Het
Ticrr A G 7: 79,346,438 (GRCm39) E1866G probably benign Het
Tspan8 T C 10: 115,669,156 (GRCm39) S64P possibly damaging Het
Ugt2b37 C T 5: 87,402,265 (GRCm39) G122D probably benign Het
Uqcrc2 A G 7: 120,237,111 (GRCm39) E53G probably damaging Het
Vcan T C 13: 89,852,071 (GRCm39) D963G probably damaging Het
Vmn2r24 T A 6: 123,764,226 (GRCm39) Y368N possibly damaging Het
Wdr5 A G 2: 27,418,323 (GRCm39) T208A probably benign Het
Zbtb18 A G 1: 177,275,936 (GRCm39) Y423C probably damaging Het
Zc3h6 A G 2: 128,839,696 (GRCm39) probably null Het
Other mutations in Olfml2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Olfml2a APN 2 38,837,226 (GRCm39) critical splice acceptor site probably null
IGL02367:Olfml2a APN 2 38,844,680 (GRCm39) missense probably benign 0.15
IGL03140:Olfml2a APN 2 38,837,303 (GRCm39) missense probably damaging 1.00
R0559:Olfml2a UTSW 2 38,849,832 (GRCm39) missense probably damaging 1.00
R0781:Olfml2a UTSW 2 38,849,765 (GRCm39) missense probably damaging 0.99
R1110:Olfml2a UTSW 2 38,849,765 (GRCm39) missense probably damaging 0.99
R1187:Olfml2a UTSW 2 38,849,825 (GRCm39) missense probably damaging 1.00
R1626:Olfml2a UTSW 2 38,841,275 (GRCm39) missense probably damaging 1.00
R1634:Olfml2a UTSW 2 38,850,231 (GRCm39) missense probably benign 0.03
R2127:Olfml2a UTSW 2 38,831,699 (GRCm39) missense probably damaging 1.00
R2987:Olfml2a UTSW 2 38,837,306 (GRCm39) missense probably damaging 0.97
R4428:Olfml2a UTSW 2 38,831,755 (GRCm39) missense probably damaging 0.96
R4564:Olfml2a UTSW 2 38,850,306 (GRCm39) missense probably benign 0.40
R4609:Olfml2a UTSW 2 38,847,733 (GRCm39) missense probably damaging 0.98
R4667:Olfml2a UTSW 2 38,839,022 (GRCm39) missense probably damaging 0.99
R4703:Olfml2a UTSW 2 38,841,250 (GRCm39) missense probably damaging 1.00
R4827:Olfml2a UTSW 2 38,850,033 (GRCm39) missense probably damaging 1.00
R5588:Olfml2a UTSW 2 38,850,047 (GRCm39) missense probably damaging 1.00
R6063:Olfml2a UTSW 2 38,841,155 (GRCm39) missense probably benign 0.03
R6484:Olfml2a UTSW 2 38,849,780 (GRCm39) missense probably damaging 1.00
R6788:Olfml2a UTSW 2 38,850,238 (GRCm39) nonsense probably null
R7345:Olfml2a UTSW 2 38,850,139 (GRCm39) missense probably damaging 1.00
R7474:Olfml2a UTSW 2 38,850,273 (GRCm39) missense probably damaging 0.98
R7971:Olfml2a UTSW 2 38,831,794 (GRCm39) splice site probably null
R8073:Olfml2a UTSW 2 38,847,766 (GRCm39) missense probably damaging 1.00
R8846:Olfml2a UTSW 2 38,850,255 (GRCm39) missense probably damaging 1.00
R9108:Olfml2a UTSW 2 38,831,753 (GRCm39) missense probably benign 0.10
R9425:Olfml2a UTSW 2 38,847,721 (GRCm39) missense probably damaging 1.00
Z1177:Olfml2a UTSW 2 38,850,296 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- ACACAGCATGAGGTGATTGTG -3'
(R):5'- TACTGGGCACTGAGAAAGCAC -3'

Sequencing Primer
(F):5'- AGCAGACCTCTCTGTGCAC -3'
(R):5'- GGCACTGAGAAAGCACTCAAAGC -3'
Posted On 2017-02-10