Incidental Mutation 'R5879:Ugt2b37'
ID 455705
Institutional Source Beutler Lab
Gene Symbol Ugt2b37
Ensembl Gene ENSMUSG00000057425
Gene Name UDP glucuronosyltransferase 2 family, polypeptide B37
Synonyms 0610033E06Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R5879 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 87388351-87402647 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 87402265 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 122 (G122D)
Ref Sequence ENSEMBL: ENSMUSP00000075255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075858]
AlphaFold Q8VCN3
Predicted Effect probably benign
Transcript: ENSMUST00000075858
AA Change: G122D

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000075255
Gene: ENSMUSG00000057425
AA Change: G122D

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:UDPGT 24 527 5.5e-256 PFAM
Pfam:Glyco_tran_28_C 328 449 2.5e-9 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh16a1 C T 7: 44,796,930 (GRCm39) W66* probably null Het
Arhgap39 T C 15: 76,636,007 (GRCm39) D76G probably damaging Het
Arhgef2 G A 3: 88,550,924 (GRCm39) probably null Het
C1qtnf2 T C 11: 43,376,835 (GRCm39) M99T probably damaging Het
Cyren A G 6: 34,851,593 (GRCm39) L87P probably damaging Het
Eml3 G A 19: 8,912,379 (GRCm39) C392Y possibly damaging Het
Ephb4 C A 5: 137,358,678 (GRCm39) P287Q probably benign Het
Fat4 G T 3: 38,941,485 (GRCm39) R126L probably benign Het
Flt3 T C 5: 147,271,719 (GRCm39) M858V probably damaging Het
Gprin3 A C 6: 59,331,698 (GRCm39) I203R probably benign Het
Insr G T 8: 3,248,173 (GRCm39) Y457* probably null Het
Ipo13 G A 4: 117,760,400 (GRCm39) T649I possibly damaging Het
Krba1 A G 6: 48,392,678 (GRCm39) D818G possibly damaging Het
Llgl1 G A 11: 60,603,806 (GRCm39) G1016R probably benign Het
Loxl4 A G 19: 42,596,066 (GRCm39) V142A probably benign Het
Mthfd1 A G 12: 76,340,992 (GRCm39) I464V probably benign Het
Mycs C A X: 5,380,131 (GRCm39) K316N probably damaging Het
Ncor2 A G 5: 125,103,839 (GRCm39) probably benign Het
Nlrc3 A G 16: 3,781,909 (GRCm39) F516S probably damaging Het
Oacyl A G 18: 65,882,743 (GRCm39) S540G probably damaging Het
Olfml2a A T 2: 38,850,242 (GRCm39) T653S probably damaging Het
Or8s16 C T 15: 98,211,369 (GRCm39) V21I probably benign Het
Pcnx2 A T 8: 126,500,685 (GRCm39) N1468K probably damaging Het
Plbd1 A G 6: 136,611,503 (GRCm39) I258T probably damaging Het
Ppargc1b C G 18: 61,442,164 (GRCm39) D591H probably damaging Het
Pramel21 A T 4: 143,344,161 (GRCm39) Y487F possibly damaging Het
Prop1 C T 11: 50,844,153 (GRCm39) V27M probably damaging Het
Rfx4 T G 10: 84,650,625 (GRCm39) probably null Het
Rgs11 C T 17: 26,422,437 (GRCm39) probably benign Het
Slc6a5 T A 7: 49,595,260 (GRCm39) F541I probably damaging Het
Srgap3 A T 6: 112,699,807 (GRCm39) V1057E possibly damaging Het
Synpo2 A T 3: 122,907,946 (GRCm39) W457R probably damaging Het
Tet2 T A 3: 133,193,721 (GRCm39) N238Y possibly damaging Het
Tiam2 T A 17: 3,487,540 (GRCm39) M687K probably damaging Het
Ticrr A G 7: 79,346,438 (GRCm39) E1866G probably benign Het
Tspan8 T C 10: 115,669,156 (GRCm39) S64P possibly damaging Het
Uqcrc2 A G 7: 120,237,111 (GRCm39) E53G probably damaging Het
Vcan T C 13: 89,852,071 (GRCm39) D963G probably damaging Het
Vmn2r24 T A 6: 123,764,226 (GRCm39) Y368N possibly damaging Het
Wdr5 A G 2: 27,418,323 (GRCm39) T208A probably benign Het
Zbtb18 A G 1: 177,275,936 (GRCm39) Y423C probably damaging Het
Zc3h6 A G 2: 128,839,696 (GRCm39) probably null Het
Other mutations in Ugt2b37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00401:Ugt2b37 APN 5 87,390,340 (GRCm39) missense possibly damaging 0.90
IGL00567:Ugt2b37 APN 5 87,401,933 (GRCm39) missense probably damaging 1.00
IGL00787:Ugt2b37 APN 5 87,390,288 (GRCm39) missense probably benign 0.00
IGL01560:Ugt2b37 APN 5 87,399,698 (GRCm39) missense probably damaging 1.00
IGL01617:Ugt2b37 APN 5 87,399,738 (GRCm39) missense probably damaging 1.00
IGL01982:Ugt2b37 APN 5 87,390,291 (GRCm39) missense probably damaging 1.00
IGL02299:Ugt2b37 APN 5 87,390,174 (GRCm39) missense probably benign 0.00
IGL02323:Ugt2b37 APN 5 87,398,423 (GRCm39) splice site probably benign
IGL02326:Ugt2b37 APN 5 87,388,861 (GRCm39) missense probably benign 0.25
IGL02516:Ugt2b37 APN 5 87,388,741 (GRCm39) missense probably damaging 1.00
IGL03285:Ugt2b37 APN 5 87,388,734 (GRCm39) missense probably damaging 1.00
R0076:Ugt2b37 UTSW 5 87,402,080 (GRCm39) missense probably benign 0.31
R0141:Ugt2b37 UTSW 5 87,388,842 (GRCm39) missense probably damaging 1.00
R0312:Ugt2b37 UTSW 5 87,398,524 (GRCm39) missense probably damaging 1.00
R0359:Ugt2b37 UTSW 5 87,398,443 (GRCm39) missense probably benign 0.10
R0523:Ugt2b37 UTSW 5 87,399,691 (GRCm39) missense possibly damaging 0.91
R1938:Ugt2b37 UTSW 5 87,388,716 (GRCm39) missense probably damaging 1.00
R1962:Ugt2b37 UTSW 5 87,402,193 (GRCm39) missense probably damaging 1.00
R2496:Ugt2b37 UTSW 5 87,402,569 (GRCm39) missense probably damaging 0.97
R3704:Ugt2b37 UTSW 5 87,390,846 (GRCm39) missense possibly damaging 0.55
R4430:Ugt2b37 UTSW 5 87,401,951 (GRCm39) missense probably benign 0.00
R4825:Ugt2b37 UTSW 5 87,398,498 (GRCm39) missense possibly damaging 0.91
R5043:Ugt2b37 UTSW 5 87,399,719 (GRCm39) nonsense probably null
R5098:Ugt2b37 UTSW 5 87,390,812 (GRCm39) missense probably damaging 1.00
R5174:Ugt2b37 UTSW 5 87,399,739 (GRCm39) missense probably benign 0.00
R5522:Ugt2b37 UTSW 5 87,388,759 (GRCm39) missense probably benign 0.14
R5999:Ugt2b37 UTSW 5 87,402,036 (GRCm39) missense probably benign 0.25
R6374:Ugt2b37 UTSW 5 87,390,279 (GRCm39) missense probably damaging 1.00
R6454:Ugt2b37 UTSW 5 87,388,836 (GRCm39) missense probably damaging 1.00
R6857:Ugt2b37 UTSW 5 87,388,705 (GRCm39) missense probably damaging 0.98
R6875:Ugt2b37 UTSW 5 87,390,288 (GRCm39) missense probably benign 0.00
R6916:Ugt2b37 UTSW 5 87,402,459 (GRCm39) missense probably benign 0.07
R7099:Ugt2b37 UTSW 5 87,388,848 (GRCm39) missense probably benign 0.00
R7239:Ugt2b37 UTSW 5 87,402,590 (GRCm39) missense probably benign
R7470:Ugt2b37 UTSW 5 87,401,971 (GRCm39) missense probably benign 0.24
R7810:Ugt2b37 UTSW 5 87,402,118 (GRCm39) missense probably damaging 1.00
R7841:Ugt2b37 UTSW 5 87,398,489 (GRCm39) missense probably benign 0.05
R7860:Ugt2b37 UTSW 5 87,402,189 (GRCm39) missense probably damaging 1.00
R7861:Ugt2b37 UTSW 5 87,390,299 (GRCm39) nonsense probably null
R8200:Ugt2b37 UTSW 5 87,388,750 (GRCm39) nonsense probably null
R8211:Ugt2b37 UTSW 5 87,390,235 (GRCm39) missense probably benign 0.07
R8282:Ugt2b37 UTSW 5 87,402,440 (GRCm39) missense probably benign 0.01
R8312:Ugt2b37 UTSW 5 87,390,799 (GRCm39) missense probably benign 0.15
R8520:Ugt2b37 UTSW 5 87,388,714 (GRCm39) missense probably benign 0.04
R8688:Ugt2b37 UTSW 5 87,390,240 (GRCm39) missense possibly damaging 0.52
R8695:Ugt2b37 UTSW 5 87,390,243 (GRCm39) missense probably benign 0.00
R8772:Ugt2b37 UTSW 5 87,402,345 (GRCm39) missense probably benign 0.00
R8839:Ugt2b37 UTSW 5 87,402,415 (GRCm39) missense probably damaging 1.00
R9087:Ugt2b37 UTSW 5 87,401,996 (GRCm39) missense probably benign 0.01
R9139:Ugt2b37 UTSW 5 87,399,636 (GRCm39) missense probably benign 0.09
R9424:Ugt2b37 UTSW 5 87,402,217 (GRCm39) missense probably damaging 0.99
R9432:Ugt2b37 UTSW 5 87,402,046 (GRCm39) missense probably damaging 0.97
R9498:Ugt2b37 UTSW 5 87,402,244 (GRCm39) missense probably benign 0.07
R9711:Ugt2b37 UTSW 5 87,402,532 (GRCm39) missense possibly damaging 0.85
R9718:Ugt2b37 UTSW 5 87,390,802 (GRCm39) missense probably benign 0.11
R9783:Ugt2b37 UTSW 5 87,388,840 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCTGTAACCTGCAGTGAAGC -3'
(R):5'- TACAGAGGGGCCATGAAGTCAC -3'

Sequencing Primer
(F):5'- CTGCAGTGAAGCGAAGACTGTAC -3'
(R):5'- GCCATGAAGTCACTGTTCTGAGAC -3'
Posted On 2017-02-10