Mutagenetix > Incidental Mutation

Incidental Mutation 'R5879:Vmn2r24'

455713

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r24

Ensembl Gene

ENSMUSG00000072780

Gene Name

vomeronasal 2, receptor 24

Synonyms

EG243628

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R5879 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

123755930-123793239 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 123764226 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 368 (Y368N)

Ref Sequence

ENSEMBL: ENSMUSP00000074602 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000075095]

AlphaFold

D3YUI0

Predicted Effect

possibly damaging
Transcript: ENSMUST00000075095
AA Change: Y368N

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000074602
Gene: ENSMUSG00000072780
AA Change: Y368N

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	469	1.6e-32	PFAM
Pfam:NCD3G	518	571	1.1e-22	PFAM
Pfam:7tm_3	602	839	1.1e-54	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.9%
20x: 93.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aldh16a1	C	T	7: 44,796,930 (GRCm39)	W66*	probably null	Het
Arhgap39	T	C	15: 76,636,007 (GRCm39)	D76G	probably damaging	Het
Arhgef2	G	A	3: 88,550,924 (GRCm39)		probably null	Het
C1qtnf2	T	C	11: 43,376,835 (GRCm39)	M99T	probably damaging	Het
Cyren	A	G	6: 34,851,593 (GRCm39)	L87P	probably damaging	Het
Eml3	G	A	19: 8,912,379 (GRCm39)	C392Y	possibly damaging	Het
Ephb4	C	A	5: 137,358,678 (GRCm39)	P287Q	probably benign	Het
Fat4	G	T	3: 38,941,485 (GRCm39)	R126L	probably benign	Het
Flt3	T	C	5: 147,271,719 (GRCm39)	M858V	probably damaging	Het
Gprin3	A	C	6: 59,331,698 (GRCm39)	I203R	probably benign	Het
Insr	G	T	8: 3,248,173 (GRCm39)	Y457*	probably null	Het
Ipo13	G	A	4: 117,760,400 (GRCm39)	T649I	possibly damaging	Het
Krba1	A	G	6: 48,392,678 (GRCm39)	D818G	possibly damaging	Het
Llgl1	G	A	11: 60,603,806 (GRCm39)	G1016R	probably benign	Het
Loxl4	A	G	19: 42,596,066 (GRCm39)	V142A	probably benign	Het
Mthfd1	A	G	12: 76,340,992 (GRCm39)	I464V	probably benign	Het
Mycs	C	A	X: 5,380,131 (GRCm39)	K316N	probably damaging	Het
Ncor2	A	G	5: 125,103,839 (GRCm39)		probably benign	Het
Nlrc3	A	G	16: 3,781,909 (GRCm39)	F516S	probably damaging	Het
Oacyl	A	G	18: 65,882,743 (GRCm39)	S540G	probably damaging	Het
Olfml2a	A	T	2: 38,850,242 (GRCm39)	T653S	probably damaging	Het
Or8s16	C	T	15: 98,211,369 (GRCm39)	V21I	probably benign	Het
Pcnx2	A	T	8: 126,500,685 (GRCm39)	N1468K	probably damaging	Het
Plbd1	A	G	6: 136,611,503 (GRCm39)	I258T	probably damaging	Het
Ppargc1b	C	G	18: 61,442,164 (GRCm39)	D591H	probably damaging	Het
Pramel21	A	T	4: 143,344,161 (GRCm39)	Y487F	possibly damaging	Het
Prop1	C	T	11: 50,844,153 (GRCm39)	V27M	probably damaging	Het
Rfx4	T	G	10: 84,650,625 (GRCm39)		probably null	Het
Rgs11	C	T	17: 26,422,437 (GRCm39)		probably benign	Het
Slc6a5	T	A	7: 49,595,260 (GRCm39)	F541I	probably damaging	Het
Srgap3	A	T	6: 112,699,807 (GRCm39)	V1057E	possibly damaging	Het
Synpo2	A	T	3: 122,907,946 (GRCm39)	W457R	probably damaging	Het
Tet2	T	A	3: 133,193,721 (GRCm39)	N238Y	possibly damaging	Het
Tiam2	T	A	17: 3,487,540 (GRCm39)	M687K	probably damaging	Het
Ticrr	A	G	7: 79,346,438 (GRCm39)	E1866G	probably benign	Het
Tspan8	T	C	10: 115,669,156 (GRCm39)	S64P	possibly damaging	Het
Ugt2b37	C	T	5: 87,402,265 (GRCm39)	G122D	probably benign	Het
Uqcrc2	A	G	7: 120,237,111 (GRCm39)	E53G	probably damaging	Het
Vcan	T	C	13: 89,852,071 (GRCm39)	D963G	probably damaging	Het
Wdr5	A	G	2: 27,418,323 (GRCm39)	T208A	probably benign	Het
Zbtb18	A	G	1: 177,275,936 (GRCm39)	Y423C	probably damaging	Het
Zc3h6	A	G	2: 128,839,696 (GRCm39)		probably null	Het

Other mutations in Vmn2r24

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00954:Vmn2r24	APN	6	123,792,596 (GRCm39)	missense	probably damaging	1.00
IGL01382:Vmn2r24	APN	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
IGL01592:Vmn2r24	APN	6	123,764,445 (GRCm39)	missense	probably benign	0.30
IGL01754:Vmn2r24	APN	6	123,781,120 (GRCm39)	missense	probably damaging	1.00
IGL01939:Vmn2r24	APN	6	123,764,404 (GRCm39)	missense	probably benign
IGL02140:Vmn2r24	APN	6	123,757,631 (GRCm39)	missense	probably damaging	0.98
IGL02272:Vmn2r24	APN	6	123,763,843 (GRCm39)	missense	possibly damaging	0.94
IGL02568:Vmn2r24	APN	6	123,792,812 (GRCm39)	missense	probably benign	0.36
IGL02748:Vmn2r24	APN	6	123,793,057 (GRCm39)	missense	possibly damaging	0.90
IGL03022:Vmn2r24	APN	6	123,755,967 (GRCm39)	missense	probably damaging	0.99
IGL03343:Vmn2r24	APN	6	123,793,070 (GRCm39)	missense	probably damaging	1.00
R0357:Vmn2r24	UTSW	6	123,792,369 (GRCm39)	frame shift	probably null
R0453:Vmn2r24	UTSW	6	123,757,350 (GRCm39)	critical splice acceptor site	probably null
R0538:Vmn2r24	UTSW	6	123,793,012 (GRCm39)	missense	probably benign	0.32
R0607:Vmn2r24	UTSW	6	123,763,893 (GRCm39)	missense	probably benign
R1381:Vmn2r24	UTSW	6	123,763,692 (GRCm39)	missense	probably damaging	1.00
R1589:Vmn2r24	UTSW	6	123,783,479 (GRCm39)	splice site	probably benign
R1848:Vmn2r24	UTSW	6	123,793,183 (GRCm39)	missense	probably damaging	1.00
R2035:Vmn2r24	UTSW	6	123,793,019 (GRCm39)	missense	probably damaging	1.00
R2077:Vmn2r24	UTSW	6	123,792,358 (GRCm39)	missense	probably damaging	1.00
R2122:Vmn2r24	UTSW	6	123,792,353 (GRCm39)	missense	possibly damaging	0.81
R2145:Vmn2r24	UTSW	6	123,755,972 (GRCm39)	missense	probably benign
R2483:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R2512:Vmn2r24	UTSW	6	123,763,985 (GRCm39)	missense	probably benign	0.01
R3001:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3002:Vmn2r24	UTSW	6	123,781,231 (GRCm39)	missense	probably benign	0.00
R3236:Vmn2r24	UTSW	6	123,755,984 (GRCm39)	nonsense	probably null
R3623:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3624:Vmn2r24	UTSW	6	123,792,997 (GRCm39)	missense	probably damaging	1.00
R3835:Vmn2r24	UTSW	6	123,764,412 (GRCm39)	missense	probably benign	0.33
R4074:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4075:Vmn2r24	UTSW	6	123,764,374 (GRCm39)	missense	possibly damaging	0.92
R4812:Vmn2r24	UTSW	6	123,756,144 (GRCm39)	missense	probably benign	0.00
R4825:Vmn2r24	UTSW	6	123,792,739 (GRCm39)	missense	probably benign	0.02
R5351:Vmn2r24	UTSW	6	123,793,223 (GRCm39)	missense	possibly damaging	0.80
R5665:Vmn2r24	UTSW	6	123,763,938 (GRCm39)	missense	possibly damaging	0.62
R5790:Vmn2r24	UTSW	6	123,792,499 (GRCm39)	missense	probably benign
R5808:Vmn2r24	UTSW	6	123,792,597 (GRCm39)	nonsense	probably null
R5923:Vmn2r24	UTSW	6	123,792,751 (GRCm39)	missense	probably damaging	0.96
R5969:Vmn2r24	UTSW	6	123,755,981 (GRCm39)	missense	probably benign	0.00
R6050:Vmn2r24	UTSW	6	123,792,691 (GRCm39)	missense	probably damaging	1.00
R6171:Vmn2r24	UTSW	6	123,764,205 (GRCm39)	missense	probably damaging	0.98
R6174:Vmn2r24	UTSW	6	123,793,236 (GRCm39)	missense	probably benign	0.00
R6356:Vmn2r24	UTSW	6	123,783,368 (GRCm39)	missense	possibly damaging	0.93
R6562:Vmn2r24	UTSW	6	123,757,386 (GRCm39)	missense	probably benign	0.01
R6563:Vmn2r24	UTSW	6	123,781,137 (GRCm39)	missense	possibly damaging	0.86
R6584:Vmn2r24	UTSW	6	123,792,764 (GRCm39)	missense	possibly damaging	0.53
R6630:Vmn2r24	UTSW	6	123,763,981 (GRCm39)	missense	probably benign	0.00
R6803:Vmn2r24	UTSW	6	123,755,960 (GRCm39)	missense	possibly damaging	0.64
R6864:Vmn2r24	UTSW	6	123,756,117 (GRCm39)	missense	possibly damaging	0.89
R7252:Vmn2r24	UTSW	6	123,764,191 (GRCm39)	missense	possibly damaging	0.90
R7369:Vmn2r24	UTSW	6	123,792,638 (GRCm39)	missense	probably damaging	0.99
R7646:Vmn2r24	UTSW	6	123,793,169 (GRCm39)	missense	probably benign	0.20
R7799:Vmn2r24	UTSW	6	123,757,422 (GRCm39)	missense	probably benign	0.00
R7803:Vmn2r24	UTSW	6	123,757,438 (GRCm39)	missense	probably benign	0.00
R7959:Vmn2r24	UTSW	6	123,755,949 (GRCm39)	missense	possibly damaging	0.86
R8215:Vmn2r24	UTSW	6	123,756,077 (GRCm39)	missense	probably benign	0.10
R8796:Vmn2r24	UTSW	6	123,757,500 (GRCm39)	missense	probably benign
R9172:Vmn2r24	UTSW	6	123,783,432 (GRCm39)	missense	probably damaging	1.00
R9300:Vmn2r24	UTSW	6	123,793,030 (GRCm39)	missense	possibly damaging	0.46
R9369:Vmn2r24	UTSW	6	123,792,357 (GRCm39)	missense	probably damaging	1.00
R9375:Vmn2r24	UTSW	6	123,792,542 (GRCm39)	missense	probably damaging	1.00
R9523:Vmn2r24	UTSW	6	123,763,950 (GRCm39)	missense	possibly damaging	0.89
R9546:Vmn2r24	UTSW	6	123,764,266 (GRCm39)	missense	probably damaging	0.98
RF006:Vmn2r24	UTSW	6	123,783,378 (GRCm39)	missense	probably damaging	1.00
RF016:Vmn2r24	UTSW	6	123,781,174 (GRCm39)	missense	probably benign	0.04
X0023:Vmn2r24	UTSW	6	123,764,359 (GRCm39)	missense	probably damaging	0.99
Z1088:Vmn2r24	UTSW	6	123,781,155 (GRCm39)	missense	probably benign	0.00
Z1177:Vmn2r24	UTSW	6	123,763,719 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GCATTTGGTGACACTCATGATTTTC -3'
(R):5'- ACTCTGAGTGACAGCTCCTCATG -3'

Sequencing Primer
(F):5'- GGTGACACTCATGATTTTCTGATTAG -3'
(R):5'- TCCTCATGGAGTGCCTGG -3'

Posted On

2017-02-10