Incidental Mutation 'R5879:Or8s16'
ID 455733
Institutional Source Beutler Lab
Gene Symbol Or8s16
Ensembl Gene ENSMUSG00000062037
Gene Name olfactory receptor family 8 subfamily S member 16
Synonyms GA_x6K02T2N22H-3824-2865, MOR160-3, Olfr257, GA_x6K02T2NBG7-5440777-5441736, Olfr285
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R5879 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 98210470-98211429 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 98211369 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 21 (V21I)
Ref Sequence ENSEMBL: ENSMUSP00000150788 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079736] [ENSMUST00000216901]
AlphaFold Q7TS17
Predicted Effect probably benign
Transcript: ENSMUST00000079736
AA Change: V21I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000078672
Gene: ENSMUSG00000062037
AA Change: V21I

DomainStartEndE-ValueType
Pfam:7tm_4 29 304 9.3e-47 PFAM
Pfam:7tm_1 39 286 5.9e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216901
AA Change: V21I

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh16a1 C T 7: 44,796,930 (GRCm39) W66* probably null Het
Arhgap39 T C 15: 76,636,007 (GRCm39) D76G probably damaging Het
Arhgef2 G A 3: 88,550,924 (GRCm39) probably null Het
C1qtnf2 T C 11: 43,376,835 (GRCm39) M99T probably damaging Het
Cyren A G 6: 34,851,593 (GRCm39) L87P probably damaging Het
Eml3 G A 19: 8,912,379 (GRCm39) C392Y possibly damaging Het
Ephb4 C A 5: 137,358,678 (GRCm39) P287Q probably benign Het
Fat4 G T 3: 38,941,485 (GRCm39) R126L probably benign Het
Flt3 T C 5: 147,271,719 (GRCm39) M858V probably damaging Het
Gprin3 A C 6: 59,331,698 (GRCm39) I203R probably benign Het
Insr G T 8: 3,248,173 (GRCm39) Y457* probably null Het
Ipo13 G A 4: 117,760,400 (GRCm39) T649I possibly damaging Het
Krba1 A G 6: 48,392,678 (GRCm39) D818G possibly damaging Het
Llgl1 G A 11: 60,603,806 (GRCm39) G1016R probably benign Het
Loxl4 A G 19: 42,596,066 (GRCm39) V142A probably benign Het
Mthfd1 A G 12: 76,340,992 (GRCm39) I464V probably benign Het
Mycs C A X: 5,380,131 (GRCm39) K316N probably damaging Het
Ncor2 A G 5: 125,103,839 (GRCm39) probably benign Het
Nlrc3 A G 16: 3,781,909 (GRCm39) F516S probably damaging Het
Oacyl A G 18: 65,882,743 (GRCm39) S540G probably damaging Het
Olfml2a A T 2: 38,850,242 (GRCm39) T653S probably damaging Het
Pcnx2 A T 8: 126,500,685 (GRCm39) N1468K probably damaging Het
Plbd1 A G 6: 136,611,503 (GRCm39) I258T probably damaging Het
Ppargc1b C G 18: 61,442,164 (GRCm39) D591H probably damaging Het
Pramel21 A T 4: 143,344,161 (GRCm39) Y487F possibly damaging Het
Prop1 C T 11: 50,844,153 (GRCm39) V27M probably damaging Het
Rfx4 T G 10: 84,650,625 (GRCm39) probably null Het
Rgs11 C T 17: 26,422,437 (GRCm39) probably benign Het
Slc6a5 T A 7: 49,595,260 (GRCm39) F541I probably damaging Het
Srgap3 A T 6: 112,699,807 (GRCm39) V1057E possibly damaging Het
Synpo2 A T 3: 122,907,946 (GRCm39) W457R probably damaging Het
Tet2 T A 3: 133,193,721 (GRCm39) N238Y possibly damaging Het
Tiam2 T A 17: 3,487,540 (GRCm39) M687K probably damaging Het
Ticrr A G 7: 79,346,438 (GRCm39) E1866G probably benign Het
Tspan8 T C 10: 115,669,156 (GRCm39) S64P possibly damaging Het
Ugt2b37 C T 5: 87,402,265 (GRCm39) G122D probably benign Het
Uqcrc2 A G 7: 120,237,111 (GRCm39) E53G probably damaging Het
Vcan T C 13: 89,852,071 (GRCm39) D963G probably damaging Het
Vmn2r24 T A 6: 123,764,226 (GRCm39) Y368N possibly damaging Het
Wdr5 A G 2: 27,418,323 (GRCm39) T208A probably benign Het
Zbtb18 A G 1: 177,275,936 (GRCm39) Y423C probably damaging Het
Zc3h6 A G 2: 128,839,696 (GRCm39) probably null Het
Other mutations in Or8s16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01986:Or8s16 APN 15 98,210,660 (GRCm39) missense probably damaging 0.99
IGL02658:Or8s16 APN 15 98,211,237 (GRCm39) missense probably damaging 1.00
R1423:Or8s16 UTSW 15 98,211,324 (GRCm39) missense probably damaging 0.99
R1442:Or8s16 UTSW 15 98,211,068 (GRCm39) missense probably damaging 0.98
R1863:Or8s16 UTSW 15 98,211,372 (GRCm39) missense probably benign 0.02
R1938:Or8s16 UTSW 15 98,211,261 (GRCm39) missense probably damaging 1.00
R4815:Or8s16 UTSW 15 98,210,561 (GRCm39) missense probably damaging 1.00
R5248:Or8s16 UTSW 15 98,211,311 (GRCm39) missense probably damaging 1.00
R6000:Or8s16 UTSW 15 98,211,317 (GRCm39) missense probably benign 0.08
R6371:Or8s16 UTSW 15 98,211,219 (GRCm39) missense possibly damaging 0.46
R7466:Or8s16 UTSW 15 98,211,261 (GRCm39) missense probably damaging 1.00
R7708:Or8s16 UTSW 15 98,211,029 (GRCm39) missense probably damaging 1.00
R8261:Or8s16 UTSW 15 98,210,546 (GRCm39) missense probably benign 0.00
R8734:Or8s16 UTSW 15 98,210,954 (GRCm39) missense probably damaging 1.00
R9462:Or8s16 UTSW 15 98,211,186 (GRCm39) missense possibly damaging 0.90
Predicted Primers PCR Primer
(F):5'- ACCAGATTCTCCAGCATCTTGG -3'
(R):5'- TCATGTCTGGACCAACAGTG -3'

Sequencing Primer
(F):5'- CAGCATCTTGGGTGTGGAGAC -3'
(R):5'- CAACAGTGGATGAAATTTGGATCCTG -3'
Posted On 2017-02-10