Incidental Mutation 'R5879:Oacyl'
ID 455736
Institutional Source Beutler Lab
Gene Symbol Oacyl
Ensembl Gene ENSMUSG00000046610
Gene Name O-acyltransferase like
Synonyms 5330437I02Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R5879 (G1)
Quality Score 225
Status Not validated
Chromosome 18
Chromosomal Location 65831339-65884672 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 65882743 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 540 (S540G)
Ref Sequence ENSEMBL: ENSMUSP00000113626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115097] [ENSMUST00000117694]
AlphaFold Q8BML2
Predicted Effect probably benign
Transcript: ENSMUST00000115097
AA Change: S613G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000110749
Gene: ENSMUSG00000046610
AA Change: S613G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
NRF 24 145 3.58e-13 SMART
Blast:NRF 152 191 1e-6 BLAST
Pfam:Acyl_transf_3 274 664 6.8e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000117694
AA Change: S540G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113626
Gene: ENSMUSG00000046610
AA Change: S540G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Blast:NRF 24 118 4e-14 BLAST
Pfam:Acyl_transf_3 201 591 6.7e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134343
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh16a1 C T 7: 44,796,930 (GRCm39) W66* probably null Het
Arhgap39 T C 15: 76,636,007 (GRCm39) D76G probably damaging Het
Arhgef2 G A 3: 88,550,924 (GRCm39) probably null Het
C1qtnf2 T C 11: 43,376,835 (GRCm39) M99T probably damaging Het
Cyren A G 6: 34,851,593 (GRCm39) L87P probably damaging Het
Eml3 G A 19: 8,912,379 (GRCm39) C392Y possibly damaging Het
Ephb4 C A 5: 137,358,678 (GRCm39) P287Q probably benign Het
Fat4 G T 3: 38,941,485 (GRCm39) R126L probably benign Het
Flt3 T C 5: 147,271,719 (GRCm39) M858V probably damaging Het
Gprin3 A C 6: 59,331,698 (GRCm39) I203R probably benign Het
Insr G T 8: 3,248,173 (GRCm39) Y457* probably null Het
Ipo13 G A 4: 117,760,400 (GRCm39) T649I possibly damaging Het
Krba1 A G 6: 48,392,678 (GRCm39) D818G possibly damaging Het
Llgl1 G A 11: 60,603,806 (GRCm39) G1016R probably benign Het
Loxl4 A G 19: 42,596,066 (GRCm39) V142A probably benign Het
Mthfd1 A G 12: 76,340,992 (GRCm39) I464V probably benign Het
Mycs C A X: 5,380,131 (GRCm39) K316N probably damaging Het
Ncor2 A G 5: 125,103,839 (GRCm39) probably benign Het
Nlrc3 A G 16: 3,781,909 (GRCm39) F516S probably damaging Het
Olfml2a A T 2: 38,850,242 (GRCm39) T653S probably damaging Het
Or8s16 C T 15: 98,211,369 (GRCm39) V21I probably benign Het
Pcnx2 A T 8: 126,500,685 (GRCm39) N1468K probably damaging Het
Plbd1 A G 6: 136,611,503 (GRCm39) I258T probably damaging Het
Ppargc1b C G 18: 61,442,164 (GRCm39) D591H probably damaging Het
Pramel21 A T 4: 143,344,161 (GRCm39) Y487F possibly damaging Het
Prop1 C T 11: 50,844,153 (GRCm39) V27M probably damaging Het
Rfx4 T G 10: 84,650,625 (GRCm39) probably null Het
Rgs11 C T 17: 26,422,437 (GRCm39) probably benign Het
Slc6a5 T A 7: 49,595,260 (GRCm39) F541I probably damaging Het
Srgap3 A T 6: 112,699,807 (GRCm39) V1057E possibly damaging Het
Synpo2 A T 3: 122,907,946 (GRCm39) W457R probably damaging Het
Tet2 T A 3: 133,193,721 (GRCm39) N238Y possibly damaging Het
Tiam2 T A 17: 3,487,540 (GRCm39) M687K probably damaging Het
Ticrr A G 7: 79,346,438 (GRCm39) E1866G probably benign Het
Tspan8 T C 10: 115,669,156 (GRCm39) S64P possibly damaging Het
Ugt2b37 C T 5: 87,402,265 (GRCm39) G122D probably benign Het
Uqcrc2 A G 7: 120,237,111 (GRCm39) E53G probably damaging Het
Vcan T C 13: 89,852,071 (GRCm39) D963G probably damaging Het
Vmn2r24 T A 6: 123,764,226 (GRCm39) Y368N possibly damaging Het
Wdr5 A G 2: 27,418,323 (GRCm39) T208A probably benign Het
Zbtb18 A G 1: 177,275,936 (GRCm39) Y423C probably damaging Het
Zc3h6 A G 2: 128,839,696 (GRCm39) probably null Het
Other mutations in Oacyl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00585:Oacyl APN 18 65,882,711 (GRCm39) missense possibly damaging 0.65
IGL00972:Oacyl APN 18 65,858,572 (GRCm39) missense possibly damaging 0.95
IGL01970:Oacyl APN 18 65,882,785 (GRCm39) missense possibly damaging 0.77
IGL02030:Oacyl APN 18 65,870,981 (GRCm39) missense probably damaging 0.99
IGL02706:Oacyl APN 18 65,882,792 (GRCm39) missense probably damaging 1.00
R0529:Oacyl UTSW 18 65,875,290 (GRCm39) missense probably damaging 0.97
R0607:Oacyl UTSW 18 65,880,962 (GRCm39) missense possibly damaging 0.61
R0724:Oacyl UTSW 18 65,870,896 (GRCm39) splice site probably benign
R1138:Oacyl UTSW 18 65,858,521 (GRCm39) missense probably damaging 1.00
R1482:Oacyl UTSW 18 65,871,043 (GRCm39) missense probably damaging 1.00
R1551:Oacyl UTSW 18 65,875,280 (GRCm39) missense probably benign 0.02
R1649:Oacyl UTSW 18 65,883,167 (GRCm39) missense probably damaging 1.00
R1919:Oacyl UTSW 18 65,843,618 (GRCm39) missense possibly damaging 0.87
R4271:Oacyl UTSW 18 65,871,038 (GRCm39) missense probably damaging 1.00
R5443:Oacyl UTSW 18 65,883,253 (GRCm39) missense probably benign
R5525:Oacyl UTSW 18 65,878,427 (GRCm39) missense probably benign 0.00
R6132:Oacyl UTSW 18 65,859,426 (GRCm39) missense probably damaging 1.00
R6367:Oacyl UTSW 18 65,858,515 (GRCm39) missense probably damaging 1.00
R7009:Oacyl UTSW 18 65,855,609 (GRCm39) nonsense probably null
R7097:Oacyl UTSW 18 65,853,323 (GRCm39) missense probably benign 0.00
R7122:Oacyl UTSW 18 65,853,323 (GRCm39) missense probably benign 0.00
R7132:Oacyl UTSW 18 65,831,480 (GRCm39) missense probably damaging 1.00
R7260:Oacyl UTSW 18 65,831,438 (GRCm39) missense probably damaging 1.00
R7403:Oacyl UTSW 18 65,870,966 (GRCm39) missense probably benign 0.15
R7501:Oacyl UTSW 18 65,858,369 (GRCm39) splice site probably null
R7759:Oacyl UTSW 18 65,843,631 (GRCm39) missense probably damaging 1.00
R7892:Oacyl UTSW 18 65,870,918 (GRCm39) missense probably benign 0.00
R7921:Oacyl UTSW 18 65,858,454 (GRCm39) missense probably benign
R7977:Oacyl UTSW 18 65,831,462 (GRCm39) missense probably benign 0.18
R7987:Oacyl UTSW 18 65,831,462 (GRCm39) missense probably benign 0.18
R9065:Oacyl UTSW 18 65,840,484 (GRCm39) missense probably damaging 1.00
R9318:Oacyl UTSW 18 65,858,415 (GRCm39) missense probably benign
R9561:Oacyl UTSW 18 65,831,414 (GRCm39) missense possibly damaging 0.52
R9609:Oacyl UTSW 18 65,843,599 (GRCm39) missense probably benign
R9613:Oacyl UTSW 18 65,864,524 (GRCm39) missense probably damaging 0.99
R9747:Oacyl UTSW 18 65,880,962 (GRCm39) missense possibly damaging 0.65
Z1177:Oacyl UTSW 18 65,858,418 (GRCm39) missense probably benign 0.04
Predicted Primers PCR Primer
(F):5'- CAAGGCCTTGTAATAGGGTGG -3'
(R):5'- CAAAGTCAGCTGTGCTCAAG -3'

Sequencing Primer
(F):5'- ATGTTGGGCAGCTCACAAC -3'
(R):5'- TCAGCTGTGCTCAAGAAGAGTG -3'
Posted On 2017-02-10