Mutagenetix > Incidental Mutation

Incidental Mutation 'R5885:Vmn2r97'

456063

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r97

Ensembl Gene

ENSMUSG00000091491

Gene Name

vomeronasal 2, receptor 97

Synonyms

EG627367

MMRRC Submission

043237-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R5885 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18914300-18958087 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18947773 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 763 (Y763C)

Ref Sequence

ENSEMBL: ENSMUSP00000129313 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168710] [ENSMUST00000232219]

AlphaFold

K7N6Z2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000168710
AA Change: Y763C

PolyPhen 2 Score 0.501 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000129313
Gene: ENSMUSG00000091491
AA Change: Y763C

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	82	442	2.9e-36	PFAM
Pfam:NCD3G	513	566	4.9e-21	PFAM
Pfam:7tm_3	599	834	1.7e-52	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000232219

Coding Region Coverage

1x: 99.9%
3x: 99.4%
10x: 97.4%
20x: 91.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A530099J19Rik	A	T	13: 19,729,349 (GRCm38)		noncoding transcript	Het
Acot10	T	A	15: 20,666,104 (GRCm38)	M184L	probably benign	Het
Adgrv1	A	T	13: 81,424,271 (GRCm38)	S4924T	probably benign	Het
Atp10a	T	A	7: 58,813,800 (GRCm38)	M1027K	possibly damaging	Het
Axl	T	A	7: 25,766,852 (GRCm38)	K510I	probably damaging	Het
Azi2	T	A	9: 118,047,560 (GRCm38)	I48N	probably damaging	Het
Cysltr2	T	C	14: 73,029,491 (GRCm38)	K260E	probably benign	Het
Dnah3	T	C	7: 120,069,704 (GRCm38)	I720V	probably benign	Het
Dnah8	C	T	17: 30,794,717 (GRCm38)	P3811S	probably damaging	Het
Epas1	A	G	17: 86,827,544 (GRCm38)	D535G	probably damaging	Het
Fam47e	A	G	5: 92,565,968 (GRCm38)	K152R	probably damaging	Het
Fbxl3	A	T	14: 103,083,231 (GRCm38)	I260K	probably benign	Het
Fcgr3	A	G	1: 171,057,711 (GRCm38)	V115A	probably damaging	Het
Fgf12	G	T	16: 28,398,294 (GRCm38)	D98E	possibly damaging	Het
Flt3	T	C	5: 147,349,629 (GRCm38)	T716A	probably damaging	Het
Gad1-ps	G	A	10: 99,445,147 (GRCm38)		noncoding transcript	Het
Grin2a	A	G	16: 9,761,905 (GRCm38)	Y165H	possibly damaging	Het
Ifna4	T	A	4: 88,842,362 (GRCm38)	W168R	probably damaging	Het
Itga11	A	G	9: 62,762,850 (GRCm38)	Y752C	probably damaging	Het
Khdrbs3	A	G	15: 69,024,698 (GRCm38)		probably null	Het
Kif24	A	T	4: 41,423,463 (GRCm38)	Y263N	probably damaging	Het
Lama5	G	T	2: 180,201,831 (GRCm38)	T441K	probably damaging	Het
Lrrc47	T	A	4: 154,015,972 (GRCm38)	V335D	possibly damaging	Het
Map1b	A	T	13: 99,430,081 (GRCm38)	I2044N	unknown	Het
Mast2	C	T	4: 116,314,838 (GRCm38)	G638S	probably damaging	Het
Myo9a	T	C	9: 59,871,220 (GRCm38)	S1420P	probably benign	Het
Neurl2	T	C	2: 164,832,891 (GRCm38)	T184A	probably damaging	Het
Nfatc3	A	G	8: 106,096,312 (GRCm38)	I577V	probably benign	Het
Nipal3	A	T	4: 135,471,977 (GRCm38)	V186E	probably damaging	Het
Pgbd5	G	A	8: 124,384,466 (GRCm38)	T162M	probably damaging	Het
Plod2	T	A	9: 92,606,656 (GRCm38)		probably null	Het
Psg22	T	A	7: 18,718,332 (GRCm38)	L19Q	probably damaging	Het
Psg27	T	A	7: 18,561,786 (GRCm38)	N245Y	probably damaging	Het
Ptprc	T	A	1: 138,088,508 (GRCm38)	I539F	probably damaging	Het
Rad1	T	C	15: 10,488,057 (GRCm38)	L59P	probably damaging	Het
Slc2a9	G	A	5: 38,440,674 (GRCm38)	R137W	probably damaging	Het
Spats2l	C	T	1: 57,946,162 (GRCm38)	A458V	probably damaging	Het
Sptbn5	A	G	2: 120,076,663 (GRCm38)		probably benign	Het
Stox1	C	A	10: 62,664,848 (GRCm38)	L644F	probably damaging	Het
Sv2b	C	T	7: 75,156,753 (GRCm38)	G213E	probably damaging	Het
Tas2r121	T	G	6: 132,700,291 (GRCm38)	L239F	probably damaging	Het
Trrap	T	A	5: 144,794,793 (GRCm38)	V854E	probably damaging	Het
Xkr6	T	A	14: 63,606,911 (GRCm38)	W128R	probably damaging	Het

Other mutations in Vmn2r97

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r97	APN	17	18,947,659 (GRCm38)	missense	probably benign	0.37
IGL00962:Vmn2r97	APN	17	18,929,228 (GRCm38)	missense	probably damaging	1.00
IGL01704:Vmn2r97	APN	17	18,947,811 (GRCm38)	missense	probably damaging	0.99
IGL01888:Vmn2r97	APN	17	18,929,024 (GRCm38)	nonsense	probably null
IGL02429:Vmn2r97	APN	17	18,930,334 (GRCm38)	missense	possibly damaging	0.94
IGL02742:Vmn2r97	APN	17	18,929,170 (GRCm38)	missense	probably damaging	0.97
IGL02934:Vmn2r97	APN	17	18,929,685 (GRCm38)	missense	probably benign	0.00
IGL02978:Vmn2r97	APN	17	18,948,036 (GRCm38)	missense	probably benign	0.01
IGL03230:Vmn2r97	APN	17	18,929,406 (GRCm38)	missense	probably benign	0.10
IGL03241:Vmn2r97	APN	17	18,928,176 (GRCm38)	missense	probably benign	0.11
IGL03050:Vmn2r97	UTSW	17	18,947,638 (GRCm38)	missense	possibly damaging	0.84
PIT4469001:Vmn2r97	UTSW	17	18,929,616 (GRCm38)	missense	probably benign	0.00
R0482:Vmn2r97	UTSW	17	18,947,668 (GRCm38)	missense	probably damaging	1.00
R0514:Vmn2r97	UTSW	17	18,914,472 (GRCm38)	missense	probably benign	0.25
R0944:Vmn2r97	UTSW	17	18,947,403 (GRCm38)	missense	probably benign	0.13
R1061:Vmn2r97	UTSW	17	18,928,178 (GRCm38)	nonsense	probably null
R1546:Vmn2r97	UTSW	17	18,947,848 (GRCm38)	missense	probably damaging	1.00
R1725:Vmn2r97	UTSW	17	18,929,135 (GRCm38)	missense	probably benign	0.43
R1860:Vmn2r97	UTSW	17	18,947,386 (GRCm38)	missense	probably benign	0.01
R1938:Vmn2r97	UTSW	17	18,929,331 (GRCm38)	missense	probably benign	0.01
R1944:Vmn2r97	UTSW	17	18,940,238 (GRCm38)	missense	probably benign	0.00
R2027:Vmn2r97	UTSW	17	18,929,682 (GRCm38)	missense	unknown
R2106:Vmn2r97	UTSW	17	18,947,838 (GRCm38)	missense	probably damaging	1.00
R2151:Vmn2r97	UTSW	17	18,947,322 (GRCm38)	nonsense	probably null
R2153:Vmn2r97	UTSW	17	18,947,322 (GRCm38)	nonsense	probably null
R2154:Vmn2r97	UTSW	17	18,947,322 (GRCm38)	nonsense	probably null
R2516:Vmn2r97	UTSW	17	18,947,552 (GRCm38)	missense	probably benign
R3739:Vmn2r97	UTSW	17	18,928,151 (GRCm38)	missense	probably damaging	1.00
R3744:Vmn2r97	UTSW	17	18,929,628 (GRCm38)	missense	probably benign
R3885:Vmn2r97	UTSW	17	18,928,334 (GRCm38)	missense	possibly damaging	0.90
R3899:Vmn2r97	UTSW	17	18,947,611 (GRCm38)	missense	probably damaging	0.96
R4115:Vmn2r97	UTSW	17	18,928,070 (GRCm38)	missense	probably benign	0.01
R4247:Vmn2r97	UTSW	17	18,947,280 (GRCm38)	missense	possibly damaging	0.83
R4287:Vmn2r97	UTSW	17	18,948,075 (GRCm38)	intron	probably benign
R4439:Vmn2r97	UTSW	17	18,930,354 (GRCm38)	missense	probably benign	0.00
R4523:Vmn2r97	UTSW	17	18,929,071 (GRCm38)	missense	probably benign	0.03
R4783:Vmn2r97	UTSW	17	18,929,288 (GRCm38)	missense	probably benign
R4948:Vmn2r97	UTSW	17	18,947,299 (GRCm38)	missense	possibly damaging	0.95
R4981:Vmn2r97	UTSW	17	18,940,174 (GRCm38)	nonsense	probably null
R5029:Vmn2r97	UTSW	17	18,947,911 (GRCm38)	missense	probably damaging	1.00
R5200:Vmn2r97	UTSW	17	18,928,353 (GRCm38)	missense	probably damaging	1.00
R5541:Vmn2r97	UTSW	17	18,928,355 (GRCm38)	nonsense	probably null
R5637:Vmn2r97	UTSW	17	18,947,366 (GRCm38)	nonsense	probably null
R5765:Vmn2r97	UTSW	17	18,947,180 (GRCm38)	nonsense	probably null
R6272:Vmn2r97	UTSW	17	18,947,599 (GRCm38)	missense	possibly damaging	0.70
R6553:Vmn2r97	UTSW	17	18,930,304 (GRCm38)	nonsense	probably null
R6818:Vmn2r97	UTSW	17	18,947,931 (GRCm38)	missense	possibly damaging	0.95
R6880:Vmn2r97	UTSW	17	18,914,508 (GRCm38)	missense	probably benign	0.00
R7012:Vmn2r97	UTSW	17	18,947,494 (GRCm38)	missense	probably damaging	0.99
R7023:Vmn2r97	UTSW	17	18,914,401 (GRCm38)	missense	probably damaging	1.00
R7044:Vmn2r97	UTSW	17	18,914,367 (GRCm38)	missense	probably benign	0.05
R7191:Vmn2r97	UTSW	17	18,930,286 (GRCm38)	missense	probably damaging	1.00
R7503:Vmn2r97	UTSW	17	18,928,208 (GRCm38)	missense	probably benign
R7862:Vmn2r97	UTSW	17	18,947,154 (GRCm38)	missense	probably damaging	1.00
R7876:Vmn2r97	UTSW	17	18,929,064 (GRCm38)	missense	probably damaging	0.97
R7890:Vmn2r97	UTSW	17	18,929,540 (GRCm38)	missense	probably benign	0.00
R7936:Vmn2r97	UTSW	17	18,930,400 (GRCm38)	missense	probably damaging	1.00
R7978:Vmn2r97	UTSW	17	18,947,592 (GRCm38)	missense	probably damaging	1.00
R8405:Vmn2r97	UTSW	17	18,914,540 (GRCm38)	critical splice donor site	probably null
R8755:Vmn2r97	UTSW	17	18,947,842 (GRCm38)	missense	probably damaging	1.00
R8790:Vmn2r97	UTSW	17	18,940,210 (GRCm38)	missense	probably damaging	1.00
R8850:Vmn2r97	UTSW	17	18,929,345 (GRCm38)	missense	probably benign	0.00
R9060:Vmn2r97	UTSW	17	18,914,323 (GRCm38)	start codon destroyed	probably null	0.94
R9079:Vmn2r97	UTSW	17	18,929,378 (GRCm38)	missense	probably benign
R9252:Vmn2r97	UTSW	17	18,947,587 (GRCm38)	missense	probably benign	0.00
R9278:Vmn2r97	UTSW	17	18,914,500 (GRCm38)	missense	probably benign	0.00
R9342:Vmn2r97	UTSW	17	18,929,106 (GRCm38)	missense	probably benign
R9422:Vmn2r97	UTSW	17	18,929,071 (GRCm38)	missense	probably benign	0.03
R9496:Vmn2r97	UTSW	17	18,928,965 (GRCm38)	missense	probably damaging	1.00
R9571:Vmn2r97	UTSW	17	18,929,657 (GRCm38)	missense	probably benign
R9601:Vmn2r97	UTSW	17	18,914,508 (GRCm38)	missense	probably benign
R9672:Vmn2r97	UTSW	17	18,929,180 (GRCm38)	missense	probably benign	0.00
R9773:Vmn2r97	UTSW	17	18,947,959 (GRCm38)	missense	probably benign	0.01
R9795:Vmn2r97	UTSW	17	18,947,299 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGTCAGTTTTCCAGGGAGAATG -3'
(R):5'- CTGTGCTGGAAGCCAAGATAG -3'

Sequencing Primer
(F):5'- GGGCCAAACTACATCATTCCTATATG -3'
(R):5'- GATAGAGAATACTTCCATGGCTACC -3'

Posted On

2017-02-15