Mutagenetix > Incidental Mutation

Incidental Mutation 'R5889:Itpr3'

456244

Institutional Source

Beutler Lab

Gene Symbol

Itpr3

Ensembl Gene

ENSMUSG00000042644

Gene Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

tf, Ip3r3, Itpr-3

MMRRC Submission

044090-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5889 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

27057304-27122223 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 27115065 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 2037 (E2037G)

Ref Sequence

ENSEMBL: ENSMUSP00000038150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049308]

AlphaFold

P70227

PDB Structure

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor [X-RAY DIFFRACTION]

Predicted Effect

probably damaging
Transcript: ENSMUST00000049308
AA Change: E2037G

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000038150
Gene: ENSMUSG00000042644
AA Change: E2037G

Domain	Start	End	E-Value	Type
MIR	113	167	7.75e-6	SMART
MIR	174	224	1.16e-4	SMART
MIR	232	288	1.21e-7	SMART
MIR	295	402	9.38e-14	SMART
Pfam:RYDR_ITPR	473	670	7.8e-64	PFAM
low complexity region	881	889	N/A	INTRINSIC
Pfam:RYDR_ITPR	1175	1333	5.8e-16	PFAM
low complexity region	1549	1567	N/A	INTRINSIC
low complexity region	1831	1851	N/A	INTRINSIC
Pfam:RIH_assoc	1863	1973	2.6e-34	PFAM
transmembrane domain	2203	2225	N/A	INTRINSIC
Pfam:Ion_trans	2235	2527	8.1e-20	PFAM
coiled coil region	2631	2660	N/A	INTRINSIC

Meta Mutation Damage Score

0.1903

Coding Region Coverage

1x: 99.9%
3x: 99.5%
10x: 97.6%
20x: 92.3%

Validation Efficiency

100% (63/63)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 57 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930568D16Rik	T	C	2: 35,354,449 (GRCm38)	E297G	probably damaging	Het
Astn1	C	T	1: 158,600,380 (GRCm38)	P707L	possibly damaging	Het
Cep290	T	C	10: 100,499,074 (GRCm38)	S319P	possibly damaging	Het
Chrna4	A	C	2: 181,028,658 (GRCm38)	L435W	probably damaging	Het
Cilp	C	A	9: 65,280,343 (GRCm38)	A1240D	possibly damaging	Het
Col17a1	A	G	19: 47,649,072 (GRCm38)	F1249S	possibly damaging	Het
Creb3l3	T	C	10: 81,092,533 (GRCm38)		probably benign	Het
Cyp4f40	C	A	17: 32,675,757 (GRCm38)	T432N	probably benign	Het
Dsg1c	T	G	18: 20,283,601 (GRCm38)	I853R	possibly damaging	Het
Ebna1bp2	T	A	4: 118,621,423 (GRCm38)	D34E	probably damaging	Het
Edc4	C	T	8: 105,888,022 (GRCm38)	T112I	possibly damaging	Het
Enpep	T	A	3: 129,312,578 (GRCm38)	Y333F	probably damaging	Het
Exoc6	A	G	19: 37,582,245 (GRCm38)	H291R	probably damaging	Het
Fbln5	G	T	12: 101,765,226 (GRCm38)	N236K	probably damaging	Het
Fndc8	A	T	11: 82,898,729 (GRCm38)	T238S	probably damaging	Het
Frem3	T	C	8: 80,614,288 (GRCm38)	V1070A	probably damaging	Het
Gabra4	A	T	5: 71,571,891 (GRCm38)	N515K	possibly damaging	Het
Gemin5	A	G	11: 58,122,355 (GRCm38)	V1422A	possibly damaging	Het
Gm10118	A	G	10: 63,927,111 (GRCm38)		probably benign	Het
Grm5	A	G	7: 87,603,073 (GRCm38)	D177G	probably damaging	Het
Gtf2h4	G	A	17: 35,670,900 (GRCm38)	P147L	possibly damaging	Het
Hgsnat	T	C	8: 25,963,367 (GRCm38)	D265G	probably damaging	Het
Hsd17b4	T	A	18: 50,177,209 (GRCm38)	L513Q	probably damaging	Het
Hsd17b7	A	T	1: 169,955,918 (GRCm38)	M307K	probably benign	Het
Hspa5	T	C	2: 34,774,617 (GRCm38)	V361A	probably damaging	Het
Iqgap2	A	G	13: 95,632,042 (GRCm38)	V1450A	probably benign	Het
Lama5	T	C	2: 180,193,674 (GRCm38)		probably benign	Het
Manba	G	T	3: 135,524,598 (GRCm38)	G311*	probably null	Het
Mettl24	T	A	10: 40,746,490 (GRCm38)	V236E	probably benign	Het
Myh3	A	G	11: 67,086,375 (GRCm38)	D310G	probably damaging	Het
Ncoa4	A	T	14: 32,166,659 (GRCm38)		probably benign	Het
Nop56	G	T	2: 130,275,982 (GRCm38)	R126L	probably damaging	Het
Nos3	C	A	5: 24,368,777 (GRCm38)		probably benign	Het
Olfr156	T	C	4: 43,820,492 (GRCm38)	M290V	possibly damaging	Het
Pcdhga3	T	A	18: 37,676,609 (GRCm38)	V705D	probably damaging	Het
Prom2	C	T	2: 127,529,411 (GRCm38)	A776T	possibly damaging	Het
Prss48	A	G	3: 85,998,185 (GRCm38)	I127T	probably damaging	Het
Rtca	T	C	3: 116,499,583 (GRCm38)	Y193C	possibly damaging	Het
Samd9l	T	C	6: 3,376,460 (GRCm38)	Y267C	probably damaging	Het
Scube3	A	G	17: 28,160,913 (GRCm38)	R272G	possibly damaging	Het
Sprr1a	G	T	3: 92,484,644 (GRCm38)	H17N	probably benign	Het
Ssfa2	T	A	2: 79,657,728 (GRCm38)	D718E	probably damaging	Het
Stard3	G	C	11: 98,375,535 (GRCm38)	Q120H	probably benign	Het
Supt6	A	G	11: 78,212,748 (GRCm38)	I1377T	probably damaging	Het
Svop	A	T	5: 114,065,631 (GRCm38)	S30T	probably benign	Het
Syne2	T	A	12: 76,072,252 (GRCm38)	L5882*	probably null	Het
Tanc2	G	T	11: 105,921,807 (GRCm38)	R1359L	probably benign	Het
Tmc7	A	C	7: 118,566,326 (GRCm38)	L55R	probably benign	Het
Trappc11	G	A	8: 47,519,578 (GRCm38)	A320V	probably benign	Het
Ttll8	G	C	15: 88,933,939 (GRCm38)	P178A	probably damaging	Het
Ttn	T	C	2: 76,730,649 (GRCm38)	E20809G	probably damaging	Het
Tubb2a	A	T	13: 34,075,468 (GRCm38)	V113E	possibly damaging	Het
Ube2d1	A	T	10: 71,259,869 (GRCm38)		probably benign	Het
Usp48	T	C	4: 137,616,412 (GRCm38)	V452A	probably benign	Het
Vldlr	T	A	19: 27,239,664 (GRCm38)	I39N	probably damaging	Het
Wbp1l	C	T	19: 46,654,180 (GRCm38)	R191*	probably null	Het
Zyg11b	C	T	4: 108,237,380 (GRCm38)	W669*	probably null	Het

Other mutations in Itpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Itpr3	APN	17	27,083,629 (GRCm38)	missense	probably benign	0.05
IGL00980:Itpr3	APN	17	27,110,956 (GRCm38)	missense	probably benign
IGL01151:Itpr3	APN	17	27,091,529 (GRCm38)	missense	probably damaging	1.00
IGL01289:Itpr3	APN	17	27,099,765 (GRCm38)	missense	probably damaging	0.99
IGL01403:Itpr3	APN	17	27,118,595 (GRCm38)	missense	probably damaging	0.97
IGL01666:Itpr3	APN	17	27,117,178 (GRCm38)	missense	probably benign	0.02
IGL01897:Itpr3	APN	17	27,111,262 (GRCm38)	missense	probably damaging	1.00
IGL02003:Itpr3	APN	17	27,121,475 (GRCm38)	missense	probably damaging	1.00
IGL02012:Itpr3	APN	17	27,104,095 (GRCm38)	missense	probably benign
IGL02063:Itpr3	APN	17	27,120,023 (GRCm38)	missense	probably benign	0.01
IGL02146:Itpr3	APN	17	27,117,275 (GRCm38)	missense	probably damaging	1.00
IGL02158:Itpr3	APN	17	27,098,442 (GRCm38)	missense	probably damaging	1.00
IGL02177:Itpr3	APN	17	27,099,614 (GRCm38)	missense	possibly damaging	0.74
IGL02247:Itpr3	APN	17	27,098,179 (GRCm38)	missense	probably damaging	1.00
IGL02606:Itpr3	APN	17	27,114,512 (GRCm38)	splice site	probably benign
IGL02651:Itpr3	APN	17	27,106,398 (GRCm38)	missense	probably damaging	0.99
IGL02902:Itpr3	APN	17	27,104,556 (GRCm38)	missense	probably benign	0.21
IGL03001:Itpr3	APN	17	27,089,612 (GRCm38)	splice site	probably benign
IGL03004:Itpr3	APN	17	27,097,978 (GRCm38)	missense	possibly damaging	0.90
IGL03065:Itpr3	APN	17	27,091,933 (GRCm38)	missense	probably damaging	1.00
IGL03117:Itpr3	APN	17	27,119,266 (GRCm38)	missense	probably damaging	1.00
IGL03181:Itpr3	APN	17	27,111,268 (GRCm38)	missense	probably benign
IGL03404:Itpr3	APN	17	27,091,518 (GRCm38)	missense	probably damaging	1.00
Allure	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
alopecia	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98
Beauty	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
Opuesto	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
Paradox	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
Pulchritude	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R0010:Itpr3	UTSW	17	27,120,977 (GRCm38)	missense	probably damaging	1.00
R0055:Itpr3	UTSW	17	27,098,322 (GRCm38)	missense	probably damaging	1.00
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0104:Itpr3	UTSW	17	27,095,992 (GRCm38)	missense	probably benign	0.01
R0195:Itpr3	UTSW	17	27,114,114 (GRCm38)	missense	probably damaging	1.00
R0212:Itpr3	UTSW	17	27,089,319 (GRCm38)	missense	probably damaging	1.00
R0454:Itpr3	UTSW	17	27,113,819 (GRCm38)	missense	probably benign
R0485:Itpr3	UTSW	17	27,111,929 (GRCm38)	missense	probably damaging	0.98
R0501:Itpr3	UTSW	17	27,107,289 (GRCm38)	missense	probably benign	0.09
R0781:Itpr3	UTSW	17	27,110,555 (GRCm38)	missense	probably benign	0.00
R0890:Itpr3	UTSW	17	27,089,011 (GRCm38)	nonsense	probably null
R1028:Itpr3	UTSW	17	27,091,369 (GRCm38)	missense	probably benign	0.04
R1144:Itpr3	UTSW	17	27,114,923 (GRCm38)	missense	probably benign	0.01
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1458:Itpr3	UTSW	17	27,118,372 (GRCm38)	missense	probably benign	0.01
R1463:Itpr3	UTSW	17	27,117,154 (GRCm38)	splice site	probably benign
R1472:Itpr3	UTSW	17	27,114,225 (GRCm38)	missense	probably benign	0.09
R1529:Itpr3	UTSW	17	27,105,485 (GRCm38)	splice site	probably null
R1533:Itpr3	UTSW	17	27,095,560 (GRCm38)	missense	possibly damaging	0.71
R1537:Itpr3	UTSW	17	27,114,147 (GRCm38)	missense	possibly damaging	0.96
R1618:Itpr3	UTSW	17	27,116,607 (GRCm38)	critical splice acceptor site	probably null
R1672:Itpr3	UTSW	17	27,089,013 (GRCm38)	missense	probably benign
R1726:Itpr3	UTSW	17	27,111,690 (GRCm38)	missense	probably damaging	0.96
R1865:Itpr3	UTSW	17	27,120,023 (GRCm38)	missense	probably benign	0.01
R1940:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R2023:Itpr3	UTSW	17	27,102,811 (GRCm38)	missense	possibly damaging	0.76
R2063:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2064:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2065:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2067:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2068:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2219:Itpr3	UTSW	17	27,115,053 (GRCm38)	missense	probably benign
R2248:Itpr3	UTSW	17	27,115,059 (GRCm38)	missense	probably damaging	1.00
R2291:Itpr3	UTSW	17	27,113,579 (GRCm38)	missense	possibly damaging	0.92
R2320:Itpr3	UTSW	17	27,095,915 (GRCm38)	missense	probably benign
R2864:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R2865:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R3778:Itpr3	UTSW	17	27,095,472 (GRCm38)	missense	possibly damaging	0.57
R3881:Itpr3	UTSW	17	27,113,840 (GRCm38)	missense	probably benign	0.01
R3979:Itpr3	UTSW	17	27,091,572 (GRCm38)	missense	probably damaging	1.00
R3979:Itpr3	UTSW	17	27,085,131 (GRCm38)	missense	probably benign	0.23
R4224:Itpr3	UTSW	17	27,107,258 (GRCm38)	missense	probably damaging	1.00
R4259:Itpr3	UTSW	17	27,106,324 (GRCm38)	missense	probably damaging	1.00
R4321:Itpr3	UTSW	17	27,111,974 (GRCm38)	missense	probably benign	0.00
R4466:Itpr3	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
R4493:Itpr3	UTSW	17	27,104,612 (GRCm38)	missense	probably damaging	1.00
R4597:Itpr3	UTSW	17	27,093,283 (GRCm38)	missense	probably damaging	1.00
R4823:Itpr3	UTSW	17	27,085,147 (GRCm38)	missense	probably benign	0.30
R4921:Itpr3	UTSW	17	27,098,005 (GRCm38)	missense	probably damaging	1.00
R4974:Itpr3	UTSW	17	27,083,608 (GRCm38)	missense	probably damaging	0.96
R5063:Itpr3	UTSW	17	27,089,911 (GRCm38)	missense	possibly damaging	0.94
R5079:Itpr3	UTSW	17	27,098,423 (GRCm38)	missense	probably damaging	1.00
R5303:Itpr3	UTSW	17	27,116,689 (GRCm38)	missense	probably benign	0.38
R5518:Itpr3	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
R5521:Itpr3	UTSW	17	27,107,334 (GRCm38)	missense	probably benign	0.09
R5566:Itpr3	UTSW	17	27,115,952 (GRCm38)	missense	possibly damaging	0.71
R5567:Itpr3	UTSW	17	27,103,906 (GRCm38)	missense	possibly damaging	0.66
R5579:Itpr3	UTSW	17	27,113,519 (GRCm38)	missense	probably damaging	1.00
R5610:Itpr3	UTSW	17	27,118,566 (GRCm38)	missense	probably benign	0.42
R5658:Itpr3	UTSW	17	27,107,878 (GRCm38)	missense	possibly damaging	0.74
R5856:Itpr3	UTSW	17	27,106,405 (GRCm38)	missense	probably damaging	1.00
R5872:Itpr3	UTSW	17	27,086,976 (GRCm38)	missense	probably benign	0.02
R5878:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R5907:Itpr3	UTSW	17	27,117,893 (GRCm38)	missense	probably damaging	1.00
R5930:Itpr3	UTSW	17	27,110,921 (GRCm38)	missense	possibly damaging	0.49
R5987:Itpr3	UTSW	17	27,104,601 (GRCm38)	missense	probably damaging	1.00
R6029:Itpr3	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
R6195:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6213:Itpr3	UTSW	17	27,111,200 (GRCm38)	missense	probably benign	0.03
R6233:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6376:Itpr3	UTSW	17	27,095,475 (GRCm38)	missense	possibly damaging	0.94
R6514:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6515:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6516:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6955:Itpr3	UTSW	17	27,121,467 (GRCm38)	missense	probably damaging	1.00
R7002:Itpr3	UTSW	17	27,110,580 (GRCm38)	missense	probably benign	0.00
R7064:Itpr3	UTSW	17	27,089,295 (GRCm38)	missense	probably damaging	1.00
R7257:Itpr3	UTSW	17	27,118,561 (GRCm38)	missense	probably benign	0.00
R7349:Itpr3	UTSW	17	27,107,812 (GRCm38)	splice site	probably null
R7469:Itpr3	UTSW	17	27,121,054 (GRCm38)	missense	possibly damaging	0.74
R7493:Itpr3	UTSW	17	27,094,800 (GRCm38)	missense	probably benign	0.09
R7510:Itpr3	UTSW	17	27,089,039 (GRCm38)	missense	probably damaging	0.97
R7565:Itpr3	UTSW	17	27,110,888 (GRCm38)	missense	probably benign	0.01
R7616:Itpr3	UTSW	17	27,088,977 (GRCm38)	missense	probably damaging	1.00
R7728:Itpr3	UTSW	17	27,098,114 (GRCm38)	missense	probably damaging	1.00
R7779:Itpr3	UTSW	17	27,096,063 (GRCm38)	missense	probably damaging	1.00
R7788:Itpr3	UTSW	17	27,118,597 (GRCm38)	nonsense	probably null
R7871:Itpr3	UTSW	17	27,117,179 (GRCm38)	missense	probably damaging	1.00
R7889:Itpr3	UTSW	17	27,116,777 (GRCm38)	missense	probably damaging	1.00
R7966:Itpr3	UTSW	17	27,112,028 (GRCm38)	critical splice donor site	probably null
R8065:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8067:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8230:Itpr3	UTSW	17	27,107,737 (GRCm38)	critical splice donor site	probably null
R8263:Itpr3	UTSW	17	27,115,913 (GRCm38)	nonsense	probably null
R8264:Itpr3	UTSW	17	27,104,112 (GRCm38)	synonymous	silent
R8269:Itpr3	UTSW	17	27,093,284 (GRCm38)	missense	possibly damaging	0.60
R8271:Itpr3	UTSW	17	27,087,648 (GRCm38)	missense	probably damaging	1.00
R8316:Itpr3	UTSW	17	27,106,225 (GRCm38)	missense	possibly damaging	0.50
R8354:Itpr3	UTSW	17	27,115,919 (GRCm38)	missense	possibly damaging	0.74
R8413:Itpr3	UTSW	17	27,111,926 (GRCm38)	missense	probably damaging	1.00
R8437:Itpr3	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
R8676:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8679:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8846:Itpr3	UTSW	17	27,112,022 (GRCm38)	missense	probably damaging	1.00
R8884:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8885:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8886:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8887:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8888:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8891:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8896:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8975:Itpr3	UTSW	17	27,116,654 (GRCm38)	missense	possibly damaging	0.56
R9025:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9026:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9063:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9087:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9088:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9089:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9090:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9091:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9200:Itpr3	UTSW	17	27,107,662 (GRCm38)	missense	probably damaging	0.99
R9270:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9271:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9294:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R9389:Itpr3	UTSW	17	27,095,925 (GRCm38)	missense	possibly damaging	0.84
R9433:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9434:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9443:Itpr3	UTSW	17	27,105,549 (GRCm38)	missense	probably damaging	1.00
R9472:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9474:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9475:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9476:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9477:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9507:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9508:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9511:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9694:Itpr3	UTSW	17	27,115,953 (GRCm38)	missense	probably damaging	0.99
R9789:Itpr3	UTSW	17	27,089,941 (GRCm38)	missense	probably benign	0.15
V7732:Itpr3	UTSW	17	27,111,026 (GRCm38)	splice site	probably null
V7732:Itpr3	UTSW	17	27,111,024 (GRCm38)	splice site	probably benign
Z1088:Itpr3	UTSW	17	27,113,528 (GRCm38)	missense	possibly damaging	0.50
Z1177:Itpr3	UTSW	17	27,119,987 (GRCm38)	missense	probably damaging	1.00
Z1177:Itpr3	UTSW	17	27,114,929 (GRCm38)	missense	probably damaging	1.00
Z31818:Itpr3	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- CCGACATGACAGTGAGAATGC -3'
(R):5'- CTGCCGTACCATGGAAGAGATG -3'

Sequencing Primer
(F):5'- GCAGAGCGCATCCTCATCAG -3'
(R):5'- GTACCATGGAAGAGATGCCCTC -3'

Posted On

2017-02-15