|Institutional Source||Beutler Lab|
|Gene Name||stathmin-like 3|
|Is this an essential gene?||Possibly non essential (E-score: 0.338)|
|Stock #||R5903 (G1)|
|Chromosomal Location||181306459-181314500 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||T to C at 181308780 bp|
|Amino Acid Change||Lysine to Glutamic Acid at position 78 (K78E)|
|Ref Sequence||ENSEMBL: ENSMUSP00000099334 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000103045]|
|Predicted Effect||possibly damaging
AA Change: K78E
PolyPhen 2 Score 0.810 (Sensitivity: 0.84; Specificity: 0.93)
AA Change: K78E
|Meta Mutation Damage Score||0.0776|
|Coding Region Coverage||
|Validation Efficiency||98% (58/59)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Stmn3||
(F):5'- ACCATCTTGGCACATCCATC -3'
(R):5'- TAACGGCACCCCTTCTTAAC -3'
(F):5'- ATCTTGGCACATCCATCTTTCATC -3'
(R):5'- GTGCTGGAAATAAACCTCTCATCCTG -3'