Incidental Mutation 'R5903:Trdv5'
ID 456465
Institutional Source Beutler Lab
Gene Symbol Trdv5
Ensembl Gene ENSMUSG00000076873
Gene Name T cell receptor delta variable 5
Synonyms Gm6683
MMRRC Submission 044101-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R5903 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 54386119-54386658 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 54386242 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 74 (H74Q)
Ref Sequence ENSEMBL: ENSMUSP00000100458 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000103685]
AlphaFold A0A075B661
Predicted Effect probably benign
Transcript: ENSMUST00000103685
AA Change: H74Q

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000100458
Gene: ENSMUSG00000076873
AA Change: H74Q

DomainStartEndE-ValueType
IGv 35 113 2.06e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000196323
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196615
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.8%
Validation Efficiency 98% (58/59)
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130230L23Rik A G 5: 66,145,661 (GRCm39) V150A unknown Het
Abraxas1 T C 5: 100,965,824 (GRCm39) probably null Het
Actl7a G T 4: 56,743,827 (GRCm39) R118L probably damaging Het
Atg2b T C 12: 105,605,618 (GRCm39) D1449G possibly damaging Het
Atg7 G A 6: 114,683,254 (GRCm39) W439* probably null Het
Atp6v0a2 T A 5: 124,789,343 (GRCm39) I370N probably damaging Het
B4galt1 T C 4: 40,807,760 (GRCm39) D347G probably damaging Het
Baz2b C T 2: 59,790,233 (GRCm39) C660Y probably damaging Het
Ccdc88c T C 12: 100,896,801 (GRCm39) Y1390C probably damaging Het
Cdcp1 G A 9: 123,002,837 (GRCm39) Q745* probably null Het
Cep97 G A 16: 55,739,889 (GRCm39) S185L probably damaging Het
Clec4d A G 6: 123,244,020 (GRCm39) H43R probably damaging Het
Cntn3 T A 6: 102,219,094 (GRCm39) M509L probably benign Het
Cntrob A C 11: 69,200,201 (GRCm39) S564R possibly damaging Het
Cyp2j8 T A 4: 96,395,514 (GRCm39) N37I possibly damaging Het
Edc4 A G 8: 106,617,219 (GRCm39) T1029A probably benign Het
Fhip2b A T 14: 70,829,121 (GRCm39) V64E probably damaging Het
Fmnl1 G T 11: 103,062,270 (GRCm39) probably null Het
Fzd6 T A 15: 38,870,783 (GRCm39) M1K probably null Het
Gle1 C A 2: 29,830,293 (GRCm39) T283N probably benign Het
Hsd17b14 T C 7: 45,215,386 (GRCm39) V161A probably damaging Het
Hsf2 T C 10: 57,380,819 (GRCm39) S218P probably benign Het
Ipo7 T A 7: 109,650,020 (GRCm39) C736S probably damaging Het
Itpkb G T 1: 180,241,540 (GRCm39) V737L probably damaging Het
Itpr1 T C 6: 108,466,758 (GRCm39) probably benign Het
Kcnh8 G T 17: 53,110,364 (GRCm39) V192L possibly damaging Het
Kctd10 G A 5: 114,518,523 (GRCm39) probably benign Het
Kdm3a C A 6: 71,609,234 (GRCm39) probably benign Het
Kif5a T A 10: 127,066,447 (GRCm39) M990L probably benign Het
Klf12 A G 14: 100,260,124 (GRCm39) S202P probably damaging Het
Krt81 T G 15: 101,358,083 (GRCm39) Q390P probably damaging Het
Lrig3 T C 10: 125,844,347 (GRCm39) S604P probably damaging Het
Ms4a1 A T 19: 11,235,612 (GRCm39) V48D probably damaging Het
Mta1 C T 12: 113,100,239 (GRCm39) P688L probably damaging Het
Oas1h T C 5: 121,009,040 (GRCm39) V250A probably damaging Het
Or10c1 A T 17: 37,521,912 (GRCm39) Y277* probably null Het
Or52z13 G T 7: 103,247,128 (GRCm39) G202* probably null Het
P2rx3 T C 2: 84,831,071 (GRCm39) E265G possibly damaging Het
Pdzd8 A G 19: 59,333,718 (GRCm39) I101T possibly damaging Het
Psme4 A T 11: 30,791,589 (GRCm39) N1148I probably benign Het
Rnf213 T C 11: 119,312,195 (GRCm39) L874P probably damaging Het
Sart3 T C 5: 113,889,300 (GRCm39) Y508C probably damaging Het
Sez6l2 T C 7: 126,569,305 (GRCm39) probably benign Het
Slc9b1 C T 3: 135,098,655 (GRCm39) probably benign Het
Stmn3 T C 2: 180,950,573 (GRCm39) K78E possibly damaging Het
Thsd4 T A 9: 60,301,389 (GRCm39) N302I possibly damaging Het
Tubb4b C T 2: 25,113,993 (GRCm39) R77H probably benign Het
Ugt1a6a C T 1: 88,142,845 (GRCm39) P113L probably damaging Het
Unc5a T A 13: 55,147,503 (GRCm39) C438S possibly damaging Het
Zan C A 5: 137,440,396 (GRCm39) C1946F unknown Het
Other mutations in Trdv5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02867:Trdv5 APN 14 54,386,429 (GRCm39) unclassified probably benign
R5878:Trdv5 UTSW 14 54,386,255 (GRCm39) missense probably benign 0.28
R6125:Trdv5 UTSW 14 54,386,298 (GRCm39) missense possibly damaging 0.52
R9070:Trdv5 UTSW 14 54,386,258 (GRCm39) missense probably damaging 1.00
Z1177:Trdv5 UTSW 14 54,386,681 (GRCm39) unclassified probably benign
Z1177:Trdv5 UTSW 14 54,386,145 (GRCm39) missense possibly damaging 0.81
Predicted Primers PCR Primer
(F):5'- AAACTGTGCTCCAGGGGTTTG -3'
(R):5'- GATGCAGACGCTACTATGGC -3'

Sequencing Primer
(F):5'- GTTTGGGTACAGGCTCCC -3'
(R):5'- CTTCTTCACAGACAAGGATGTGCTG -3'
Posted On 2017-02-15